Cited by 69Salmonella and Campylobacter epidemiologyBacterial Genetics and BiotechnologyHelicobacter pylori-related gastroenterology studies

Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming

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Liu, Xiaoyun, Gao, Beile, Novik, Veronica, Galán, Jorge E.·2012·PLoS Pathogens

Abstract

Campylobacter jejuni is the major cause of bacterial food-borne illness in the USA and Europe. An important virulence attribute of this bacterial pathogen is its ability to enter and survive within host cells. Here we show through a quantitative proteomic analysis that upon entry into host cells, C. jejuni undergoes a significant metabolic downshift. Furthermore, our results indicate that intracellular C. jejuni reprograms its respiration, favoring the respiration of fumarate. These results explain the poor ability of C. jejuni obtained from infected cells to grow under standard laboratory conditions and provide the bases for the development of novel anti microbial strategies that would target relevant metabolic pathways.

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Crossref · 10.1371/journal.ppat.1002562

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  • Nitrate reduction is an important pathway for Campylobacter during host colonization.

    “It has recently been demonstrated that nitrate reduction is an important pathway for Campylobacter during host colonization.”

    From Nitrate and periplasmic nitrate reductases (2014) · cites this paper as [74]

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  1. [7]Kelly DJ 2008 Complexity and versatility in the phisiology and metabolism of Campylobacter. Nachamkin I Szymanski CM Blaser MJ Campylobacter. Third ed Washington, DC ASM Press 41 61
  2. [26]Atack J Kelly D 2009 Oxidative stress in Campylobacter jejuni: responses, resistance and regulation. Future Microbiol 4 677 690 19659424

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Authors
Liu, X., Gao, B., Novik, V., & Galán, J. E.
Affiliations
  • Yale University (US)
  • Harvard University (US)
Corresponding author
Galán, Jorge E.
Venue
PLoS Pathogens
Published
2012-03-08
Volume
8
Issue
3
Pages
e1002562
ISSN
  • 1553-7366 (ISSN-L)
  • 1553-7374
OpenAlex
W2029470813
Cited by
69
References
34
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 2 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 8 · 2012: 1
FWCI
13.77
Type
journal article
Language
en
Open access
Locations
  • PLoS Pathogens (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
Ellison Medical Foundation
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords
Campylobacter jejuni, intracellular survival, host cell invasion, metabolic reprogramming, fumarate respiration, bacterial metabolism, food poisoning, antimicrobial drug targets, host-pathogen interaction
MeSH terms
Animals, Bacterial Proteins, Chlorocebus aethiops, Energy Metabolism, Food Contamination, Fumarates, Gene Expression Regulation, Campylobacter jejuni, Bacterial Physiological Phenomena, COS Cells, Proteomics, Host-Pathogen Interactions, Metabolome, Cellular Reprogramming

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