Exercise and Hippocampal Memory Systems

Voss, Michelle W.; Soto, Carmen; Yoo, Seungwoo; Sodoma, Matthew; Vivar, Carmen; van Praag, Henriette

doi:10.1016/j.tics.2019.01.006

Cited by 235Memory and Neural MechanismsPhysical Activity and HealthNeurogenesis and neuroplasticity mechanisms

Exercise and Hippocampal Memory Systems

Open access

Voss, Michelle W., Soto, Carmen, Yoo, Seungwoo, Sodoma, Matthew, Vivar, Carmen, van Praag, Henriette·2019·Trends in Cognitive Sciences

DOI 10.1016/j.tics.2019.01.006PMC PMC6422697

Open this paper in CoChat — free account

Abstract

No medications prevent or reverse age-related cognitive decline. Physical activity (PA) enhances memory in rodents, but findings are mixed in human studies. As a result, exercise guidelines specific for brain health are absent. Here, we re-examine results from human studies, and suggest the use of more sensitive tasks to evaluate PA effects on age-related changes in the hippocampus, such as relational memory and mnemonic discrimination. We discuss recent advances from rodent and human studies into the underlying mechanisms at both the central and peripheral levels, including neurotrophins and myokines that could contribute to improved memory. Finally, we suggest guidelines for future research to help expedite well-founded PA recommendations for the public.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tics.2019.01.006

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Evidence for exercise benefits on cognition remains variable, probably because of lack of randomized controlled trials across the lifespan with standardized exercise interventions and comparable cognitive assessment methods.
“Of note, evidence for the benefits of exercise on cognition remains variable, probably owing to the lack of randomized controlled trials throughout the lifespan with standardized exercise interventions and comparable methods for cognitive assessment139–142.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [140]
In humans, chronic exercise training does not consistently increase plasma BDNF; studies report no change, an increase, or a decrease.
“whereas chronic exercise training has been shown to not alter140, increase or even decrease plasma levels of BDNF140,145.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [140]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · cited 1× · see citing works
“While other association networks also show reduced functional connectivity with aging, the default network uniquely mirrors the spatial topography of structural connections of the medial temporal lobe and the cortical spread of AD pathology [79], and functional connectivity has been observed to predict risk of later c…”
Background
The Physical Activity Guidelines for Americans
Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018) · JAMA · doi:10.1001/jama.2018.14854 · Cited by 9,755 · cited 4× · see citing works
“If the pace of increased life expectancy [1] and inactivity [2] continues, an unprecedented percentage of future generations may live with cognitive impairment.”
BackgroundResultInfluential
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322 · see citing works
Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
Self-citation
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180 · see citing works
Hippocampal electrical activity and voluntary movement in the rat
Vanderwolf, C. H. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90092-3 · Cited by 1,928 · see citing works
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works
Disruption of Large-Scale Brain Systems in Advanced Aging
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., & Buckner, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.038 · Cited by 1,592 · see citing works
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Pattern separation in the hippocampus
Yassa, M. A., & Stark, C. E. L. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.006 · Cited by 1,544 · see citing works
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422 · see citing works
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353 · see citing works
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345 · see citing works
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble
Kontis, V., Bennett, J. E., Mathers, C. D., Li, G., Foreman, K. J., & Ezzati, M. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32381-9 · Cited by 1,221 · see citing works
Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., Cholerton, B. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.307 · Cited by 1,171 · see citing works
Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial
Nagamatsu, L. S., Chan, A., Davis, J. C., Beattie, B. L., Graf, P., Voss, M. W., Sharma, D., & Liu-Ambrose, T. Y. L. (2013) · Journal of Aging Research · doi:10.1155/2013/861893 · Cited by 1,090 · see citing works
Self-citation
Regulation of Muscle Fiber Type and Running Endurance by PPARδ
Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
Bakker, A., Kirwan, C. B., Miller, M. I., & Stark, C. E. L. (2008) · Science · doi:10.1126/science.1152882 · Cited by 1,050 · see citing works
Bridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
Self-citation
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus
Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works
Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies
Blondell, S. J., Hammersley-Mather, R., & Veerman, J. L. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-510 · Cited by 928 · see citing works
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
Rasmussen, P., Brassard, P., Adser, H., Pedersen, M. V., Leick, L., Hart, E., Secher, N. H., Pedersen, B. K., & Pilegaard, H. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048512 · Cited by 914 · see citing works
The effects of acute exercise on mood, cognition, neurophysiology, and neurochemical pathways: a review.
Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911 · see citing works
A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor
Szuhany, K. L., Bugatti, M., & Otto, M. W. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.10.003 · Cited by 909 · see citing works
VEGF links hippocampal activity with neurogenesis, learning and memory
Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850 · see citing works
The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function.
FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works
Corridors of migrating neurons in the human brain and their decline during infancy
Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H.-H., Wong, M., Gupta, N., Berger, M. S., Huang, E., Garcia-Verdugo, J.-M., et al. (2011) · Nature · doi:10.1038/nature10487 · Cited by 849 · see citing works
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults
Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841 · see citing works
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Sleiman, S. F., Henry, J., Al-Haddad, R., El Hayek, L., Abou Haidar, E., Stringer, T., Ulja, D., Karuppagounder, S. S., Holson, E. B., Ratan, R. R., et al. (2016) · eLife · doi:10.7554/elife.15092 · Cited by 810 · see citing works
Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
Nakashiba, T., Cushman, J. D., Pelkey, K. A., Renaudineau, S., Buhl, D. L., McHugh, T. J., Barrera, V. R., Chittajallu, R., Iwamoto, K. S., McBain, C. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.046 · Cited by 805 · see citing works
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model
Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., et al. (2018) · Science · doi:10.1126/science.aan8821 · Cited by 802 · see citing works
Self-citation
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777 · see citing works
The Impact of Resistance Exercise on the Cognitive Function of the Elderly
CASSILHAS, R. C., VIANA, V. A. R., GRASSMANN, V., SANTOS, R. T., SANTOS, R. F., TUFIK, S., & MELLO, M. T. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318060111f · Cited by 770 · see citing works
Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain
Carro, E., Nuñez, A., Busiguina, S., & Torres-Aleman, I. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02926.2000 · Cited by 762 · see citing works
Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis
Bäckman, L., Jones, S., Berger, A.-K., Laukka, E. J., & Small, B. J. (2005) · Neuropsychology · doi:10.1037/0894-4105.19.4.520 · Cited by 735 · see citing works
Blood BDNF Concentrations Reflect Brain-Tissue BDNF Levels across Species
Klein, A. B., Williamson, R., Santini, M. A., Clemmensen, C., Ettrup, A., Rios, M., Knudsen, G. M., & Aznar, S. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000738 · Cited by 726 · see citing works
A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children
Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., Pontifex, M. B., Raine, L. B., Konkel, A., Hillman, C. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.049 · Cited by 687 · see citing works
Self-citation
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
Heldt, S. A., Stanek, L., Chhatwal, J. P., & Ressler, K. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001957 · Cited by 684 · see citing works
Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis
Beydoun, M. A., Beydoun, H. A., Gamaldo, A. A., Teel, A., Zonderman, A. B., & Wang, Y. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-643 · Cited by 671 · see citing works
Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641 · see citing works
TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634 · see citing works
Running-induced systemic cathepsin B secretion is associated with memory function
Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628 · see citing works
Self-citation
Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults
Yassa, M. A., Lacy, J. W., Stark, S. M., Albert, M. S., Gallagher, M., & Stark, C. E. L. (2011) · Hippocampus · doi:10.1002/hipo.20808 · Cited by 595 · see citing works
Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.001 · Cited by 568 · see citing works
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease
Khan, U. A., Liu, L., Provenzano, F. A., Berman, D. E., Profaci, C. P., Sloan, R., Mayeux, R., Duff, K. E., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3606 · Cited by 561 · see citing works
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Morland, C., Andersson, K. A., Haugen, Ø. P., Hadzic, A., Kleppa, L., Gille, A., Rinholm, J. E., Palibrk, V., Diget, E. H., Kennedy, L. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15557 · Cited by 559 · see citing works
Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
Ding, Q., Vaynman, S., Akhavan, M., Ying, Z., & Gomez-Pinilla, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.084 · Cited by 555 · see citing works
Running enhances spatial pattern separation in mice
Creer, D. J., Romberg, C., Saksida, L. M., van Praag, H., & Bussey, T. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911725107 · Cited by 553 · see citing works
Self-citation
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
Griffin, É. W., Mullally, S. L., Foley, C., Warmington, S. A., O’Mara, S. M., & Kelly, A. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.06.005 · Cited by 543 · see citing works
Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
Scheffer, D. D. L., & Latini, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165823 · Cited by 509 · see citing works
The effects of physical activity and exercise on brain‐derived neurotrophic factor in healthy humans: A review
Huang, T., Larsen, K. T., Ried‐Larsen, M., Møller, N. C., & Andersen, L. B. (2014) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12069 · Cited by 485 · see citing works
The effects of cardiovascular exercise on human memory: a review with meta-analysis
Roig, M., Nordbrandt, S., Geertsen, S. S., & Nielsen, J. B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.012 · Cited by 460 · see citing works
Sex differences in exercise efficacy to improve cognition: a systematic review and meta-analysis of randomized controlled trials in older humans
Barha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.04.002 · Cited by 432 · see citing works
Neurobiological markers of exercise-related brain plasticity in older adults
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., Szabo, A., Phillips, S. M., Wójcicki, T. R., Mailey, E. L., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.021 · Cited by 418 · see citing works
Self-citation
Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial
Sink, K. M., Espeland, M. A., Castro, C. M., Church, T., Cohen, R., Dodson, J. A., Guralnik, J., Hendrie, H. C., Jennings, J., Katula, J., et al. (2015) · JAMA · doi:10.1001/jama.2015.9617 · Cited by 402 · see citing works
Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations
Bidlingmaier, M., Friedrich, N., Emeny, R. T., Spranger, J., Wolthers, O. D., Roswall, J., Körner, A., Obermayer-Pietsch, B. M., Hübener, C., Dahlgren, J., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3059 · Cited by 401 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms
Cassilhas, R. C., Lee, K. S., Fernandes, J., Oliveira, M. G. M., Tufik, S., Meeusen, R., & de Mello, M. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.029 · Cited by 394 · see citing works
A Randomized Controlled Trial of Multicomponent Exercise in Older Adults with Mild Cognitive Impairment
Suzuki, T., Shimada, H., Makizako, H., Doi, T., Yoshida, D., Ito, K., Shimokata, H., Washimi, Y., Endo, H., & Kato, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061483 · Cited by 390 · see citing works
Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment
Nagamatsu, L. S. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.379 · Cited by 385 · see citing works
Vascular hippocampal plasticity after aerobic exercise in older adults.
Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.114 · Cited by 382 · see citing works
Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity
Lacy, J. W., Yassa, M. A., Stark, S. M., Muftuler, L. T., & Stark, C. E. L. (2011) · Learning & Memory · doi:10.1101/lm.1971111 · Cited by 382 · see citing works
Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial.
ten Brinke, L. F., Bolandzadeh, N., Nagamatsu, L. S., Hsu, C. L., Davis, J. C., Miran-Khan, K., & Liu-Ambrose, T. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-093184 · Cited by 380 · see citing works
The Mental Activity and eXercise (MAX) Trial
Barnes, D. E., Santos‐Modesitt, W., Poelke, G., Kramer, A. F., Castro, C. M., Middleton, L. E., & Yaffe, K. S. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.189 · Cited by 376 · see citing works
Segregated Systems of Human Brain Networks
Wig, G. S. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.09.006 · Cited by 351 · see citing works
Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay
Radka, S. F., Hoist, P. A., Fritsche, M., & Altar, C. A. (1996) · Brain Research · doi:10.1016/0006-8993(95)01321-0 · Cited by 348 · see citing works
The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis
Dinoff, A., Herrmann, N., Swardfager, W., Liu, C. S., Sherman, C., Chan, S. W., & Lanctôt, K. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163037 · Cited by 343 · see citing works
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial
Morris, J. K., Vidoni, E. D., Johnson, D. K., Sciver, A. R. V., Mahnken, J. D., Honea, R. A., Wilkins, H., Brooks, W. M., Billinger, S. A., Swerdlow, R. H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170547 · Cited by 331 · see citing works
Can physical exercise in old age improve memory and hippocampal function?
Duzel, E., van Praag, H., & Sendtner, M. (2016) · Brain · doi:10.1093/brain/awv407 · Cited by 329 · see citing works
Self-citation
Monosynaptic inputs to new neurons in the dentate gyrus
Vivar, C., Potter, M. C., Choi, J., Lee, J.-Y., Stringer, T. P., Callaway, E. M., Gage, F. H., Suh, H., & van Praag, H. (2012) · Nature Communications · doi:10.1038/ncomms2101 · Cited by 289 · see citing works
Self-citation
Endocrine Crosstalk Between Skeletal Muscle and the Brain
Delezie, J., & Handschin, C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00698 · Cited by 270 · see citing works
BDNF induction with mild exercise in the rat hippocampus
Soya, H., Nakamura, T., Deocaris, C. C., Kimpara, A., Iimura, M., Fujikawa, T., Chang, H., McEwen, B. S., & Nishijima, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.173 · Cited by 269 · see citing works
Untitled work
Head (2012) · doi:10.1001/archneurol.2011.845 · Cited by 267 · see citing works
A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays
Polacchini, A., Metelli, G., Francavilla, R., Baj, G., Florean, M., Mascaretti, L. G., & Tongiorgi, E. (2015) · Scientific Reports · doi:10.1038/srep17989 · Cited by 263 · see citing works
Functional connectivity: A source of variance in the association between cardiorespiratory fitness and cognition?
Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Malkowski, E., Alves, H., Kim, J., Morris, K. S., White, S. M., Wójcicki, T. R., et al. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.01.005 · Cited by 261 · see citing works
Self-citation
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease
Yuede, C. M., Zimmerman, S., Dong, H., Kling, M. J., Bero, A. W., Holtzman, D. M., Timson, B. F., & Csernansky, J. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.002 · Cited by 250 · see citing works
Physical activity attenuates age-related biomarker alterations in preclinical AD
Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D. F., Cook, D. B., Koscik, R. L., Gallagher, C. L., Dowling, N. M., Carlsson, C. M., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000964 · Cited by 227 · see citing works
Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study
Jonasson, L. S., Nyberg, L. H., Kramer, A. F., Lundquist, A., Riklund, K., & Boraxbekk, C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00336 · Cited by 224 · see citing works
Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging
Voss, M. W., Weng, T. B., Burzynska, A. Z., Wong, C. N., Cooke, G. E., Clark, R., Fanning, J. T., Salerno, E. A., Gothe, N. P., Olson, E. A., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.044 · Cited by 218 · see citing works
Self-citation
Spatial Navigation in Preclinical Alzheimer’s Disease
Allison, S. L., Fagan, A. M., Morris, J. C., & Head, D. M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150855 · Cited by 213 · see citing works
Integrating new findings and examining clinical applications of pattern separation
Leal, S. L., & Yassa, M. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0065-1 · Cited by 213 · see citing works
Neurobiological Changes in the Hippocampus During Normative Aging
Lister, J. P., & Barnes, C. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.125 · Cited by 210 · see citing works
Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
Van der Borght, K., Kóbor‐Nyakas, D. É., Klauke, K., Eggen, B. J. L., Nyakas, C., Van der Zee, E. A., & Meerlo, P. (2009) · Hippocampus · doi:10.1002/hipo.20545 · Cited by 210 · see citing works
Adult hippocampal neurogenesis reduces memory interference in humans: opposing effects of aerobic exercise and depression
Déry, N., Pilgrim, M., Gibala, M. J., Gillen, J. B., Wojtowicz, J. M., MacQUEEN, G. M., & Becker, S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00066 · Cited by 208 · see citing works
Aerobic Fitness and Executive Control of Relational Memory in Preadolescent Children
Chaddock, L., Hillman, C. H., BUCK, S. M., & Cohen, N. J. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e9af48 · Cited by 207 · see citing works
Neurocognitive Aging and the Hippocampus across Species
Leal, S. L., & Yassa, M. A. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.10.003 · Cited by 207 · see citing works
A behavioral analysis of dentate gyrus function
Kesner, R. P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63030-1 · Cited by 204 · see citing works
Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region
Niibori, Y., Yu, T., Epp, J. R., Akers, K. G., Josselyn, S. A., & Frankland, P. W. (2012) · Nature Communications · doi:10.1038/ncomms2261 · Cited by 195 · see citing works
Rapid stimulation of human dentate gyrus function with acute mild exercise
Suwabe, K., Byun, K., Hyodo, K., Reagh, Z. M., Roberts, J. M., Matsushita, A., Saotome, K., Ochi, G., Fukuie, T., Suzuki, K., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805668115 · Cited by 174 · see citing works
Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of A lzheimer's Disease
Tapia‐Rojas, C., Aránguiz, F. C., Varela‐Nallar, L., & Inestrosa, N. C. (2015) · Brain Pathology · doi:10.1111/bpa.12255 · Cited by 168 · see citing works
Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant
Ivy, A. S., Rodriguez, F. G., Garcia, C., Chen, M. J., & Russo‐Neustadt, A. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00044-3 · Cited by 164 · see citing works
Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders
Chirles, T. J., Reiter, K. E., Weiss, L. R., Alfini, A. J., Nielson, K. A., & Smith, J. C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161151 · Cited by 164 · see citing works
Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation
Liu, H., Zhao, G., Cai, K., Zhao, H., & Li-de, S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.030 · Cited by 162 · see citing works
Measuring and Validating the Levels of Brain-Derived Neurotrophic Factor in Human Serum
Naegelin, Y., Dingsdale, H., Säuberli, K., Schädelin, S., Kappos, L., & Barde, Y. (2018) · eNeuro · doi:10.1523/eneuro.0419-17.2018 · Cited by 155 · see citing works
Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice
Lin, T.-W., Shih, Y.-H., Chen, S.-J., Lien, C.-H., Chang, C.-Y., Huang, T.-Y., Chen, S.-H., Jen, C. J., & Kuo, Y.-M. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.12.005 · Cited by 153 · see citing works
Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise
Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., Kolind, S. H., Foxley, S., Jenkinson, M., Nichols, T. E., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.090 · Cited by 152 · cited 1× · see citing works
“However, a study in young to middle-age adults found that anterior hippocampal volume changes from 6 weeks of training that improved fitness increased markers of myelination rather than cerebral blood volume [67].”
Background
Running rewires the neuronal network of adult-born dentate granule cells
Vivar, C., Peterson, B. D., & van Praag, H. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.031 · Cited by 143 · see citing works
Self-citation
Functional network integrity presages cognitive decline in preclinical Alzheimer disease
Buckley, R. F., Schultz, A. P., Hedden, T., Papp, K. V., Hanseeuw, B. J., Marshall, G. A., Sepulcre, J., Smith, E. E., Rentz, D. M., Johnson, K. A., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004059 · Cited by 143 · see citing works
Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women
Currie, J. M. S., Ramsbottom, R., Ludlow, H., Nevill, A. M., & Gilder, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.12.043 · Cited by 135 · see citing works
Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and dorsal CA1 during a temporal ordering for spatial locations task
Hunsaker, M. R., & Kesner, R. P. (2008) · Hippocampus · doi:10.1002/hipo.20455 · Cited by 133 · see citing works
High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats
Freitas, D. A., Rocha‐Vieira, E., Soares, B. A., Nonato, L. F., da Fonseca, S. F., Martins, J. B., Mendonça, V. A., Lacerda, A. C. R., Massensini, A. R., Poortamns, J. R., et al. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.027 · Cited by 131 · see citing works
A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease
Moore, K. M., Girens, R., Larson, S. K., Jones, M. R., Restivo, J. L., Holtzman, D. M., Cirrito, J. R., Yuede, C. M., Zimmerman, S., & Timson, B. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.11.004 · Cited by 129 · see citing works
The concentrations of serum, plasma and platelet BDNF are all increased by treadmill VO2max performance in healthy college men
Hyun-Chul, C., Kim, J., Kim, S.-Y., Son, Y. H., Lee, N., & Jung, S. H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.025 · Cited by 128 · see citing works
Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle
Tang, K., Xia, F. C., Wagner, P. D., & Breen, E. C. (2009) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2009.10.007 · Cited by 127 · see citing works
Aerobic fitness relates to learning on a virtual Morris Water Task and hippocampal volume in adolescents
Herting, M. M., & Nagel, B. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.012 · Cited by 126 · see citing works
Spatial reconstruction by patients with hippocampal damage is dominated by relational memory errors
Watson, P. D., Voss, J. L., Warren, D. E., Tranel, D., & Cohen, N. J. (2013) · Hippocampus · doi:10.1002/hipo.22115 · Cited by 123 · see citing works
The Acute Effects of Aerobic Exercise on the Functional Connectivity of Human Brain Networks
Weng, T. B., Pierce, G. L., Darling, W. G., Falk, D. M., Magnotta, V. A., & Voss, M. W. (2016) · Brain Plasticity · doi:10.3233/bpl-160039 · Cited by 122 · see citing works
Self-citation
Physical activity over a decade modifies age-related decline in perfusion, gray matter volume, and functional connectivity of the posterior default-mode network—A multimodal approach
Boraxbekk, C., Salami, A., Wåhlin, A., & Nyberg, L. H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.12.010 · Cited by 118 · see citing works
Cardiovascular fitness modulates brain activation associated with spatial learning
Holzschneider, K., Wolbers, T., Röder, B., & Hötting, K. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.021 · Cited by 114 · see citing works
Running Changes the Brain: the Long and the Short of It
Vivar, C., & van Praag, H. (2017) · Physiology · doi:10.1152/physiol.00017.2017 · Cited by 114 · see citing works
Self-citation
Aerobic fitness, hippocampal viscoelasticity, and relational memory performance
Schwarb, H. D., Johnson, C. L., Daugherty, A. M., Hillman, C. H., Kramer, A. F., Cohen, N. J., & Barbey, A. K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.061 · Cited by 108 · see citing works
Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years
Vidoni, E. D., Honea, R. A., Billinger, S. A., Swerdlow, R. H., & Burns, J. M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.016 · Cited by 105 · see citing works
Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults
Whiteman, A., Young, D. E., He, X., Chen, T. C., WAGENAAR, R. C., Stern, C. E., & Schön, K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.023 · Cited by 104 · see citing works
Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults.
Kleemeyer, M. M., Kühn, S., Prindle, J., Bodammer, N. C., Brechtel, L., Garthe, A., Kempermann, G., Schaefer, S., & Lindenberger, U. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.026 · Cited by 98 · see citing works
Physical Activity Is Positively Associated with Episodic Memory in Aging
Hayes, S. M., Alosco, M. L., Hayes, J. P., Cadden, M. H., Peterson, K. M., Allsup, K., Forman, D. E., Sperling, R. A., & Verfaellie, M. H. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000910 · Cited by 97 · see citing works
Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice
Zhao, G., Liu, H. L., Zhang, H., & Tong, X. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.038 · Cited by 95 · see citing works
Aerobic fitness enhances relational memory in preadolescent children: the FITKids randomized control trial.
Monti, J. M., Hillman, C. H., & Cohen, N. J. (2012) · Hippocampus · doi:10.1002/hipo.22023 · Cited by 95 · see citing works
Cardiorespiratory Fitness Is Associated With Cognitive Performance in Older But Not Younger Adults
Hayes, S. M., Forman, D. E., & Verfaellie, M. H. (2014) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbu167 · Cited by 93 · see citing works
High Plasticity of New Granule Cells in the Aging Hippocampus
Trinchero, M. F., Büttner, K. A., Cuevas, J. N. S., Temprana, S. G., Fontanet, P., Monzón-Salinas, M. C., Ledda, F., Paratcha, G., & Schinder, A. F. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.064 · Cited by 93 · see citing works
Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer’s disease
Marlatt, M. W., Potter, M. C., Bayer, T. A., van Praag, H., & Lucassen, P. J. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_237 · Cited by 92 · see citing works
Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly
Stein, A. M., da Silva, T. M. V., Coelho, F. G. D. M., Arantes, F. J., Costa, J. L. R., Teodoro, E. F., & Galduróz, J. C. F. (2018) · Dementia & Neuropsychologia · doi:10.1590/1980-57642018dn12-020003 · Cited by 89 · see citing works
Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease
Law, L. L., Rol, R. N., Schultz, S. A., Dougherty, R. J., Edwards, D. F., Koscik, R. L., Gallagher, C. L., Carlsson, C. M., Bendlin, B. B., Zetterberg, H., et al. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.01.001 · Cited by 88 · see citing works
Voluntary Running and Environmental Enrichment Restores Impaired Hippocampal Neurogenesis in a Triple Transgenic Mouse Model of Alzheimers Disease
Rodriguez, J. J., Noristani, H. N., Olabarria, M., Fletcher, J. A., Somerville, T. D. D., Yeh, C., & Verkhratsky, A. (2011) · Current Alzheimer Research · doi:10.2174/156720511797633214 · Cited by 83 · see citing works
Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults
Rosano, C., Guralnik, J. M., Pahor, M., Glynn, N. W., Newman, A. B., Ibrahim, T. S., Erickson, K. I., Cohen, R. A., Shaaban, C. E., MacCloud, R. L., et al. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.11.007 · Cited by 82 · see citing works
Entorhinal volume, aerobic fitness, and recognition memory in healthy young adults: A voxel-based morphometry study
Whiteman, A., Young, D. E., Budson, A. E., Stern, C. E., & Schön, K. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.049 · Cited by 81 · see citing works
Running improves pattern separation during novel object recognition
Bolz, L., Heigele, S., & Bischofberger, J. (2015) · Brain Plasticity · doi:10.3233/bpl-150010 · Cited by 80 · see citing works
Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats
Yau, S., Lau, B. W.-M., Zhang, E.-D., Lee, J. C.-D., Li, A., Lee, T. M.-C., Ching, Y.-P., Xu, A., & So, K. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.07.019 · Cited by 80 · see citing works
Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men
Jung, S. H., Kim, J., Davis, J. M., Blair, S. N., & Hyun-Chul, C. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1658-5 · Cited by 79 · see citing works
Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease
Cho, J., Shin, M., Kim, D., Lee, I., Kim, S., & Kang, H. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000612 · Cited by 77 · see citing works
Acute running stimulates hippocampal dopaminergic neurotransmission in rats, but has no influence on brain-derived neurotrophic factor
Goekint, M., Bos, I., Heyman, E., MEEUSEN, R. R., Michotte, Y. M., & Sarre, S. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00306.2011 · Cited by 76 · see citing works
The Influence of Childhood Aerobic Fitness on Learning and Memory
Raine, L. B., Lee, H., Saliba, B. J., Chaddock‐Heyman, L., Hillman, C. H., & Kramer, A. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072666 · Cited by 76 · see citing works
A new perspective of the hippocampus in the origin of exercise–brain interactions
Rendeiro, C., & Rhodes, J. S. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1665-6 · Cited by 73 · see citing works
Pattern Separation and Completion in Olfaction
Wilson, D. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04017.x · Cited by 68 · see citing works
Does Aerobic Exercise Influence Intrinsic Brain Activity? An Aerobic Exercise Intervention among Healthy Old Adults
Flodin, P., Jonasson, L. S., Riklund, K., Nyberg, L. H., & Boraxbekk, C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00267 · Cited by 67 · see citing works
Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons
Sah, N., Peterson, B. D., Lubejko, S. T., Vivar, C., & van Praag, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-11268-z · Cited by 63 · see citing works
Self-citation
Preferential Targeting of Lateral Entorhinal Inputs onto Newly Integrated Granule Cells
Woods, N. I., Vaaga, C. E., Chatzi, C. A., Adelson, J. D., Collie, M. F., Perederiy, J. V., Tovar, K. R., & Westbrook, G. L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1737-17.2018 · Cited by 62 · see citing works
Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults
Suwabe, K., Hyodo, K., Byun, K., Ochi, G., Fukuie, T., Shimizu, T., Kato, M., Yassa, M. A., & Soya, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-04850-y · Cited by 59 · see citing works
Exercise-mimetic AICAR transiently benefits brain function
Guerrieri, D., & van Praag, H. (2015) · Oncotarget · doi:10.18632/oncotarget.4715 · Cited by 57 · see citing works
Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease
Jensen, C. S., Portelius, E., Siersma, V., Høgh, P., Wermuth, L., Blennow, K., Zetterberg, H., Waldemar, G., Hasselbalch, S. G., & Simonsen, A. H. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000449408 · Cited by 57 · see citing works
Cardiorespiratory fitness is associated with enhanced hippocampal functional connectivity in healthy young adults
Stillman, C. M., Uyar, F., Huang, H., Grove, G., Watt, J. C., Wollam, M. E., & Erickson, K. I. (2018) · Hippocampus · doi:10.1002/hipo.22827 · Cited by 54 · see citing works
Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project
Zavala-Crichton, J. P., Esteban‐Cornejo, I., Solis‐Urra, P., Mora-González, J., Cadenas‐Sánchez, C., Rodríguez‐Ayllón, M., Migueles, J. H., Molina‐García, P., Verdejo‐Román, J., Kramer, A. F., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041101 · Cited by 47 · see citing works
Downstream Consequences of Exercise Through the Action of BDNF
Sleiman, S. F., & Chao, M. V. (2015) · Brain Plasticity · doi:10.3233/bpl-150017 · Cited by 41 · see citing works
Exploring behavioral pattern separation and risk for emotional disorders
Bernstein, E. E., & McNally, R. J. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.08.006 · Cited by 38 · see citing works
Macular Carotenoids, Aerobic Fitness, and Central Adiposity Are Associated Differentially with Hippocampal-Dependent Relational Memory in Preadolescent Children
Hassevoort, K. M., Khazoum, S. E., Walker, J. A., Barnett, S. M., Raine, L. B., Hammond, B. R., Renzi‐Hammond, L. M., Kramer, A. F., Khan, N. A., Hillman, C. H., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.01.016 · Cited by 36 · see citing works
Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells
Moon, H. Y., Javadi, S., Stremlau, M. H., Yoon, K. J., Becker, B., Kang, S.-U., Zhao, X., & van Praag, H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.041 · Cited by 34 · see citing works
Translating the impact of exercise on cognition: Methodological issues in animal research
Hatchard, T., Ting, J., & Messier, C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.043 · Cited by 33 · see citing works
Examining the Effects of Exercise on Pattern Separation and the Moderating Effects of Mood Symptoms
Bernstein, E. E., & McNally, R. J. (2018) · Behavior Therapy · doi:10.1016/j.beth.2018.09.007 · Cited by 30 · see citing works
FMRI activity during associative encoding is correlated with cardiorespiratory fitness and source memory performance in older adults
Hayes, S. M., Hayes, J. P., Williams, V. J., Liu, H., & Verfaellie, M. H. (2017) · Cortex · doi:10.1016/j.cortex.2017.01.002 · Cited by 28 · see citing works
Pre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders
Pfeil, J. M., Böhringer, D., Deissler, H. L., Faerber, L., Goepfert, J. C., Heiduschka, P., Kleeberger, S. M., Klettner, A., Krohne, T. U., Schneiderhan‐Marra, N., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145375 · Cited by 25 · see citing works
Memory systems
Eichenbaum, H. (2010) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.49 · Cited by 24 · see citing works
Maximal Fitness Testing in Sedentary Elderly at Substantial Risk of Disability: LIFE-P Study Experience
Church, T. S., Gill, T. M., Newman, A. B., Blair, S. N., Earnest, C. P., & Pahor, M. (2008) · Journal of Aging and Physical Activity · doi:10.1123/japa.16.4.408 · Cited by 23 · see citing works
Physical Activity Is Associated with Reduced Implicit Learning but Enhanced Relational Memory and Executive Functioning in Young Adults
Stillman, C. M., Watt, J. C., Grove, G., Wollam, M. E., Uyar, F., Mataró, M., Cohen, N. J., Howard, D. V., Howard, J. H., & Erickson, K. I. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162100 · Cited by 22 · see citing works
Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer’s disease
Fernandez, A. M., Santi, A., & Aleman, I. T. (2018) · Brain Plasticity · doi:10.3233/bpl-180071 · Cited by 22 · see citing works
Intact CA3 in the hippocampus is only sufficient for contextual behavior based on well‐learned and unaltered visual background
Ahn, J., & Lee, I. (2014) · Hippocampus · doi:10.1002/hipo.22292 · Cited by 20 · see citing works
Neural maturation enhanced by exercise-induced extracellular derivatives
Moon, H. Y., Yoon, K. J., Lee, W. S., Cho, H.-S., Kim, D., & Kim, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-60930-6 · Cited by 14 · see citing works
Remodeling of myelinated fibers and internal capillaries in distal peripheral nerves following aerobic exercise in aged rats
Sakita, M., Murakami, S., Fujino, H., Hayashi, S., Kameyama, K., Saito, T., & Kumagai, S. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00257.2018 · Cited by 13 · see citing works
Hypothesized Mechanisms Through Which Exercise May Attenuate Memory Interference
Crawford, L. K., Li, H., Zou, L., Wei, G., & Loprinzi, P. D. (2020) · Medicina · doi:10.3390/medicina56030129 · Cited by 12 · see citing works
The orphan nuclear receptor TLX: an emerging master regulator of cross-talk between microglia and neural precursor cells
Lucassen, P. J., van Dam, A., Kandel, P., Bielefeld, P., Kőrösi, A., Fitzsimons, C. P., & Maletić‐Savatić, M. (2019) · Neuronal Signaling · doi:10.1042/ns20180208 · Cited by 6 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

[4]Leshner AI (2017) Preventing Cognitive Decline and Dementia: A Way Forward. 28650595
[161]Rendeiro C and Rhodes JS (2018) A new perspective of the hippocampus in the origin of exercise-brain interactions. Brain Struct Funct. 29671055
[163]Suwabe K (2018) Rapid stimulation of human dentate gyrus function with acute mild exercise. Proc Natl Acad Sci U S A. PMC6187140 30249651

Sorted by citations

Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927 · see citing works
Self-citation
Exercise hormone irisin is a critical regulator of cognitive function
Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00438-z · Cited by 403 · see citing works
The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works
Exercise sustains the hallmarks of health
Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270 · see citing works
Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration
Pluvinage, J. V., & Wyss-Coray, T. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0255-9 · Cited by 191 · see citing works
Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease
Gaitán, J. M., Moon, H. Y., Stremlau, M., Dubal, D. B., Cook, D. B., Okonkwo, O. C., & van Praag, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.660181 · Cited by 160 · see citing works
Protective actions of exercise-related FNDC5/irisin in memory and Alzheimer's disease
de Freitas, G. B., Lourenco, M. V., & De Felice, F. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15039 · Cited by 120 · see citing works
α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity
Letsinger, A. C., Gu, Z., & Yakel, J. L. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2021.11.006 · Cited by 74 · see citing works

Authors: Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H.
Affiliations: University of Iowa (US)
Instituto Politécnico Nacional (MX)
Florida Atlantic University (US)
Corresponding author: Voss, Michelle W.
ORCID: Voss, Michelle W.
Yoo, Seungwoo
Sodoma, Matthew
Vivar, Carmen
Venue: Trends in Cognitive Sciences
Publisher: Elsevier BV
Published: 2019-04
Volume: 23
Issue: 4
Pages: 318-333
ISSN: 1364-6613 (ISSN-L)
DOI: 10.1016/j.tics.2019.01.006
PMC: PMC6422697
OpenAlex: W2913278175
Cited by: 235
References: 170
Citations by year: 2026: 23 · 2025: 33 · 2024: 35 · 2023: 41 · 2022: 33 · 2021: 30 · 2020: 22 · 2019: 14 · 2018: 3
FWCI: 3.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 348 d)
Locations: Trends in Cognitive Sciences (acceptedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Consejo Nacional de Ciencia y Tecnología (INFR-2016 268247)
Fundación Miguel Alemán, A.C.
National Institute on Aging
National Institute of General Medical Sciences (RO1 AG055500, T32 GM108540)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Physiology › Physical Activity and Health
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: physical activity, hippocampus, age-related cognitive decline, memory, relational memory, mnemonic discrimination, neurotrophins, myokines, brain health, exercise recommendations, neuroplasticity
MeSH terms: Aging, Animals, Hippocampus, Humans, Memory, Exercise

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exercise and Hippocampal Memory Systems

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks