Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population
Open accessAbstract
BACKGROUND/AIMS: Anti-ganglionic nicotinic acetylcholine receptor (gAChR) antibodies are observed in autoimmune diseases, as well as in patients with autoimmune autonomic ganglionopathy. However, the genetic background of anti-gAChR antibodies is unclear. Here, we investigated HLA alleles in autoimmune hepatitis (AIH) patients with or without anti-gAChR antibodies. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 260 patients with type-1 autoimmune hepatitis (AIH) were genotyped for HLA-A, B, DRB1, and DQB1 loci. Anti-gAChR antibodies in the sera form AIH patients were measured using the luciferase immunoprecipitation system, and examined allelic association in patients with or without anti-gAChR antibodies. METHODOLOGY/ METHODS: We detected anti-α3 or -β4 gAChR antibodies in 11.5% (30/260) of patients with AIH. Among AIH patients there was no significant association between HLA-A, B DQB1 alleles and the positivity for anti-gAChR antibodies. Whereas the HLA-DRB1*0403 allele showed a significantly increased frequency in AIH patients with anti-gAChR antibodies compared with those without anti-gAChR antibodies. CONCLUSIONS/SIGNIFICANCE: The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies. Our findings suggest that particular HLA class II molecules might control the development of anti-gAChR antibodies in the autoimmune response to gAChR.
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Anti-gAChR antibodies are associated with autonomic dysfunction (e.g., POTS) in autoimmune rheumatic diseases.
“we noted the possibility that anti-gAChR antibodies are associated with autonomic dysfunction (e.g., POTS) in autoimmune rheumatic diseases.12,13”
From Autoimmune postural orthostatic tachycardia syndrome (2018) · cites this paper as [12]
The cut-off points for the LIPS assay were verified using all data collected in previous studies.
“To evaluate the diagnostic accuracy of this assay, we verified the cut-off points for all data collected in the previous study.12,13”
From Autoimmune postural orthostatic tachycardia syndrome (2018) · cites this paper as [12]
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- Authors
- Maeda, Y., Migita, K., Higuchi, O., Mukaino, A., Furukawa, H., Komori, A., Nakamura, M., Hashimoto, S., Nagaoka, S., Abiru, S., Yatsuhashi, H., Matsuo, H., Kawakami, A., Yasunami, M., & Nakane, S.
- Affiliations
- Nagasaki Kawatana Medical Center (JP)
- Nagasaki Medical Center (JP)
- University of Tsukuba (JP)
- Nagasaki University (JP)
- Kumamoto University (JP)
- Corresponding author
- Migita, Kiyoshi
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-01-25
- Volume
- 11
- Issue
- 1
- Pages
- e0146048
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4726510
- OpenAlex
- W2260235192
- Cited by
- 25
- References
- 28
- Citations by year
- 2024: 3 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Terrestrial Environment Research Center (University of Tsukuba) (submittedVersion, other-oa)
- Funders
- Japan Society for the Promotion of Science (26293076, 25461305)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- HLA-DRB1*0403, HLA class II, autoimmune hepatitis, type 1 autoimmune hepatitis, HLA-DRB1 alleles, autoimmune autonomic ganglionopathy, genetic association, Japanese patients
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Autoantibodies, Autoimmune Diseases, Female, Follow-Up Studies, Gene Frequency, Genes, MHC Class II, Genes, MHC Class I, Genotype, HLA Antigens, HLA-D Antigens, Humans, Japan, Male, Middle Aged, Nerve Tissue Proteins, Receptors, Nicotinic, Comorbidity, Case-Control Studies, Age of Onset, Hepatitis, Autoimmune, Genetic Predisposition to Disease, Asian People, Young Adult, HLA-DRB1 Chains
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