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Probing the role of PPARγ in the regulation of late-onset Alzheimer’s disease-associated genes

Barrera, Julio, Subramanian, Shobana, Chiba-Falek, Ornit·2018·PLOS ONE
DOI 10.1371/journal.pone.0196943
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  2. AC Naj, Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease, Nat Genet, 43, 436, 10.1038/ng.801 · DOI · Paper page
  3. P Hollingworth, Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease, Nat Genet, 43, 429, 10.1038/ng.803 · DOI · Paper page
  4. JC Lambert, 2009, Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nature genetics, 41, 1094, 10.1038/ng.439 · DOI · Paper page
  5. L Jones, 2010, Genetic evidence for the involvement of lipid metabolism in Alzheimer's disease, Biochimica et biophysica acta, 1801, 754, 10.1016/j.bbalip.2010.04.005 · DOI
  6. SL Rosenthal, 2014, Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways, Curr Genet Med Rep, 2, 85, 10.1007/s40142-014-0034-x · DOI
  7. A Singleton, 2004, The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases, Human molecular genetics, 13, R123, 10.1093/hmg/ddh093 · DOI
  8. C Linnertz, 2014, The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes, Alzheimers Dement, 10, 541, 10.1016/j.jalz.2013.08.280 · DOI
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  12. F Zou, 2012, Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants, PLoS genetics, 8, e1002707, 10.1371/journal.pgen.1002707 · DOI
  13. S Villapol, 2017, Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation, Cell Mol Neurobiol
  14. W Cai, 2017, Peroxisome proliferator-activated receptor gamma (PPARgamma): A master gatekeeper in CNS injury and repair, Prog Neurobiol
  15. C Janani, 2015, PPAR gamma gene—a review, Diabetes Metab Syndr, 9, 46, 10.1016/j.dsx.2014.09.015 · DOI · Paper page
  16. YC Chen, 2012, Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and neurodegenerative disorders, Mol Neurobiol, 46, 114, 10.1007/s12035-012-8259-8 · DOI
  17. A Grupe, 2007, Evidence for novel susceptibility genes for late-onset Alzheimer’s disease from a genome-wide association study of putative functional variants, Human Molecular Genetics, 16, 865, 10.1093/hmg/ddm031 · DOI · Paper page
  18. R Abraham, 2008, A genome-wide association study for late-onset Alzheimer’s disease using DNA pooling, BMC Medical Genomics, 1, 44, 10.1186/1755-8794-1-44 · DOI · Paper page
  19. L Bertram, 2008, Genome-wide association analysis reveals putative Alzheimer’s disease susceptibility loci in addition to APOE, American Journal of Human Genetics, 83, 623, 10.1016/j.ajhg.2008.10.008 · DOI · Paper page
  20. GW Beecham, 2009, Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease, American Journal of Human Genetics, 84, 35, 10.1016/j.ajhg.2008.12.008 · DOI · Paper page
  21. MM Carrasquillo, 2009, Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer’s disease, Nature Genetics, 41, 192, 10.1038/ng.305 · DOI · Paper page
  22. D Harold, 2009, Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease, Nature Genetics, 41, 1088, 10.1038/ng.440 · DOI · Paper page
  23. JC Lambert, 2009, Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nature Genetics, 41, 1094, 10.1038/ng.439 · DOI · Paper page
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  25. S Seshadri, 2010, Genome-wide analysis of genetic loci associated with Alzheimer disease, JAMA, 303, 1832, 10.1001/jama.2010.574 · DOI · Paper page
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  32. M Cifdaloz, 2017, Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1, Nat Commun, 8, 2249, 10.1038/s41467-017-02353-y · DOI
  33. K Lewis, 2017, RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner, Molecular and cellular biology, 37, 10.1128/MCB.00128-17 · DOI
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  35. M Musicco, 2013, Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study, Neurology, 81, 322, 10.1212/WNL.0b013e31829c5ec1 · DOI · Paper page
  36. M Yarchoan, 2017, Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology, J Alzheimers Dis, 56, 699, 10.3233/JAD-160977 · DOI
  37. J Ott, 2000, Predicting the range of linkage disequilibrium, Proc Natl Acad Sci U S A, 97, 2, 10.1073/pnas.97.1.2 · DOI

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Metadata

Authors
Barrera, J., Subramanian, S., & Chiba-Falek, O.
ORCID
Chiba-Falek, Ornit
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2018-05-03
Volume
13
Issue
5
Pages
e0196943
ISSN
1932-6203
DOI
10.1371/journal.pone.0196943
Cited by
21
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
National Institute on Aging (R01AG040370, R01AG057522)

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