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Cited by 925Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.

Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction

Packard, René R S, Libby, Peter·2008·Clinical Chemistry
DOI 10.1373/clinchem.2007.097360
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Abstract

Recent investigations of atherosclerosis have focused on inflammation, providing new insight into mechanisms of disease. Inflammatory cytokines involved in vascular inflammation stimulate the generation of endothelial adhesion molecules, proteases, and other mediators, which may enter the circulation in soluble form. These primary cytokines also induce production of the messenger cytokine interleukin-6, which stimulates the liver to increase production of acute-phase reactants such as C-reactive protein. In addition, platelets and adipose tissue can generate inflammatory mediators relevant to atherothrombosis. Despite the irreplaceable utility of plasma lipid profiles in assessment of atherosclerotic risk, these profiles provide an incomplete picture. Indeed, many cardiovascular events occur in individuals with plasma cholesterol concentrations below the National Cholesterol Education Program thresholds of 200 mg/dL for total cholesterol and 130 mg/dL for low-density lipoprotein (LDL) cholesterol. The concept of the involvement of inflammation in atherosclerosis has spurred the discovery and adoption of inflammatory biomarkers for cardiovascular risk prediction. C-reactive protein is currently the best validated inflammatory biomarker; in addition, soluble CD40 ligand, adiponectin, interleukin 18, and matrix metalloproteinase 9 may provide additional information for cardiovascular risk stratification and prediction. This review retraces the biology of atherothrombosis and the evidence supporting the role of inflammatory biomarkers in predicting primary cardiovascular events in this biologic context.

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Crossref · 10.1373/clinchem.2007.097360

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Research works printed but not linked: 11

  1. 2004, Am J Med, 116 Suppl 6A, 9S
  2. 1996, Atherosclerosis, 124 Suppl, S1
  3. 1998, Am J Pathol, 152, 199
  4. 1992, Am J Pathol, 140, 301
  5. 2006, J Clin Invest, 116, 59
  6. 1993, Am J Pathol, 143, 1551
  7. 2007, Arterioscler Thromb Vasc Biol, 27, e302
  8. 2006, Atherosclerosis
  9. 2007, Am J Epidemiol, 165, 164
  10. 2007, Arterioscler Thromb Vasc Biol
  11. 2001, Clin Chem Lab Med, 39, 380

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Metadata

Authors
Packard, R. R. S., & Libby, P.
Affiliations
  • Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
  • Brigham and Women's Hospital (US)
Corresponding author
Libby, Peter
ORCID
Libby, Peter
Venue
Clinical Chemistry
Publisher
Oxford University Press (OUP)
Published
2008-01-01
Volume
54
Issue
1
Pages
24-38
ISSN
  • 0009-9147 (ISSN-L)
  • 1530-8561
DOI
10.1373/clinchem.2007.097360
OpenAlex
W2023647145
Cited by
925
References
169
Citations by year
2026: 10 · 2025: 18 · 2024: 10 · 2023: 20 · 2022: 19 · 2021: 39 · 2020: 44 · 2019: 39 · 2018: 37 · 2017: 39 · 2016: 61 · 2015: 69 · 2014: 65 · 2013: 93 · 2012: 81
FWCI
5.48
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Clinical Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
atherosclerosis, vascular inflammation, inflammatory markers, cardiovascular risk prediction, C-reactive protein, interleukin-6, atherothrombosis, platelets, adipose tissue, soluble CD40 ligand, adiponectin, IL-18, MMP-9, endothelial adhesion molecules, acute phase proteins, low LDL cholesterol
MeSH terms
Cardiovascular Diseases, Humans, Inflammation, Risk, Biomarkers, Inflammation Mediators, Atherosclerosis

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