Cited by 224Birth, Development, and HealthPregnancy and preeclampsia studiesGenetic Syndromes and Imprinting

Placental adaptations to the maternal–fetal environment: implications for fetal growth and developmental programming

Sandovici, Ionel, Hoelle, Katharina, Angiolini, Emily, Constância, Miguel·2012·Reproductive BioMedicine Online

Abstract

The placenta is a transient organ found in eutherian mammals that evolved primarily to provide nutrients for the developing fetus. The placenta exchanges a wide array of nutrients, endocrine signals, cytokines and growth factors with the mother and the fetus, thereby regulating intrauterine development. Recent studies show that the placenta is not just a passive organ mediating maternal-fetal exchange. It can adapt its capacity to supply nutrients in response to intrinsic and extrinsic variations in the maternal-fetal environment. These dynamic adaptations are thought to occur to maximize fetal growth and viability at birth in the prevailing conditions in utero. However, some of these adaptations may also affect the development of individual fetal tissues, with patho-physiological consequences long after birth. Here, this review summarizes current knowledge on the causes, possible mechanisms and consequences of placental adaptive responses, with a focus on the regulation of transporter-mediated processes for nutrients. This review also highlights the emerging roles that imprinted genes and epigenetic mechanisms of gene regulation may play in placental adaptations to the maternal-fetal environment.

Integrity signals

Registry

Crossref · 10.1016/j.rbmo.2012.03.017

Cites

153 of 153 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The mouse is favored for developmental programming research because of the ease of genetic manipulations, which enable imbalances to be created among maternal supply, placental size and fetal demands.

    “The mouse is favored because of the ease of genetic manipulations, which enable, for example, imbalances to be created among maternal supply, placental size and fetal demands (482).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [482]

  • Changes in nutritional state and food intake during pregnancy often accompany, and are confounding factors in studying, other environmental challenges such as hypoxia, heat stress, exercise and alterations in housing, lighting and noise levels.

    “In addition, changes in nutritional state and food intake during pregnancy often accompany, and are confounding factors in studying, other environmental challenges such as hypoxia, heat stress, exercise and alterations in housing, lighting and noise levels (482).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [482]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sandovici, I., Hoelle, K., Angiolini, E., & Constância, M.
Affiliations
University of Cambridge (GB)
Corresponding author
  • Sandovici, Ionel
  • Constância, Miguel
Venue
Reproductive BioMedicine Online
Publisher
Elsevier BV
Published
2012-07
Volume
25
Issue
1
Pages
68-89
ISSN
1472-6483 (ISSN-L)
OpenAlex
W2047911553
Cited by
224
References
153
Citations by year
2026: 19 · 2025: 9 · 2024: 22 · 2023: 22 · 2022: 12 · 2021: 21 · 2020: 15 · 2019: 17 · 2018: 12 · 2017: 13 · 2016: 22 · 2015: 15 · 2014: 8 · 2013: 11 · 2012: 6
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Locations
  • Reproductive BioMedicine Online (publishedVersion)
  • PubMed (publishedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BB/I014594/1, BBS/E/T/000PR6193)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
placental adaptation, fetal growth, developmental programming, nutrient transporters, nutrient exchange, imprinted genes, epigenetic regulation, placenta, fetal viability, placental mammals
MeSH terms
Adaptation, Physiological, Amino Acids, Animals, Calcium, Female, Fetus, Folic Acid, Gestational Age, Glucose, Humans, Maternal-Fetal Exchange, Placenta, Pregnancy, Signal Transduction, Genomic Imprinting, Gene Expression Regulation, Developmental, Prenatal Nutritional Physiological Phenomena, Epigenesis, Genetic, Fetal Development

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review