The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial
Open accessAbstract
BACKGROUND: There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, executive function, functional ability and depression in early AD. METHODS AND FINDINGS: This study was a 26-week randomized controlled trial comparing the effects of 150 minutes per week of aerobic exercise vs. non-aerobic stretching and toning control intervention in individuals with early AD. A total of 76 well-characterized older adults with probable AD (mean age 72.9 [7.7]) were enrolled and 68 participants completed the study. Exercise was conducted with supervision and monitoring by trained exercise specialists. Neuropsychological tests and surveys were conducted at baseline,13, and 26 weeks to assess memory and executive function composite scores, functional ability (Disability Assessment for Dementia), and depressive symptoms (Cornell Scale for Depression in Dementia). Cardiorespiratory fitness testing and brain MRI was performed at baseline and 26 weeks. Aerobic exercise was associated with a modest gain in functional ability (Disability Assessment for Dementia) compared to individuals in the ST group (X2 = 8.2, p = 0.02). There was no clear effect of intervention on other primary outcome measures of Memory, Executive Function, or depressive symptoms. However, secondary analyses revealed that change in cardiorespiratory fitness was positively correlated with change in memory performance and bilateral hippocampal volume. CONCLUSIONS: Aerobic exercise in early AD is associated with benefits in functional ability. Exercise-related gains in cardiorespiratory fitness were associated with improved memory performance and reduced hippocampal atrophy, suggesting cardiorespiratory fitness gains may be important in driving brain benefits. TRIAL REGISTRATION: ClinicalTrials.gov NCT01128361.
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Self-citationATS Statement: Guidelines for the Six-Minute Walk Test
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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
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Cited by
Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., & Ward, P. B. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.007 · Cited by 526
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Duggal, N. A., Niemiro, G., Harridge, S. D. R., Simpson, R. J., & Lord, J. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0177-9 · Cited by 436
Modifiable Risk Factors for Alzheimer’s Disease
Edwards III, G. A., Gamez, N., Escobedo Jr., G., Calderon, O., & Moreno-Gonzalez, I. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00146 · Cited by 253
Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235
Physical Exercise and Neuroinflammation in Major Depressive Disorder
Ignácio, Z. M., da Silva, R. S., Plissari, M. E., Quevedo, J., & Réus, G. Z. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01670-1 · Cited by 153
Metadata
- Authors
- Morris, J. K., Vidoni, E. D., Johnson, D. K., Van Sciver, A., Mahnken, J. D., Honea, R. A., Wilkins, H. M., Brooks, W. M., Billinger, S. A., Swerdlow, R. H., & Burns, J. M.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-02-10
- Volume
- 12
- Issue
- 2
- Pages
- e0170547
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2587087311
- Cited by
- 329
- References
- 20
- FWCI
- 20.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Morris, J. K., Vidoni, E. D., Johnson, D. K., Van Sciver, A., Mahnken, J. D., Honea, R. A., Wilkins, H. M., Brooks, W. M., Billinger, S. A., Swerdlow, R. H., & Burns, J. M. (2017). Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial. PLOS ONE. https://doi.org/10.1371/journal.pone.0170547
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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