The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis
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Abstract
Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in health and diseases. Therefore, we used heparin affinity proteomics to identify extracellular HBPs in pancreas and plasma of normal mice and in a caerulein mouse model of AP. Many new extracellular HBPs (360) were discovered in the pancreas, taking the total number of HBPs known to 786. Extracellular pancreas HBPs form highly interconnected protein-protein interaction networks in both normal pancreas (NP) and AP. Thus, HBPs represent an important set of extracellular proteins with significant regulatory potential in the pancreas. HBPs in NP are associated with biological functions such as molecular transport and cellular movement that underlie pancreatic homeostasis. However, in AP HBPs are associated with additional inflammatory processes such as acute phase response signalling, complement activation and mitochondrial dysfunction, which has a central role in the development of AP. Plasma HBPs in AP included known AP biomarkers such as serum amyloid A, as well as emerging targets such as histone H2A. Other HBPs such as alpha 2-HS glycoprotein (AHSG) and histidine-rich glycoprotein (HRG) need further investigation for potential applications in the management of AP. Pancreas HBPs are extracellular and so easily accessible and are potential drug targets in AP, whereas plasma HBPs represent potential biomarkers for AP. Thus, their identification paves the way to determine which HBPs may have potential applications in the management of AP.
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Meneghetti, M. C. Z., Deboni, P., Palomino, C. M. V., Braga, L. P., Cavalheiro, R. P., Viana, G. M., Yates, E. A., Nader, H. B., & de Lima, M. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.23.916940
Peer Review #2 of "Analysis of protein-heparin interactions using a portable SPR instrument (v0.2)"
(2022) · PeerJ Analytical Chemistry · doi:10.7287/peerj-achem.15v0.2/reviews/2
Peer Review #2 of "Analysis of protein-heparin interactions using a portable SPR instrument (v0.1)"
(2022) · PeerJ Analytical Chemistry · doi:10.7287/peerj-achem.15v0.1/reviews/2
Peer Review #3 of "Analysis of protein-heparin interactions using a portable SPR instrument (v0.1)"
(2022) · PeerJ Analytical Chemistry · doi:10.7287/peerj-achem.15v0.1/reviews/3
Peer Review #1 of "Analysis of protein-heparin interactions using a portable SPR instrument (v0.1)"
(2022) · PeerJ Analytical Chemistry · doi:10.7287/peerj-achem.15v0.1/reviews/1
Nakamura, M., & Sato, A. (2022) · Trends in glycoscience and glycotechnology · doi:10.4052/tigg.1957.1j
The Glycosaminoglycan‐Dependent Interactome of Neurexin‐1 in Human Fetal Glial Cells
Critcher, M., Wu, H., Lu, Y., & Huang, M. L. (2025) · Proteoglycan Research · doi:10.1002/pgr2.70039
Serum amyloid A in the gut-liver axis: Implications for alcohol-associated pathology
Zhong, W., Weinman, S. A., & Tikhanovich, I. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.04.003
- Authors
- Nunes, Q. M., Su, D., Brownridge, P. J., Simpson, D. M., Sun, C., Li, Y., Bui, T. P., Zhang, X., Huang, W., Rigden, D. J., Beynon, R. J., Sutton, R., & Fernig, D. G.
- Affiliations
- University of Liverpool (GB)
- Wenzhou University (CN)
- Corresponding author
- Nunes, Quentin M.
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2019-06-18
- Volume
- 14
- Issue
- 6
- Pages
- e0217633
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC6581253
- OpenAlex
- W2951159369
- Cited by
- 42
- References
- 68
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 19 · 2021: 3 · 2020: 7
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Cancer and Polio Research Fund
- National Institute for Health and Care Research (CTF-2017-06-013, 15/20/01, ACF-2007-07-001, CL-2014-07-001, EME/15/20/01, NF-SI-0515-10084)
- Royal College of Surgeons of England
- North West Cancer Research
- Bộ Giáo dục và Ðào tạo
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- acute pancreatitis, heparin-binding protein, extracellular proteins, cerulein-induced pancreatitis, protein-protein interaction network, acute phase response, complement activation, mitochondrial dysfunction, serum amyloid A, histone H2A, fetuin-A, histidine-rich glycoprotein, plasma biomarkers, therapeutic target, pancreatic homeostasis
- MeSH terms
- Histidine-Rich Glycoprotein, Serum Amyloid A Protein, Animals, Disease Models, Animal, Heparin, Homeostasis, Humans, Pancreas, Pancreatitis, Protein Binding, Proteins, Biomarkers, Proteome, Proteomics, Mice, alpha-2-HS-Glycoprotein
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