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Cryo-Electron Tomographic Structure of an Immunodeficiency Virus Envelope Complex In Situ
Open accessAbstract
The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowledge of the unliganded, trimeric Env structure is key for an understanding of viral entry and immune escape, and for the design of vaccines to elicit neutralizing antibodies. We have used cryo-electron tomography and averaging to obtain the structure of the SIV Env complex prior to fusion. Our result reveals novel details of Env organisation, including tight interaction between monomers in the gp41 trimer, associated with a three-lobed, membrane-distal gp120 trimer. A cavity exists at the gp41-gp120 trimer interface. Our model for the spike structure agrees with previously predicted interactions between gp41 monomers, and furthers our understanding of gp120 interactions within an intact spike.
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Cited by
Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
White, J. M., Delos, S. E., Brecher, M., & Schornberg, K. (2008) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230802058320 · Cited by 892
Structure and assembly of immature HIV
Briggs, J. A. G., Riches, J. D., Glass, B., Bartonova, V., Zanetti, G., & Kräusslich, H.-G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903535106 · Cited by 368
Self-citationA saposin-lipoprotein nanoparticle system for membrane proteins
Frauenfeld, J., Löving, R., Armache, J.-P., Sonnen, A. F.-P., Guettou, F., Moberg, P., Zhu, L., Jegerschöld, C., Flayhan, A., Briggs, J. A. G., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3801 · Cited by 293
Self-citationViral and host factors regulating HIV-1 envelope protein trafficking and particle incorporation
Anokhin, B., & Spearman, P. (2022) · Viruses · doi:10.3390/v14081729 · Cited by 21
Metadata
- Authors
- Zanetti, G., Briggs, J. A. G., Grünewald, K., Sattentau, Q. J., & Fuller, S. D.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-08-25
- Volume
- 2
- Issue
- 8
- Pages
- e83
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W1991112092
- Cited by
- 232
- References
- 0
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zanetti, G., Briggs, J. A. G., Grünewald, K., Sattentau, Q. J., & Fuller, S. D. (2006). Cryo-Electron Tomographic Structure of an Immunodeficiency Virus Envelope Complex In Situ. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.0020083
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