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Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation
Open accessAbstract
BACKGROUND: Health in early life is crucial for health later in life. Exposure to air pollution during embryonic and early-life development can result in placental epigenetic modification and foetus reprogramming, which can influence disease susceptibility in later life. Objectives: The aim of this paper was to investigate the placental adaptation in the level of global DNA methylation and differential gene expression in the methylation cycle in new-borns exposed to high fine particulate matter in the foetal stage. STUDY DESIGN: This is a nested case-control study. We enrolled pregnant healthy women attending prenatal care clinics in Tehran, Iran, who were residents of selected polluted and unpolluted regions, before the 14th week of pregnancy. We calculated the regional background levels of particle mass- particles with aerodynamics diameter smaller than 2.5 μm (PM2.5) and 10 μm (PM10)-of two regions of interest. At the time of delivery, placental tissue was taken for gene expression and DNA methylation analyses. We also recorded birth outcomes (the new-born's sex, birth date, birth weight and length, head and chest circumference, gestational age, Apgar score, and level of neonatal care required). RESULTS: As regards PM2.5 and PM10 concentrations in different time windows of pregnancy, there were significantly independent positive correlations between PM10 and PM2.5 in the first trimester of all subjects and placental global DNA methylation levels (p-value = 0.01, p-value = 0.03, respectively). The gene expression analysis showed there was significant correlation between S-adenosylmethionine expression and PM2.5 (p = 0.003) and PM10 levels in the first trimester (p = 0.03). CONCLUSION: Our data showed prenatal exposures to air pollutants in the first trimester could influence placental adaptation by DNA methylation.
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“In a cohort study, exposure to PM2.5 during the first trimester was significantly associated with decreased (2.2%) global DNA methylation in placenta tissue [178] and was also significantly correlated with gene expression of S-adenosylmethionine (SAM), a key substrate involved in methyl group transfers [184].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [184]
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Metadata
- Authors
- Maghbooli, Z., Hossein-nezhad, A., Adabi, E., Asadollah-pour, E., Sadeghi, M., Mohammad-nabi, S., Zakeri Rad, L., Malek Hosseini, A.-A., Radmehr, M., Faghihi, F., Aghaei, A., Omidifar, A., Aghababei, Y., & Behzadi, H.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Milad Hospital (IR)
- Islamic Azad University, Tehran (IR)
- Shahid Beheshti University (IR)
- Corresponding author
- Maghbooli, Zhila
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-07-06
- Volume
- 13
- Issue
- 7
- Pages
- e0199772
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6034814
- OpenAlex
- W2822549645
- Cited by
- 113
- References
- 25
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 9 · 2023: 14 · 2022: 23 · 2021: 17 · 2020: 11 · 2019: 15 · 2018: 3
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- Locations
- PLoS ONE (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- The National Institute for Medical Research Development of Iran (940173)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- air pollution, prenatal exposure, PM2.5, PM10, placental DNA methylation, global DNA methylation, placental adaptation, S-adenosylmethionine, first trimester, epigenetic reprogramming, birth outcomes, neonatal outcomes
- MeSH terms
- Acclimatization, Adult, Air Pollution, Birth Weight, Female, Humans, Infant, Newborn, Iran, Placenta, Pregnancy, Cohort Studies, Biomarkers, Case-Control Studies, Maternal Exposure, DNA Methylation, Epigenesis, Genetic, Particulate Matter
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