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Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
Open accessAbstract
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The understanding of apical complex function, the basis for its novel structure, and the mechanism for its motility are greatly impeded by lack of knowledge of its molecular composition. We have partially purified the conoid/apical complex, identified approximately 200 proteins that represent 70% of its cytoskeletal protein components, characterized seven novel proteins, and determined the sequence of recruitment of five of these proteins into the cytoskeleton during cell division. Our results provide new markers for the different subcompartments within the apical complex, and revealed previously unknown cellular compartments, which facilitate our understanding of how the invasion machinery is built. Surprisingly, the extreme apical and extreme basal structures of this highly polarized cell originate in the same location and at the same time very early during parasite replication.
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Citations
Cited by
Tagging of Endogenous Genes in a Toxoplasma gondii Strain Lacking Ku80
Huynh, M.-H., & Carruthers, V. B. (2009) · Eukaryotic Cell · doi:10.1128/ec.00358-08 · Cited by 506
Cell division in apicomplexan parasites
Francia, M. E., & Striepen, B. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3184 · Cited by 301
Woo, Y. H., Ansari, H., Otto, T. D., Klinger, C. M., Kolisko, M., Michálek, J., Saxena, A., Shanmugam, D., Tayyrov, A., Veluchamy, A., et al. (2015) · eLife · doi:10.7554/elife.06974 · Cited by 295
Self-citationBeck, J. R., Rodriguez-Fernandez, I. A., Cruz de Leon, J., Huynh, M.-H., Carruthers, V. B., Morrissette, N. S., & Bradley, P. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001094 · Cited by 217
Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa
Dos Santos Pacheco, N., Brusini, L., Haase, R., Tosetti, N., Maco, B., Brochet, M., Vadas, O., & Soldati-Favre, D. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01212-x · Cited by 46
Metadata
- Authors
- Hu, K., Johnson, J., Florens, L., Fraunholz, M., Suravajjala, S., DiLullo, C., Yates, J., Roos, D. S., & Murray, J. M.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-02-24
- Volume
- 2
- Issue
- 2
- Pages
- e13
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2082460216
- Cited by
- 303
- References
- 0
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hu, K., Johnson, J., Florens, L., Fraunholz, M., Suravajjala, S., DiLullo, C., Yates, J., Roos, D. S., & Murray, J. M. (2006). Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.0020013
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