Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

Review article: the role of butyrate on colonic function

HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,464 · see citing works

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327 · see citing works

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287 · see citing works

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840 · see citing works

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works

GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789 · see citing works

(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G

Taggart, A. K. P., Kero, J. T., Gan, X., Cai, T., Cheng, K., Ippolito, M. C., Ren, N., Kaplan, R. A., Wu, K., Wu, T.-J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500213200 · Cited by 651 · see citing works

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

the IBSEN study group, Franke, A., Balschun, T. C., Karlsen, T. H., Skiecevičienė, J., Nikolaus, S., Gabriele Mayr, B., Domingues, F. S., Albrecht, M., Nothnagel, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.221 · Cited by 590 · see citing works

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

Huber, S., Gagliani, N., Esplugues, E., O'Connor, W., Huber, F. J., Chaudhry, A., Kamanaka, M., Kobayashi, Y., Booth, C. J., Rudensky, A. Y., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.020 · Cited by 581 · see citing works

Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases

Dupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517 · see citing works

Regulatory Lymphocytes and Intestinal Inflammation

Ízcue, A., Coombes, J. L., & Powrie, F. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 505 · see citing works

Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

Manicassamy, S., Reizis, B., Ravindran, R., Nakaya, H. I., Gonzalez, R. M. S., Wang, Y., & Pulendran, B. (2010) · Science · doi:10.1126/science.1188510 · Cited by 500 · see citing works

A functional role for NLRP6 in intestinal inflammation and tumorigenesis

Chen, G. Y., Liu, M., Wang, F., Bertin, J., & Núñez, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100412 · Cited by 436 · see citing works

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18

Salcedo, R., Worschech, A., Cardone, M., Jones, Y., Gyulai, Z., Dai, R.-M., Wang, E., Ma, W., Haines, D., O'hUigin, C., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100199 · Cited by 429 · see citing works

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

Uronis, J. M., Mühlbauer, M., Herfarth, H. H., Rubinas, T. C., Jones, G. S., & Jobin, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006026 · Cited by 425 · see citing works

IL-18 production downstream of the NLRP3 inflammasome confers protection against colorectal tumor formation

Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M., & Kanneganti, T.-D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002046 · Cited by 411 · see citing works

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

Larsson, E., Tremaroli, V., Lee, Y. S., Koren, O., Nookaew, I., Fricker, A. D., Nielsen, J., Ley, R. E., & Bäckhed, F. (2011) · Gut · doi:10.1136/gutjnl-2011-301104 · Cited by 386 · see citing works

Pellagra: Dermatitis, dementia, and diarrhea

Hegyi, J., Schwartz, R. A., & Hegyi, V. (2004) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2004.01959.x · Cited by 379 · see citing works

Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

Jeon, S. G., Kayama, H., Ueda, Y., Takahashi, T., Asahara, T., Tsuji, H., Tsuji, N. M., Kiyono, H., Ma, J. S., Kusu, T., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002714 · Cited by 343 · see citing works

Gastrointestinal microflora, food components and colon cancer prevention

Davis, C. D., & Milner, J. A. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.06.001 · Cited by 335 · see citing works

Nicotinic Acid: Pharmacological Effects and Mechanisms of Action

Gille, A., Bodor, E. T., Ahmed, K., & Offermanns, S. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094746 · Cited by 313 · see citing works

Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

Ganapathy, V., Thangaraju, M., Prasad, P. D., Martin, P. M., & Singh, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.08.006 · Cited by 290 · see citing works

G protein-coupled receptors for energy metabolites as new therapeutic targets

Blad, C. C., Tang, C., & Offermanns, S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3777 · Cited by 272 · see citing works

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

Lukasova, M., Malaval, C., Gille, A., Kero, J. T., & Offermanns, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41651 · Cited by 267 · see citing works

Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages

MILLARD, A. L., MERTES, P. M., ITTELET, D., VILLARD, F., JEANNESSON, P., & BERNARD, J. (2002) · Clinical and Experimental Immunology · doi:10.1046/j.0009-9104.2002.01977.x · Cited by 220 · see citing works

CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in <i>ApcMin/+</i> Mice

Erdman, S. E., Sohn, J. J., Rao, V. P., Nambiar, P. R., Ge, Z., Fox, J. G., & Schauer, D. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3104 · Cited by 211 · see citing works

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice

Li, Y., Kundu, P., Seow, S. W., de Matos, C. T., Aronsson, L., Chin, K. C., Kärre, K., Pettersson, S., & Greicius, G. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs137 · Cited by 206 · see citing works

Colonic Gene Expression in Conventional and Germ-Free Mice with a Focus on the Butyrate Receptor GPR109A and the Butyrate Transporter SLC5A8

Cresci, G., Thangaraju, M., Mellinger, J. D., Liu, K., & Ganapathy, V. (2009) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-009-1045-x · Cited by 164 · see citing works

Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells

Garrett, W. S., Punit, S., Gallini, C. A., Michaud, M., Zhang, D., Sigrist, K. S., Lord, G. M., Glickman, J. N., & Glimcher, L. H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.015 · Cited by 155 · see citing works

Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10

Ueda, Y., Kayama, H., Jeon, S. G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M., & Takeda, K. (2010) · International Immunology · doi:10.1093/intimm/dxq449 · Cited by 138 · see citing works

Butyrate inhibits functional differentiation of human monocyte-derived dendritic cells

Wang, B., Morinobu, A., Horiuchi, M., Liu, J., & Kumagai, S. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2008.04.016 · Cited by 84 · see citing works

Estimation of the Potential Antitumor Activity of Microencapsulated Lactobacillus acidophilus Yogurt Formulation in the Attenuation of Tumorigenesis in Apc(Min/+) Mice

Urbanska, A. M., Bhathena, J., Martoni, C., & Prakash, S. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0363-2 · Cited by 80 · see citing works

Association Between Il-18 Gene Promoter Polymorphisms and Inflammatory Bowel Disease in a Japanese Population

Takagawa, T., Tamura, K., Takeda, N., Tomita, T., Ohda, Y., Fukunaga, K., Hida, N., Ohnishi, K., Hori, K., Kosaka, T., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000182868.67025.b9 · Cited by 47 · see citing works

Untitled work

Kalina (2002) · doi:10.1002/1521-4141(200209)32:9

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works

The role of short-chain fatty acids in microbiota–gut–brain communication

Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works

Gut microbiota, metabolites and host immunity

Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172 · see citing works

The microbiome and innate immunity

Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012 · see citing works

The microbiota in adaptive immune homeostasis and disease

Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846 · see citing works

You are what you eat: Diet, health and the gut microbiota

Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works

Short-chain fatty acids: Linking diet, the microbiome and immunity

Mann, E. R., Lam, Y. K., & Uhlig, H. H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01014-8 · Cited by 1,595 · see citing works

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7734 · Cited by 1,439 · see citing works

Cancer and the microbiota

Garrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404 · see citing works

Regulation of immune cell function by short‐chain fatty acids

Corrêa‐Oliveira, R., Fachi, J. L., Vieira, A., Sato, F. T., & Vinolo, M. A. R. (2016) · Clinical &amp; Translational Immunology · doi:10.1038/cti.2016.17 · Cited by 1,346 · see citing works

The microbiome and human cancer

Sepich-Poore, G. D., Zitvogel, L., Straussman, R., Hasty, J., Wargo, J. A., & Knight, R. (2021) · Science · doi:10.1126/science.abc4552 · Cited by 1,332 · see citing works

Colonic bacterial composition in Parkinson's disease

Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., Mutlu, E., & Shannon, K. M. (2015) · Movement Disorders · doi:10.1002/mds.26307 · Cited by 1,281 · see citing works

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

Park, J., Kim, M., Kang, S. G., Jannasch, A. H., Cooper, B., Patterson, J., & Kim, C. H. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.44 · Cited by 1,307 · see citing works

Homeostatic Immunity and the Microbiota

Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261 · see citing works

Microbes, Metabolites, and the Gut-Lung Axis

Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028 · see citing works

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine

Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927 · see citing works

Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation

Kasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A., & Kimura, I. (2015) · Nutrients · doi:10.3390/nu7042839 · Cited by 904 · see citing works

Diet, metabolites, and “western-lifestyle” inflammatory diseases

Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.014 · Cited by 879 · see citing works

Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works

The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis

Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works

The Intestinal Microbiota in Colorectal Cancer.

Tilg, H., Adolph, T. E., Gerner, R. R., & Moschen, A. R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.004 · Cited by 777 · see citing works

Mechanisms and consequences of intestinal dysbiosis

Weiss, G. A., & Hennet, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2509-x · Cited by 775 · see citing works

Gut microbiota induce IGF-1 and promote bone formation and growth

Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750 · see citing works

Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation

Kim, C. H., Park, J., & Kim, M. (2014) · Immune Network · doi:10.4110/in.2014.14.6.277 · Cited by 704 · see citing works

Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health

Chambers, E. S., Preston, T., Frost, G., & Morrison, D. J. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0248-8 · Cited by 691 · see citing works

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Martens, E. C., Neumann, M., & Desai, M. S. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0036-x · Cited by 711 · see citing works

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naive Parkinson's disease patients

Bedarf, J. R., Hildebrand, F., Coelho, L. P., Sunagawa, S., Bahram, M., Goeser, F., Bork, P., & Wüllner, U. (2017) · Genome Medicine · doi:10.1186/s13073-017-0428-y · Cited by 642 · see citing works

The role of the microbiome in cancer development and therapy

Bhatt, A. P., Redinbo, M. R., & Bultman, S. J. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21398 · Cited by 653 · see citing works

The influence of the microbiome on respiratory health

Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611 · see citing works

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

Kennedy, E. A., King, K. Y., & Baldridge, M. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01534 · Cited by 602 · see citing works

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

Chen, G., Ran, X., Li, B., Li, Y., He, D., Huang, B., Fu, S., Liu, J., & Wang, W. (2018) · eBioMedicine · doi:10.1016/j.ebiom.2018.03.030 · Cited by 580 · see citing works

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

Rosser, E. C., Piper, C. J. M., Matei, D. E., Blair, P. A., Rendeiro, A. F., Orford, M., Alber, D. G., Krausgruber, T., Catalan, D., Klein, N., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.003 · Cited by 579 · see citing works

Brain-Gut-Microbiota Axis in Parkinson’s Disease

Mulak, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10609 · Cited by 583 · see citing works

Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation

Bach Knudsen, K. E., Lærke, H. N., Hedemann, M. S., Nielsen, T. S., Ingerslev, A. K., Gundelund Nielsen, D. S., Theil, P. K., Purup, S., Hald, S., Schioldan, A. G., et al. (2018) · Nutrients · doi:10.3390/nu10101499 · Cited by 572 · see citing works

Development and maintenance of intestinal regulatory T cells

Tanoue, T., Atarashi, K., & Honda, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.36 · Cited by 553 · see citing works

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

Luu, M., Pautz, S., Kohl, V., Singh, R., Romero, R., Lucas, S., Hofmann, J., Raifer, H., Vachharajani, N., Carrascosa, L. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08711-2 · Cited by 508 · see citing works

Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria

Fu, X., Liu, Z., Zhu, C., Mou, H., & Kong, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1542587 · Cited by 497 · see citing works

Microbiome and Anticancer Immunosurveillance

Zitvogel, L., Ayyoub, M., Routy, B., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.03.001 · Cited by 478 · see citing works

The role of inflammation and the gut microbiome in depression and anxiety

Peirce, J. M., & Alviña, K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24476 · Cited by 466 · see citing works

Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

Iljazovic, A., Roy, U., Gálvez, E. J. C., Lesker, T. R., Zhao, B., Gronow, A., Amend, L., Will, S. E., Hofmann, J. D., Pils, M. C., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-0296-4 · Cited by 454 · see citing works

Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer

Zeng, H., Umar, S., Rust, B., Lazarova, D., & Bordonaro, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051214 · Cited by 480 · see citing works

Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells

Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Surendra, A., Kumar, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.051 · Cited by 473 · see citing works

Host–microbiota maladaptation in colorectal cancer

Janney, A., Powrie, F., & Mann, E. H. (2020) · Nature · doi:10.1038/s41586-020-2729-3 · Cited by 445 · see citing works

The effect of short-chain fatty acids on human monocyte-derived dendritic cells

Nastasi, C., Candela, M., Bonefeld, C. M., Geisler, C., Hansen, M., Krejsgaard, T., Biagi, E., Andersen, M. H., Brigidi, P., Ødum, N., et al. (2015) · Scientific Reports · doi:10.1038/srep16148 · Cited by 414 · see citing works

The gut-bone axis: How bacterial metabolites bridge the distance

Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403 · see citing works

Complex regulatory effects of gut microbial short-chain fatty acids on immune tolerance and autoimmunity

Kim, C. H. (2023) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-023-00987-1 · Cited by 420 · see citing works

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

Kim, C. H. (2021) · Cellular &amp; Molecular Immunology · doi:10.1038/s41423-020-00625-0 · Cited by 404 · see citing works

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works

Exploring Braak’s hypothesis of Parkinson’s disease

Rietdijk, C. D., Perez-Pardo, P., Garssen, J., van Wezel, R. J. A., & Kraneveld, A. D. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00037 · Cited by 395 · see citing works

Immune regulation by microbiome metabolites

Kim, C. H. (2018) · Immunology · doi:10.1111/imm.12930 · Cited by 375 · see citing works

The Immunomodulatory Functions of Butyrate

Siddiqui, M. T., & Cresci, G. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300989 · Cited by 381 · see citing works

Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention

Song, M., & Chan, A. T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.07.012 · Cited by 355 · see citing works

Organoids in immunological research

Bar-Ephraim, Y. E., Kretzschmar, K., & Clevers, H. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0248-y · Cited by 361 · see citing works

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Fachi, J. L., Felipe, J. D. S., Pral, L. P., da Silva, B. K., Corrêa, R. O., de Andrade, M. C. P., da Fonseca, D. M., Basso, P. J., Câmara, N. O. S., de Sales e Souza, É. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.054 · Cited by 364 · see citing works

Microbiome-modulated metabolites at the interface of host immunity

Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354 · see citing works

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343 · see citing works

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338 · see citing works

Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis

Scott, N. A., Andrusaite, A., Andersen, P., Lawson, M., Alcon-Giner, C., Leclaire, C., Caim, S., Le Gall, G., Shaw, T., Connolly, J. P. R., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao4755 · Cited by 336 · see citing works

Inflammatory Bowel Disease as a Model for Translating the Microbiome

Huttenhower, C., Kostic, A. D., & Xavier, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.013 · Cited by 332 · see citing works

Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex

Rizzetto, L., Fava, F., Tuohy, K. M., & Selmi, C. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.008 · Cited by 331 · see citing works

Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells

Wenzel, T. J., Gates, E. J., Ranger, A. L., & Klegeris, A. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103493 · Cited by 320 · see citing works

The Role of the Immune System in Metabolic Health and Disease

Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323 · see citing works

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

Lindefeldt, M., Eng, A., Darban, H., Bjerkner, A., Zetterström, C. K., Allander, T., Andersson, B., Borenstein, E., Dahlin, M., & Prast-Nielsen, S. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-018-0073-2 · Cited by 310 · see citing works

Gut Microbiota, Immune System, and Bone

D’Amelio, P., & Sassi, F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0331-y · Cited by 315 · see citing works

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works

Microbial Short-Chain Fatty Acids and Blood Pressure Regulation

Pluznick, J. L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0722-5 · Cited by 301 · see citing works

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells

Kespohl, M., Vachharajani, N., Luu, M., Harb, H., Pautz, S., Wolff, S., Sillner, N., Walker, A., Schmitt-Kopplin, P., Boettger, T., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01036 · Cited by 294 · see citing works

The Role of the Microbiota in Inflammation, Carcinogenesis, and Cancer Therapy

Dzutsev, A., Goldszmid, R. S., Viaud, S., Zitvogel, L., & Trinchieri, G. (2015) · European Journal of Immunology · doi:10.1002/eji.201444972 · Cited by 300 · see citing works

Microbes and Cancer

Dzutsev, A., Badger, J. H., Perez-Chanona, E., Roy, S., Salcedo, R., Smith, C. K., & Trinchieri, G. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052133 · Cited by 302 · see citing works

Food, immunity, and the microbiome

Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292 · see citing works

Microbiome effects on immunity, health and disease in the lung

Shukla, S. D., Budden, K. F., Neal, R., & Hansbro, P. M. (2017) · Clinical &amp; Translational Immunology · doi:10.1038/cti.2017.6 · Cited by 287 · see citing works

Fusobacterium nucleatum in colorectal carcinoma tissue according to tumor location

Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.53 · Cited by 284 · see citing works

Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review

Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02654-5 · Cited by 254 · see citing works

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical &amp; Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250 · see citing works

Microbiota-mediated inflammation and antimicrobial defense in the intestine

Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238 · see citing works

Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence

Frei, R., Akdis, M., & O’Mahony, L. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000151 · Cited by 240 · see citing works

Impacts of microbiome metabolites on immune regulation and autoimmunity

Haase, S., Haghikia, A., Wilck, N., Müller, D. N., & Linker, R. A. (2018) · Immunology · doi:10.1111/imm.12933 · Cited by 239 · see citing works

The critical role of gut microbiota in obesity

Cheng, Z., Zhang, L., Yang, L., & Chu, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1025706 · Cited by 233 · see citing works

The Microbiome as a Modifier of Neurodegenerative Disease Risk

Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226 · see citing works

Butyrate suppresses demyelination and enhances remyelination

Chen, T., Noto, D., Hoshino, Y., Mizuno, M., & Miyake, S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1552-y · Cited by 229 · see citing works

The role of the gut microbiota in dietary interventions for depression and anxiety

Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229 · see citing works

Myeloid suppressor cells in cancer and autoimmunity

Sica, A., & Massarotti, M. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.07.010 · Cited by 201 · see citing works

Dietary fiber in the prevention of obesity and obesity-related chronic diseases: From epidemiological evidence to potential molecular mechanisms

Waddell, I. S., & Orfila, C. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2061909 · Cited by 211 · see citing works

Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia

Narushima, S., Sugiura, Y., Oshima, K., Atarashi, K., Hattori, M., Suematsu, M., & Honda, K. (2014) · Gut Microbes · doi:10.4161/gmic.28572 · Cited by 210 · see citing works

Gut microbiota, diet, and obesity-related disorders: the good, the bad, and the future challenges

Portune, K. J., Benítez‐Páez, A., Del Pulgar, E. M. G., Cerrudo, V., & Sanz, Y. (2017) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201600252 · Cited by 201 · see citing works

Immunomodulating activity and therapeutic effects of short chain fatty acids and tryptophan post-biotics in inflammatory bowel disease

Russo, E., Giudici, F., Fiorindi, C., Ficari, F., Scaringi, S., & Amedei, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02754 · Cited by 204 · see citing works

The role of the gut microbiota in multiple sclerosis

Correale, J., Hohlfeld, R., & Baranzini, S. E. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00697-8 · Cited by 207 · see citing works

The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies

Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.042 · Cited by 203 · see citing works

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells

Takahashi, D., Hoshina, N., Kabumoto, Y., Maeda, Y., Suzuki, A., Tanabe, H., Isobe, J., Yamada, T., Muroi, K., Yanagisawa, Y., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102913 · Cited by 205 · see citing works

Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions

Nicolas, G. R., & Chang, P. V. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.04.006 · Cited by 195 · see citing works

The cross talk between microbiota and the immune system: metabolites take center stage

Shapiro, H., Thaiss, C. A., Levy, M., & Elinav, E. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.07.003 · Cited by 189 · see citing works

Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota

Li, J.-Y., Yu, M., Pal, S., Tyagi, A. M., Dar, H., Adams, J., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133473 · Cited by 198 · see citing works

Probiotics and colon cancer

Drago, L. (2019) · Microorganisms · doi:10.3390/microorganisms7030066 · Cited by 171 · see citing works

Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?

Derosa, L., Routy, B., Desilets, A., Daillère, R., Terrisse, S., Kroemer, G., & Zitvogel, L. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0236 · Cited by 170 · see citing works

Dietary α-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones—Microbiota—Inflammation Axis in Rats

Wang, T., Sha, L., Li, Y., Zhu, L., Wang, Z., Li, K., Lu, H., Bao, T., Guo, L., Zhang, X., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00284 · Cited by 162 · see citing works

Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation

Lewis, G., Wang, B., Shafiei Jahani, P., Hurrell, B. P., Banie, H., Aleman Muench, G. R., Maazi, H., Helou, D. G., Howard, E., Galle-Treger, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02051 · Cited by 163 · see citing works

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

Yang, D., Zhao, D., Ali Shah, S. Z., Wu, W., Lai, M., Zhang, X., Li, J., Guan, Z., Zhao, H., Li, W., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01155 · Cited by 162 · see citing works

Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell–Mediated Ureteritis and Hydronephrosis

Park, J., Goergen, C. J., HogenEsch, H., & Kim, C. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502046 · Cited by 166 · see citing works

A case for immediate-release niacin

Bassan, M. M. (2011) · Heart & Lung · doi:10.1016/j.hrtlng.2010.07.019 · Cited by 8 · see citing works

Abstract and Niacin Overview

Jafri, H., Karas, R. H., & Kuvin, J. T. (2009)

Understanding niacin formulations.

Pieper, J. A. (2002) · PubMed · Cited by 51 · see citing works

Does nicotinic acid (niacin) lower blood pressure?

Bays, H. E., & Rader, D. J. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01934.x · Cited by 38 · see citing works

What's the deal with niacin development: is laropiprant add-on therapy a winning strategy to beat a straight flush?

Bays, H. E., & Ballantyne, C. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283325083 · Cited by 29 · see citing works