Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo
Open accessAbstract
Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue. Accordingly, a trend was noted for an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor. Thus, this study suggests an effect of ghrelin on human thyrocytes and thereby emphasizes the relevance of examining whether ghrelin also influences the metabolic homeostasis through altered thyroid hormone production.
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A thyroid cell study in primary cultures of human thyrocytes showed a ghrelin-induced decrease in TSH-induced production of thyroglobulin and mRNA expression of thyroperoxidase as well as a trend towards inhibition of TSH-stimulated expression of sodium-iodine symporter and TSH-receptor.
“A thyroid cell study in primary cultures of human thyrocytes showed a ghrelin-induced decrease in the TSH-induced production of thyroglobulin and mRNA expression of thyroperoxidase as well as a trend towards an inhibition of TSH-stimulated expression of the sodium-iodine symporter and the TSH-receptor (Barington et al., 2017).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Barington et al., 2017
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- Authors
- Barington, M., Brorson, M. M., Hofman-Bang, J., Rasmussen, Å. K., Holst, B., & Feldt-Rasmussen, U.
- Affiliations
- Copenhagen University Hospital (DK)
- University of Copenhagen (DK)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-09-20
- Volume
- 12
- Issue
- 9
- Pages
- e0184992
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC5607171
- OpenAlex
- W2755099123
- Cited by
- 16
- References
- 62
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 8 · 2020: 3 · 2018: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Rigshospitalet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- ghrelin, thyroid-stimulating hormone, thyroid follicular cells, thyroglobulin, thyroid peroxidase, sodium iodide symporter, TSH receptor, thyroid hormone synthesis, thyroid hormone regulation
- MeSH terms
- Cell Differentiation, Cells, Cultured, Humans, Receptors, Thyrotropin, Thyroglobulin, Thyroid Gland, Thyrotropin, Ghrelin, Receptors, Ghrelin
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