The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics
Open accessAbstract
Proteomic and lipidomic profiling was performed over a time course of acute hepatitis C virus (HCV) infection in cultured Huh-7.5 cells to gain new insights into the intracellular processes influenced by this virus. Our proteomic data suggest that HCV induces early perturbations in glycolysis, the pentose phosphate pathway, and the citric acid cycle, which favor host biosynthetic activities supporting viral replication and propagation. This is followed by a compensatory shift in metabolism aimed at maintaining energy homeostasis and cell viability during elevated viral replication and increasing cellular stress. Complementary lipidomic analyses identified numerous temporal perturbations in select lipid species (e.g. phospholipids and sphingomyelins) predicted to play important roles in viral replication and downstream assembly and secretion events. The elevation of lipotoxic ceramide species suggests a potential link between HCV-associated biochemical alterations and the direct cytopathic effect observed in this in vitro system. Using innovative computational modeling approaches, we further identified mitochondrial fatty acid oxidation enzymes, which are comparably regulated during in vitro infection and in patients with histological evidence of fibrosis, as possible targets through which HCV regulates temporal alterations in cellular metabolic homeostasis.
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Citations
Cites
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Silencing of microRNAs in vivo with ‘antagomirs’
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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
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The Natural History of Community-Acquired Hepatitis C in the United States
Alter, M. J., Margolis, H. S., Krawczynski, K., Judson, F. N., Mares, A., Alexander, W. J., Hu, P. Y., Miller, J. K., Gerber, M. A., Sampliner, R. E., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272702 · Cited by 1,592
The key role of anaplerosis and cataplerosis for citric acid cycle function
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“In order to ensure continued TCA cycle function in macromolecular biosynthesis, cells must replenish the pools of metabolic intermediates (anaplerosis) depleted during lipid, protein, and nucleic acid synthesis [36,39].”
BackgroundContinuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
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Hepatitis C virus infection protein network
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Global analysis of cellular protein translation by pulsed SILAC
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Self-citationDiamond, D. L., Jacobs, J. M., Paeper, B., Proll, S. C., Gritsenko, M. A., Carithers, R. L., Larson, A. M., Yeh, M. M., Camp, D. G., Smith, R. D., et al. (2007) · Hepatology · doi:10.1002/hep.21751 · Cited by 114 · cited 10×
“(ANOVA) differences associated with fibrosis stage [20].”
BackgroundMethodResultInfluentialSelf-citation
Cited by
Dengue Virus-Induced Autophagy Regulates Lipid Metabolism
Heaton, N. S., & Randall, G. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.10.006 · Cited by 705
Viral activation of cellular metabolism
Sanchez, E. L., & Lagunoff, M. (2015) · Virology · doi:10.1016/j.virol.2015.02.038 · Cited by 560
Rewiring cellular networks by members of the Flaviviridae family
Neufeldt, C. J., Cortese, M., Acosta, E. G., & Bartenschlager, R. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.170 · Cited by 409
The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate
Riganti, C., Gazzano, E., Polimeni, M., Aldieri, E., & Ghigo, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.006 · Cited by 408
Multifaceted roles for lipids in viral infection
Heaton, N. S., & Randall, G. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.03.007 · Cited by 381
Metadata
- Authors
- Diamond, D. L., Syder, A. J., Jacobs, J. M., Sorensen, C. M., Walters, K.-A., Proll, S. C., McDermott, J. E., Gritsenko, M. A., Zhang, Q., Zhao, R., Metz, T. O., Camp, D. G., Waters, K. M., Smith, R. D., Rice, C. M., & Katze, M. G.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-01-08
- Volume
- 6
- Issue
- 1
- Pages
- e1000719
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2046984465
- Cited by
- 412
- References
- 10
- FWCI
- 17.50
- Type
- journal article
- Language
- en
- Open access
- gold
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- Diamond, D. L., Syder, A. J., Jacobs, J. M., Sorensen, C. M., Walters, K.-A., Proll, S. C., McDermott, J. E., Gritsenko, M. A., Zhang, Q., Zhao, R., Metz, T. O., Camp, D. G., Waters, K. M., Smith, R. D., Rice, C. M., & Katze, M. G. (2010). Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1000719
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
