Cited by 348Cervical Cancer and HPV ResearchVirus-based gene therapy researchCancer-related Molecular Pathways

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression

Open access

Pyeon, Dohun, Pearce, Shane M., Lank, Simon M., Ahlquist, Paul, Lambert, Paul F.·2009·PLoS Pathogens

DOI 10.1371/journal.ppat.1000318PMC PMC2642596

Open this paper in CoChat — free account Open PDF

Abstract

Human papillomaviruses (HPVs) are DNA viruses associated with major human cancers. As such there is a strong interest in developing new means, such as vaccines and microbicides, to prevent HPV infections. Developing the latter requires a better understanding of the infectious life cycle of HPVs. The HPV infectious life cycle is closely linked to the differentiation state of the stratified epithelium it infects, with progeny virus only made in the terminally differentiating suprabasal compartment. It has long been recognized that HPV must first establish its infection within the basal layer of stratified epithelium, but why this is the case has not been understood. In part this restriction might reflect specificity of expression of entry receptors. However, this hypothesis could not fully explain the differentiation restriction of HPV infection, since many cell types can be infected with HPVs in monolayer cell culture. Here, we used chemical biology approaches to reveal that cell cycle progression through mitosis is critical for HPV infection. Using infectious HPV16 particles containing the intact viral genome, G1-synchronized human keratinocytes as hosts, and early viral gene expression as a readout for infection, we learned that the recipient cell must enter M phase (mitosis) for HPV infection to take place. Late M phase inhibitors had no effect on infection, whereas G1, S, G2, and early M phase cell cycle inhibitors efficiently prevented infection. We conclude that host cells need to pass through early prophase for successful onset of transcription of the HPV encapsidated genes. These findings provide one reason why HPVs initially establish infections in the basal compartment of stratified epithelia. Only this compartment of the epithelium contains cells progressing through the cell cycle, and therefore it is only in these cells that HPVs can establish their infection. By defining a major condition for cell susceptibility to HPV infection, these results also have potentially important implications for HPV control.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.ppat.1000318

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 15,068
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., & Fusenig, N. E. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.3.761 · Cited by 4,170
Papillomaviruses and cancer: from basic studies to clinical application
Hausen, H. Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc798 · Cited by 4,031
Human papillomavirus and cervical cancer
Burd, E. M. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.1.1-17.2003 · Cited by 2,420
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
Mayer, T. U., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L., & Mitchison, T. J. (1999) · Science · doi:10.1126/science.286.5441.971 · Cited by 1,752
Papillomavirus infections — a major cause of human cancers
Hausen, H. Z. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(96)00020-0 · Cited by 1,532
Cdk1 is sufficient to drive the mammalian cell cycle
Santamarı́a, D., Barrière, C., Cerqueira, A., Hunt, S. L., Tardy, C., Newton, K., Cáceres, J. F., Dubus, P. R., Malumbres, M., & Barbacid, M. (2007) · Nature · doi:10.1038/nature06046 · Cited by 1,096
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
Bernardi, R., & Pandolfi, P. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2277 · Cited by 876
Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors
Gray, N. S., Wodicka, L. M., Thunnissen, A. M. W. H., Norman, T., Kwon, S., Espinoza, F. H., Morgan, D. O., Barnes, G., Leclerc, S., Meijer, L., et al. (1998) · Science · doi:10.1126/science.281.5376.533 · Cited by 808
Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
Lewis, P. F., & Emerman, M. (1994) · Journal of Virology · doi:10.1128/jvi.68.1.510-516.1994 · Cited by 797

Flagged first, then by citations

Show all 52 references

Sorted by citations

Items 201–300 of 348

Chondroitin Sulfate Proteoglycans Are De Facto Cellular Receptors for Human Papillomavirus 16 under High Serum Conditions
Fons, N. R., Kines, R. C., Thompson, C. D., Day, P. M., Lowy, D. R., & Schiller, J. T. (2022) · Journal of Virology · doi:10.1128/jvi.01857-21 · Cited by 14
Human Papillomavirus Minor Capsid Protein L2 Mediates Intracellular Trafficking into and Passage beyond the Endoplasmic Reticulum
Morante, A. V., Baboolal, D. D., Simon, X., Pan, E. M. C.-Y., & Meneses, P. I. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01505-22 · Cited by 14
HPV Infection and Oral Microbiota: Interactions and Future Implications
Xia, Q., & Pierson, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041424 · Cited by 14
Evidence for Tethering of Human Cytomegalovirus Genomes to Host Chromosomes
Mauch-Mücke, K., Schön, K., Paulus, C., & Nevels, M. M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.577428 · Cited by 14
Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare
Holubeková, V., Kolková, Z., Kašubová, I., Samec, M., Mazuráková, A., Koklesová, L., Kubatka, P., Rokos, T., Kozubík, E., Biringer, K., et al. (2022) · BioMolecular Concepts · doi:10.1515/bmc-2022-0005 · Cited by 13
Optimization of human papillomavirus-based pseudovirus techniques for efficient gene transfer
Gilson, T. D., Gibson, R. T., & Androphy, E. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-72027-1 · Cited by 12
HPV-16 virions can remain infectious for 2 weeks on senescent cells but require cell cycle re-activation to allow virus entry
Broniarczyk, J. K., Ring, N., Massimi, P., Giacca, M., & Banks, L. (2018) · Scientific Reports · doi:10.1038/s41598-017-18809-6 · Cited by 12
Role of plasmonics in detection of deadliest viruses: a review
Sohrabi, F., Saeidifard, S., Ghasemi, M., Asadishad, T., Hamidi, S. M., & Hosseini, S. M. (2021) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-021-01657-9 · Cited by 12
The microbiota as a modulator of mucosal inflammation and HIV/HPV pathogenesis: From association to causation
Moreno, E., Ron, R., & Villar, S. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1072655 · Cited by 11
HPV Testing and its Role in Cervical Cancer Screening
Clarke, M. A. (2023) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000793 · Cited by 11
The role of HR-HPV integration in the progression of premalignant lesions into different cancer types
Catalán-Castorena, O., Garibay‐Cerdenares, O. L., Illades‐Aguiar, B., Rodríguez-Ruiz, H. A., Zubillaga‐Guerrero, M. I., Leyva‐Vázquez, M. A., Encarnación‐Guevara, S., & Alarcón‐Romero, L. D. C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34999 · Cited by 13
Revolutionizing cervical cancer diagnostics: A shift from traditional techniques to biosensors
Naikoo, U. M., Pilloton, R., Farooqi, H., & Narang, J. (2025) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2025.100587 · Cited by 11
Topological implications of DNA tumor viral episomes
Kim, E. T., & Kim, K.-D. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.12.154 · Cited by 11
Integration of HIV in the Human Genome: Which Sites Are Preferential? A Genetic and Statistical Assessment
Gonçalves, J., Moreira, E., Sequeira, I. J., Rodrigues, A. S., Rueff, J., & Brás, A. (2016) · International Journal of Genomics · doi:10.1155/2016/2168590 · Cited by 11
Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways
Zhang, X., Lim, K., Qiu, Y., Hazawa, M., & Wong, R. W.-C. (2025) · Viruses · doi:10.3390/v17020151 · Cited by 11
Confined no more: Viral mechanisms of nuclear entry and egress
Molenberghs, F., Bogers, J., & Vos, W. H. D. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105875 · Cited by 11
Updates in the cause of sinonasal inverted papilloma and malignant transformation to squamous cell carcinoma
Tong, C. C. L., & Palmer, J. N. (2020) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0000000000000692 · Cited by 12
Novel antivirals inhibit early steps in HPV infection
Huang, H.-S., Pyeon, D., Pearce, S. M., Lank, S. M., Griffin, L., Ahlquist, P., & Lambert, P. F. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.12.007 · Cited by 10
Viral Noncoding RNAs in Cancer Biology
Li, Z., Fu, S., & Sun, L. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-1498-7_14 · Cited by 10
Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development
Kannampuzha, S., Gopalakrishnan, A. V., Padinharayil, H., Alappat, R. R., Anilkumar, K. V., George, A., Dey, A., Vellingiri, B., Madhyastha, H., Ganesan, R., et al. (2023) · Pathogens · doi:10.3390/pathogens12060770 · Cited by 10
Prevalence of cervical intraepithelial lesions and associated factors among women attending a cervical cancer clinic in Western Uganda; results based on Pap smear cytology
Ssedyabane, F., Niyonzima, N., Najjuma, J. N., Birungi, A., Atwine, R., Tusubira, D., Randall, T. C., Castro, C. M., Lee, H., & Ngonzi, J. N. J. (2024) · SAGE Open Medicine · doi:10.1177/20503121241252265 · Cited by 12
Risk Stratification in HPV-Associated Oropharyngeal Cancer: Limitations of Current Approaches and the Search for Better Solutions
Garb, B. F., Mohebbi, E., Lawas, M., Xia, S., Maag, G., Ahn, P. H., D’Silva, N. J., Rozek, L. S., & Sartor, M. A. (2025) · Cancers · doi:10.3390/cancers17030357 · Cited by 9
Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade
Guo, Y., Zhang, X., Xu, Q., Gong, F., Shi, X., Li, C., Huang, R., Nie, F., Zhu, W., Li, J., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0851-1 · Cited by 9
Human Papillomavirus Genotyping as a Tool for Cervical Cancer Prevention: From Commercially Available Human Papillomavirus DNA Test to Next-Generation Sequencing
Dias, T. C., Longatto‐Filho, A., & Campanella, N. C. (2020) · Future Science OA · doi:10.2144/fsoa-2019-0159 · Cited by 9
HPV virions hitchhike a ride on retromer complexes
Sapp, M. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305245110 · Cited by 9
Retraction Note: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Gupta, S. M., & Mania‐Pramanik, J. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0545-6 · Cited by 9
Retracted
A Mathematical Model of Cell Cycle Dysregulation Due to Human Papillomavirus Infection
Miller, A., Münger, K., & Adler, F. R. (2017) · Bulletin of Mathematical Biology · doi:10.1007/s11538-017-0299-9 · Cited by 8
The Natural History of Cervical Cancer and the Case for MicroRNAs: Is Human Papillomavirus Infection the Whole Story?
Palomino-Vizcaíno, G., Bañuelos-Villegas, E. G., & Álvarez-Salas, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312991 · Cited by 7
The vaginal microbiome, papillomavirus infection, and cervical cancer: established associations in search of model systems and mechanistic answers
Passarelli, G. V., Whang, S. N., Gilbert, N. M., & Hu, J. (2026) · mBio · doi:10.1128/mbio.02677-25 · Cited by 8
Folliculin Prevents Lysosomal Degradation of Human Papillomavirus To Support Infectious Cell Entry
Ishii, Y., Yamaji, T., Sekizuka, T., Homma, Y., Mori, S., Takeuchi, T., & Kukimoto, I. (2023) · Journal of Virology · doi:10.1128/jvi.00056-23 · Cited by 7
Papel del virus del papiloma humano en el desarrollo del cáncer del cuello uterino.
Núñez-Troconis, J. (2023) · Investigación Clínica · doi:10.54817/ic.v64n2a09 · Cited by 10
Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity
Molenberghs, F., Verschuuren, M., Vandeweyer, L., Peeters, S., Bogers, J., Perez-Novo, C. A., Berghe, W. V., Reu, H. D., Cools, N., Schelhaas, M., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05194-3 · Cited by 7
A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
Chen, C., Köberle, B., Kaufmann, A. M., & Albers, A. E. (2010) · Cancers · doi:10.3390/cancers2031528 · Cited by 7
Eradicating HPV-Associated Cancer Through Immunization: A Glass Half Full…
Frazer, I. H. (2018) · Viral Immunology · doi:10.1089/vim.2017.0119 · Cited by 7
Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma
Chaikhoutdinov, I., & Goldenberg, D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6176-0_7 · Cited by 7
Infection and transmission dynamics of rKSHV.219 in primary endothelial cells
Jeffery, H. C., Wheat, R. L., Blackbourn, D. J., Nash, G. B., & Butler, L. M. (2013) · Journal of Virological Methods · doi:10.1016/j.jviromet.2013.06.001 · Cited by 7
TRIM16 mediates secretory autophagy in head and neck cancer-associated fibroblasts
Ly, T., Pickard, B., Pandey, A., Yap, M., Opara, J. K., Arnold, L., Martínez-Rivera, N., Rosa‐Molinar, E., New, J., Werner, L. R., et al. (2025) · Autophagy · doi:10.1080/15548627.2025.2508064 · Cited by 6
Role of innate immunity in tumor microenvironment of HPV-associated anal cancer: The hypothetical beneficial role of γδ T cells.
Martino, S. D., Capasso, B., Cis, L., D’Orsi, L., Canali, G., Capasso, P., Gaetano, A. D., Mercantini, P., Mascagni, D., Gaetano, C., et al. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104771 · Cited by 6
HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells
He, C., Lv, X., Liu, J., Ruan, J., Chen, P., Huang, C., Angeletti, P. C., Hua, G., Moness, M. L., Shi, D., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00233-3 · Cited by 6
Human Papillomavirus Biology, Pathogenesis, and Potential for Drug Discovery: A Literature Review for HIV Nurse Clinical Scientists
Walhart, T. A. (2015) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2015.07.001 · Cited by 6
Human Papilloma Virus-Infected Cells
Cruz‐Gregorio, A., & Aranda‐Rivera, A. K. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-40086-5_8 · Cited by 6
La infección por virus del papiloma humano afecta el pronóstico del cáncer orofaríngeo escamocelular. Revisión de la literatura / Human Papillomavirus Infection Affects Squamous Oropharyngeal Cancer Prognosis. Literature Review
Díaz, M. G., Vargas, L. A. M., Torres, A. M., Galindo, A. I. C., Erira, H. A. T., & Robayo, D. A. G. (2015) · Universitas Odontologica · doi:10.11144/javeriana.uo33-71.ivph · Cited by 6
Current Perspectives in Human Papillomavirus
Saxena, S. K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73828 · Cited by 7
An overview of the functions and mechanisms of APOBEC3A in tumorigenesis
Yang, Y., Liu, N., & Gong, L. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.08.020 · Cited by 6
Viral interference of nucleocytoplasmic transport
Chien, C., Mobbs, G. W., Ehrenkranz, J. R. L., & Hoelz, A. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110815 · Cited by 6
Topoisomerase IIα orchestrates secretion of IL-6 and IL-8 with human papillomavirus replication
Liu, Y., Han, Z., Kaminski, P. J., Tao, C., Li, X., Liu, M., Yang, L., Jia, Y., Xu, J., & Hong, S. (2025) · Virologica Sinica · doi:10.1016/j.virs.2025.11.004 · Cited by 5
Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the trans- Golgi network during virus entry
Choi, J., Speckhart, K., Tsai, B., & DiMaio, D. (2024) · mBio · doi:10.1128/mbio.02811-24 · Cited by 5
Diverse Papillomavirus Types Induce Endosomal Tubulation
Siddiqa, A., Massimi, P., Pim, D., & Banks, L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00175 · Cited by 5
Human Papillomavirus Infection and Lung Cancer
Cardona, A. F., Ruíz-Patiño, A., Ricaurte, L., Rojas, L., Zatarain-Barrón, Z. L., Arrieta, O. G., & Rosell, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80706 · Cited by 5
Clathrin-independent endocytosis of Human Papillomaviruses is facilitated by actin nucleation promoting factor WASHPreprint
Brinkert, P., Krebs, L., Ventayol, P. S., Greune, L., Bannach, C., Bucher, D., Kollasser, J., Dersch, P., Boulant, S., Stradal, T. E. B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.18.448076 · Cited by 5
Cutaneous human papillomavirus E6 impairs the cGAS-STING pathway
Brooke, G., Dacus, D., Pollina, R., Asano, K., & Wallace, N. A. (2026) · mSphere · doi:10.1128/msphere.00859-25 · Cited by 4
ErbB2/HER2 receptor tyrosine kinase regulates human papillomavirus promoter activity
Mikuličić, S., Shamun, M., Massenberg, A., Franke, A.-L., Freitag, K., Döring, T., Strunk, J., Tenzer, S., Lang, T., & Florin, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1335302 · Cited by 4
Too many cooks in the kitchen: HPV driven carcinogenesis – The result of collaboration or competition?
Weimer, K. (2024) · Tumour Virus Research · doi:10.1016/j.tvr.2024.200311 · Cited by 4
Temporal gating of nuclear import: How Merkel cell polyomavirus exploits the cell cycle for nuclear entry
Wang, K., Eady, A. N., Amaya, I., Stanczak, A., & Spriggs, C. C. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013217 · Cited by 4
The SETD2 Methyltransferase Supports Productive HPV31 Replication through the LEDGF/CtIP/Rad51 Pathway
Mac, M., DeVico, B. M., Raspanti, S. M., & Moody, C. A. (2023) · Journal of Virology · doi:10.1128/jvi.00201-23 · Cited by 4
The Larynx is Protected from Secondary and Vertical Papillomavirus Infection in Immunocompetent Mice
King, R. E., Rademacher, J., Ward-Shaw, E. T., Hu, R., Bilger, A., Blaine‐Sauer, S., Spurgeon, M. E., Thibeault, S. L., & Lambert, P. F. (2023) · The Laryngoscope · doi:10.1002/lary.31228 · Cited by 4
Cervical cancer studies on prevention and treatment
Darlin, L. (2013) · Lund University Publications (Lund University) · Cited by 4
Therapeutic Strategies in Advanced Cervical Cancer Detection, Prevention and Treatment
Sebutsoe, X., Tsotetsi, N. J. N., Jantjies, Z. E., Raphela-Choma, P. P., Choene, M. S., & Motadi, L. R. (2024) · OncoTargets and Therapy · doi:10.2147/ott.s475132 · Cited by 3
HPV16 entry requires dynein for minus-end transport and utilizes kinesin Kif11 for plus-end transport along microtubules during mitosis
Keiffer, T. R., DiGiuseppe, S., Guion, L. G. M., Bienkowska‐Haba, M., Zwolińska, K., Siddiqa, A., Kushwaha, A., & Sapp, M. J. (2024) · Journal of Virology · doi:10.1128/jvi.00937-24 · Cited by 3
The COPII Transport Complex Participates in HPV16 Infection
Day, P. M., Thompson, C. D., Weisberg, A. S., & Schiller, J. T. (2025) · Viruses · doi:10.3390/v17050616 · Cited by 3
The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection
Woo, T.-T., Takeo, Y., Harwood, M. C., Houck, E. T., DiMaio, D., & Tsai, B. (2025) · Science Advances · doi:10.1126/sciadv.adz6792 · Cited by 3
Identification of HPV16-p16INK4a mediated methylation in oral potentially malignant disorder
Buenahora, M. R., Lafaurie, G. I., & Perdomo, S. J. (2020) · Epigenetics · doi:10.1080/15592294.2020.1834923 · Cited by 4
Cells infected with human papilloma pseudovirus display nuclear reorganization and heterogenous infection kinetics
Molenberghs, F., Verschuuren, M., Barbier, M., Bogers, J., Cools, N., Delputte, P., Schelhaas, M., & Vos, W. H. D. (2022) · Cytometry Part A · doi:10.1002/cyto.a.24663 · Cited by 3
The Follow-Up Necessity in Human Papilloma Virus-Positive vs. Human Papilloma Virus-Negative Oral Mucosal Lesions: A Retrospective Study
Rushiti, A., Castellani, C., Cerrato, A., Fedrigo, M., Sbricoli, L., Bressan, E. A., Angelini, A., & Bacci, C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm13010058 · Cited by 3
STINGing Defenses: Unmasking the Mechanisms of DNA Oncovirus-Mediated Immune Escape
Martínez-López, M. F., Muslin, C., & Kyriakidis, N. C. (2024) · Viruses · doi:10.3390/v16040574 · Cited by 3
[Metastatic oropharyngeal squamous cell carcinoma in cervical lymph nodes associated to HPV infection type 16 and 45; clinical, morphological and molecular study of two cases].
Soria-Céspedes, D., Aguilar, G. C., Lara-Torres, C. O., Marle, J. F. S., Hernández-Peña, R. E., & Ortíz-Hidalgo, C. (2013) · PubMed · Cited by 3
Adult Stem Cell Niches — Stem Cells in the Female Reproductive System
Kessler, M., Zietlow, R., & Meyer, T. F. (2014) · InTech eBooks · doi:10.5772/58842 · Cited by 4
Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes
Wang, H.-K., Wei, Q., Moldoveanu, Z., Huh, W. K., Vu, H., Broker, T. R., Mestecky, J. F., & Chow, L. T. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.04.038 · Cited by 3
The Life Cycle of Human Papillomavirus
Xue, J., Vesper, B. J., & Radosevich, J. A. (2012) · Springer eBooks · doi:10.1007/978-94-007-5437-9_3 · Cited by 3
Biomarkers for detection of human papillomavirus (HPV)
Kolte, S. S., & Naaz, S. (2021) · Indian Journal of Gynecologic Oncology · doi:10.1007/s40944-021-00529-5 · Cited by 2
High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity
Cabibi, D., Giannone, A. G., Quattrocchi, A., Coco, R. L., Formisano, E., Porcasi, R., Benfante, V., Comelli, A., & Capra, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105354 · Cited by 2
Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin
Diversi, F., Dabin, J., Mazza, E., Rinaldin, M., Reis, F. D. C., Hackett, J. A., & Heppenstall, P. A. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102501 · Cited by 2
The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses
Brinkert, P., Krebs, L., Ventayol, P. S., Greune, L., Bannach, C., Amakiri, C., Bucher, D., Kollasser, J., Dersch, P., Boulant, S., et al. (2025) · EMBO Reports · doi:10.1038/s44319-025-00594-3 · Cited by 6
The cervicovaginal microbiome: an emerging determinant of HPV infection and disease
Spurgeon, M. E. (2026) · Journal of Virology · doi:10.1128/jvi.01706-25 · Cited by 2
Vaginal Intraepithelial Neoplasia
Ip, P. P. C., & Tse, K. Y. (2015) · Springer eBooks · doi:10.1007/978-3-319-22509-8_10 · Cited by 2
L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016
Chen, X., Chen, H., Chen, Y., Tang, L., Liu, J., & Ou, Y.-J. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1530624 · Cited by 2
Differences and Similarities Between HPV-Associated OPSCC and Cervical Cancer
Economopoulou, P., & Psyrri, A. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-21100-8_10 · Cited by 2
Molecular Basis of Gynecologic Diseases
Mok, S. C., Wong, K., Lu, K. H., Münger, K., & Nagymányoki, Z. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374419-7.00023-8 · Cited by 2
Cervical Cancer: Screening, Vaccination, and Preventive Strategies
Rossi, P. G., & Carozzi, F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65138-3 · Cited by 3
HPV Infection and Gynecological Cancers
Bharani, V., Kumar, R., & Bharani, B. (2019) · Springer eBooks · doi:10.1007/978-981-13-3438-2_32 · Cited by 2
Reproductive Organ Cancer
Tang, J., Cheng, X., Xie, J., Cao, Z., Zhai, Y., & Song, B. (2021) · Springer eBooks · doi:10.1007/978-981-16-1037-0_42 · Cited by 2
Reserve and basal cells of epithelia of cervix uteri as a source of cervical neoplasies by human papilloma viruses
Анатольевич, Е. В., Mikhailov, V. M., & Семёнович, Ч. В. (2019) · Genes and Cells · doi:10.23868/201903011 · Cited by 2
The Potential of Raman Spectroscopy for Cytological Diagnosis of ThinPrep Samples From a Cervical Cancer Screening Population
Ramos, I. (2017) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d7kr02 · Cited by 2
In Situ Cryo-ET Redefines HPV Disassembly and Transport ParadigmsPreprint
Sutanto, R., Rana, J. K., Cheng, C.-Y., Mosalaganti, S., & See, P. D. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.06.674660 · Cited by 2
The Diagnostic Significance of Combined Screening and Human Papillomavirus 16 and 18 Cycle Threshold Values for CIN2+ Cervical Lesions
Bai, X. L., Liu, Y., Jia, Y.-J., Li, D., & Du, N. (2024) · International Journal of Women s Health · doi:10.2147/ijwh.s488125 · Cited by 1
The Sibylline Relationship Between Human Papillomavirus and Endometrial Cancer: Scarcity of Strong Evidence Linking Both Conditions
Bichri, K., Ghanmi, A. E., Kouhen, F., Hamdi, S., Fichtali, K., Mansouri, F. E., Bakkouri, J. E., & Ghazi, B. (2025) · Viruses · doi:10.3390/v17050607 · Cited by 1
HaCaT Keratinocytes: A Differentiation-Competent Platform for Episomal Replication of HPV Type 11
Dey-Rao, R., & Melendy, T. (2026) · Viruses · doi:10.3390/v18020230 · Cited by 1
APOBEC3B regulates HPV replication by inducing R-loop formation and DNA damage
Templeton, C. W., Gulik, J. S., & Laimins, L. A. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014088 · Cited by 1
Regulation of HPV-16 infection by ubiquitination of the L1 major capsid protein
Trejo-Cerro, Ó., Bergant, M., Wlodarczyk, P., Repnik, U., Lovšin, N., Myers, M. P., Garcea, R. L., Banks, L., & Broniarczyk, J. K. (2026) · Journal of Virology · doi:10.1128/jvi.00285-26 · Cited by 1
The interplay between HPV, vaginal microbiota and host immunity in cervical carcinogenesis
Moghaddam, N. A., Mohabbat, A., Jigheh, M. P., Mahboubi, A., Ravanlo, Z. Z., Shanehbandi, D., Shokri, S., & Baghi, H. B. (2026) · Discover Oncology · doi:10.1007/s12672-026-05169-9 · Cited by 1
La infección por virus del papiloma humano afecta el pronóstico del cáncer orofaríngeo escamocelular. Revisión de la literatura
Díaz, M. G., Vargas, L. A. M., Vargas, M., & Torres, A. M. (2014) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 1
Molecular Basis of Gynecologic Diseases
Mok, S. C., Wong, K., Lu, K. H., Münger, K., & Nagymányoki, Z. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802761-5.00023-7 · Cited by 1
Human Papillomaviruses
Menezes, L., Morano, J. P., & Mundra, L. S. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2410-3_2 · Cited by 1
Filaggrin, Human Papillomavirus, and the Cervix
Fage, S. W., Iftner, T., Thyssen, J. P., & Kjær, S. K. (2014) · Springer eBooks · doi:10.1007/978-3-642-54379-1_33 · Cited by 1
HPV Assessment in Oropharynx Cancer: What is the Gold Standard?
Economopoulou, P., Kotsantis, I., & Psyrri, A. K. (2018) · Springer eBooks · doi:10.1007/978-3-319-98854-2_10 · Cited by 1
Expression of human papillomavirus L1 protein and NuMA1 at cervical intraepithelial neoplasia
Анатольевич, Е. В., Lisyanskaya, A. S., & Manikhas, G. (2019) · The Scientific Notes of the Pavlov University · doi:10.24884/1607-4181-2019-26-2-18-27 · Cited by 1
Enjeux et limites de la désescalade thérapeutique dans la prise en charge du cancer de l’oropharynx lié au papillomavirus
Modesto, A., Graff-Cailleaud, P., Blanchard, P., Boisselier, P., & Pointreau, Y. (2022) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2022.06.018 · Cited by 1
Bioinformatics analysis of HPV associated host microRNA functions and identification of viral microRNA
Qian, K. (2013) · Työväentutkimus Vuosikirja · Cited by 1
Pathogenesis of Papillomaviruses in Humans
Doorbar, J. (2015) · Wiley eBooks · doi:10.1002/9781118644843.ch13 · Cited by 1
Rastreamento de lesões intraepiteliais anais em mulheres imunocompetentes portadoras de lesão intraepitelial de alto grau e câncer de colo uterino
Rodrigues, V. D. O. (2021) · doi:10.34019/ufjf/di/2021/00007 · Cited by 1

Authors: Pyeon, D., Pearce, S. M., Lank, S. M., Ahlquist, P., & Lambert, P. F.
Affiliations: University of Wisconsin–Madison (US)
Howard Hughes Medical Institute (US)
Corresponding author: Ahlquist, Paul
Lambert, Paul F.
ORCID: Pyeon, Dohun
Pearce, Shane M.
Ahlquist, Paul
Lambert, Paul F.
Venue: PLoS Pathogens
Publisher: Public Library of Science (PLoS)
Published: 2009-02-27
Volume: 5
Issue: 2
Pages: e1000318
ISSN: 1553-7366 (ISSN-L)
1553-7374
DOI: 10.1371/journal.ppat.1000318
PMC: PMC2642596
OpenAlex: W2074766470
Cited by: 348
References: 52
Citations by year: 2026: 14 · 2025: 22 · 2024: 22 · 2023: 17 · 2022: 16 · 2021: 27 · 2020: 19 · 2019: 25 · 2018: 17 · 2017: 25 · 2016: 26 · 2015: 24 · 2014: 20 · 2013: 30 · 2012: 15
FWCI: 9.85
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Pathogens (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Howard Hughes Medical Institute
University of Wisconsin-Madison
National Institutes of Health (CA022443)
National Cancer Institute (CA022443, P01CA022443)
National Institute of Allergy and Infectious Diseases (R33AI071947, AI071947, R21AI071947)
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: human papillomavirus, HPV16, cell cycle progression, mitosis, stratified epithelium, keratinocytes, G1 phase, viral gene expression, microbicides, HPV vaccine, viral entry receptor
MeSH terms: Antiviral Agents, Cell Cycle, Cell Division, Cell Survival, Cells, Cultured, Etoposide, Humans, Orthomyxoviridae, Prophase, Transcription, Genetic, Virion, Keratinocytes, Gene Expression Regulation, Viral, Aphidicolin, Genome, Viral, Human papillomavirus 16

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks