The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation
Open accessAbstract
BACKGROUND: Health in early life is crucial for health later in life. Exposure to air pollution during embryonic and early-life development can result in placental epigenetic modification and foetus reprogramming, which can influence disease susceptibility in later life. Objectives: The aim of this paper was to investigate the placental adaptation in the level of global DNA methylation and differential gene expression in the methylation cycle in new-borns exposed to high fine particulate matter in the foetal stage. STUDY DESIGN: This is a nested case-control study. We enrolled pregnant healthy women attending prenatal care clinics in Tehran, Iran, who were residents of selected polluted and unpolluted regions, before the 14th week of pregnancy. We calculated the regional background levels of particle mass- particles with aerodynamics diameter smaller than 2.5 μm (PM2.5) and 10 μm (PM10)-of two regions of interest. At the time of delivery, placental tissue was taken for gene expression and DNA methylation analyses. We also recorded birth outcomes (the new-born's sex, birth date, birth weight and length, head and chest circumference, gestational age, Apgar score, and level of neonatal care required). RESULTS: As regards PM2.5 and PM10 concentrations in different time windows of pregnancy, there were significantly independent positive correlations between PM10 and PM2.5 in the first trimester of all subjects and placental global DNA methylation levels (p-value = 0.01, p-value = 0.03, respectively). The gene expression analysis showed there was significant correlation between S-adenosylmethionine expression and PM2.5 (p = 0.003) and PM10 levels in the first trimester (p = 0.03). CONCLUSION: Our data showed prenatal exposures to air pollutants in the first trimester could influence placental adaptation by DNA methylation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“In a cohort study, exposure to PM2.5 during the first trimester was significantly associated with decreased (2.2%) global DNA methylation in placenta tissue [178] and was also significantly correlated with gene expression of S-adenosylmethionine (SAM), a key substrate involved in methyl group transfers [184].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [184]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Child Health, Developmental Plasticity, and Epigenetic Programming
Hochberg, Z., Feil, R., Constância, M., Fraga, M. F., Junien, C., Carel, J., Boileau, P., Bouc, Y. L., Deal, C., Lillycrop, K. A., et al. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0039 · Cited by 657
Hermann, A., Goyal, R., & Jeltsch, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403427200 · Cited by 593
Nelissen, E. C. M., van Montfoort, A. P. A., Dumoulin, J. C. M., & Evers, J. L. H. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq052 · Cited by 400
Particulate Air Pollution and Fetal Health
Glinianaia, S. V., Rankin, J. M., Bell, R., Pless‐Mulloli, T., & Howel, D. (2004) · Epidemiology · doi:10.1097/01.ede.0000101023.41844.ac · Cited by 371
A review of the literature on the effects of ambient air pollution on fetal growth
Maisonet, M., Correa, A., Misra, D. P., & Jaakkola, J. J. K. (2004) · Environmental Research · doi:10.1016/j.envres.2004.01.001 · Cited by 328
Update of WHO air quality guidelines
Krzyżanowski, M., & Cohen, A. (2008) · Air Quality Atmosphere & Health · doi:10.1007/s11869-008-0008-9 · Cited by 308
Imprinted Genes, Placental Development and Fetal Growth
Fowden, A. L., Sibley, C. P., Reik, W., & Constância, M. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091506 · Cited by 273
Particulate Urban Air Pollution Affects the Functional Morphology of Mouse Placenta1
Veras, M. M., Damaceno-Rodrigues, N. R., Caldini, E. G., Ribeiro, A. A. C. M., Mayhew, T. M., Saldiva, P. H. N., & Dolhnikoff, M. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.069591 · Cited by 243
Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.03.017 · Cited by 224
Acute Effects of Summer Air Pollution on Respiratory Symptom Reporting in Children
Schwartz, J. E., Dockery, D. W., Neas, L., Wypij, D., Ware, J. H., Spengler, J. D., Koutrakis, P., Speizer, F. E., & Ferris, B. G. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.5.7952546 · Cited by 223
Cited by
Sorted by citations
Air pollution and DNA methylation: effects of exposure in humans
Rider, C. F., & Carlsten, C. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0713-2 · Cited by 368
Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339
“2%) global DNA methylation in placenta tissue [178] and was also significantly correlated with gene expression of S-adenosylmethionine (SAM), a key substrate involved in methyl group transfers [184].”
BackgroundSaenen, N. D., Martens, D. S., Neven, K. Y., Alfano, R., Bové, H., Janssen, B. G., Roels, H. A., Plusquin, M., Vrijens, K., & Nawrot, T. S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0688-z · Cited by 267
Prenatal epigenetics diets play protective roles against environmental pollution
Li, S., Chen, M., Li, Y., & Tollefsbol, T. O. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0659-4 · Cited by 129
Rahman, M. M., Shu, Y., Chow, T., Lurmann, F., Yu, X., Martinez, M. P., Carter, S., Eckel, S. P., Chen, J., Chen, Z., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp9509 · Cited by 120
Outdoor Air Pollution and Childhood Respiratory Disease: The Role of Oxidative Stress
Dondi, A., Carbone, C., Manieri, E., Zama, D., Bono, C. D., Betti, L., Biagi, C., & Lanari, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054345 · Cited by 135
Isaevska, E., Moccia, C., Asta, F., Cibella, F., Gagliardi, L., Ronfani, L., Rusconi, F., Stazi, M. A., & Richiardi, L. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110504 · Cited by 100
Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism
Soda, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103106 · Cited by 95
Mukherjee, S., Dasgupta, S., Mishra, P. K., & Chaudhury, K. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16056-x · Cited by 96
Familari, M., Nääv, Å., Erlandsson, L., de Iongh, R. U., Isaxon, C., Strandberg, B., Lundh, T., Hansson, S. R., & Malmqvist, E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218799 · Cited by 89
Yuan, L., Zhang, Y., Wang, W., Chen, R., Liu, Y., Liu, C., Kan, H., Gao, Y., & Tian, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124904 · Cited by 88
Ghazi, T., Naidoo, P., Naidoo, R. N., & Chuturgoon, A. A. (2021) · Cells · doi:10.3390/cells10113025 · Cited by 92
Shi, X., Zheng, Y., Cui, H., Zhang, Y., & Jiang, M. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113893 · Cited by 90
Al-Rifai, R. H., Abdo, N. M., Paulo, M. S., Saha, S., & Ahmed, L. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668447 · Cited by 78
The Impact of Air Pollution on Our Epigenome: How Far Is the Evidence? (A Systematic Review)
Alfano, R., Herceg, Z., Nawrot, T. S., Chadeau‐Hyam, M., Ghantous, A., & Plusquin, M. (2018) · Current Environmental Health Reports · doi:10.1007/s40572-018-0218-8 · Cited by 78
Findley, A. S., Monziani, A., Richards, A. L., Rhodes, K., Ward, M. C., Kalita, C. A., Alazizi, A., Pazokitoroudi, A., Sankararaman, S., Wen, X., et al. (2021) · eLife · doi:10.7554/elife.67077 · Cited by 68
Liang, W., Zhu, H., Xu, J., Zhao, Z., Zhou, L., Zhu, Q., Cai, J., & Ji, L. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114802 · Cited by 66
Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health
Covarrubias, D. G., Ramírez‐Díaz, I., Guzmán-Linares, J., Limón, I. D., Manuel-Sánchez, D. M., Molina-Herrera, A., Coral-García, M. Á., Anastasio, E., Anaya‐Hernández, A., López‐Salazar, P., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2023.1306600 · Cited by 65
Environment factors, DNA methylation, and cancer
Liu, J., Huang, B., Ding, F., & Li, Y. (2023) · Environmental Geochemistry and Health · doi:10.1007/s10653-023-01749-8 · Cited by 59
Vlahos, A., Mansell, T., Saffery, R., & Novakovic, B. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008236 · Cited by 56
Estimation of stillbirths attributable to ambient fine particles in 137 countries
Xue, T., Tong, M., Li, J., Wang, R., Guan, T., Li, J., Li, P., Liu, H., Lu, H. S., Li, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34250-4 · Cited by 53
Hu, J., & Yu, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.03.096 · Cited by 49
Rosa, M. J., Hair, G. M., Just, A. C., Kloog, I., Svensson, K., Pizano-Zárate, M. L., Pantic, I., Schnaas, L., Tamayo‐Ortiz, M., Baccarelli, A., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.109073 · Cited by 48
Yang, S., Lee, S., Lee, S., Kim, H., Kim, H., Kim, J., Lim, H., Park, M. J., Cho, H., Yoon, J., et al. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.09.008 · Cited by 46
Effect of PM2.5 on macrosomia in China: A nationwide prospective cohort study
Chen, S., Wang, S., Li, T., Zhu, H., Liang, S., Xu, K., Zhang, Y., Yuan, X., Yang, Y., Pan, H., et al. (2019) · Pediatric Obesity · doi:10.1111/ijpo.12584 · Cited by 46
Maternal exposure to PM2.5 was linked to elevated risk of stillbirth
Xie, G., Sun, L., Yang, W., Wang, R., Shang, L., Yang, L., Qi, C., Xin, J., Yue, J., & Chung, M. C. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.131169 · Cited by 46
Select Early-Life Environmental Exposures and DNA Methylation in the Placenta
Mortillo, M., & Marsit, C. J. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00385-1 · Cited by 43
Syama, K. P., Blais, E., & Kumarathasan, P. (2025) · Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178999 · Cited by 39
Seo, M., & Anderson, G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105102545 · Cited by 38
Prenatal exposure to particulate matter and placental gene expression
Enquobahrie, D. A., MacDonald, J. W., Hussey, M. R., Bammler, T. K., Loftus, C. T., Paquette, A. G., Byington, N., Marsit, C. J., Szpiro, A. A., Kaufman, J. D., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107310 · Cited by 36
Ni, Y., Szpiro, A. A., Young, M. T., Loftus, C. T., Bush, N. R., LeWinn, K. Z., Sathyanarayana, S., Enquobahrie, D. A., Davis, R. L., Kratz, M., et al. (2021) · Environmental Health Perspectives · doi:10.1289/ehp7486 · Cited by 36
Deyssenroth, M. A., Rosa, M. J., Eliot, M., Kelsey, K. T., Kloog, I., Schwartz, J. D., Wellenius, G. A., Peng, S., Hao, K., Marsit, C. J., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111342 · Cited by 40
Chen, C., Zhu, Y., Liu, C., Chen, R., Yan, Y., Ren, Y., Li, X., Wang, J., Ge, W., Kan, H., et al. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117629 · Cited by 36
Epigenetics as a Biomarker for Early-Life Environmental Exposure
Schrott, R., Song, A., & Ladd‐Acosta, C. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00373-5 · Cited by 38
Exposure to particulate matter, prenatal depressive symptoms and HPA axis dysregulation
Ahlers, N. E., & Weiss, S. J. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07166 · Cited by 32
Kang, J., Liao, J., Xu, S., Xia, W., Li, Y., Chen, S., & Lü, B. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110673 · Cited by 33
Honkova, K., Rössnerová, A., Chvojkova, I., Milcová, A., Margaryan, H., Pastorková, A., Ambrož, A., Rössner, P., Jiřík, V., Rubeš, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031666 · Cited by 30
Ren, Y., Yao, X., Liu, Y., Liu, S., Li, X., Huang, Q., Liu, F., Li, N., Lu, Y., Yuan, Z., et al. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3715-2 · Cited by 30
Zanini, M. J., Domínguez, C., Fernández-Oliva, T., Sánchez, O., Toda, M. T., Foraster, M., Dadvand, P., & Llurba, E. (2020) · Current Hypertension Reports · doi:10.1007/s11906-020-01088-4 · Cited by 29
Irizar, H., Chun, Y., Hsu, H. L., Li, Y., Zhang, L., Arditi, Z., Grishina, G. T., Grishin, A. V., Vicencio, A. G., Pandey, G. S., et al. (2024) · Allergy · doi:10.1111/all.16174 · Cited by 29
Zhang, H., & Zhao, Y. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11143-x · Cited by 28
Zhou, Y., Zhu, Q., Wang, P., Li, J., Luo, R., Zhao, W., Zhang, L., Shi, H., & Zhang, Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119481 · Cited by 27
Zheng, Y., Bian, J., Hart, J. E., Laden, F., Wen, T. S.-T., Zhao, J., Qin, H., & Hu, H. Z. (2022) · Atmospheric Environment · doi:10.1016/j.atmosenv.2022.119409 · Cited by 23
Seasonal Variation of Chronic Villitis of Unknown Etiology
Freedman, A. A., Goldstein, J. A., Miller, G. E., Borders, A. E. B., Keenan‐Devlin, L. S., & Ernst, L. M. (2019) · Pediatric and Developmental Pathology · doi:10.1177/1093526619892353 · Cited by 20
Wang, Y., Hu, C., Fang, T., Jin, Y., & Wu, R. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4983 · Cited by 23
Nutrition paves the way to environmental toxicants and influences fetal development during pregnancy
Meyyazhagan, A., Bhotla, H. K., Tsibizova, V. I., Pappuswamy, M., Chaudhary, A., Arumugam, V. A., Qasem, M. A., & Renzo, G. C. D. (2023) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102351 · Cited by 22
Zordão, O. P., Campolim, C. M., Yariwake, V. Y., Castro, G., Ferreira, C. K. D. O., Santos, A., Norberto, S., Veras, M. M., Saad, M. J. A., Saldiva, P. H. N., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1069243 · Cited by 19
PM10 Alters Trophoblast Cell Function and Modulates miR‐125b‐5p Expression
Chaiwangyen, W., Pintha, K., Tantipaiboonwong, P., Nuntaboon, P., Khantamat, O., & de Sousa, F. L. P. (2022) · BioMed Research International · doi:10.1155/2022/3697944 · Cited by 18
Li, Z., Fu, J., Zhou, L., Tang, Y., Hua, Q., Liu, L., & Zhao, J. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113266 · Cited by 19
Tong, M., Li, P., Wang, M., Sun, Y., Han, Y., Liu, H., Li, J., Li, J., Wu, F., Guan, T., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac103 · Cited by 16
Kao, C.-C., Chen, C., Avelino, J. L., Cortez, M.-S. P., Tayo, L. L., Lin, Y., Tsai, M.-H., Lin, C.-W., Hsu, Y.-C., Hsieh, L., et al. (2019) · Aerosol and Air Quality Research · doi:10.4209/aaqr.2019.10.0550 · Cited by 16
Nazzari, S., Cagliero, L., Grumi, S., Pisoni, E., Mallucci, G., Bergamaschi, R. C., Maccarini, J., Giorda, R., & Provenzi, L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02206-9 · Cited by 18
Zeng, Z., Xu, X., Wang, Q., Zhang, Z., Meng, P., & Huo, X. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119665 · Cited by 15
Starling, A. P., Wood, C., Liu, C., Kechris, K. J., Yang, I. V., Friedman, C., Thomas, D. S. K., Peel, J. L., Adgate, J. L., Magzamen, S. L., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113881 · Cited by 17
Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality
Scieszka, D. P., Bolt, A. M., McCormick, M. A., Brigman, J. L., & Campen, M. J. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1267667 · Cited by 15
Srividhya, D., Korlimarla, A., Ravikumar, G., Snijesh, V. P., Kaku, S. M., & Visweswariah, A. M. (2022) · Birth Defects Research · doi:10.1002/bdr2.2119 · Cited by 15
Tsamou, M., Nawrot, T. S., Carollo, R. M., Trippas, A.-J., Lefebvre, W., Vanpoucke, C., & Vrijens, K. (2020) · Environment International · doi:10.1016/j.envint.2020.105860 · Cited by 13
Prenatal PM2.5 affects atopic dermatitis depending on maternal anxiety and gender: COCOA study
Kim, S., Yang, S., Lim, H., Lee, S., Park, M. J., Song, K., Choi, E. J., Oh, H. Y., Kim, H., Shin, Y., et al. (2021) · Clinical and Translational Allergy · doi:10.1002/clt2.12070 · Cited by 13
Li, G., Hu, W., Lu, H., Liu, J., Li, X., He, J., Zhu, J., Zhao, H., Hao, J., & Huang, F. (2023) · Pediatric Obesity · doi:10.1111/ijpo.13004 · Cited by 11
Lupus, DNA Methylation, and Air Pollution: A Malicious Triad
Rasking, L., Roelens, C., Sprangers, B., Thienpont, B., Nawrot, T. S., & Vusser, K. D. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192215050 · Cited by 13
Bellizzi, D., Guarasci, F., Iannone, F., Passarino, G., & Rose, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_7 · Cited by 10
Impact assessment of particulate pollution on maternal mortality in Nigeria
Emetere, M. E., & Oladimeji, T. E. (2022) · Scientific Reports · doi:10.1038/s41598-022-19518-5 · Cited by 9
Fine particulate matter‑induced cardiac developmental toxicity (Review)
Meng, X., Du, W., & Sun, Z. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12756 · Cited by 11
Kim, H., Lee, S. H., Yang, D. Y., Lee, S., Kim, J., Kim, H., Choi, K., Lee, S., Yang, S., Suh, D. I., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125471 · Cited by 9
Consequences of the exposome to gestational diabetes mellitus
Rudge, M. V. C., Alves, F. C. B., Hallur, R. L. S., de Oliveira, R. G., Vega, S., Reyes, D. R. A., Floriano, J. F., Prudêncio, C. B., Garcia, G. A., Reis, F. V. D. S., et al. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130282 · Cited by 9
Early-life exposure to residential black carbon and childhood cardiometabolic health
Friedman, C., Dabelea, D., Glueck, D. H., Allshouse, W. B., Adgate, J. L., Keller, K. P., Martenies, S. E., Magzamen, S. L., & Starling, A. P. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117285 · Cited by 9
Kumar, S. H., Acharyya, S., Chouksey, A., Soni, N., Nazeer, N., & Mishra, P. K. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108675 · Cited by 9
GPR61 methylation in cord blood: a potential target of prenatal exposure to air pollutants
Feng, F., Huang, L., Zhou, G., Wang, J., Zhang, R. Q., Li, Z., Zhang, Y., & Ba, Y. (2020) · International Journal of Environmental Health Research · doi:10.1080/09603123.2020.1773414 · Cited by 8
Health impact assessment of air pollution in Lisbon, Portugal
Abe, K. C., Rodrigues, M. A., & Miraglia, S. G. E. K. (2022) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2022.2118192 · Cited by 8
Epigenetic reprogramming by air pollution: linking prenatal exposures to birth outcomes
Parikh, G., & Patel, B. M. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05345-5 · Cited by 8
Wan, Z., Zhang, S., Zhuang, G., Liu, W., Qiu, C., Lai, H., & Liu, W. (2024) · European Journal of Public Health · doi:10.1093/eurpub/ckae094 · Cited by 7
Dong, M., Liu, X., Xiao, J., Sun, X., Ye, Y., Feng, B., Zeng, W., Hu, J., Li, X., Guo, L., et al. (2020) · Atmospheric Environment · doi:10.1016/j.atmosenv.2020.117523 · Cited by 7
RUNX1 gene expression changes in the placentas of women smokers
Bermúdez, L. G., Madariaga, I., Zuñiga, M., Olaya, M., Cañas, A., Rodríguez, L., Moreno, O. M., & Rojas, A. P. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10334 · Cited by 7
Ambient PM2.5 exposure and salivary cortisol output during pregnancy in a multi-ethnic urban sample
Cowell, W., Kloog, I., Just, A. C., Coull, B. A., Carroll, K. N., & Wright, R. J. (2022) · Inhalation Toxicology · doi:10.1080/08958378.2022.2051647 · Cited by 7
Ziemendorff, A., Böhm-González, S. T., Meireson, E., Weyers, S., Nawrot, T. S., Bijnens, E. M., & Gielen, M. (2025) · Environmental Research · doi:10.1016/j.envres.2025.120952 · Cited by 6
Zhang, T., Jiang, W., Huang, Y., Wang, C., Cao, J., Qiu, W., Huang, R., Zhang, J., Ye, W., & Zhang, Q. (2025) · BMC Public Health · doi:10.1186/s12889-025-22913-y · Cited by 6
Orenshtein, S., Sheiner, E., Kloog, I., & Wainstock, T. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.101050 · Cited by 6
Jie, X., Wu, H., Yang, M., He, M., Zhao, G., Ling, S., Huang, Y., Yue, B., Yang, N., & Zhang, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.995700 · Cited by 7
Xu, R., Zhang, Y., Gao, Y., Jia, S., Choi, S., Xu, Y., & Gong, J. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135018 · Cited by 5
Inhaled ultrafine particles, epigenetics and systemic autoimmune rheumatic diseases
Farhat, S. C. L., Yariwake, V. Y., Veras, M. M., Braga, A. L. F., Sallum, A. M. E., & Silva, C. A. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102640 · Cited by 5
Chen, K., Liu, H., Wang, T., Luo, M., Ruan, X., Sun, M., Li, Z., Wei, J., & Qin, J. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126471 · Cited by 4
Tong, M., Lin, W., Liu, H., Gong, J., Zhang, J. J., & Xue, T. (2023) · Environmental Health · doi:10.1186/s12940-023-01016-4 · Cited by 4
Hou, Y., Yan, W., Li, G., & Sang, N. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165004 · Cited by 3
Zheng, Y., He, D., Cai, X. T., Zhang, X., Zheng, C., & Yao, Y. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-025-03603-5 · Cited by 3
Morris, R. H., Chabrier, G., Counsell, S. J., McGonnell, I. M., & Thornton, C. (2022) · Developmental Neuroscience · doi:10.1159/000524829 · Cited by 3
Luo, Y., Zhang, Y., Pan, H., & Chen, S. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.735699 · Cited by 3
Tang, W., Xu, W., Pan, Y.-R., Cai, Q., Wen, L., Xu, J., Wang, Y., Li, J.-Z., Liu, T., & Wang, L. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/6633118 · Cited by 2
Impacts of PM 2.5 on stillbirth and the potential mechanism: a narrative review
Li, Z., Liu, R., & Zhang, E. (2025) · Reviews on Environmental Health · doi:10.1515/reveh-2025-0090 · Cited by 2
Itziou, A., Michou, V., Lakioti, E., & Karayannis, V. (2026) · Applied Sciences · doi:10.3390/app16041898 · Cited by 2
Ambient air pollution and human epigenetic modifications
Xu, R., Li, S., Abramson, M. J., & Guo, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820951-6.00010-7 · Cited by 2
Can Breathing Poor-quality Air Lead to Poor-quality Sleep in Children?
Balmes, J. R. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202210-1968ed · Cited by 2
The role of climate change in maternal nutrition and fetal development: a narrative review
Musa, A., Imam, M. U., Ibrahim, K. G., & Kasimu, S. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.02.001 · Cited by 1
Yuan, X., Li, X., Chen, K., Lim, E. L., Wei, Y., Jin, R., Weng, L., Karasaki, T., Luo, H., Qing, L., et al. (2026) · The Innovation · doi:10.1016/j.xinn.2026.101347 · Cited by 1
Early-life air pollution exposure: epigenetics and child allergy
Li, G., Xiao, Y., Wu, Z., Zeng, X., & Liu, J. (2026) · Epigenomics · doi:10.1080/17501911.2026.2671164 · Cited by 1
Airborne contaminant exposure and bone development: a systematic review and meta-analysis
Vera-Colón, M. K. M., Meletz, R. M., Phillipson, C. N., & Sparks, N. R. L. (2026) · Toxicological Sciences · doi:10.1093/toxsci/kfag067 · Cited by 1
Yang, D. Y., Yang, S., Park, Y. J., Lee, S.-H., Kim, H., Lim, S., Herkenrath, M., Song, A.-Y., Kim, J., Kim, H.-B., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76298-6 · Cited by 1
How much innovation is enough? The case of Australian small firms
Gronum, S., & Verreynne, M. (2011) · Swinburne figshare (Swinburne University of Technology) · doi:10.25916/sut.26273014 · Cited by 1
Epigenetics, exposome and development of the intestinal microbiota in the neonate
Benitez, P. S., & y Terrón, R. P. (2020) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2020.13.2.0367 · Cited by 1
Asthma Epigenetics: Elucidating an Expanding Paradigm
Miller, R. L., & Chen, J. (2022) · Springer eBooks · doi:10.1007/978-3-030-94475-9_16 · Cited by 1
Domenico, M. D. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2019.tde-25102019-133152
Metadata
- Authors
- Maghbooli, Z., Hossein-nezhad, A., Adabi, E., Asadollah-pour, E., Sadeghi, M., Mohammad-nabi, S., Zakeri Rad, L., Malek Hosseini, A.-A., Radmehr, M., Faghihi, F., Aghaei, A., Omidifar, A., Aghababei, Y., & Behzadi, H.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Milad Hospital (IR)
- Islamic Azad University, Tehran (IR)
- Shahid Beheshti University (IR)
- Corresponding author
- Maghbooli, Zhila
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-07-06
- Volume
- 13
- Issue
- 7
- Pages
- e0199772
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6034814
- OpenAlex
- W2822549645
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 9 · 2023: 14 · 2022: 23 · 2021: 17 · 2020: 11 · 2019: 15 · 2018: 3
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- The National Institute for Medical Research Development of Iran (940173)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- air pollution, prenatal exposure, PM2.5, PM10, placental DNA methylation, global DNA methylation, placental adaptation, S-adenosylmethionine, first trimester, epigenetic reprogramming, birth outcomes, neonatal outcomes
- MeSH terms
- Acclimatization, Adult, Air Pollution, Birth Weight, Female, Humans, Infant, Newborn, Iran, Placenta, Pregnancy, Cohort Studies, Biomarkers, Case-Control Studies, Maternal Exposure, DNA Methylation, Epigenesis, Genetic, Particulate Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
