Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease
Open accessAbstract
No treatment strategies effectively limit the progression of Alzheimer's disease (AD), a common and debilitating neurodegenerative disorder. The absence of viable treatment options reflects the fact that the pathophysiology and genotypic causes of the disease are not well understood. The advent of genome-wide association studies (GWAS) has made it possible to broadly investigate genotypic alterations driving phenotypic occurrences. Recent studies have associated single nucleotide polymorphisms (SNPs) in two paralogous scaffolding proteins, NEDD9 and CASS4, and the kinase PTK2B, with susceptibility to late-onset AD (LOAD). Intriguingly, NEDD9, CASS4, and PTK2B have been much studied as interacting partners regulating oncogenesis and metastasis, and all three are known to be active in the brain during development and in cancer. However, to date, the majority of studies of these proteins have emphasized their roles in the directly cancer relevant processes of migration and survival signaling. We here discuss evidence for roles of NEDD9, CASS4 and PTK2B in additional processes, including hypoxia, vascular changes, inflammation, microtubule stabilization and calcium signaling, as potentially relevant to the pathogenesis of LOAD. Reciprocally, these functions can better inform our understanding of the action of NEDD9, CASS4 and PTK2B in cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous SNPs in the CASS4 locus have been linked to AD.
“Although numerous singlenucleotide polymorphisms (SNPs) in the CASS4 locus have been linked to AD (Beck et al., 2014; Bellenguez et al., 2022; EADB et al., 2026; Lambert et al., 2013; Lin et al., 2017; Schwartzentruber et al., 2021)”
From Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis (2026) · cites this paper as Beck et al., 2014
The Introduction’s genetic-evidence section reports that one CASS4 SNP, rs7274581, was associated with late-onset AD at genome-wide significance. Table 1 likewise lists only that CASS4 SNP. The paper therefore supports a CASS4 SNP association, but not the claim that numerous SNPs in the locus have been linked to AD. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPTK2B encodes the protein PYK2 and is a suggested CASS4-binding partner.
“Moreover, mutations in the focal adhesion gene PTK2B , which encodes the protein PYK2 and is a suggested CASS4binding partner (Barrett et al., 2013; Beck et al., 2014), have also been linked to increased AD risk in GWAS studies (Lambert et al., 2013; Lin et al., 2017; Ramos de Matos et al., 2018; Schwartzentruber et al., 2021; Wang et al., 2015b).”
From Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis (2026) · cites this paper as Beck et al., 2014
Pyk2 and CASS4 are members of the FAK and CAS families of proteins that interact physically and mediate cell adhesion signalling.
“Pyk2 and CASS4 are members of the FAK and CAS families of proteins that interact physically and mediate cell adhesion signalling [8].”
From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works
A general framework for estimating the relative pathogenicity of human genetic variants
Kircher, M., Witten, D. M., Jain, P., O'Roak, B. J., Cooper, G. M., & Shendure, J. (2014) · Nature Genetics · doi:10.1038/ng.2892 · Cited by 6,183 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459 · see citing works
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works
<i>TREM2</i> Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works
Focal adhesion kinase: in command and control of cell motility
Mitra, S. K., Hanson, D. R., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,586 · see citing works
Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works
Motzer, R. J., Bander, N. H., & Nanus, D. M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609193351207 · Cited by 2,239 · see citing works
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works
US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008
Egan, B. M. (2010) · JAMA · doi:10.1001/jama.2010.650 · Cited by 2,197 · see citing works
Amyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works
The Pathobiology of Vascular Dementia
Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Cohen, H. T., & McGovern, F. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043172 · Cited by 1,575 · see citing works
Lev, S., Moreno, H., Martinez, R., Canoll, P., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., & Schlessinger, J. (1995) · Nature · doi:10.1038/376737a0 · Cited by 1,381 · see citing works
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works
The GSK3 hypothesis of Alzheimer’s disease
Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191 · see citing works
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086 · see citing works
Demuro, A., Mina, E. W., Kayed, R., Milton, S. C. F., Parker, I., & Glabe, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500997200 · Cited by 1,038 · see citing works
Tau pathology in Alzheimer disease and other tauopathies
Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works
Review Article: Genetics of Alzheimer Disease
Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029 · see citing works
Biomarker Modeling of Alzheimer’s Disease
Jack, C. R., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.12.003 · Cited by 1,002 · see citing works
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
Hanger, D. P., Anderton, B. H., & Noble, W. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.003 · Cited by 965 · see citing works
Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
Sanz‐Moreno, V., Gadéa, G., Ahn, J., Paterson, H., Marra, P., Pinner, S. E., Sahai, E. A., & Marshall, C. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.043 · Cited by 959 · see citing works
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
Đikić, I., Tokiwa, G. Y., Lev, S., Courtneidge, S. A., & Schlessinger, J. (1996) · Nature · doi:10.1038/383547a0 · Cited by 955 · see citing works
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 947 · see citing works
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas
Sawada, Y., Tamada, M., Dubin‐Thaler, B. J., Cherniavskaya, O., Sakai, R., Tanaka, S., & Sheetz, M. P. (2006) · Cell · doi:10.1016/j.cell.2006.09.044 · Cited by 945 · see citing works
HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium
Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890 · see citing works
Self-citationAppraising the brain's energy budget
Raichle, M. E., & Gusnard, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172399499 · Cited by 888 · see citing works
Alonso, A. D. C., Grundke-Iqbal, I., & Iqbal, K. (1996) · Nature Medicine · doi:10.1038/nm0796-783 · Cited by 859 · see citing works
The Genetics of Alzheimer Disease: Back to the Future
Bertram, L., Lill, C. M., & Tanzi, R. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.013 · Cited by 834 · see citing works
Aggregation of vascular risk factors and risk of incident Alzheimer disease
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790 · see citing works
Angiotensin II revisited: new roles in inflammation, immunology and aging
Benigni, A., Cassis, P., & Remuzzi, G. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000080 · Cited by 757 · see citing works
The acetylation of tau inhibits its function and promotes pathological tau aggregation
Cohen, T. J., Guo, J. L., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q., & Lee, V. M. Y. (2011) · Nature Communications · doi:10.1038/ncomms1255 · Cited by 724 · see citing works
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
Crowley, S. D., Gurley, S. B., Herrera, M., Ruiz, P., Griffiths, R., Kumar, A. P., Kim, H., Smithies, O., Le, T. H., & Coffman, T. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605545103 · Cited by 706 · see citing works
Animal models of Alzheimer's disease and frontotemporal dementia
Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2420 · Cited by 676 · see citing works
Untreated Blood Pressure Level Is Inversely Related to Cognitive Functioning: The Framingham Study
Elias, M. F., Wolf, P. A., D’Agostino, R. B., Cobb, J. L., & White, L. R. (1993) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116868 · Cited by 652 · see citing works
Emerging roles of Wnts in the adult nervous system
Inestrosa, N. C., & Arenas, E. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2755 · Cited by 611 · see citing works
Elmer, P. J., Obarzanek, E., Vollmer, W. M., Simons-Morton, D., Stevens, V. J., Young, D. R., Lin, P.-H., Champagne, C., Harsha, D. W., Svetkey, L. P., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-7-200604040-00007 · Cited by 596 · see citing works
Coon, K. D., Myers, A. J., Craig, D. W., Webster, J. A., Pearson, J. V., Lince, D. H., Zismann, V. L., Beach, T. G., Leung, D., Bryden, L., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0419 · Cited by 569 · see citing works
Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C., & Holtzman, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220484110 · Cited by 556 · see citing works
Identification of a set of genes with developmentally down-regulated expression in the mouse brain
Kumar, S., Tomooka, Y., & Noda, M. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91747-e · Cited by 552 · see citing works
Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics
Ulrich, C. M., Bigler, J., & Potter, J. D. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1801 · Cited by 550 · see citing works
Cairns, P. (2011) · Cancer Biomarkers · doi:10.3233/cbm-2011-0176 · Cited by 500 · see citing works
Presenilins and -Secretase: Structure, Function, and Role in Alzheimer DiseasePreprint
Strooper, B. D., Iwatsubo, T., & Wolfe, M. S. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006304 · Cited by 465 · see citing works
RAFTK/Pyk2-mediated cellular signalling
Avraham, H. K., Park, S., Schinkmann, K. A., & Avraham, S. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00076-5 · Cited by 459 · see citing works
Identification of genes that regulate epithelial cell migration using an siRNA screening approach
Simpson, K., Selfors, L., Bui, J., Reynolds, A., Leake, D., Khvorova, A., & Brugge, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1762 · Cited by 448 · see citing works
Tau interacts with src-family non-receptor tyrosine kinases
Lee, G. S., Newman, S. T., Gard, D. L., Band, H., & Panchamoorthy, G. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.21.3167 · Cited by 445 · see citing works
Saykin, A. J., Shen, L., Foroud, T. M., Potkin, S. G., Swaminathan, S., Kim, S., Risacher, S. L., Nho, K., Huentelman, M. J., Craig, D. W., et al. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.03.013 · Cited by 442 · see citing works
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
Ly, P. T. T., Wu, Y., Zou, H., Wang, R., Zhou, W., Kinoshita, A., Zhang, M., Yang, Y., Cai, F., Woodgett, J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64516 · Cited by 442 · see citing works
Vuori, K., Hirai, H., Aizawa, S., & Ruoslahti, E. I. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2606 · Cited by 421 · see citing works
Phosphorylation of Tau by Fyn: Implications for Alzheimer's Disease
Lee, G. S., Thangavel, R., Sharma, V. M., Litersky, J. M., Bhaskar, K., Fang, S. M., Lana, H., Andreadis, A., Hoesen, G. W. V., & Ksiȩżak-Reding, H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4162-03.2004 · Cited by 414 · see citing works
Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E. B., Xie, S. X., Joyce, S., Li, C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406361102 · Cited by 413 · see citing works
TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1
Peng, Q., Malhotra, S., Torchia, J. A., Kerr, W. G., Coggeshall, K. M., & Humphrey, M. B. (2010) · Science Signaling · doi:10.1126/scisignal.2000500 · Cited by 413 · see citing works
Calcium Signaling and Amyloid Toxicity in Alzheimer Disease
Demuro, A., Parker, I., & Stutzmann, G. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.080895 · Cited by 409 · see citing works
Slooter, A. J. C., Cruts, M., Kalmijn, S., Hofman, A., Breteler, M. M. B., Van Broeckhoven, C., & van Duijn, C. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.964 · Cited by 399 · cited 4× · see citing works
“Additionally, a significant difference (genotype: P = 0.047; allele frequency: P = 0.024) between the two groups was maintained even if only subjects without the APOE ε4 allele were considered [13].”
BackgroundInfluentialInflammation and Alzheimer’s disease
Lee, Y.-J., Han, S. B., Nam, S.-Y., Oh, K.-W., & Hong, J. T. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1006-7 · Cited by 396 · see citing works
GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.026 · Cited by 383 · see citing works
Sasaki, H., Nagura, K., Ishino, M., Tobioka, H., Kotani, K., & Sasaki, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21206 · Cited by 382 · see citing works
Combs, C. K., Johnson, D. E., Cannady, S. B., Lehman, T. M., & Landreth, G. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-00928.1999 · Cited by 349 · see citing works
Extended results of the Alzheimer's disease anti‐inflammatory prevention trial
Breitner, J. C. S., Baker, L. D., Montine, T. J., Meinert, C. L., Lyketsos, C. G., Ashe, K. H., Brandt, J., Craft, S., Evans, D. A., Green, R. C., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.12.014 · Cited by 327 · see citing works
Mechanisms underlying hypoxia-induced neuronal apoptosis
Banasiak, K. J., Xia, Y., & Haddad, G. G. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00011-3 · Cited by 302 · see citing works
Biron, K. E., Dickstein, D. L., Gopaul, R., & Jefferies, W. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023789 · Cited by 300 · see citing works
Primary Cilia in the Developing and Mature Brain
Guemez-Gamboa, A., Coufal, N. G., & Gleeson, J. G. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.024 · Cited by 296 · cited 1× · see citing works
“Further interactions between NEDD9 and AURKA in G0/G1 cells regulate integrity of the cell cilium [84], a structure important for brain patterning and function [85, 86] that is organized around a microtubule-based axoneme.”
BackgroundIntegrin signalling adaptors: not only figurants in the cancer story
Cabodi, S., Leal, M. D. P. C., Stefano, P. D., & Defilippi, P. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2967 · Cited by 291 · see citing works
Goedert, M., Cohen, E. S., Jakes, R., & Cohen, P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81418-l · Cited by 272 · see citing works
PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21
Goate, A., Owen, M., James, L., Mullan, M., Rossor, M., Haynes, A., Farrall, M., Lai, L. C., Roques, P., Williamson, R., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91725-x · Cited by 270 · see citing works
Human-Specific Transcriptional Networks in the Brain
Konopka, G., Friedrich, T., Davis‐Turak, J., Winden, K. D., Oldham, M. C., Gao, F., Chen, L., Wang, G.-Z., Luo, R., Preuss, T. M., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.034 · Cited by 264 · see citing works
Primary cilia in neurodevelopmental disorders
Valente, E. M., Rosti, R. O., Gibbs, E., & Gleeson, J. G. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.247 · Cited by 254 · see citing works
Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapyPreprint
Logue, J. S., & Morrison, D. K. (2012) · Genes & Development · doi:10.1101/gad.186965.112 · Cited by 252 · see citing works
Calkins, M. J., & Reddy, P. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.01.007 · Cited by 244 · see citing works
Genome-wide association study of Alzheimer's disease
Kamboh, M. I., Demirci, F. Y., Wang, X., Minster, R. L., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Saykin, A. J., Initiative, A. D. N., Jun, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.45 · Cited by 242 · see citing works
Pugacheva, E. N., & Golemis, E. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1309 · Cited by 241 · see citing works
Self-citationAre NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment?
Imbimbo, B. P. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00019 · Cited by 240 · see citing works
Does vascular pathology contribute to Alzheimer changes?
Kalaria, R. N., Akinyemi, R., & Ihara, M. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.032 · Cited by 238 · see citing works
Corneveaux, J. J., Myers, A. J., Allen, A. N., Pruzin, J. J., Ramirez, M., Engel, A., Nalls, M. A., Chen, K., Lee, W., Chewning, K., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq221 · Cited by 237 · see citing works
Law, S. F., Estojak, J., Wang, B., Mysliwiec, T. H., Kruh, G. D., & Golemis, E. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3327 · Cited by 230 · see citing works
Self-citationDisease-related Modifications in Tau Affect the Interaction between Fyn and Tau
Bhaskar, K., Yen, S.-H. C., & Lee, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505895200 · Cited by 223 · see citing works
Morris, M. C., Scherr, P. A., Hebert, L. E., Glynn, R. J., Bennett, D. A., & Evans, D. A. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1640 · Cited by 217 · see citing works
Savaskan, E., Höck, C., Olivieri, G., Bruttel, S., Rosenberg, C., Hulette, C., & Müller-Spahn, F. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00259-1 · Cited by 217 · see citing works
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
Kitamura, T., Asai, N., Enomoto, A., Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1695 · Cited by 212 · see citing works
Antihypertensive drugs decrease risk of Alzheimer disease
Yaşar, S., Xia, J., Yao, W., Furberg, C. D., Xue, Q., Mercado, C. I., Fitzpatrick, A. L., Fried, L. P., Kawas, C. H., Sink, K. M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a35228 · Cited by 212 · see citing works
Blaukat, A., Ivanković-Dikić, I., Gronroos, E. C., Dolfi, F., Tokiwa, G. Y., Vuori, K., & Đikić, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14893 · Cited by 208 · see citing works
Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins
Ivanković-Dikić, I., Gronroos, E. C., Blaukat, A., Barth, B. U., & Đikić, I. (2000) · Nature Cell Biology · doi:10.1038/35023515 · Cited by 204 · see citing works
Natarajan, M., Stewart, J. E., Golemis, E. A., Pugacheva, E. N., Alexandropoulos, K., Cox, B. D., Wang, W., Grammer, J. R., & Gladson, C. L. (2005) · Oncogene · doi:10.1038/sj.onc.1209199 · Cited by 194 · see citing works
Self-citationCAS proteins in normal and pathological cell growth control
Tikhmyanova, N., Little, J. L., & Golemis, E. A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0213-1 · Cited by 187 · see citing works
Self-citationEvans, D. A. (1997) · JAMA · doi:10.1001/jama.277.10.822 · Cited by 177 · see citing works
The optimal use of bexarotene in cutaneous T-cell lymphoma
Gniadecki, R., Assaf, C., Bagot, M., Dummer, R., Duvic, M. A., Knobler, R., Ranki, A., SCHWANDT, P., & Whittaker, S. J. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07975.x · Cited by 174 · see citing works
Minegishi, M., Tachibana, K., Sato, T., Iwata, S., Nojima, Y., & Morimoto, C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1365 · Cited by 168 · see citing works
Current status on Alzheimer disease molecular genetics: from past, to present, to future
Bettens, K., Sleegers, K., & Broeckhoven, C. V. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq142 · Cited by 167 · see citing works
Peers, C., Dallas, M. L., Boycott, H. E., Scragg, J. L., Pearson, H. A., & Boyle, J. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05026.x · Cited by 166 · see citing works
Miners, J. S., Ashby, E., Helmond, Z. V., Chalmers, K. A., Palmer, L. E., Love, S., & Kehoe, P. G. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00885.x · Cited by 165 · see citing works
Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling
Qian, D., Lev, S., van Oers, N. S. C., Đikić, I., Schlessinger, J., & Weiss, A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1253 · Cited by 162 · see citing works
Hu, X., Pickering, E. H., Liu, Y. C., Hall, S., Fournier, H., Katz, E., DeChairo, B. M., John, S., Eerdewegh, P. V., Soares, H. D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016616 · Cited by 161 · see citing works
The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum
Piechota, M., Korostyński, M., Solecki, W., Gieryk, A., Ślęzak, M., Bilecki, W., Ziółkowska, B., Kostrzewa, E., Cymerman, I. A., Swiech, L. J., et al. (2010) · Genome biology · doi:10.1186/gb-2010-11-5-r48 · Cited by 159 · see citing works
Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons
Hoffman, L. B., Schmeidler, J., Lesser, G. T., Beeri, M. S., Purohit, D. P., Grossman, H. T., & Haroutunian, V. (2009) · Neurology · doi:10.1212/01.wnl.0000345881.82856.d5 · Cited by 159 · see citing works
Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase
Tachibana, K., Urano, T., Fujita, H., Ohashi, Y., Kamiguchi, K., Iwata, S., Hirai, H., & Morimoto, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29083 · Cited by 158 · see citing works
Plotnikova, O. V., Nikonova, A. S., Loskutov, Y. V., Kozyulina, P. Y., Pugacheva, E. N., & Golemis, E. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-1056 · Cited by 155 · see citing works
Self-citationLate-Onset Alzheimer’s Disease Genes and the Potentially Implicated Pathways
Rosenthal, S. L., & Kamboh, M. I. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0034-x · Cited by 153 · see citing works
Sabri, A., Govindarajan, G., Griffin, T. M., Byron, K. L., Samarel, A. M., & Lucchesi, P. A. (1998) · Circulation Research · doi:10.1161/01.res.83.8.841 · Cited by 153 · see citing works
Mori, D., Yano, Y., Toyo‐oka, K., Yoshida, N., Yamada, M., Muramatsu, M., Zhang, D., Saya, H., Toyoshima, Y. Y., Kinoshita, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00878-06 · Cited by 152 · see citing works
VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells
Féliers, D., Chen, X., Akis, N., Choudhury, G. G., Madaio, M. P., & Kasinath, B. S. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00575.x · Cited by 141 · see citing works
Wang, L., Gordon, R. A., Huynh, L., Su, X., Min, K.-H. P., Han, J., Arthur, J. S. C., Kalliolias, G. D., & Ivashkiv, L. B. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.014 · Cited by 140 · see citing works
The aurora kinase A regulates GSK-3β in gastric cancer cells
Dar, A. A., Belkhiri, A., & El-Rifai, W. (2008) · Oncogene · doi:10.1038/onc.2008.434 · Cited by 136 · see citing works
The Tyrosine Kinase Pyk2 Promotes Migration and Invasion of Glioma Cells
Lipinski, C. A., Tran, N. L., Menashi, E., Rohl, C., Kloss, J. M., Bay, R. C., Berens, M. E., & Loftus, J. C. (2005) · Neoplasia · doi:10.1593/neo.04712 · Cited by 133 · see citing works
Joint Effect of the APOE Gene and Midlife Systolic Blood Pressure on Late-Life Cognitive Impairment
Peila, R., White, L. R., Petrovitch, H., Masaki, K., Ross, G. W., Havlik, R. J., & Launer, L. J. (2001) · Stroke · doi:10.1161/hs1201.100392 · Cited by 131 · see citing works
Mori, D., Yamada, M., Mimori‐Kiyosue, Y., Shirai, Y., Suzuki, A., Ohno, S., Saya, H., Wynshaw-Boris, A. J., & Hirotsune, S. (2009) · Nature Cell Biology · doi:10.1038/ncb1919 · Cited by 130 · see citing works
Genetics of Alzheimer’s Disease
Vilatela, M. E. A., López, M., & Yescas, P. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.10.017 · Cited by 129 · see citing works
Mutations in TREM2 lead to pure early‐onset dementia without bone cysts
Chouery, E., Delague, V., Bergougnoux, A., Koussa, S., Serre, J., & Mégarbané, A. (2008) · Human Mutation · doi:10.1002/humu.20836 · Cited by 129 · see citing works
van Buul, J. D., Anthony, E. C., Fernandez‐Borja, M., Burridge, K., & Hordijk, P. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500898200 · Cited by 129 · see citing works
The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1
Cain, R. J., Vanhaesebroeck, B., & Ridley, A. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200907135 · Cited by 126 · see citing works
Astier, A., Manié, S. N., Avraham, H. K., Hirai, H., Law, S. F., Zhang, Y., Golemis, E. A., Fu, Y., Druker, B. J., Haghayeghi, N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19719 · Cited by 125 · see citing works
Self-citationOkochi, M., Tagami, S., Yanagida, K., Takami, M., Kodama, T. S., Mori, K., Nakayama, T., Ihara, Y., & Takeda, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.11.028 · Cited by 123 · see citing works
Singh, M. K., Cowell, L., Seo, S., O’Neill, G. M., & Golemis, E. A. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0036-3 · Cited by 119 · see citing works
Self-citationBagnyukova, T., Serebriiskii, I. G., Zhou, Y., Hopper-Borge, E. A., Golemis, E. A., & Astsaturov, I. A. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.9.13738 · Cited by 118 · see citing works
Self-citationManié, S. N., Beck, A., Astier, A., Law, S. F., Canty, T., Hirai, H., Druker, B. J., Avraham, H. K., Haghayeghi, N., Sattler, M., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4230 · Cited by 118 · see citing works
Self-citationGlaucoma Is Associated with Peripheral Vascular Endothelial Dysfunction
Su, W.-W., Cheng, S., Ho, W., Tsay, P., Wu, S.-C., & Chang, S. H. L. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2007.10.026 · Cited by 116 · see citing works
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein
Xiong, W., Macklem, M., & Parsons, J. T. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.14.1981 · Cited by 112 · see citing works
A New Central Scaffold for Metastasis: Parsing HEF1/Cas-L/NEDD9
O’Neill, G. M., Seo, S., Serebriiskii, I. G., Lessin, S. R., & Golemis, E. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1328 · Cited by 112 · see citing works
Self-citationNolz, J. C., Nacusi, L. P., Segovis, C. M., Medeiros, R. B., Mitchell, J. S., Shimizu, Y., & Billadeau, D. D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801121 · Cited by 108 · see citing works
Targeting Pyk2 for therapeutic intervention
Lipinski, C. A., & Loftus, J. C. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903473194 · Cited by 107 · see citing works
Grolla, A. A., Sim, J. A., Lim, D., Rodriguez, J. J., Genazzani, A. A., & Verkhratsky, A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.145 · Cited by 106 · see citing works
Scheerens, H., Hessel, E. M., Malefyt, R. D. W., Leach, M. W., & Rennick, D. M. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200105)31:5 · Cited by 104 · see citing works
Self-citationTassiulas, I. O., Hu, X., Ho, H. H., Kashyap, Y., Paik, P. K., Hu, Y., Lowell, C. A., & Ivashkiv, L. B. (2004) · Nature Immunology · doi:10.1038/ni1126 · Cited by 103 · see citing works
Golubovskaya, V., Figel, S. A., Ho, B. T., Johnson, C. P., Yemma, M., Huang, G., Zheng, M., Nyberg, C., Magis, A. T., Ostrov, D. A., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs120 · Cited by 103 · see citing works
Vogel, T., Ahrens, S., Büttner, N., & KRIEGLSTEIN, K. G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp134 · Cited by 99 · see citing works
Key developments in renin–angiotensin–aldosterone system inhibition
Pessôa, B. S., van der Lubbe, N., Verdonk, K., Roks, A. J. M., Hoorn, E. J., & Danser, A. H. J. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.249 · Cited by 99 · see citing works
Genetics of Alzheimer’s Disease
Ridge, P. G., Ebbert, M., & Kauwe, J. S. K. (2013) · BioMed Research International · doi:10.1155/2013/254954 · Cited by 96 · see citing works
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
Schultze, A., & Fiedler, W. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.489548 · Cited by 94 · see citing works
Wang, L., Tassiulas, I. O., Park‐Min, K., Reid, A. C., Gil-Henn, H., Schlessinger, J., Baron, R., Zhang, J. J., & Ivashkiv, L. B. (2007) · Nature Immunology · doi:10.1038/ni1548 · Cited by 94 · see citing works
The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites
Law, S. F., O’Neill, G. M., Fashena, S. J., Einarson, M. B., & Golemis, E. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5184-5195.2000 · Cited by 90 · see citing works
Self-citationA novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1
Liu, X., Elia, A. E. H., Law, S. F., Golemis, E. A., Farley, J., & Wang, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6759 · Cited by 88 · see citing works
Self-citationA signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways
Ivashkiv, L. B. (2008) · Nature reviews. Immunology · doi:10.1038/nri2396 · Cited by 80 · see citing works
Du, Q., Ren, X.-R., Xie, Y., Wang, Q., Mei, L., & Xiong, W. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2977 · Cited by 80 · see citing works
Murasawa, S., Mori, Y., Nozawa, Y., Masaki, H., Maruyama, K., Tsutsumi, Y., Moriguchi, Y., Shibasaki, Y., Tanaka, Y., Iwasaka, T., et al. (1998) · Hypertension · doi:10.1161/01.hyp.32.4.668 · Cited by 79 · see citing works
Rapid calcium-dependent activation of Aurora-A kinase
Plotnikova, O. V., Pugacheva, E. N., Dunbrack, R. L., & Golemis, E. A. (2010) · Nature Communications · doi:10.1038/ncomms1061 · Cited by 77 · see citing works
Self-citationRegulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent
Lucas, J. T., Salimath, B. P., Slomiany, M. G., & Rosenzweig, S. A. (2010) · Oncogene · doi:10.1038/onc.2010.185 · Cited by 76 · see citing works
α2β1 and αVβ1 integrin signaling pathways mediate amyloid-β-induced neurotoxicity
Wright, S., Malinin, N. L., Powell, K. A., Yednock, T. A., Rydel, R. E., & Griswold‐Prenner, I. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.002 · Cited by 75 · see citing works
Berg, N. N., & Ostergaard, H. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1753 · Cited by 75 · see citing works
A novel Cas family member, HEPL, regulates FAK and cell spreading
Singh, M. K., Dadke, D., Nicolas, E., Serebriiskii, I. G., Apostolou, S., Canutescu, A., Egleston, B. L., & Golemis, E. A. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0953 · Cited by 74 · see citing works
Self-citationA New Paradigm for the Treatment of Alzheimer's Disease: Targeting Vascular Activation
Grammas, P., Martinez, J. M., Sanchez, A. C., Yin, X., Riley, J., Gay, D., Desobry, K., Tripathy, D., Luo, J., Evola, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-2014-132057 · Cited by 73 · see citing works
Glial Calcium Signalling in Alzheimer’s Disease
Lim, D., Ronco, V., Grolla, A. A., Verkhratsky, A., & Genazzani, A. A. (2014) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2014_19 · Cited by 73 · see citing works
Laumet, G. O., Chouraki, V. A., Grenier‐Boley, B., Legry, V., Heath, S. C., Zélénika, D., Fiévet, N., Hannequin, D., Délepine, M., Pasquier, F., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100126 · Cited by 71 · see citing works
Tian, D., Vladimir Litvak, A., & Lev, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06478.2000 · Cited by 71 · see citing works
Aurora A kinase activity influences calcium signaling in kidney cells
Plotnikova, O. V., Pugacheva, E. N., & Golemis, E. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201012061 · Cited by 71 · see citing works
Self-citationVHL Inactivation Induces HEF1 and Aurora Kinase A
Xu, J., Li, H., Wang, B., Xu, Y., Yang, J., Zhang, X., Harten, S. K., Shukla, D., Maxwell, P. H., Pei, D., et al. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010040345 · Cited by 71 · see citing works
Ahn, J., Sanz‐Moreno, V., & Marshall, C. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.101444 · Cited by 71 · see citing works
Ohashi, Y., Tachibana, K., Kamiguchi, K., Fujita, H., & Morimoto, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6446 · Cited by 69 · see citing works
Aβ(25–35) and Aβ(1–40) act on different calcium channels in CA1 hippocampal neurons
Rovira, C., Arbez, N., & Mariani, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02072-7 · Cited by 68 · see citing works
Review: The genetics of A lzheimer's disease; putting flesh on the bones
Medway, C., & Morgan, K. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12101 · Cited by 66 · see citing works
Ostergaard, H. L., Lou, O., Arendt, C., & Berg, N. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5692 · Cited by 66 · see citing works
ATP5H/KCTD2 locus is associated with Alzheimer's disease risk
Initiative, A. D. N., Boada, M., Antúnez, C., Ramírez‐Lorca, R., DeStefano, A. L., González‐Pérez, A., Gayán, J., López‐Arrieta, J., Ikram, M. A., Hernández, I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.86 · Cited by 64 · see citing works
Wu, Q., Huang, J. H., Sampson, E. R., Kim, K., Zuscik, M. J., O’Keefe, R. J., Chen, D., & Rosier, R. N. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.05.019 · Cited by 64 · see citing works
Murasawa, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909999199 · Cited by 63 · see citing works
Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection
Kamen, L. A., Schlessinger, J., & Lowell, C. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002093 · Cited by 61 · see citing works
Vincent, L., Jin, D. K., Karajannis, M. A., Shido, K., Hooper, A. T., Rashbaum, W. K., Pytowski, B., Wu, Y. L., Hicklin, D. J., Zhu, Z., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3598 · Cited by 60 · see citing works
Alzheimer’s disease: An update of the roles of receptors, astrocytes and primary cilia (Review)
Armato, U., Chakravarthy, B., Pacchiana, R., & Whitfield, J. F. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1162 · Cited by 58 · see citing works
The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc42
Cai, D. D., Felekkis, K. N., Near, R. I., O’Neill, G. M., van Seventer, J. M., Golemis, E. A., & Lerner, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.969 · Cited by 56 · see citing works
Self-citationPark, S., Avraham, H. K., & Avraham, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909932199 · Cited by 56 · see citing works
Merrill, R. A., Ahrens, J. M., Kaiser, M., Federhart, K. S., Poon, V., & Clagett-Dame, M. (2004) · Biological chemistry · doi:10.1515/bc.2004.075 · Cited by 55 · see citing works
Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury
Duan, Y., Learoyd, J., Meliton, A. Y., Leff, A. R., & Zhu, X. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-4 · Cited by 55 · see citing works
Kim, S.-H., Xia, D., Kim, S.-W., Holla, V. R., Menter, D. G., & DuBois, R. N. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2110 · Cited by 54 · see citing works
CAS proteins in health and disease: An update
Nikonova, A. S., Gaponova, A. V., Kudinov, A. E., & Golemis, E. A. (2014) · IUBMB Life · doi:10.1002/iub.1282 · Cited by 53 · see citing works
Self-citationZhong, J., Baquiran, J. B., Bonakdar, N., Lees, J. G., Ching, Y. W., Pugacheva, E. N., Fabry, B., & O’Neill, G. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035058 · Cited by 52 · see citing works
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton
Guerrero, M. S., Parsons, J. T., & Bouton, A. H. (2012) · Genes & Cancer · doi:10.1177/1947601912458585 · Cited by 52 · see citing works
Zhang, Z., Hernandez‐Lagunas, L., Horne, W. C., & Baron, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25093 · Cited by 51 · see citing works
Li, R., Wong, N. K. Y., Jabali, M. D., & Johnson, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100158200 · Cited by 50 · see citing works
c-Src Signaling Induced by the Adapters Sin and Cas Is Mediated by Rap1 GTPase
Xing, L., Ge, C., Zeltser, R., Maskevitch, G., Mayer, B. J., & Alexandropoulos, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7363-7377.2000 · Cited by 50 · see citing works
Genome-wide association study of primary open angle glaucoma risk and quantitative traits.
Gibson, J., Griffiths, H., Salvo, G. D., Cole, M., Jacob, A., MacLeod, A., Yang, Y. C., Menon, G., Cree, A. J., Ennis, S., et al. (2012) · Europe PMC (PubMed Central) · Cited by 49 · see citing works
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate
Beinke, S., Phee, H., Clingan, J. M., Schlessinger, J., Matloubian, M., & Weiss, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011556107 · Cited by 47 · see citing works
Matsui, A., Okigaki, M., Amano, K., Adachi, Y., Jin, D., Takai, S., Yamashita, T., Kawashima, S., Kurihara, T., Miyazaki, M., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.645416 · Cited by 47 · see citing works
Zhang, Z., Baron, R., & Horne, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001818200 · Cited by 46 · see citing works
Aquino, J. B., Lallemend, F., Marmigère, F., Adameyko, I. I., Golemis, E. A., & Ernfors, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.035 · Cited by 46 · see citing works
Self-citationGu, J., Lavau, C., Pugacheva, E. N., Soderblom, E. J., Moseley, M. A., & Pendergast, A. M. (2012) · Science Signaling · doi:10.1126/scisignal.2002632 · Cited by 46 · see citing works
BCR/ABL-induced Leukemogenesis Causes Phosphorylation of Hef1 and Its Association with Crkl
de Jong, R., van Wijk, A., Haataja, L., Heisterkamp, N., & Groffen, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32649 · Cited by 46 · see citing works
Zhang, Z., Neff, L., Bothwell, A. L. M., Baron, R., & Horne, W. C. (2002) · Bone · doi:10.1016/s8756-3282(02)00834-7 · Cited by 46 · see citing works
Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1
Nourry, C., Maksumova, L., Pang, M., Liu, X., & Wang, T. (2004) · BMC Cell Biology · doi:10.1186/1471-2121-5-20 · Cited by 45 · see citing works
Kondo, S., Iwata, S., Yamada, T., Inoue, Y., Ichihara, H., Kichikawa, Y., Katayose, T., Souta-Kuribara, A., Yamazaki, H., Hosono, O., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2162 · Cited by 45 · see citing works
Regelmann, A. G., Danzl, N. M., Wanjalla, C. N., & Alexandropoulos, K. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.014 · Cited by 43 · see citing works
Pyk2/CAKβ Tyrosine Kinase Activity-mediated Angiogenesis of Pulmonary Vascular Endothelial Cells
Tang, H., Qin, H., Fitzgerald, T., Sasaki, T., Landon, E. J., & Inagami, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110673200 · Cited by 42 · see citing works
Miao, Y., Li, A., Wang, L., Fan, C., Zhang, X., Xu, H., Yang, L., Liu, Y., & Wang, E. (2012) · Pathology & Oncology Research · doi:10.1007/s12253-012-9580-2 · Cited by 42 · see citing works
Li, Y., Grupe, A., Rowland, C. M., Holmans, P., Segurado, R., Abraham, R., Jones, L., Catanese, J. J., Ross, D. A., Mayo, K., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm348 · Cited by 42 · see citing works
Matsubara, H., Shibasaki, Y., Okigaki, M., Mori, Y., Masaki, H., Kosaki, A., Tsutsumi, Y., Uchiyama, Y., Fujiyama, S., Nose, A., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4695 · Cited by 42 · see citing works
The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions
Bargon, S. D., Gunning, P. W., & O’Neill, G. M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.10.008 · Cited by 40 · see citing works
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
Wang, X., Bao, X., Pal, R., Aǵbaş, A., & Michaelis, E. K. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-360 · Cited by 40 · see citing works
Ismail, H. M. (2012) · Journal of Oncology · doi:10.1155/2012/416927 · Cited by 38 · see citing works
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling
Mace, P. D., Wallez, Y., Dobaczewska, M. K., Lee, J. J., Robinson, H. H., Pasquale, E. B., & Riedl, S. J. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2152 · Cited by 37 · see citing works
Nedd9 Protein, a Cas-L Homologue, Is Upregulated After Transient Global Ischemia in Rats
Sasaki, T., Iwata, S., Okano, H. J., Urasaki, Y., Hamada, J., Tanaka, H., Dang, N. H., Okano, H., & Morimoto, C. (2005) · Stroke · doi:10.1161/01.str.0000185672.10390.30 · Cited by 37 · see citing works
It cuts two ways: microtubule loss during Alzheimer disease
Jean, D. C., & Baas, P. W. (2013) · EMBO Journal · doi:10.1038/emboj.2013.219 · Cited by 36 · see citing works
Garron, M.-L., Arsenieva, D., Zhong, J., Bloom, A. B., Lerner, A., O’Neill, G. M., & Arold, S. T. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.12.010 · Cited by 36 · see citing works
Flagged first, then by citations
3 of the 241 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [79]van Seventer GA Salmen HJ Law SF O'Neill GM Mullen MM Franz AM Kanner SB Golemis EA van Seventer JM Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway Eur J Immunol 2001 31 5 1417 1427 11465098
Cited by
Sorted by citations
Alzheimer’s Disease: An Updated Overview of Its Genetics
Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodríguez, I., Cadena-Suárez, A. R., Sánchez-Garibay, C., Pozo-Molina, G., Méndez-Catalá, C. F., Cardenas-Aguayo, M.-D.-C., Diaz-Cintra, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043754 · Cited by 336 · see citing works
Genes associated with Alzheimer&#39;s disease: an overview and current status
Giri, M., Lü, Y., & Zhang, M. (2016) · Clinical Interventions in Aging · doi:10.2147/cia.s105769 · Cited by 311 · see citing works
Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials
Miao, J., Ma, H., Yang, Y., Liao, Y., Lin, C., Zheng, J., Yu, M., & Lan, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1201982 · Cited by 293 · see citing works
Dourlen, P., Kilinc, D., Malmanche, N., Chapuis, J., & Lambert, J.-C. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02004-0 · Cited by 168 · see citing works
A Cross-Disorder Method to Identify Novel Candidate Genes for Developmental Brain Disorders
Gonzalez-Mantilla, A. J., Moreno-De-Luca, A., Ledbetter, D. H., & Martin, C. L. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2692 · Cited by 139 · see citing works
Shireby, G. L., Dempster, E. L., Policicchio, S. S. S., Smith, R. G., Pishva, E., Chioza, B. A., Davies, J. P., Burrage, J., Lunnon, K., Vellame, D. S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33394-7 · Cited by 125 · see citing works
Dourlen, P., Fernandez-Gomez, F. J., Dupont, C., Grenier-Boley, B., Bellenguez, C., Obriot, H., Caillierez, R., Sottejeau, Y., Chapuis, J., Bretteville, A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.59 · Cited by 118 · see citing works
Genomics of Alzheimer’s disease implicates the innate and adaptive immune systems
Li, Y., Laws, S. M., Miles, L. A., Wiley, J. S., Huang, X., Masters, C. L., & Gu, B. J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03986-5 · Cited by 93 · see citing works
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases
Shagisultanova, E. I., Gaponova, A. V., Gabbasov, R. T., Nicolas, É., & Golemis, E. A. (2015) · Gene · doi:10.1016/j.gene.2015.04.086 · Cited by 90 · see citing works
Self-citationPolygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China
Jiao, B., Liu, X., Zhou, L., Wang, M. H., Zhou, Y., Xiao, T., Zhang, W., Sun, R., Waye, M. M. Y., Tang, B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144898 · Cited by 82 · see citing works
Hassan, M., Raza, H., Abbasi, M. A., Moustafa, A. A., & Seo, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.115 · Cited by 61 · see citing works
A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk
Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Maat, C. A., Losada, P. M., Chen, M. B., Agam, M., Schaum, N., Khoury, N., et al. (2021) · doi:10.1101/2021.04.26.441262 · Cited by 48 · see citing works
CDT2‐controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease
Huang, F., Wang, M., Liu, R., Wang, J., Schadt, E., Haroutunian, V., Katsel, P., Zhang, B., & Wang, X. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.08.013 · Cited by 47 · see citing works
Identification of distinct and age‐dependent p16<sup>High</sup> microglia subtypes
Talma, N., Gerrits, E., Wang, B., Eggen, B. J. L., & Demaria, M. (2021) · Aging Cell · doi:10.1111/acel.13450 · Cited by 46 · see citing works
State of Play in Alzheimer’s Disease Genetics
Zhu, J.-B., Tan, C., Tan, L., & Yu, J. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170062 · Cited by 43 · see citing works
Positional Effects Revealed in Illumina Methylation Array and The Impact on Analysis
Jiao, C., Zhang, C., Dai, R., Xia, Y., Wang, K., Giase, G. M., Chen, C., & Liu, C. (2018) · Epigenomics · doi:10.2217/epi-2017-0105 · Cited by 37 · see citing works
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Deneka, A., Korben, V. A., & Golemis, E. A. (2015) · Gene · doi:10.1016/j.gene.2015.06.062 · Cited by 33 · see citing works
Self-citationHuman brain vascular multi-omics elucidates disease-risk associations
Reid, M. M., Menon, S., Liu, H., Zhou, H., Hu, Z., Frerich, S., Ding, B., Oveisgharan, S., Zhang, Z., Nelson, S., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.07.001 · Cited by 33 · see citing works
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer
Beck, T. N., Chikwem, A. J., Solanki-Patel, N., & Golemis, E. A. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00062.2014 · Cited by 26 · see citing works
Self-citationAlzheimer’s Disease: Models and Molecular Mechanisms Informing Disease and Treatments
Nystuen, K., McNamee, S. M., Akula, M., Holton, K. M., DeAngelis, M. M., & Haider, N. B. (2024) · Bioengineering · doi:10.3390/bioengineering11010045 · Cited by 27 · see citing works
McMillan, C. T., Lee, E. B., Jefferson‐George, K., Naj, A. C., Deerlin, V. M. V., Trojanowski, J. Q., & Wolk, D. A. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.581 · Cited by 26 · see citing works
Probing the role of PPARγ in the regulation of late-onset Alzheimer’s disease-associated genes
Barrera, J., Subramanian, S., & Chiba‐Falek, O. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196943 · Cited by 21 · see citing works
Knutson, D. C., Mitzey, A. M., Talton, L. E., & Clagett‐Dame, M. (2015) · Brain Research · doi:10.1016/j.brainres.2015.12.005 · Cited by 18 · see citing works
Alzheimer’s disease basics: we all should know
Das, S. K. (2025) · Neurological Research · doi:10.1080/01616412.2025.2529560 · Cited by 19 · see citing works
Hassan, M., Shahzadi, S., Alashwal, H., Zaki, N., Seo, S., & Moustafa, A. A. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3430-2 · Cited by 17 · see citing works
Sengupta, P., Das, R., Majumder, P., & Mukhopadhyay, D. (2024) · Exploration of neuroscience · doi:10.37349/en.2024.00033 · Cited by 18 · see citing works
Kurakin, A. V., & Bredesen, D. E. (2020) · Aging · doi:10.18632/aging.103883 · Cited by 14 · see citing works
Lodge, D. J., Reiley, H. B., Boley, A. M., & Donegan, J. J. (2023) · Nature Communications · doi:10.1038/s41467-023-42484-z · Cited by 9 · see citing works
The Genetic Basis of Alzheimer's Disease
Hooli, B. V., & Tanzi, R. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00034-2 · Cited by 9 · see citing works
Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers
Sil, M., Mukherjee, N., Chatterjee, I., Ghosh, A., & Goswami, A. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02379-8 · Cited by 8 · see citing works
Taming Alzheimer's disease: New perspectives, newer horizons.
Sen, D., Majumder, A., Arora, V., Yadu, N., & Chakrabarti, R. (2017) · PubMed Central · Cited by 7 · see citing works
Wang, L., Chen, J., Chai, Y., Han, W., Shen, J., Li, N., Jinyan, L., Du, Y., Liu, Z., Yu, Y., et al. (2021) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2021.1902337 · Cited by 7 · see citing works
Qi, X., Lin, H., Hou, Y., Su, X., & Gao, Y. (2021) · European Neurology · doi:10.1159/000518893 · Cited by 7 · see citing works
Bello, E., Long, K. R., Iwama, S., Steer, J., Cooper, S., Alasoo, K., Kumasaka, N., Schwartzentruber, J., Panousis, N. I., & Bassett, A. R. (2026) · iScience · doi:10.1016/j.isci.2026.115688 · Cited by 6 · see citing works
The Genetic Basis of Alzheimer’s Disease
Hooli, B. V., & Tanzi, R. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00002-2 · Cited by 6 · see citing works
The Role of Genetics in Alzheimer's Disease and Parkinson's Disease
Porter, T., Gozt, A., Mastaglia, F. L., & Laws, S. M. (2019) · Wiley eBooks · doi:10.1002/9781119356752.ch15 · Cited by 7 · see citing works
Parithathvi, A., Harshitha, P., Mumbrekar, K. D., & Dsouza, H. S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01613-6 · Cited by 5 · see citing works
Immuno‐Regulation of Brain Region‐Specific Organoids Containing Isogenic Microglia‐Like Cells
Liu, C., Ene, J., Lü, W., Syed, F., Sun, L. J., Raulin, A., Ren, Y., Wang, X. S., Kanekiyo, T., & Li, Y. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503579 · Cited by 5 · see citing works
Wei, K., Kong, W., & Wang, S. (2021) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-021-02439-2 · Cited by 4 · see citing works
Drastichová, Z., Trubacova, R., & Novotný, J. (2022) · Cells · doi:10.3390/cells11091473 · Cited by 3 · see citing works
Beric, A., Cisterna‐García, A., Martin, C., Kumar, R., Alfradique‐Dunham, I., Boyer, K., Saliu, I. O., Yamada, S., Sanford, J., Western, D., et al. (2024) · medRxiv · doi:10.1101/2024.10.18.24315717 · Cited by 2 · see citing works
Vastrad, B. M., & Vastrad, C. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.24.563759 · Cited by 2 · see citing works
Kotturshetti, I., Vastrad, B. M., Kori, V., Vastrad, C. M., & Kotrashetti, S. (2024) · Italian Journal of Medicine · doi:10.4081/itjm.2024.1830 · Cited by 1 · see citing works
Molecular determinants of astrocyte morpho-functional changes in Alzheimer’s disease
Ulzheimer, N. E. (2019) · CLOK (University of Central Lancashire)
Vastrad, B. M., & Vastrad, C. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.24.461631
Cellular senescence in the ageing brain
Talma, N. (2022) · doi:10.33612/diss.206630102
A Spatial-Correlated Multitask Linear Mixed-Effects Model for Imaging Genetics
Pu, Z., & Ge, S. (2025) · Journal of Computational Biology · doi:10.1089/cmb.2024.0721
Almeida, J. F. F., Thiebaut, A. S. C., dos Santos, L. R., de Oliveira, L. H. G., Pimassoni, L. H. S., Trancozo, M., Portela, P. M., Morelato, R. L., & Paula, F. (2026) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v7i6.8066
Pyk2 dysregulation in Alzheimer’s disease
Shanker, O. R., Kumar, S., Banerjee, J., & Dixit, A. B. (2026) · Advances in pharmacology · doi:10.1016/bs.apha.2026.08.001
Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis
Walsh, A. E., Davis, B. A., Samuels, J. D., Mills, W. A., Thanos, J. M., Johnson, A. M., Moore, K. A., Puchalski, M. A., Steacy, E. J., Wendell, B. W., et al. (2026) · Journal of Experimental Medicine · doi:10.1084/jem.20260104
- Authors
- Beck, T. N., Nicolas, E., Kopp, M. C., & Golemis, E. A.
- Affiliations
- Fox Chase Cancer Center (US)
- Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA
- Corresponding author
- Golemis, Erica A.
- Venue
- Oncoscience
- Publisher
- Impact Journals, LLC
- Published
- 2014-07-12
- Volume
- 1
- Issue
- 7
- Pages
- 486-503
- ISSN
- 2331-4737 (ISSN-L)
- PMC
- PMC4278314
- OpenAlex
- W2345736299
- Cited by
- 50
- References
- 241
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Oncoscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- TUScholarShare (Temple University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (CA-06927, CA149147, CA083638)
- National Cancer Institute (F30CA180607, U54CA149147, P50CA083638, R21CA181287, P30CA006927)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, late-onset Alzheimer's disease, NEDD9, Pyk2, scaffold proteins, single nucleotide polymorphisms, genetic susceptibility, cancer signaling, hypoxia, vascular changes, neuroinflammation, microtubule stabilization, calcium signaling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
