The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Open accessAbstract
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited with specific antibody against each of these molecules. Coa and vWbp specific antibodies confer protection against abscess formation and S. aureus lethal bacteremia, suggesting that coagulases function as protective antigens for a staphylococcal vaccine.
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Cites
1 retracted
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
Cheng, A. G., Kim, H. K., Burts, M. L., Krausz, T., Schneewind, O., & Missiakas, D. M. (2009) · The FASEB Journal · doi:10.1096/fj.09-135467 · Cited by 437
Self-citationRetractedKlevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · cited 1×
“Staphylococcal bacteremia is a frequent cause of human morbidity and mortality in hospital settings [34].”
BackgroundPassage of Heme-Iron Across the Envelope of Staphylococcus aureus
Mazmanian, S. K., Skaar, E. P., Gaspar, A. H., Humayun, M., Gornicki, P., Jelenska, J., Joachmiak, A., Missiakas, D. M., & Schneewind, O. (2003) · Science · doi:10.1126/science.1081147 · Cited by 593
Self-citationSorting of protein a to the staphylococcal cell wall
Schneewind, O., Model, P., & Fischetti, V. A. (1992) · Cell · doi:10.1016/0092-8674(92)90101-h · Cited by 552
Self-citationCell wall sorting signals in surface proteins of gram‐positive bacteria.
Schneewind, O., Mihaylova‐Petkov, D., & Model, P. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06169.x · Cited by 426
Self-citationVaccine assembly from surface proteins of Staphylococcus aureus
Stranger-Jones, Y. K., Bae, T., & Schneewind, O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606863103 · Cited by 309
Self-citationKuklin, N. A., Clark, D. J., Secore, S., Cook, J., Cope, L. D., McNeely, T., Noble, L., Brown, M. J., Zorman, J. K., Wang, X. M., et al. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2215-2223.2006 · Cited by 264 · cited 1×
“The possibility that IsdB may raise vaccine protection from staphylococcal diseases in humans is currently being tested [10].”
BackgroundHussain, M., Becker, K., von Eiff, C., Schrenzel, J., Peters, G., & Herrmann, M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.23.6778-6786.2001 · Cited by 149
Cited by
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.105 · Cited by 3,397
Thrombosis as an intravascular effector of innate immunity
Engelmann, B., & Massberg, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3345 · Cited by 1,989
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Bonaventura, A., Vecchié, A., Dagna, L., Martinod, K., Dixon, D. L., Van Tassell, B. W., Dentali, F., Montecucco, F., Massberg, S., Levi, M., et al. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00536-9 · Cited by 987
Masters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575
Metadata
- Authors
- Cheng, A. G., McAdow, M., Kim, H. K., Bae, T., Missiakas, D. M., & Schneewind, O.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-05
- Volume
- 6
- Issue
- 8
- Pages
- e1001036
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2068041880
- Cited by
- 324
- References
- 8
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- gold
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