The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
A Novel Family of Toxoplasma IMC Proteins Displays a Hierarchical Organization and Functions in Coordinating Parasite Division
Open accessAbstract
Apicomplexans employ a peripheral membrane system called the inner membrane complex (IMC) for critical processes such as host cell invasion and daughter cell formation. We have identified a family of proteins that define novel sub-compartments of the Toxoplasma gondii IMC. These IMC Sub-compartment Proteins, ISP1, 2 and 3, are conserved throughout the Apicomplexa, but do not appear to be present outside the phylum. ISP1 localizes to the apical cap portion of the IMC, while ISP2 localizes to a central IMC region and ISP3 localizes to a central plus basal region of the complex. Targeting of all three ISPs is dependent upon N-terminal residues predicted for coordinated myristoylation and palmitoylation. Surprisingly, we show that disruption of ISP1 results in a dramatic relocalization of ISP2 and ISP3 to the apical cap. Although the N-terminal region of ISP1 is necessary and sufficient for apical cap targeting, exclusion of other family members requires the remaining C-terminal region of the protein. This gate-keeping function of ISP1 reveals an unprecedented mechanism of interactive and hierarchical targeting of proteins to establish these unique sub-compartments in the Toxoplasma IMC. Finally, we show that loss of ISP2 results in severe defects in daughter cell formation during endodyogeny, indicating a role for the ISP proteins in coordinating this unique process of Toxoplasma replication.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The inner membrane complex (IMC) of Toxoplasma gondii as a peripheral membrane system has unique and critical roles in parasite replication, motility and invasion.”
From Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii (2016) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“Three proteins, IMC sub-compartment protein (ISP) 1, ISP2, and ISP3, were initially identified and shown to localize to distinct sub-compartments of the IMC in T. gondii [8].”
From Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii (2016) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“Disruption of TgISP2 markedly reduces parasite fitness and produces a severe defect in endodyogeny, the form of internal cell budding in which two daughter cells are formed within the intact mother parasite [8].”
From Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii (2016) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Palmitoylation of Intracellular Signaling Proteins: Regulation and Function
Smotrys, J. E., & Linder, M. E. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073954 · Cited by 626
Keeling, P. J., Burger, G., Durnford, D. G., Lang, B. F., Lee, R. W., Pearlman, R. E., Roger, A. J., & Gray, M. W. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.09.005 · Cited by 579
CSS-Palm 2.0: an updated software for palmitoylation sites prediction
Ren, J., Wen, L., Gao, X., Jin, C., Xue, Y., & Yao, X. (2008) · Protein Engineering Design and Selection · doi:10.1093/protein/gzn039 · Cited by 536
Biology and epidemiology of Toxoplasma gondii in man and animals
Hill, D. E., Sreekumar, C., & Dubey, J. P. (2005) · Animal Health Research Reviews · doi:10.1079/ahr2005100 · Cited by 530
Trafficking and signaling by fatty-acylated and prenylated proteins
Resh, M. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio834 · Cited by 521
Tagging of Endogenous Genes in a Toxoplasma gondii Strain Lacking Ku80
Huynh, M., & Carruthers, V. B. (2009) · Eukaryotic Cell · doi:10.1128/ec.00358-08 · Cited by 502
Self-citationMolecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii.
Burg, J. L., Perelman, D., Kasper, L. H., Ware, P. L., & Boothroyd, J. C. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.10.3584 · Cited by 433
Donald, R. G. K., Carter, D., Ullman, B., & Roos, D. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14010 · Cited by 408
Bradley, P. J., Ward, C., Cheng, S. J., Alexander, D. L., Coller, S. P., Coombs, G. H., Dunn, J. D., Ferguson, D. J. P., Sanderson, S. J., Wastling, J. M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504158200 · Cited by 398
Self-citationDHHC9 and GCP16 Constitute a Human Protein Fatty Acyltransferase with Specificity for H- and N-Ras
Swarthout, J. T., Lobo, S., Farh, L., Croke, M., Greentree, W. K., Deschenes, R. J., & Linder, M. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504113200 · Cited by 356
Flagged first, then by citations
Research works printed but not linked: 1
- E Porchet, 1977, [Freeze fracture study of Toxoplasma and Sarcocystis infective stages (author's transl)]., Z Parasitenkd, 54, 101
Cited by
Sorted by citations
Items 101–200 of 218
Torres, J. A., Pasquarelli, R. R., Back, P., Moon, A. S., & Bradley, P. J. (2021) · mBio · doi:10.1128/mbio.03622-20 · Cited by 26
Self-citationValigurová, A. B., Paskerova, G. G., Diakin, A., Kováčiková, M., & Simdyanov, T. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125063 · Cited by 26
Berry, L., Chen, C., Francia, M. E., Guérin, A., Graindorge, A., Saliou, J., Grandmougin, M., Wein, S., Bechara, C., Morlon‐Guyot, J., et al. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2889-6 · Cited by 26
Lee, S., Kang, H.-J., Lee, D., & Quan, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03073 · Cited by 26
Hammarton, T. C. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00397 · Cited by 26
Napoli, M. G. D., de Miguel, N., Lebrun, M., Moreno, S. N. J., Angel, S. O., & Corvi, M. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.02.022 · Cited by 26
An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist
Günay-Esiyok, Ö., Scheib, U., Noll, M., & Gupta, N. (2019) · Life Science Alliance · doi:10.26508/lsa.201900402 · Cited by 25
Kemp, L. E., Rusch, M., Adibekian, A., Bullen, H. E., Graindorge, A., Freymond, C., Rottmann, M., Braun‐Breton, C., Baumeister, S., Porfetye, A. T., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.460709 · Cited by 24
Varberg, J. M., Padgett, L. R., Arrizabalaga, G., & Sullivan, W. J. (2016) · mSphere · doi:10.1128/msphere.00088-15 · Cited by 24
Goodenough, U. W., Roth, R. A., Kariyawasam, T., Amelia, H., & Lee, J. (2018) · mBio · doi:10.1128/mbio.02020-18 · Cited by 24
Toxoplasma ERK7 protects the apical complex from premature degradation
O’Shaughnessy, W. J., Hu, X., Henriquez, S. A., & Reese, M. L. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202209098 · Cited by 23
Protein palmitoylation in protozoan parasites
Corvi, M. M. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/211 · Cited by 23
Butler, C., Lucas, O., Wuchty, S., Xue, B., Uversky, V. N., & White, M. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097625 · Cited by 22
Apicoplast Dynamics During Plasmodium Cell Cycle
Elaagip, A. H., Absalon, S., & Florentin, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.864819 · Cited by 21
Loss of the Conserved Alveolate Kinase MAPK2 Decouples Toxoplasma Cell Growth from Cell Division
Hu, X., O’Shaughnessy, W. J., Beraki, T. G., & Reese, M. L. (2020) · mBio · doi:10.1128/mbio.02517-20 · Cited by 21
Dogga, S. K., Bartošová‐Sojková, P., Lukeš, J., & Soldati‐Favre, D. (2015) · Protist · doi:10.1016/j.protis.2015.09.003 · Cited by 21
Morphogenesis of P lasmodium zoites is uncoupled from tensile strength
Tremp, A. Z., Carter, V., Saeed, S., & Dessens, J. T. (2013) · Molecular Microbiology · doi:10.1111/mmi.12297 · Cited by 21
Chen, C., & Gubbels, M. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-10-0608 · Cited by 21
Guiton, P. S., Sagawa, J. M., Fritz, H. M., & Boothroyd, J. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173018 · Cited by 20
Chern, J. H., Pasquarelli, R. R., Moon, A. S., Chen, A. L., Sha, J., Wohlschlegel, J. A., & Bradley, P. J. (2021) · mBio · doi:10.1128/mbio.02455-21 · Cited by 19
Self-citationPacheco, N. D. S., Puig, A. T. I., Guérin, A., Martinez, M. P., Maco, B., Tosetti, N., Betancourt, E. D., Lunghi, M., Striepen, B., Chang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44631-y · Cited by 19
Skariah, S., Bednarczyk, R. B., McIntyre, M. K., Taylor, G. A., & Mordue, D. G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101425 · Cited by 19
Martins-Duarte, É. S., Sheiner, L., Reiff, S. B., de Souza, W., & Striepen, B. (2021) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.11.004 · Cited by 19
Novel CRK-Cyclin Complex Controls Spindle Assembly Checkpoint in Toxoplasma Endodyogeny
Hawkins, L. M., Naumov, A. V., Batra, M., Wang, C., Chaput, D., & Suvorova, E. S. (2022) · mBio · doi:10.1128/mbio.03561-21 · Cited by 19
Tilley, L. D., Krishnamurthy, S., Westwood, N. J., & Ward, G. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098492 · Cited by 19
Liang, Q., Nie, L.-B., Li, T., Elsheikha, H. M., Sun, L., Zhang, Z.-W., Zhao, D., Zhu, X., & Wang, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.738794 · Cited by 18
The Toxoplasma cytoskeleton: structures, proteins, and processes
Morrissette, N. S., & Gubbels, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815041-2.00016-5 · Cited by 18
Self-citationEngelberg, K., Bauwens, C., Ferguson, D. J. P., & Gubbels, M. (2025) · mBio · doi:10.1128/mbio.01389-25 · Cited by 17
Lee, D., Kim, A., Lee, S., & Quan, F. (2016) · Acta Tropica · doi:10.1016/j.actatropica.2016.08.025 · Cited by 17
The cortical microtubules of Toxoplasma gondii underlie the helicity of parasite movement
Tengganu, I. F., Padilla, L. F. A., Lopez, J. M., Liu, J., Brown, P. T., Murray, J. M., & Hu, K. (2023) · Journal of Cell Science · doi:10.1242/jcs.261270 · Cited by 17
Back, P. S., O’Shaughnessy, W. J., Moon, A. S., Dewangan, P. S., Reese, M. L., & Bradley, P. J. (2022) · mBio · doi:10.1128/mbio.02864-21 · Cited by 16
Self-citationDubey, R., Staker, B. L., Foe, I. T., Bogyo, M. S., Myler, P. J., Ngô, H. M., & Gubbels, M. (2016) · Molecular Microbiology · doi:10.1111/mmi.13577 · Cited by 16
Palmitoylation of Plasmodium alveolins promotes cytoskeletal function
Tremp, A. Z., Al-Khattaf, F. S., & Dessens, J. T. (2017) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2017.02.003 · Cited by 16
Quan, J. J., Nikolov, L. A., Sha, J., Wohlschlegel, J. A., Coppens, I., & Bradley, P. J. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002634 · Cited by 15
Self-citationTonkin, M. L., Beck, J. R., Bradley, P. J., & Boulanger, M. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548891 · Cited by 15
Self-citationThe FIKK kinase of Toxoplasma gondii is not essential for the parasite’s lytic cycle
Skariah, S., Walwyn, O., Engelberg, K., Gubbels, M., Gaylets, C. E., Kim, N., Lynch, B., Sultan, A. A., & Mordue, D. G. (2016) · International Journal for Parasitology · doi:10.1016/j.ijpara.2016.01.001 · Cited by 15
Exploring protein myristoylation in Toxoplasma gondii
Alonso, A. M., Turowski, V. R., Ruiz, D. M., Orelo, B. D., Moresco, J. J., Yates, J. R., & Corvi, M. M. (2019) · Experimental Parasitology · doi:10.1016/j.exppara.2019.05.007 · Cited by 15
Yang, C., Doud, E. H., Sampson, E., & Arrizabalaga, G. (2023) · mBio · doi:10.1128/mbio.02254-23 · Cited by 14
Dynamically expressed genes provide candidate viability biomarkers in a model coccidian
Tucker, M. S., O’Brien, C. N., Jenkins, M. C., & Rosenthal, B. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258157 · Cited by 14
TgTKL4 Is a Novel Kinase That Plays an Important Role in Toxoplasma Morphology and Fitness
Montano, H., Anandkrishnan, R., Carruthers, V. B., & Gaji, R. Y. (2023) · mSphere · doi:10.1128/msphere.00649-22 · Cited by 14
Self-citationLiang, Q., Nie, L.-B., Elsheikha, H. M., Li, T., Sun, L., Zhang, Z., Wang, M., Fu, B., Zhu, X., & Wang, J. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011831 · Cited by 13
Shi, Y., Li, X., Xue, Y., Hu, D., & Song, X. (2024) · mBio · doi:10.1128/mbio.01336-24 · Cited by 12
Pasquarelli, R. R., Back, P., Sha, J., Wohlschlegel, J. A., & Bradley, P. J. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011707 · Cited by 12
Self-citationPasquarelli, R. R., Quan, J. J., Cheng, E. S., Yang, V. B., Britton, T. A., Sha, J., Wohlschlegel, J. A., & Bradley, P. J. (2024) · mBio · doi:10.1128/mbio.02380-24 · Cited by 11
Self-citationVo, K. C., Günay-Esiyok, Ö., Liem, N., & Gupta, N. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.11.024 · Cited by 10
Chen, K., Huang, X., Distler, U., Tenzer, S., Günay-Esiyok, Ö., & Gupta, N. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.02.032 · Cited by 10
ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii
Swapna, L. S., Stevens, G. C., Sardinha-Silva, A., Hu, L. Z., Brand, V. B., Fusca, D. D., Wan, C., Xiong, X., Boyle, J. P., Grigg, M. E., et al. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012208 · Cited by 10
Deciphering cell cycle organization of Toxoplasma endodyogeny
Batra, M., Marsilia, C., Awshah, D., Hawkins, L. M., Wang, C. C. Q., Chaput, D., Naumova, D. A., & Suvorova, E. S. (2025) · mBio · doi:10.1128/mbio.01119-25 · Cited by 10
Protein Palmitoylation and Pathogenesis in Apicomplexan Parasites
Corvi, M. M., Alonso, A. M., & Caballero, M. (2012) · BioMed Research International · doi:10.1155/2012/483969 · Cited by 10
The Basal Complex Protein PfMORN1 Is Not Required for Asexual Replication of Plasmodium falciparum
Moran, C. J., & Dvorin, J. D. (2021) · mSphere · doi:10.1128/msphere.00895-21 · Cited by 10
Vigetti, L., Labouré, T., Roumegous, C., Cannella, D., Touquet, B., Mayer, C., Couté, Y., Frénal, K., Tardieux, I., & Renesto, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115995 · Cited by 10
Chen, M., Koszti, S. G., Bonavoglia, A., Maco, B., von Rohr, O., Peng, H., Soldati‐Favre, D., & Kloehn, J. (2025) · Nature Communications · doi:10.1038/s41467-025-57302-x · Cited by 9
Proteomic characterization of the pellicle of Toxoplasma gondii
Cruz‐Mirón, R., Ramírez‐Flores, C. J., Lagunas‐Cortés, N., Mondragón-Castelán, M. E., Ríos‐Castro, E., González‐Pozos, S., Aguirre‐García, M. M., & Mondragón‐Flores, R. (2021) · Journal of Proteomics · doi:10.1016/j.jprot.2021.104146 · Cited by 9
Back, P., Senthilkumar, V., Choi, C., Quan, J. J., Lou, Q., Snyder, A. K., Ly, A. M., Lau, J. G., Zhou, Z. H., Ward, G. E., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002809 · Cited by 9
Self-citationChoi, W. H., & Park, J. S. (2020) · Biomedicines · doi:10.3390/biomedicines8040091 · Cited by 9
Morrissette, N. S., & Gubbels, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396481-6.00013-1 · Cited by 10
Self-citationPP1 phosphatase controls both daughter cell formation and amylopectin levels in Toxoplasma gondii
Khelifa, A. S., Bhaskaran, M., Boissavy, T., Mouveaux, T., Silva, T. A., Chhuon, C., Attias, M., Guerrera, I. C., de Souza, W., Dauvillée, D., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002791 · Cited by 8
A functionally divergent transcription elongation factor 1‐like protein in Toxoplasma gondii
Mitra, P., Deshmukh, A. S., Banerjee, S., Khandavalli, C., & Choudhury, C. (2021) · FEBS Letters · doi:10.1002/1873-3468.14241 · Cited by 8
Dogga, S. K., & Frénal, K. (2020) · Cellular Microbiology · doi:10.1111/cmi.13212 · Cited by 8
Pasquarelli, R. R., Sha, J., Wohlschlegel, J. A., & Bradley, P. J. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012411 · Cited by 7
Self-citationToxoplasma gondii endodyogeny: how to make perfect daughters
Bhaskaran, M., Mudiyam, V., & Gissot, M. (2025) · Trends in Parasitology · doi:10.1016/j.pt.2025.07.012 · Cited by 6
Bhaskaran, M., Mudiyam, V., Mouveaux, T., Roger, E., & Gissot, M. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012810 · Cited by 6
Toxoplasmosis: Epidemiology, Prevention and Control
Hotea, I., & Dărăbuş, G. (2023) · MDPI eBooks · doi:10.3390/books978-3-0365-2698-0 · Cited by 6
Marq, J., Gosetto, M., Altenried, A., Vadas, O., Maco, B., Pacheco, N. D. S., Tosetti, N., Soldati‐Favre, D., & Lentini, G. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00171-9 · Cited by 6
Corvi, M. M., & Turowski, V. R. (2019) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2019.04.001 · Cited by 6
Liu, Y., Cheng, S., He, G., He, D., Wang, D., Wang, S., Chen, L., Zhu, L., Feng, Y., Cui, L., et al. (2024) · mBio · doi:10.1128/mbio.02652-24 · Cited by 5
Cellular Mechanisms of Raphid Diatom Gliding
Bedoshvili, Y. D., & Likhoshway, Y. V. (2021) · Wiley eBooks · doi:10.1002/9781119526483.ch3 · Cited by 4
Koreny, L., Zeeshan, M., Barylyuk, K., Tromer, E. C., van Hooff, J. J. E., Brady, D., Ke, H., Chelaghma, S., Ferguson, D. J. P., Eme, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.26.174284 · Cited by 4
Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and gene expression
Hu, D., Li, X., Huang, J., Zou, X., Si, H., Suo, X., & Song, X. (2025) · Nature Communications · doi:10.1038/s41467-025-64751-x · Cited by 3
Tengganu, I. F., & Hu, K. (2025) · Journal of Cell Science · doi:10.1242/jcs.264400 · Cited by 3
Tonkin, M. L., Brown, S., Beck, J. R., Bradley, P. J., & Boulanger, M. J. (2012) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s174430911202297x · Cited by 3
Self-citationCheng, E. S., Moon, A. S., Barshop, W. D., Wohlschlegel, J. A., & Bradley, P. J. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-10-0458 · Cited by 3
Self-citationBack, P. S., Senthilkumar, V., Choi, C., Ly, A. M., Snyder, A. K., Lau, J. G., Ward, G. E., & Bradley, P. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.10.552545 · Cited by 3
Self-citationWu, X., Wang, M., Zhang, N. Z., Li, T., Gao, J., Sun, L., Zhu, X., & Wang, J. (2025) · The FASEB Journal · doi:10.1096/fj.202402593rr · Cited by 2
Sheng, K., Song, K., Yang, Y., Wu, H., Du, Z., Chen, X., Yang, Y., Ma, G., & Du, A. (2025) · Parasites & Vectors · doi:10.1186/s13071-025-06766-3 · Cited by 2
Tiwari, M., Gas‐Pascual, E., Teal-Urquides, J., Samuelson, J. C., & West, C. M. (2025) · Glycobiology · doi:10.1093/glycob/cwaf051 · Cited by 2
Proteomics and posttranslational protein modifications in Toxoplasma gondii
Weiss, L. M., Wastling, J. M., Jeffers, V., Sullivan, W. J., & Kim, K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815041-2.00022-0 · Cited by 2
Li, J., Xiao, Q., Tan, Q., Chen, J., Sun, L., Chen, X., Chu, Z., Wu, H., Zhang, Z., Li, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210228 · Cited by 2
WITHDRAWN: Two anchoring proteins control daughter apical complex assembly in Toxoplasma gondiiPreprint
Burette, M., Pezinsky, M., Nguyen, Q., Benharoual, A., Patray, S., Maynadier, M., Delabre, J., Mouveaux, T., Graindorge, A., Berry, L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.13.705759 · Cited by 2
Structure and molecular composition of Toxoplasma gondii pellicle
Martins-Duarte, É. S. (2025) · Current topics in membranes · doi:10.1016/bs.ctm.2025.06.004 · Cited by 1
The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii
Wang, J., Wang, M., Zhang, N., Li, T., Gao, J., Wu, X., Fu, B., Elsheikha, H. M., & Zhu, X. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013475 · Cited by 1
Zhao, L., Fu, J., Peddiraju, S., Chen, H., Huang, K., Zhang, Y., Gupta, N., Jiang, Q., & Jia, H. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013865 · Cited by 2
cGMP Signalling: Malarial Guanylyl Cyclase Leads the Way
Brochet, M. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.059 · Cited by 1
CRISPRing the Elephant in the Room
Billker, O. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.015 · Cited by 1
Chen, X.-Z., Bai, R., Qin, F.-Y., Peng, H., Ren, J., Hu, L., Li, Y.-D., & He, C. (2023) · Acta Parasitologica · doi:10.1007/s11686-023-00720-y · Cited by 1
Rawat, A., Antil, N., MEENAKSHI, M., Deshmukh, B., Rai, A. B., Nagar, A., Kumar, N., Prasad, T. S. K., Karmodiya, K., & Sharma, P. (2025) · Nature Communications · doi:10.1038/s41467-025-59476-w · Cited by 1
Mandadi, P., Anandakrishnan, R., & Gaji, R. Y. (2025) · mSphere · doi:10.1128/msphere.00438-25 · Cited by 1
Investigations into the function of Elp3 in Toxoplasma gondii
Padgett, L. R. (2017) · IUScholarWorks (Indiana University) · doi:10.7912/c2/323 · Cited by 1
Molecular dissection of cell division in apicomplexan parasites
Francia, M. E. (2013) · Cited by 1
Loss of the conserved Alveolate kinase MAPK2 decouples Toxoplasma cell growth from the cell cyclePreprint
Hu, X., O’Shaughnessy, W. J., Beraki, T. G., & Reese, M. L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.13.095091 · Cited by 1
Role of post translational modifications: glycosylation and palmitoylation in Toxoplasma gondii
Luk, F. C. Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/7xvm-tc57
Host-Pathogen interactions of the innate immune system
Kim, E. (2018) · eScholarship (California Digital Library)
Stevens, G. C. (2021) · TSpace (University of Toronto)
Toxoplasma gondii: Asexual Cycle in the Intermediate Host
Gissot, M. (2022) · Microbiology monographs · doi:10.1007/978-3-030-80682-8_8
Sanasam, B. D., & Kumar, S. (2023) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2023.111560
Khelifa, A. S. (2021) · theses.fr (ABES) · doi:10.70675/a336262czffc2z432bz9667z99caaa5d20cc
Li, C., Zhu, X., & Chen, Q. (2025) · Transboundary and Emerging Diseases · doi:10.1155/tbed/8359440
Bauwens, C., Engelberg, K., & Gubbels, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680297
Metadata
- Authors
- Beck, J. R., Rodriguez-Fernandez, I. A., Cruz de Leon, J., Huynh, M.-H., Carruthers, V. B., Morrissette, N. S., & Bradley, P. J.
- Affiliations
- University of California, Los Angeles (US)
- University of Michigan (US)
- University of California, Irvine (US)
- Corresponding author
- Bradley, Peter J.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-09-09
- Volume
- 6
- Issue
- 9
- Pages
- e1001094
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC2936552
- OpenAlex
- W1996756350
- Cited by
- 217
- References
- 61
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 15 · 2023: 13 · 2022: 10 · 2021: 22 · 2020: 15 · 2019: 20 · 2018: 8 · 2017: 14 · 2016: 17 · 2015: 15 · 2014: 12 · 2013: 12 · 2012: 13
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (4r01ai064616-10, NIH-R01)
- U.S. Public Health Service (R01 #A121423)
- National Institute of Allergy and Infectious Diseases (R01 #AI064616, T32AI07323, R01AI067981, R01AI046675, T32AI007323)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Toxoplasma gondii Research Studies
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Coccidia and coccidiosis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Keywords
- Toxoplasma gondii, inner membrane complex, apical cap, protein subcellular targeting, myristoylation, palmitoylation, endodyogeny, cell division, Apicomplexa, parasite replication
- MeSH terms
- Amino Acid Sequence, Animals, Cell Division, Cell Membrane, Cells, Cultured, Fibroblasts, Humans, Immunoglobulin G, Immunization, Male, Membrane Proteins, Mice, Inbred BALB C, Molecular Sequence Data, RNA, Messenger, Toxoplasma, Toxoplasmosis, Blotting, Western, Protozoan Proteins, Mutagenesis, Site-Directed, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, Mice, Foreskin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
