Cited by 925Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAdipokines, Inflammation, and Metabolic Diseases

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Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction

Packard, René R S, Libby, Peter·2008·Clinical Chemistry

DOI 10.1373/clinchem.2007.097360

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Abstract

Recent investigations of atherosclerosis have focused on inflammation, providing new insight into mechanisms of disease. Inflammatory cytokines involved in vascular inflammation stimulate the generation of endothelial adhesion molecules, proteases, and other mediators, which may enter the circulation in soluble form. These primary cytokines also induce production of the messenger cytokine interleukin-6, which stimulates the liver to increase production of acute-phase reactants such as C-reactive protein. In addition, platelets and adipose tissue can generate inflammatory mediators relevant to atherothrombosis. Despite the irreplaceable utility of plasma lipid profiles in assessment of atherosclerotic risk, these profiles provide an incomplete picture. Indeed, many cardiovascular events occur in individuals with plasma cholesterol concentrations below the National Cholesterol Education Program thresholds of 200 mg/dL for total cholesterol and 130 mg/dL for low-density lipoprotein (LDL) cholesterol. The concept of the involvement of inflammation in atherosclerosis has spurred the discovery and adoption of inflammatory biomarkers for cardiovascular risk prediction. C-reactive protein is currently the best validated inflammatory biomarker; in addition, soluble CD40 ligand, adiponectin, interleukin 18, and matrix metalloproteinase 9 may provide additional information for cardiovascular risk stratification and prediction. This review retraces the biology of atherothrombosis and the evidence supporting the role of inflammatory biomarkers in predicting primary cardiovascular events in this biologic context.

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Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Self-citation
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Self-citation
Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604

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Research works printed but not linked: 11

2004, Am J Med, 116 Suppl 6A, 9S
1996, Atherosclerosis, 124 Suppl, S1
1998, Am J Pathol, 152, 199
1992, Am J Pathol, 140, 301
2006, J Clin Invest, 116, 59
1993, Am J Pathol, 143, 1551
2007, Arterioscler Thromb Vasc Biol, 27, e302
2006, Atherosclerosis
2007, Am J Epidemiol, 165, 164
2007, Arterioscler Thromb Vasc Biol
2001, Clin Chem Lab Med, 39, 380

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RETRACTED: Prediction of Cardiovascular Events in Statin-Treated Stable Coronary Patients by Lipid and Nonlipid Biomarkers
Arsenault, B. J., Barter, P. J., DeMicco, D. A., Bao, W., Preston, G. M., LaRosa, J. C., Grundy, S. M., DEEDWANIA, P. C., Greten, H., WENGER, N. K., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.06.052 · Cited by 36
Retracted
Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-κB activation
Huang, M., Kempuraj, D., Papadopoulou, N., Kourelis, T., Donelan, J., Manola, A., & Theoharides, T. C. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0120 · Cited by 36
Inhibition of nuclear translocation of notch intracellular domain (NICD) by diosgenin prevented atherosclerotic disease progression
Binesh, A., Devaraj, S. N., & Devaraj, H. (2018) · Biochimie · doi:10.1016/j.biochi.2018.02.011 · Cited by 36
Hematological Parameters as Prognostic Biomarkers in Patients with Cardiovascular Diseases
Júnior, J. G. D. M. M., Torres, D. D. O. C., & Filho, D. C. S. (2019) · Current Cardiology Reviews · doi:10.2174/1573403x15666190225123544 · Cited by 36
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Schneiderman, J., Schäfer, K., Kolodgie, F. D., Savion, N., Kotev‐Emeth, S., Dardik, R., Simon, A. J., Halak, M., Pariente, C., Engelberg, I. S., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.001727 · Cited by 36
Association of Exposure to Perfluoroalkyl Substances and Risk of the Acute Coronary Syndrome: A Case-Control Study in Shijiazhuang Hebei Province
Li, H., Chen, J., Lu, J., Yang, J., Tan, Z., Li, L., Xiao, F., An, Z., Ma, C., Liu, Y., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2022.137464 · Cited by 35
Individual and Neighborhood Socioeconomic Status and Inflammation in Mexican American Women
Gallo, L. C., Fortmann, A. L., Monteros, K. E. D. L., Mills, P. J., Barrett-Connor, E. L., Roesch, S. C., & Matthews, K. A. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31824f5f6d · Cited by 35
Prevalence and Correlates of Peripheral Arterial Disease in Nigerians with Type 2 Diabetes
Soyoye, D. O., Ikem, R. T., Kolawole, B. A., Oluwadiya, K. S., Bolarinwa, R. A., & Adebayo, O. (2016) · Advances in Medicine · doi:10.1155/2016/3529419 · Cited by 37
Monocyte adhesion to atherosclerotic matrix proteins is enhanced by Asn-Gly-Arg deamidation
Dutta, B., Park, J. E., Kumar, S., Hao, P., Gallart‐Palau, X., Serra, A., Ren, Y., Sorokin, V. A., Lee, C. N., Ho, H. H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06202-2 · Cited by 35
Transporting mitochondrion-targeting photosensitizers into cancer cells by low-density lipoproteins for fluorescence-feedback photodynamic therapy
Wang, C., Zhao, X., Jiang, H., Wang, J., Zhong, W., Xue, K., & Zhu, C. (2020) · Nanoscale · doi:10.1039/d0nr07342c · Cited by 35
LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38α-mediated pathway
Feng, H., Tan, M., Wu, D. D., Xu, X., & Cui, M. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00895.2009 · Cited by 35
Inhibition of differentiation of monocyte to macrophages in atherosclerosis by oligomeric proanthocyanidins –In-vivo and in-vitro study
Mohana, T., Vijayan, N. A., Jamuna, S., Sadullah, M. S. S., & Devaraj, S. N. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.04.028 · Cited by 34
Soluble CXCL16 and long-term outcome in acute ischemic stroke
Ueland, T., Smedbakken, L. M., Hallén, J., Atar, D., Januzzi, J. L., Halvorsen, B. L., Jensen, J. K., & Aukrust, P. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.004 · Cited by 34
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Wypasek, E., Undas, A., Śnieżek-Maciejewska, M., Kapelak, B., Plicner, D., Stępień, E. Ł., & Sadowski, J. (2010) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2010.090305 · Cited by 34
Biochemical markers for cardiovascular disease in recently postmenopausal women with or without hot flashes
Tuomikoski, P., Mikkola, T. S., Hämäläinen, E. K., Tikkanen, M. J., Turpeinen, U., & Ylikorkala, O. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181acefd5 · Cited by 33
Lignans 7‐hydroxymatairesinol and 7‐hydroxymatairesinol 2 exhibit anti‐inflammatory activity in human aortic endothelial cells
Spilioti, E., Holmbom, B. R., Papavassiliou, A. G., & Moutsatsou, P. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300318 · Cited by 38
Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases
Mastella, A. K., Moresco, R. N., da Silva, D. B., Becker, A. M., Duarte, M., Giovelli, L. L., da Silva, S. H., Rossato, L. L., Moretto, M. B., & da Silva, J. E. P. (2009) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.12.002 · Cited by 34
Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway
Yang, H., Zhao, P., & Tian, S. (2015) · Journal of Diabetes Research · doi:10.1155/2016/9128050 · Cited by 34
Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients
Sardo, M. A., Mandraffino, G., Riggio, S., D’Ascola, A., Alibrandi, A., Saitta, C., Imbalzano, E., Castaldo, M., Cinquegrani, M., & Saitta, A. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05407.x · Cited by 33
miR-505-3p controls chemokine receptor up-regulation in macrophages: role in familial hypercholesterolemia
Escate, R., Mata, P., Cepeda, J. M., Padró, T., & Badimón, L. (2017) · The FASEB Journal · doi:10.1096/fj.201700476r · Cited by 33
Gut Microbiota Composition Affects Procyanidin A2-Attenuated Atherosclerosis in ApoE–/– Mice by Modulating the Bioavailability of Its Microbial Metabolites
Yang, S., Zhang, Y., Li, W., You, B., Yu, J., Huang, X., & Yang, R. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00430 · Cited by 33
Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals
Ludvigsen, T. P., Kirk, R. K., Christoffersen, B. Ø., Pedersen, H. D., Martinussen, T., Kildegaard, J., Heegaard, P. M. H., Lykkesfeldt, J., & Olsen, L. H. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0670-2 · Cited by 33
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions
Trusca, V. G., Fuior, E. V., Florea, I. C., Kardassis, D., Simionescu, M., & Gafencu, A. V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179572 · Cited by 33
Activated Leukocyte Cell Adhesion Molecule and Prognosis in Acute Ischemic Stroke
Smedbakken, L. M., Jensen, J. K., Hallén, J., Atar, D., Januzzi, J. L., Halvorsen, B. L., Aukrust, P., & Ueland, T. (2011) · Stroke · doi:10.1161/strokeaha.110.612440 · Cited by 33
Circulating markers of inflammation and endothelial dysfunction in Arab adolescent subjects: Reference ranges and associations with age, gender, body mass and insulin sensitivity
Al-Isa, A. N., Thalib, L., & Akanji, A. O. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.07.056 · Cited by 33
Sargachromenol protects against vascular inflammation by preventing TNF-α-induced monocyte adhesion to primary endothelial cells via inhibition of NF-κB activation
Gwon, W., Joung, E., Kwon, M., Lim, S.-J., Utsuki, T., & Kim, H. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.014 · Cited by 33
Role of ADAMs in Endothelial Cell Permeability
Ponnuchamy, B., & Khalil, R. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.177394 · Cited by 33
Differential proteomic distribution of TTR (pre-albumin) forms in serum and HDL of patients with high cardiovascular risk
Cubedo, J., Padró, T., Rodrigo Alonso, K., Juan Cinca, A., Mata, P., & Badimón, L. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.024 · Cited by 32
Coronary aspirate TNFα reflects saphenous vein bypass graft restenosis risk in diabetic patients
Baars, T., Konorza, T. F. M., Kahlert, P., Möhlenkamp, S., Erbel, R. M., Heusch, G., & Kleinbongard, P. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-12 · Cited by 32
Early sport practice is related to lower prevalence of cardiovascular and metabolic outcomes in adults independently of overweight and current physical activity.
Fernandes, R., & Zanesco, A. (2015) · Medicina · doi:10.1016/j.medici.2015.10.003 · Cited by 32
The Role of Tumor Necrosis Factor Associated Factors (TRAFs) in Vascular Inflammation and Atherosclerosis
Gissler, M. C., Stachon, P., Wolf, D., & Marchini, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.826630 · Cited by 34
Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article
Saffi, M. A. L. (2015) · World Journal of Cardiology · doi:10.4330/wjc.v7.i1.26 · Cited by 34

Authors: Packard, R. R. S., & Libby, P.
Affiliations: Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Brigham and Women's Hospital (US)
Corresponding author: Libby, Peter
ORCID: Libby, Peter
Venue: Clinical Chemistry
Publisher: Oxford University Press (OUP)
Published: 2008-01-01
Volume: 54
Issue: 1
Pages: 24-38
ISSN: 0009-9147 (ISSN-L)
1530-8561
DOI: 10.1373/clinchem.2007.097360
OpenAlex: W2023647145
Cited by: 925
References: 169
Citations by year: 2026: 10 · 2025: 18 · 2024: 10 · 2023: 20 · 2022: 19 · 2021: 39 · 2020: 44 · 2019: 39 · 2018: 37 · 2017: 39 · 2016: 61 · 2015: 69 · 2014: 65 · 2013: 93 · 2012: 81
FWCI: 5.48
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: atherosclerosis, vascular inflammation, inflammatory markers, cardiovascular risk prediction, C-reactive protein, interleukin-6, atherothrombosis, platelets, adipose tissue, soluble CD40 ligand, adiponectin, IL-18, MMP-9, endothelial adhesion molecules, acute phase proteins, low LDL cholesterol
MeSH terms: Cardiovascular Diseases, Humans, Inflammation, Risk, Biomarkers, Inflammation Mediators, Atherosclerosis

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Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction

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