Progesterone-associated arginine decline at luteal phase of menstrual cycle and associations with related amino acids and nuclear factor kB activation
Open accessAbstract
BACKGROUND/OBJECTIVES: Given their role in female reproduction, the effects of progesterone on arginine and related amino acids, polyamines and NF-κB p65 activation were studied across the menstrual cycle. METHODS: Arginine, ornithine and citrulline as well as putrescine, spermidine, spermine, and N-acetyl-putrescine were determined in plasma, NF-κB p65 activation in peripheral blood mononuclear cells and progesterone in serum of 28 women at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase. RESULTS: Arginine and related amino acids declined from T1 and T2 to T3 and T4, while progesterone increased. At T3, arginine, ornithine, and citrulline were inversely related with progesterone. Changes (ΔT3-T2) in arginine, ornithine, and citrulline were inversely related with changes (ΔT3-T2) in progesterone. Ornithine and citrulline were positively related with arginine, as were changes (ΔT3-T2) in ornithine and citrulline with changes (ΔT3-T2) in arginine. At T2, NF-κB p65 activation was positively related with arginine. Polyamines did not change and were not related to progesterone. All results described were significant at P < 0.001. CONCLUSIONS: This study for the first time provides data, at the plasma and PBMC level, supporting a proposed regulatory node of arginine and related amino acids, progesterone and NF-κB p65 at luteal phase of the menstrual cycle, aimed at successful preparation of pregnancy.
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Progesterone functions catabolically to increase amino acid oxidation and decreases muscle protein synthesis.
“functions catabolically to increase amino acid oxidation and decreases muscle protein synthesis [78–81]”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [79]
The Introduction reports increased amino acid oxidation in the luteal phase, when progesterone rises, but does not establish that progesterone causes the increase. It discusses a possible rise in whole-body protein turnover, not a decrease in muscle protein synthesis; the paper does not report that outcome. (LLM, conf=0.86)
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International society of sports nutrition position stand: nutritional concerns of the female athlete
Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works
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- Authors
- Faustmann, G., Meinitzer, A., Magnes, C., Tiran, B., Obermayer-Pietsch, B., Gruber, H.-J., Ribalta, J., Rock, E., Roob, J. M., & Winklhofer-Roob, B. M.
- Affiliations
- University of Graz (AT)
- Medical University of Graz (AT)
- Joanneum Research (AT)
- Universitat Rovira i Virgili (ES)
- Unité de Nutrition Humaine (FR)
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-07-10
- Volume
- 13
- Issue
- 7
- Pages
- e0200489
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6039037
- OpenAlex
- W2827627817
- Cited by
- 16
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Seventh Framework Programme (244995)
- Bundesministerium für Wissenschaft, Forschung und Wirtschaft (GZ 651.483/0001-II/2/2010, GZ 651.484/0001-II/2/2010, GZ 650.874/1-VI/2/2003)
- Fifth Framework Programme (QLK1-CT-1999-00830)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- progesterone, L-arginine, ornithine, citrulline, luteal phase, menstrual cycle, polyamines, putrescine, spermidine, spermine, plasma amino acids, peripheral blood mononuclear cells, female reproduction, pregnancy preparation
- MeSH terms
- Adult, Amino Acids, Arginine, Citrulline, Female, Follicular Phase, Humans, Leukocytes, Mononuclear, Luteal Phase, Ornithine, Progesterone, Putrescine, Reference Values, Spermidine, Spermine, Transcription Factor RelA, NF-kappa B p50 Subunit, Healthy Volunteers
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