The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon
Open accessAbstract
Specific intestinal microbiota has been shown to induce Foxp3(+) regulatory T cell development. However, it remains unclear how development of another regulatory T cell subset, Tr1 cells, is regulated in the intestine. Here, we analyzed the role of two probiotic strains of intestinal bacteria, Lactobacillus casei and Bifidobacterium breve in T cell development in the intestine. B. breve, but not L. casei, induced development of IL-10-producing Tr1 cells that express cMaf, IL-21, and Ahr in the large intestine. Intestinal CD103(+) dendritic cells (DCs) mediated B. breve-induced development of IL-10-producing T cells. CD103(+) DCs from Il10(-/-), Tlr2(-/-), and Myd88(-/-) mice showed defective B. breve-induced Tr1 cell development. B. breve-treated CD103(+) DCs failed to induce IL-10 production from co-cultured Il27ra(-/-) T cells. B. breve treatment of Tlr2(-/-) mice did not increase IL-10-producing T cells in the colonic lamina propria. Thus, B. breve activates intestinal CD103(+) DCs to produce IL-10 and IL-27 via the TLR2/MyD88 pathway thereby inducing IL-10-producing Tr1 cells in the large intestine. Oral B. breve administration ameliorated colitis in immunocompromised mice given naïve CD4(+) T cells from wild-type mice, but not Il10(-/-) mice. These findings demonstrate that B. breve prevents intestinal inflammation through the induction of intestinal IL-10-producing Tr1 cells.
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Metadata
- Authors
- Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., Okumura, R., Hara, H., Yoshida, H., Yamamoto, M., Nomoto, K., & Takeda, K.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-05-31
- Volume
- 8
- Issue
- 5
- Pages
- e1002714
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2060839471
- Cited by
- 344
- References
- 67
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., Okumura, R., Hara, H., Yoshida, H., Yamamoto, M., Nomoto, K., & Takeda, K. (2012). Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1002714
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