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Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets

Kalozoumi, Georgia, Kel-Margoulis, Olga, Vafiadaki, Elizabeth, Greenberg, David, Bernard, Hélène, Soreq, Hermona, Depaulis, Antoine, Sanoudou, Despina·2018·PLOS ONE
DOI 10.1371/journal.pone.0201742PMC PMC6095496
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Fig 1 Electroencephalographic and histological consequences of kainate injection into the dorsal hippocampus in mice. A. EEG recordings performed at 6, 12 and 24h post-KA (n = 6), showing examples of EEG patterns recorded during the focal status epilepticus in the cortex (Cx) and injected hippocampus (Hipp). At 6 h post-KA there was no epileptiform activity in the cortex, whereas a discharge of spike and poly-spikes was observed in the hippocampus. At 12h, bursts of spikes were regularly observed in the hippocampus and ipsilateral cortex, whereas only occasional spikes were recorded in either the cortex or the hippocampus between 22 and 24h. B. Fluoro-jade B labeling 24h post-injection in saline-injected mouse (left) and KA-injected mouse (right), indicating the presence of injured cells in CA1, CA3 and hilus area. C. Nissl staining 24h post-injection in saline-injected mouse (left) and KA-injected mouse (right) indicating that most cells were pyknotic in CA1, CA3 and hilus area. Bar = 500 μm. * = track of the injection cannula.
Fig 1 Electroencephalographic and histological consequences of kainate injection into the dorsal hippocampus in mice. A. EEG recordings performed at 6, 12 and 24h post-KA (n = 6), showing examples of EEG patterns recorded during the focal status epilepticus in the cortex (Cx) and injected hippocampus (Hipp). At 6 h post-KA there was no epileptiform activity in the cortex, whereas a discharge of spike and poly-spikes was observed in the hippocampus. At 12h, bursts of spikes were regularly observed in the hippocampus and ipsilateral cortex, whereas only occasional spikes were recorded in either the cortex or the hippocampus between 22 and 24h. B. Fluoro-jade B labeling 24h post-injection in saline-injected mouse (left) and KA-injected mouse (right), indicating the presence of injured cells in CA1, CA3 and hilus area. C. Nissl staining 24h post-injection in saline-injected mouse (left) and KA-injected mouse (right) indicating that most cells were pyknotic in CA1, CA3 and hilus area. Bar = 500 μm. * = track of the injection cannula.CC BY · PubMed Central
Fig 2 Comparison of the significant transcript changes across 6, 12 and 24h post KA injection. Area-proportional Venn diagram with the number of significantly changed probe sets at each post-injection time point. A total of 54 animals were used (n = 9/time-point/treatment) for the microarray analysis, and SAM was applied for the analysis of KA- versus saline-injected hippocampi at each time point interrogated (thresholds: fold change ≥ |2|, FDR = 0%).
Fig 2 Comparison of the significant transcript changes across 6, 12 and 24h post KA injection. Area-proportional Venn diagram with the number of significantly changed probe sets at each post-injection time point. A total of 54 animals were used (n = 9/time-point/treatment) for the microarray analysis, and SAM was applied for the analysis of KA- versus saline-injected hippocampi at each time point interrogated (thresholds: fold change ≥ |2|, FDR = 0%).CC BY · PubMed Central
Fig 3 Schematic representation of the network of downstream molecules regulated by Cybb at 24h. The analysis was performed using the “Master regulators in networks (TRANSPATH®)” workflow (geneXplain 2.2 web edition) (thresholds: Score >0.2 and Z-Score >1), for all the significantly changed transcripts detected by microarrays in KA- versus saline-injected hippocampi at 24h (SAM analysis, thresholds: fold change > |2|, FDR = 0%, n = 9/time-point/treatment). Red: genes overexpressed at 24h, blue: genes not significantly changed, p: phosphorylation.
Fig 3 Schematic representation of the network of downstream molecules regulated by Cybb at 24h. The analysis was performed using the “Master regulators in networks (TRANSPATH®)” workflow (geneXplain 2.2 web edition) (thresholds: Score >0.2 and Z-Score >1), for all the significantly changed transcripts detected by microarrays in KA- versus saline-injected hippocampi at 24h (SAM analysis, thresholds: fold change > |2|, FDR = 0%, n = 9/time-point/treatment). Red: genes overexpressed at 24h, blue: genes not significantly changed, p: phosphorylation.CC BY · PubMed Central
Fig 4 Summary diagram of the key biological changes detected during epileptogenesis. At 6h multiple neuroexcitation-induced immediate and early response genes are significantly changed. At 12h specific ion conduction, neurotransmission, astrocyte/microglial activation, inflammation and apoptosis related mechanisms are significantly altered. Importantly, at 24h, the silent phase of epileptogenesis, Nox2 (Cybb) and Vim are predicted to act as upstream regulators of key biological processes ultimately leading to activated glia, NOX-mediated ROS, neuroinflammation and neurodegeneration. The presence or absence of KA-induced epileptiform activity is denoted with orange and white color, respectively. The spontaneous epileptiform activity is marked with blue color.
Fig 4 Summary diagram of the key biological changes detected during epileptogenesis. At 6h multiple neuroexcitation-induced immediate and early response genes are significantly changed. At 12h specific ion conduction, neurotransmission, astrocyte/microglial activation, inflammation and apoptosis related mechanisms are significantly altered. Importantly, at 24h, the silent phase of epileptogenesis, Nox2 (Cybb) and Vim are predicted to act as upstream regulators of key biological processes ultimately leading to activated glia, NOX-mediated ROS, neuroinflammation and neurodegeneration. The presence or absence of KA-induced epileptiform activity is denoted with orange and white color, respectively. The spontaneous epileptiform activity is marked with blue color.CC BY · PubMed Central

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Metadata

Authors
Kalozoumi, G., Kel-Margoulis, O., Vafiadaki, E., Greenberg, D., Bernard, H., Soreq, H., Depaulis, A., & Sanoudou, D.
ORCID
Kalozoumi, Georgia
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2018-08-16
Volume
13
Issue
8
Pages
e0201742
ISSN
1932-6203
DOI
10.1371/journal.pone.0201742
PMC
PMC6095496
Cited by
38
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • INSERM
  • European Union 6th Framework Program for Research and Technological Development (VALAPODYN, contract # LSHG-CT-2006-037277)

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CoChat. (2026). Citation check: Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets. https://app.cochat.ai/papers/10.1371/journal.pone.0201742
The paper
Kalozoumi, G., Kel-Margoulis, O., Vafiadaki, E., Greenberg, D., Bernard, H., Soreq, H., Depaulis, A., & Sanoudou, D. (2018). Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets. PLOS ONE. https://doi.org/10.1371/journal.pone.0201742