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The role of integration in oncogenic progression of HPV-associated cancers

McBride, Alison A., Warburton, Alix·2017·PLOS Pathogens
DOI 10.1371/journal.ppat.1006211PMC PMC5383336
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Fig 1 Types of HPV integration. A. Circular HPV genome. B. Linear HPV genome. URR (upstream regulatory region), PE (early promoter), and pAE and pAL (early and late polyadenylation sites) are indicated. The light blue circles in the URR represent E2 binding sites, and the dark blue square is the E1 binding site in the origin of replication (ori). C. In Type 1 integration, a single viral genome is integrated into the host DNA. In Type 2 integration, multiple genomes are integrated in tandem in a head-to-tail orientation. This often is accompanied by focal rearrangement and amplification of flanking cellular sequences.
Fig 1 Types of HPV integration. A. Circular HPV genome. B. Linear HPV genome. URR (upstream regulatory region), PE (early promoter), and pAE and pAL (early and late polyadenylation sites) are indicated. The light blue circles in the URR represent E2 binding sites, and the dark blue square is the E1 binding site in the origin of replication (ori). C. In Type 1 integration, a single viral genome is integrated into the host DNA. In Type 2 integration, multiple genomes are integrated in tandem in a head-to-tail orientation. This often is accompanied by focal rearrangement and amplification of flanking cellular sequences.CC0 · PubMed Central
Fig 2 Models of integration events that promote oncogenesis. The five integration models shown in Table 1 are shown in the diagram, as indicated to the left. URR (upstream regulatory region), and PE (early promoter), are indicated. The light blue circles in the URR represent E2 binding sites, and the dark blue square is the E1 binding site in the origin of replication (ori).
Fig 2 Models of integration events that promote oncogenesis. The five integration models shown in Table 1 are shown in the diagram, as indicated to the left. URR (upstream regulatory region), and PE (early promoter), are indicated. The light blue circles in the URR represent E2 binding sites, and the dark blue square is the E1 binding site in the origin of replication (ori).CC0 · PubMed Central

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Research works printed but not linked: 39

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Cited by

Metadata

Authors
McBride, A. A., & Warburton, A.
Venue
PLOS Pathogens
Publisher
Public Library of Science (PLoS)
Published
2017-04-06
Volume
13
Issue
4
Pages
e1006211
ISSN
1553-7374
DOI
10.1371/journal.ppat.1006211
PMC
PMC5383336
Cited by
376
References
0
Language
en
Licence
creativecommons.org/publicdomain/zero/1.0/ (vor)

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