Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up
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Osteosarcoma is regarded as a radio-resistant disease.
“Although osteosarcoma is regarded as a radio-resistant disease, radiotherapy as local control may be considered if resection of a primary tumour is not possible or anticipated to lead to unacceptable morbidities such as in pelvic, trunk or craniofacial primary sites of disease 104 .”
From Osteosarcoma (2022) · cites this paper as [104]
The recommended recurrence regimens include high-dose ifosfamide with or without etoposide and gemcitabine and docetaxel.
“The regimens include high-dose ifosfamide with or without etoposide and gemcitabine and docetaxel.”
From Osteosarcoma (2022) · cites this paper as [104]
Several chemotherapy regimens are recommended by NCCN and ESMO guidelines at the time of osteosarcoma recurrence.
“Several chemotherapy regimens are recommended by the National Cancer Care Network (NCCN) and European Society of Medical Oncology (ESMO) guidelines at the time of osteosarcoma recurrence 104,141 .”
From Osteosarcoma (2022) · cites this paper as [104]
Bone and soft-tissue sarcomas remain difficult to monitor across diagnosis, treatment, and follow-up.
“remain difficult to monitor across diagnosis, treatment, and follow-up [ 1 , 2 ]”
From Signals Alongside Scans: A Genomics-Guided Framework for Liquid Biopsy in Bone and Soft-Tissue Sarcomas (2026) · cites this paper as [1]
Bone and soft-tissue sarcomas are rare, heterogeneous mesenchymal malignancies.
“Bone and soft-tissue sarcomas are rare, heterogeneous mesenchymal malignancies”
From Signals Alongside Scans: A Genomics-Guided Framework for Liquid Biopsy in Bone and Soft-Tissue Sarcomas (2026) · cites this paper as [1]
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Self-citationInoperable or incompletely resected craniofacial osteosarcoma treated by particle radiotherapy
Seidensaal, K., Dostal, M., Liermann, J., Adeberg, S., Weykamp, F., Schmid, M. P., Freudlsperger, C., Hoffmann, J., Hompland, I., Herfarth, K. K., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.927399 · Cited by 13 · see citing works
From biology to personalized medicine: Recent knowledge in osteosarcoma
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Tirtei, E., Michelsen, S. W., Haveman, L., Meazza, C., Oliveira, J., Rasool, A., Palmerini, E., Wilson, W., Gaspar, N., Strauss, S. J., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.71044 · Cited by 13 · see citing works
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Self-citationThe hypoxia-related signature predicts prognosis, pyroptosis and drug sensitivity of osteosarcoma
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Emerging roles of long non-coding RNAs in osteosarcoma
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How to Preserve Fertility in Reproductive-Age Women with Cancer
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Self-citationImpact of Age at Diagnosis on Cardiotoxicity in High-Grade Osteosarcoma and Ewing Sarcoma Patients
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Self-citationGenetic predisposition in sarcomas: clinical implications and management
Connolly, E. A., Boye, K., Bonvalot, S., Kratz, C. P., Leithner, A., Malkin, D. M., Messiou, C., Miah, A. B., Pantziarka, P., Timmermann, B., et al. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103203 · Cited by 11 · see citing works
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Extraskeletal Ewing’s sarcoma of the mediastinum: Case report
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Self-citationAutomated detection of bone lesions using CT and MRI: a systematic review
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PET-CT in Clinical Adult Oncology—VI. Primary Cutaneous Cancer, Sarcomas and Neuroendocrine Tumors
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Establishment, Maintenance, and Performance of the Cooperative Osteosarcoma Study Group (COSS)
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Self-citationImplementing precision oncology for sarcoma patients: the CCCLMUmolecular tumor board experience
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Current indications for denosumab in benign bone tumours
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- Authors
- Strauss, S. J., Frezza, A. M., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J. Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J. V. M. G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., de Álava, E., Dei Tos, A. P., Garcia del Muro, X., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Gaspar, N., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Gronchi, A., Haas, R., Hassan, A. B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R. L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D. A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., López Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A. B., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M. A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A. A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M. A. J., van der Graaf, W. T. A., van Houdt, W. J., Frebourg, T., Ladenstein, R., Casali, P. G., & Stacchiotti, S.
- Affiliations
- University College London Hospitals NHS Foundation Trust (GB)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Instituto Português de Oncologia Francisco Gentil (PT)
- Homi Bhabha National Institute (IN)
- University of Duisburg-Essen (DE)
- Instituto Nazionale Tumori Regina Elena (IT)
- Olgahospital (DE)
- Centre Léon Bérard (FR)
- Institut Gustave Roussy (FR)
- Institut Curie (FR)
- Oslo University Hospital (NO)
- Royal Manchester Children's Hospital (GB)
- Vienna General Hospital (AT)
- Centro di Riferimento Oncologico (IT)
- Skåne University Hospital (SE)
- Ospedale Regina Margherita (IT)
- Université Paris-Saclay (FR)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Leiden University Medical Center (NL)
- Candiolo Cancer Institute (IT)
- University of Milan (IT)
- University of Oxford (GB)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- University of Mannheim (DE)
- University of Helsinki (FI)
- Institute of Cancer Research (GB)
- Université Libre de Bruxelles (BE)
- University Medical Center Groningen (NL)
- St Anna Children's Hospital (AT)
- National Cancer Center Hospital (JP)
- Masaryk Memorial Cancer Institute (CZ)
- KU Leuven (BE)
- University of Graz (AT)
- Tel Aviv Sourasky Medical Center (IL)
- Centre Hospitalier Universitaire Vaudois (CH)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- Istituto Ortopedico Rizzoli (IT)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Helios Hospital Berlin-Buch (DE)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Aarhus University Hospital (DK)
- Azienda Ospedale - Università Padova (IT)
- Universitair Ziekenhuis Leuven (BE)
- Erasmus MC Cancer Institute (NL)
- Royal Marsden Hospital (GB)
- Institute of Oncology Ljubljana (SI)
- ORCID
- Strauss, S.J.
- Frezza, A.M.
- Bajpai, J.
- Bauer, S.
- Biagini, R.
- Bielack, S.
- Blay, J.Y.
- Bolle, S.
- Bonvalot, S.
- Boye, K.
- Brennan, B.
- Buonadonna, A.
- Dufresne, A.
- Fagioli, F.
- Ferraresi, V.
- Ferrari, A.
- Gaspar, N.
- Gelderblom, H.
- Gouin, F.
- Grignani, G.
- Gronchi, A.
- Haas, R.
- Hindi, N.
- Hohenberger, P.
- Joensuu, H.
- Jones, R.L.
- Jutte, P.
- Kager, L.
- Kasper, B.
- Kawai, A.
- Krákorová, D.A.
- Legius, E.
- Leithner, A.
- Messiou, C.
- Miah, A.B.
- Mir, O.
- Montemurro, M.
- Morland, B.
- Morosi, C.
- Palmerini, E.
- Pantaleo, M.A.
- Piana, R.
- Piperno-Neumann, S.
- Reichardt, P.
- Rutkowski, P.
- Safwat, A.A.
- Sangalli, C.
- Sbaraglia, M.
- Scheipl, S.
- Schöffski, P.
- Sleijfer, S.
- Strauss, D.
- Trama, A.
- Unk, M.
- Ladenstein, R.
- Casali, P.G.
- Stacchiotti, S.
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 32
- Issue
- 12
- Pages
- 1520-1536
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W3197355167
- Cited by
- 513
- References
- 99
- Citations by year
- 2026: 137 · 2025: 118 · 2024: 111 · 2023: 88 · 2022: 54 · 2021: 4
- FWCI
- 41.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- IRIS (submittedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Lirias (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- SERVAL (Université de Lausanne) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- European Society for Medical Oncology
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- primary bone sarcoma, osteosarcoma, Ewing sarcoma, conventional chondrosarcoma, pediatric bone tumors, diagnosis, treatment, follow-up
- MeSH terms
- Bone Neoplasms, Follow-Up Studies, Humans, Sarcoma, Osteosarcoma
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