Relationship of Adiponectin with Markers of Systemic Inflammation, Atherogenic Dyslipidemia, and Heart Failure in Patients with Coronary Heart Disease
Abstract
Background: Adiponectin, an adipocyte-derived hormone, appears to be a modulator of lipid metabolism and systemic inflammation and is present in particularly low concentrations in patients with coronary heart disease (CHD). However, the clinical importance of adiponectin in individuals at markedly high risk for future cardiovascular morbidity and mortality has not been fully elucidated. We examined the associations between serum adiponectin and several biomarkers related to cardiovascular disease and heart failure in a large high-risk population comprising patients with prevalent CHD. Methods: We measured fasting adiponectin, interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and markers of lipoprotein metabolism in 1174 patients with CHD. Results: After adjustment for age and sex, adiponectin was associated with HDL-cholesterol (HDL-C; r = 0.25; P <0.0001), NT-proBNP (r = 0.17; P <0.0001), and plasma triglyceride (r = −0.21; P <0.0001) concentrations. There was, however, no statistically significant association between adiponectin and markers of systemic inflammation. In partial correlation analyses further adjusted for body mass index, alcohol intake, smoking status, presence of diabetes and/or hypertension, lipid-lowering drug therapy, and fasting plasma glucose, adiponectin remained significantly associated with HDL-C (r = 0.21; P <0.0001), NT-proBNP (r = 0.15; P <0.0001), and plasma triglycerides (r = −0.16; P <0.0001). Conclusions: Serum adiponectin is associated with the presence of atherogenic dyslipidemia and with NT-proBNP concentration but not with markers of systemic inflammation in patients with manifest CHD. Thus, atherogenic dyslipidemia may link adiponectin with the progression of atherosclerosis. Moreover, serum adiponectin may be related to BNP in patients with CHD.
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A disparity in the inflammatory cytokine system occurs in obese individuals with heart failure: pro-inflammatory cytokines IL-6, IL-1β, ANP, and TNF-α increase, while anti-inflammatory cytokines IL-10 and TGF-β do not correspondingly increase.
“It appears that a disparity in the inflammatory cytokine system occurs in obese individuals with heart failure since, while pro-inflammatory cytokines such as interleukin (IL)-6, IL-1β, atrial natriuretic peptide (ANP), and tumor necrosis factor (TNF)-α increase, there is not a corresponding increase in anti-inflammatory cytokines such as IL-10 and TGF-β (122, 366).”
From Cardiac remodeling in obesity (2008) · cites this paper as [366]
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- Authors
- von Eynatten, M., Hamann, A., Twardella, D., Nawroth, P. P., Brenner, H., & Rothenbacher, D.
- Affiliations
- Department of Medicine I (Endocrinology and Metabolism), Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany
- Heidelberg University (DE)
- Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05-01
- Volume
- 52
- Issue
- 5
- Pages
- 853-859
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2171233936
- Cited by
- 140
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 8
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adiponectin, coronary artery disease, atherogenic dyslipidemia, heart failure, NT-proBNP, systemic inflammation, interleukin-6, C-reactive protein, HDL cholesterol, triglycerides, lipoprotein metabolism, atherosclerosis progression
- MeSH terms
- Adult, Aged, Coronary Disease, Cross-Sectional Studies, Female, Heart Failure, Humans, Inflammation, Male, Middle Aged, Peptide Fragments, Risk Factors, Socioeconomic Factors, Biomarkers, Prevalence, Multivariate Analysis, Ventricular Function, Left, Natriuretic Peptide, Brain, Dyslipidemias, Atherosclerosis, Adiponectin
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