DNA binding by the Rad9A subunit of the Rad9-Rad1-Hus1 complex

Hwang, Bor-Jang; Gonzales, Rex; Corzine, Sage; Stenson, Emilee; Pidugu, Lakshmi; Lu, A-Lien

doi:10.1371/journal.pone.0272645

DNA binding by the Rad9A subunit of the Rad9-Rad1-Hus1 complex

The Rad9-Rad1-Hus1 checkpoint clamp activates the DNA damage response and promotes DNA repair. DNA loading on the central channel of the Rad9-Rad1-Hus1 complex is required to execute its biological functions. Because Rad9A has the highest DNA affinity among the three subunits, we determined the d…