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Cited by 269

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network

Open access
de Pinieux, Gonzague, Karanian, Marie, Le Loarer, Francois, Le Guellec, Sophie, Chabaud, Sylvie, Terrier, Philippe, Bouvier, Corinne, Batistella, Maxime, Neuville, Agnès, Robin, Yves-Marie, Emile, Jean-Francois, Moreau, Anne, Larousserie, Frederique, Leroux, Agnes, Stock, Nathalie, Lae, Marick, Collin, Francoise, Weinbreck, Nicolas, Aubert, Sebastien, Mishellany, Florence, Charon-Barra, Celine, Croce, Sabrina, Doucet, Laurent, Quintin-Rouet, Isabelle, Chateau, Marie-Christine, Bazille, Celine, Valo, Isabelle, Chetaille, Bruno, Ortonne, Nicolas, Brouchet, Anne, Rochaix, Philippe, Demuret, Anne, Ghnassia, Jean-Pierre, Mescam, Lenaig, Macagno, Nicolas, Birtwisle-Peyrottes, Isabelle, Delfour, Christophe, Angot, Emilie, Pommepuy, Isabelle, Ranchere, Dominique, Chemin-Airiau, Claire, Jean-Denis, Myriam, Fayet, Yohan, Courrèges, Jean-Baptiste, Mesli, Nouria, Berchoud, Juliane, Toulmonde, Maud, Italiano, Antoine, Le Cesne, Axel, Penel, Nicolas, Ducimetiere, Francoise, Gouin, Francois, Coindre, Jean-Michel, Blay, Jean-Yves, on behalf of the NetSarc/RePPS/ResSos and French Sarcoma Group- Groupe d’Etude des Tumeurs Osseuses (GSF-GETO) networks·2021·PLOS ONE
DOI 10.1371/journal.pone.0246958
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Abstract

Background: Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases of sarcomas and connective tumors of intermediate malignancy (TIM) in France. Methods: The nationwide incidence of sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification and confirmed by a second independent review by expert pathologists. Simple clinical characteristics, yearly variations and correlation of incidence with published clinical trials are presented and analyzed. Results: Over 150 different histological subtypes are reported from the 25172 patients with sarcomas (n = 18712, 74,3%) or TIM (n = 6460, 25.7%), with n = 5838, n = 6153, n = 6654, and n = 6527 yearly cases from 2013 to 2016. Over these 4 years, the yearly incidence of sarcomas and TIM was therefore 70.7 and 24.4 respectively, with a combined incidence of 95.1/10 6 /year, higher than previously reported. GIST, liposarcoma, leiomyosarcomas, undifferentiated sarcomas represented 13%, 13%, 11% and 11% of tumors. Only GIST, as a single entity had a yearly incidence above 10/10 6 /year. There were respectively 30, 64 and 66 different histological subtypes of sarcomas or TIM with an incidence ranging from 10 to 1/10 6 , 1–0.1/10 6 , or < 0.1/10 6 /year respectively. The 2 latter incidence groups represented 21% of the patients with 130 histotypes. Published phase III and phase II clinical trials (p<10 −6 ) are significantly higher with sarcomas subtypes with an incidence above 1/10 6 per. Conclusions: This nationwide registry of sarcoma patients, with exhaustive histology review by sarcoma experts, shows that the incidence of sarcoma and TIM is higher than reported, and that tumors with a very low incidence (1<10 6 /year) are less likely to be included in clinical trials.

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Authors
de Pinieux, G., Karanian, M., Le Loarer, F., Le Guellec, S., Chabaud, S., Terrier, P., Bouvier, C., Batistella, M., Neuville, A., Robin, Y.-M., Emile, J.-F., Moreau, A., Larousserie, F., Leroux, A., Stock, N., Lae, M., Collin, F., Weinbreck, N., Aubert, S., Mishellany, F., Charon-Barra, C., Croce, S., Doucet, L., Quintin-Rouet, I., Chateau, M.-C., Bazille, C., Valo, I., Chetaille, B., Ortonne, N., Brouchet, A., Rochaix, P., Demuret, A., Ghnassia, J.-P., Mescam, L., Macagno, N., Birtwisle-Peyrottes, I., Delfour, C., Angot, E., Pommepuy, I., Ranchere, D., Chemin-Airiau, C., Jean-Denis, M., Fayet, Y., Courrèges, J.-B., Mesli, N., Berchoud, J., Toulmonde, M., Italiano, A., Le Cesne, A., Penel, N., Ducimetiere, F., Gouin, F., Coindre, J.-M., Blay, J.-Y., & on behalf of the NetSarc/RePPS/ResSos and French Sarcoma Group- Groupe d’Etude des Tumeurs Osseuses (GSF-GETO) networks
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2021-02-25
Volume
16
Issue
2
Pages
e0246958
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0246958
OpenAlex
W3131890445
Cited by
269
References
23
FWCI
26.52
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. https://app.cochat.ai/papers/10.1371/journal.pone.0246958
The paper
de Pinieux, G., Karanian, M., Le Loarer, F., Le Guellec, S., Chabaud, S., Terrier, P., Bouvier, C., Batistella, M., Neuville, A., Robin, Y.-M., Emile, J.-F., Moreau, A., Larousserie, F., Leroux, A., Stock, N., Lae, M., Collin, F., Weinbreck, N., Aubert, S., . . . on behalf of the NetSarc/RePPS/ResSos and French Sarcoma Group- Groupe d’Etude des Tumeurs Osseuses (GSF-GETO) networks. (2021). Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. PLOS ONE. https://doi.org/10.1371/journal.pone.0246958

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.