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Cited by 4Developmental Biology and Gene RegulationDiptera species taxonomy and behaviorChromosomal and Genetic Variations

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Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid

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Li, Muzi, Kasan, Koray, Saha, Zinnia, Yoon, Yoseop, Schmidt-Ott, Urs·2023·PLOS ONE
DOI 10.1371/journal.pone.0274716PMC PMC9810180

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Abstract

The C2H2 zinc finger gene cucoid establishes anterior-posterior (AP) polarity in the early embryo of culicine mosquitoes. This gene is unrelated to genes that establish embryo polarity in other fly species (Diptera), such as the homeobox gene bicoid , which serves this function in the traditional model organism Drosophila melanogaster . The cucoid gene is a conserved single copy gene across lower dipterans but nothing is known about its function in other species, and its evolution in higher dipterans, including Drosophila, is unresolved. We found that cucoid is a member of the ZAD-containing C2H2 zinc finger (ZAD-ZNF) gene family and is orthologous to 27 of the 91 members of this family in D . melanogaster , including M1BP , ranshi , ouib , nom , zaf1 , odj , Nnk , trem , Zif , and eighteen uncharacterized genes. Available knowledge of the functions of cucoid orthologs in Drosophila melanogaster suggest that the progenitor of this lineage specific expansion may have played a role in regulating chromatin. We also describe many aspects of the gene duplication history of cucoid in the brachyceran lineage of D . melanogaster , thereby providing a framework for predicting potential redundancies among these genes in D . melanogaster .

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Metadata

Authors
Li, M., Kasan, K., Saha, Z., Yoon, Y., & Schmidt-Ott, U.
Affiliations
  • University of Chicago (US)
  • University of California, Irvine (US)
ORCID
Venue
PLOS ONE
Publisher
Public Library of Science (PLoS)
Published
2023-01-03
Volume
18
Issue
1
Pages
e0274716
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0274716
PMC
PMC9810180
OpenAlex
W4313461042
Cited by
4
References
2
Citations by year
2025: 4
FWCI
0.35
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Knowledge@UChicago (University of Chicago) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Chicago (cc-by)
Funders
National Institute of General Medical Sciences (R01GM127366)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Diptera species taxonomy and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords
embryonic polarity, anterior-posterior axis, Drosophila melanogaster, chromatin regulation, Bicoid, gene family evolution
MeSH terms
Animals, Drosophila, Drosophila melanogaster, Culicidae, Transcription Factors, Zinc Fingers, Drosophila Proteins

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