The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Abstract
Recent investigations of atherosclerosis have focused on inflammation, providing new insight into mechanisms of disease. Inflammatory cytokines involved in vascular inflammation stimulate the generation of endothelial adhesion molecules, proteases, and other mediators, which may enter the circulation in soluble form. These primary cytokines also induce production of the messenger cytokine interleukin-6, which stimulates the liver to increase production of acute-phase reactants such as C-reactive protein. In addition, platelets and adipose tissue can generate inflammatory mediators relevant to atherothrombosis. Despite the irreplaceable utility of plasma lipid profiles in assessment of atherosclerotic risk, these profiles provide an incomplete picture. Indeed, many cardiovascular events occur in individuals with plasma cholesterol concentrations below the National Cholesterol Education Program thresholds of 200 mg/dL for total cholesterol and 130 mg/dL for low-density lipoprotein (LDL) cholesterol. The concept of the involvement of inflammation in atherosclerosis has spurred the discovery and adoption of inflammatory biomarkers for cardiovascular risk prediction. C-reactive protein is currently the best validated inflammatory biomarker; in addition, soluble CD40 ligand, adiponectin, interleukin 18, and matrix metalloproteinase 9 may provide additional information for cardiovascular risk stratification and prediction. This review retraces the biology of atherothrombosis and the evidence supporting the role of inflammatory biomarkers in predicting primary cardiovascular events in this biologic context.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It has now become clear that low-grade chronic inflammation is a key player in the pathogenesis of most CNCDs.”
From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [6]
Citations
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Self-citationInflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Self-citationPearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,094
Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G. D. O., Pepys, M. B., & Gudnason, V. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032804 · Cited by 2,953
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087481.55887.c9 · Cited by 2,679
Self-citationCloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602
Galis, Z. S., Sukhova, G. K., Lark, M. W., & Libby, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117619 · Cited by 2,537
Self-citationThe many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087480.94275.97 · Cited by 2,298
Self-citationC-Reactive Protein Levels and Outcomes after Statin Therapy
Ridker, P. M., Cannon, C. P., Morrow, D., Rifai, N., Rose, L. M., McCabe, C. H., Pfeffer, M. A., & Braunwald, E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042378 · Cited by 2,292
Ridker, P. M., Buring, J. E., Cook, N. R., & Rifai, N. (2003) · Circulation · doi:10.1161/01.cir.0000055014.62083.05 · Cited by 2,292
The immune response in atherosclerosis: a double-edged sword
Hansson, G. K., & Libby, P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1882 · Cited by 2,220
Self-citationBoring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Pathophysiology of coronary artery disease
Libby, P., & Theroux, P. (2005) · Circulation · doi:10.1161/circulationaha.105.537878 · Cited by 1,965
Self-citationDirect Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
Pasceri, V., Willerson, J. T., & Yeh, E. T. H. (2000) · Circulation · doi:10.1161/01.cir.102.18.2165 · Cited by 1,944
Ridker, P. M., Buring, J. E., Rifai, N., & Cook, N. R. (2007) · JAMA · doi:10.1001/jama.297.6.611 · Cited by 1,814
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,782
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,751
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710
Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645
Current Concepts of the Pathogenesis of the Acute Coronary Syndromes
Libby, P. (2001) · Circulation · doi:10.1161/01.cir.104.3.365 · Cited by 1,575
Self-citationGu, L., Okada, Y., Clinton, S. K., Gerard, C. J., Sukhova, G. K., Libby, P., & Rollins, B. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80139-2 · Cited by 1,574
Self-citationRidker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511
Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein
Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., & Braunwald, E. (1999) · Circulation · doi:10.1161/01.cir.100.3.230 · Cited by 1,471
Fibrinogen and risk of cardiovascular disease. The Framingham Study
Kannel, W. B. (1987) · JAMA · doi:10.1001/jama.258.9.1183 · Cited by 1,387
Role of cholesterol and lipid organization in disease
Maxfield, F. R., & Tabas, I. A. (2005) · Nature · doi:10.1038/nature04399 · Cited by 1,331
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329
Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Crowe, T., Sasiela, W. J., Tsai, J., Orazem, J., Magorien, R. D., O'Shaughnessy, C., & Ganz, P. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042000 · Cited by 1,325
Tacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323
Immune cell migration in inflammation: present and future therapeutic targets
Luster, A. D., Alon, R., & von Andrian, U. H. (2005) · Nature Immunology · doi:10.1038/ni1275 · Cited by 1,313
Świrski, F. K., Libby, P., Aïkawa, E., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,308
Self-citationNovel Risk Factors for Systemic Atherosclerosis
Ridker, P. M., Stampfer, M. J., & Rifai, N. (2001) · JAMA · doi:10.1001/jama.285.19.2481 · Cited by 1,290
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
Cybulsky, M. I., Iiyama, K., Li, H., Zhu, S.-N., Chen, M., Iiyama, M., Davis, V., Gutierrez-Ramos, J.-C., Connelly, P. W., & Milstone, D. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11871 · Cited by 1,244
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,186
Inflammation and cardiovascular disease mechanisms
Libby, P. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.456s · Cited by 1,114
Self-citationRelation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
Kuller, L. H., Tracy, R. P., Shaten, J., & Meilahn, E. N. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008963 · Cited by 1,098
Major Risk Factors as Antecedents of Fatal and Nonfatal Coronary Heart Disease Events
Greenland, P. (2003) · JAMA · doi:10.1001/jama.290.7.891 · Cited by 1,053
Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019
T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.
Stemme, S., Faber, B., Holm, J., Wiklund, O., Witztum, J. L., & Hansson, G. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3893 · Cited by 943
Reduction of atherosclerosis in mice by inhibition of CD40 signalling
Mach, F., Schönbeck, U., Sukhova, G. K., Atkinson, E., & Libby, P. (1998) · Nature · doi:10.1038/28204 · Cited by 910
Self-citationFibrinogen and Risk of Cardiovascular Disease
Kannel, W. B. (1987) · JAMA · doi:10.1001/jama.1987.03400090067035 · Cited by 894
C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages
Zwaka, T. P., Hombach, V., & Torzewski, J. (2001) · Circulation · doi:10.1161/01.cir.103.9.1194 · Cited by 848
Soluble CD40 Ligand in Acute Coronary Syndromes
Heeschen, C., Dimmeler, S., Hamm, C. W., van den Brand, M. J., Boersma, E. H., Zeiher, A. M., & Simoons, M. L. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022600 · Cited by 827
Plasminogen-Activator Inhibitor Type 1 and Coronary Artery Disease
Kohler, H. P., & Grant, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422406 · Cited by 805
Rajavashisth, T. B., Andalibi, A., Territo, M., Berliner, J. A., Navab, M., Fogelman, A. M., & Lusis, A. J. (1990) · Nature · doi:10.1038/344254a0 · Cited by 775
Zoccali, C., Mallamaci, F., Tripepi, G. L., Benedetto, F. A., Cutrupi, S., Parlongo, S., Malatino, L., Bonanno, G., Seminara, G., Rapisarda, F., et al. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131134 · Cited by 756
Blankenberg, S., Rupprecht, H. J., Poirier, O., Bickel, C., Smieja, M., Hafner, G., Meyer, J., Cambien, F., & Tiret, L. (2003) · Circulation · doi:10.1161/01.cir.0000058700.41738.12 · Cited by 755
Mach, F., Schönbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J., Pober, J. S., & Libby, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1931 · Cited by 730
Self-citationMoulton, K. S., Heller, E., Konerding, M. A., Flynn, E., Palinski, W., & Folkman, J. (1999) · Circulation · doi:10.1161/01.cir.99.13.1726 · Cited by 688
Li, H., Cybulsky, M. I., Gimbrone, M. A., & Libby, P. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.2.197 · Cited by 686
Self-citationSukhova, G. K., Schönbeck, U., Aïkawa, E., Schöen, F. J., Poole, A. R., Billinghurst, R. C., & Libby, P. (1999) · Circulation · doi:10.1161/01.cir.99.19.2503 · Cited by 660
Self-citationMoulton, K. S., Vakili, K., Zurakowski, D., Soliman, M., Butterfield, C., Sylvin, E., Lo, K.-M., Gillies, S., Javaherian, K., & Folkman, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730843100 · Cited by 652
Devaraj, S., Xu, D. Y., & Jialal, I. (2003) · Circulation · doi:10.1161/01.cir.0000052617.91920.fd · Cited by 641
Amento, E. P., Ehsani, N., Palmer, H., & Libby, P. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1223 · Cited by 609
Self-citationConsequences of cellular cholesterol accumulation: basic concepts and physiological implications
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16452 · Cited by 608
Libby, P., & Simon, D. I. (2001) · Circulation · doi:10.1161/01.cir.103.13.1718 · Cited by 605
Self-citationThögersen, A. M., Jansson, J.-H., Boman, K., Nilsson, T. K., Weinehall, L., Huhtasaari, F., & Hallmans, G. (1998) · Circulation · doi:10.1161/01.cir.98.21.2241 · Cited by 602
Inflammation and atherosclerosis: role of C-Reactive protein in risk assessment
Libby, P., & Ridker, P. M. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.006 · Cited by 601
Self-citationKai, H., Ikeda, H., Yasukawa, H., Kai, M., Seki, Y., Kuwahara, F., Ueno, T., Sugi, K., & Imaizumi, T. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00250-2 · Cited by 591
Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
Libby, P., & Aikawa, M. (2002) · Nature Medicine · doi:10.1038/nm1102-1257 · Cited by 581
Self-citationInterleukin-18 Is a Strong Predictor of Cardiovascular Death in Stable and Unstable Angina
Blankenberg, S., Tiret, L., Bickel, C., Peetz, D., Cambien, F., Meyer, J., & Rupprecht, H. J. (2002) · Circulation · doi:10.1161/01.cir.0000020546.30940.92 · Cited by 566
Calabrò, P., Willerson, J. T., & Yeh, E. T. H. (2003) · Circulation · doi:10.1161/01.cir.0000096055.62724.c5 · Cited by 566
Consequences of cellular cholesterol accumulation: basic concepts and physiological implications
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216452 · Cited by 553
Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., & Schönbeck, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011022 · Cited by 509
Self-citationVaughan, D. E. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01420.x · Cited by 508
Yasmin, Y., Wallace, S. M. L., McEniery, C. M., Dakham, Z., Pusalkar, P., Maki-Petaja, K. M., Ashby, M. J., Cockcroft, J. R., & Wilkinson, I. B. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000151373.33830.41 · Cited by 502
Mach, F., Schönbeck, U., Bonnefoy, J., Pober, J. S., & Libby, P. (1997) · Circulation · doi:10.1161/01.cir.96.2.396 · Cited by 493
Self-citationMacrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice
Gough, P. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25074 · Cited by 470
Mach, F., Sauty, A., Iarossi, A. S., Sukhova, G. K., Neote, K. S., Libby, P., & Luster, A. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6993 · Cited by 466
Self-citationSoluble CD40L and Cardiovascular Risk in Women
Schönbeck, U., Varo, N., Libby, P., Buring, J. E., & Ridker, P. M. (2001) · Circulation · doi:10.1161/hc4401.099447 · Cited by 458
Self-citationAdiponectin: a key adipocytokine in metabolic syndrome
Okamoto, Y., Kihara, S., Funahashi, T., Matsuzawa, Y., & Libby, P. (2006) · Clinical Science · doi:10.1042/cs20050182 · Cited by 445
Self-citationC-Reactive Protein Modulates Risk Prediction Based on the Framingham Score
Köenig, W., Löwel, H., Baumert, J. J., & Meisinger, C. (2004) · Circulation · doi:10.1161/01.cir.0000120707.98922.e3 · Cited by 440
Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease
Matsuzawa, Y. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0380 · Cited by 434
The response‐to‐retention hypothesis of atherogenesis reinforced
Williams, K. J., & Tabas, I. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199810000-00012 · Cited by 395
Adipose Tissue and Atherosclerosis
Fantuzzi, G., & Mazzone, T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.131755 · Cited by 383
PAI-1, Obesity, Insulin Resistance and Risk of Cardiovascular Events
Juhan-Vague, I., & Alessi, M. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657607 · Cited by 379
Clinton, S. K., Underwood, R., Hayes, L., Sherman, M. L., Kufe, D. W., & Libby, P. (1992) · PubMed Central · Cited by 378
Self-citationNovel Inflammatory Markers of Coronary Risk
Libby, P., & Ridker, P. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1148 · Cited by 375
Self-citationInhibition of CD40 signaling limits evolution of established atherosclerosis in mice
Schönbeck, U., Sukhova, G. K., Shimizu, K., Mach, F., & Libby, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7458 · Cited by 358
Self-citationJongstra‐Bilen, J., Haidari, M., Zhu, S.-N., Chen, M., Guha, D., & Cybulsky, M. I. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060245 · Cited by 338
Lipids, risk factors and ischaemic heart disease
Castelli, W. P. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05851-0 · Cited by 337
Healy, A. M., Pickard, M. D., Pradhan, A. D., Wang, Y., Chen, Z., Croce, K., Sakuma, M., Shi, C., Zago, A. C., Garasic, J. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.607333 · Cited by 336
Self-citationSchönbeck, U., Mach, F., Sukhova, G. K., Murphy, C., Bonnefoy, J., Fabunmi, R. P., & Libby, P. (1997) · Circulation Research · doi:10.1161/01.res.81.3.448 · Cited by 334
Self-citationTsimikas, S., Willerson, J. T., & Ridker, P. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.066 · Cited by 332
Interleukin-18 and the Risk of Coronary Heart Disease in European Men
Blankenberg, S., Luc, G., Ducimetière, P., Arveiler, D., Ferrières, J., Amouyel, P., Evans, A., Cambien, F., & Tiret, L. (2003) · Circulation · doi:10.1161/01.cir.0000099509.76044.a2 · Cited by 332
Lara‐Castro, C., Fu, Y., Chung, B. H., & Garvey, W. T. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32814a645f · Cited by 320
Dawson, S. J., Hamsten, A., Wiman, B., HENNEY, A. M., & Humphries, S. E. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.1.183 · Cited by 317
Kawakami, A., Aikawa, M., Alcaide, P., Luscinskas, F. W., Libby, P., & Sacks, F. M. (2006) · Circulation · doi:10.1161/circulationaha.106.622514 · Cited by 305
Self-citationHackett, D., DAVIES, G., & Maseri, A. (1988) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a062449 · Cited by 289
Intertwining of thrombosis and inflammation in atherosclerosis
Croce, K., & Libby, P. (2007) · Current Opinion in Hematology · doi:10.1097/00062752-200701000-00011 · Cited by 285
Self-citationInokubo, Y., Hanada, H., Ishizaka, H., Fukushi, T., Kamada, T., & Okumura, K. (2001) · American Heart Journal · doi:10.1067/mhj.2001.112238 · Cited by 283
Effect of Activation and Inhibition of the Renin-Angiotensin System on Plasma PAI-1
Brown, N. J., Ağırbaşlı, M. A., Williams, G. H., Litchfield, W. R., & Vaughan, D. E. (1998) · Hypertension · doi:10.1161/01.hyp.32.6.965 · Cited by 269
Vaughan, D. E., Rouleau, J. L., Ridker, P. M., Arnold, J. M. O., Menapace, F. J., & Pfeffer, M. A. (1997) · Circulation · doi:10.1161/01.cir.96.2.442 · Cited by 264
Mason, D. P., Kenagy, R. D., Hasenstab, D., Bowen‐Pope, D. F., Seifert, R. A., Coats, S. A., Hawkins, S. M., & Clowes, A. W. (1999) · Circulation Research · doi:10.1161/01.res.85.12.1179 · Cited by 263
Hypoadiponectinemia as a Predictor for the Development of Hypertension
Chow, W.-S., Cheung, B. M. Y., Tso, A. W. K., Xu, A., Wat, N. M. S., Fong, C. H.-Y., Ong, L. H. Y., Tam, S., Tan, K. C. B., Janus, E. D., et al. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.086835 · Cited by 262
Salmenniemi, U., Ruotsalainen, E., Pihlajamäki, J., Vauhkonen, I., Kainulainen, S., Punnonen, K. R. A., Vanninen, E. J., & Laakso, M. (2004) · Circulation · doi:10.1161/01.cir.0000150391.38660.9b · Cited by 260
Robertson, A.-K. L., & Hansson, G. K. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000245830.29764.84 · Cited by 259
Renal Pathology in Fabry Disease
Alroy, J., Sabnis, S. G., & Kopp, J. B. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000016684.07368.75 · Cited by 244
Hung, J., McQuillan, B., Chapman, C., Thompson, P. L., & Beilby, J. P. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163843.70369.12 · Cited by 240
Association of Adiponectin with Coronary Heart Disease and Mortality: The Rancho Bernardo Study
Laughlin, G. A., Barrett-Connor, E. L., May, S. J., & Langenberg, C. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk001 · Cited by 220
Elevated Levels of Interleukin-18 Predict the Development of Type 2 Diabetes
Thorand, B., Kolb, H., Baumert, J. J., Köenig, W., Chambless, L. E., Meisinger, C., Illig, T., Martin, S., & Herder, C. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2932 · Cited by 216
Steinberg, D. H. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600009-jlr200 · Cited by 205
Inflammation and Atherothrombosis
Libby, P., & Ridker, P. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.011 · Cited by 204
Self-citationLi, H., Cybulsky, M. I., Gimbrone, M. A., & Libby, P. (1993) · PubMed Central · Cited by 203
Self-citationSteinberg, D. H. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400003-jlr200 · Cited by 202
Oxidized low density lipoprotein and innate immune receptors
Miller, Y. I., Chang, M.-K., Binder, C. J., Shaw, P. X., & Witztum, J. L. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200310000-00004 · Cited by 200
Raines, E. W., & Ferri, N. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r500004-jlr200 · Cited by 186
Steinberg, D. H. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400012-jlr200 · Cited by 185
Cholesterol and atherosclerosis
Libby, P. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00161-x · Cited by 183
Self-citationAdiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers
Rothenbacher, D., Brenner, H., März, W., & Köenig, W. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi340 · Cited by 175
Kinlay, S., Schwartz, G. G., OLSSON, A. G., Rifai, N., Sasiela, W. J., Szarek, M. J., Ganz, P., & Libby, P. (2004) · Circulation · doi:10.1161/01.cir.0000136588.62638.5e · Cited by 171
Self-citationEren, M., Painter, C., Atkinson, J. B., Declerck, P. J., & Vaughan, D. E. (2002) · Circulation · doi:10.1161/01.cir.0000023186.60090.fb · Cited by 170
Wannamethee, S. G. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.14.1510 · Cited by 170
Koenig, W., Khuseyinova, N., Baumert, J., Meisinger, C., & Löwel, H. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.053 · Cited by 166
Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk
de Lemos, J. A., Hennekens, C. H., & Ridker, P. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00742-7 · Cited by 163
CD40 Ligation Induces Tissue Factor Expression in Human Vascular Smooth Muscle Cells
Schönbeck, U., Mach, F., Sukhova, G. K., Herman, M., Graber, P., Kehry, M. R., & Libby, P. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64699-8 · Cited by 160
Self-citationJabs, W. J., Theissing, E., Nitschke, M., Bechtel, M. F., Duchrow, M., Mohamed, S. A., Jahrbeck, B., Sievers, H., Steinhoff, J., & Bartels, C. (2003) · Circulation · doi:10.1161/01.cir.0000092184.43176.91 · Cited by 157
Otsuka, F., Sugiyama, S., Kojima, S., Maruyoshi, H., Funahashi, T., Matsui, K., Sakamoto, T., Yoshimura, M., Kimura, K., Umemura, S., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.054 · Cited by 156
A prospective study of fibrinogen and risk of myocardial infarction in the physicians’ health study
Ma, J., Hennekens, C. H., Ridker, P. M., & Stampfer, M. J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00007-8 · Cited by 155
Schönbeck, U., Mach, F., Sukhova, G. K., Atkinson, E., Levesque, E. B., Herman, M. P., Graber, P., Basset, P., & Libby, P. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.843 · Cited by 154
Self-citationCirculating Matrix Metalloproteinases and Their Inhibitors in Premature Coronary Atherosclerosis
Noji, Y., Kajinami, K., Kawashiri, M., Todo, Y., Horita, T., Nohara, A., Higashikata, T., Inazu, A., Koizumi, J., Takegoshi, T., et al. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.060 · Cited by 151
Festa, A., D’Agostino, R., Rich, S. S., Jenny, N. S., Tracy, R. P., & Haffner, S. M. (2003) · Circulation · doi:10.1161/01.cir.0000066908.82782.3a · Cited by 148
Leptin Induces C-Reactive Protein Expression in Vascular Endothelial Cells
Singh, P., Hoffmann, M., Wolk, R. A., Shamsuzzaman, A., & Somers, V. K. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.148353 · Cited by 140
Steinberg, D. H. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r500010-jlr200 · Cited by 136
The proatherogenic cytokine interleukin-18 is secreted by human adipocytes
Skurk, T., Kolb, H., Müller-Scholze, S., Röhrig, K., Hauner, H., & Herder, C. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01897 · Cited by 135
Bavendiek, U., Libby, P., Kilbride, M., Reynolds, R. S., Mackman, N., & Schönbeck, U. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204003200 · Cited by 134
Self-citationSamaha, F. F., Szapary, P. O., Iqbal, N., Williams, M. M., Bloedon, L. T., Kochar, A., Wolfe, M. L., & Rader, D. J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000200136.56716.30 · Cited by 129
Hiuge, A., Tenenbaum, A., Maeda, N., Benderly, M., Kumada, M., Fisman, E. Z., Tanné, D., Matas, Z., Hibuse, T., Fujita, K., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000256469.06782.d5 · Cited by 122
Adhesion of Monocytes to Vascular Cell Adhesion Molecule-1–Transduced Human Endothelial Cells
Gerszten, R. E., Lim, Y.-C., Ding, H. T., Snapp, K. R., Kansas, G. S., Dichek, D. A., Cabañas, C., Sánchez‐Madrid, F., Gimbrone, M. A., Rosenzweig, A., et al. (1998) · Circulation Research · doi:10.1161/01.res.82.8.871 · Cited by 113
Interleukin-18, the Metabolic Syndrome, and Subclinical Atherosclerosis
Zirlik, A., Abdullah, S. M., Gerdes, N., MacFarlane, L. A., Schönbeck, U., Khera, A., McGuire, D. K., Vega, G. L., Grundy, S. M., Libby, P., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149484 · Cited by 113
Self-citationSequestration of aggregated low-density lipoproteins by macrophages
Kruth, H. S. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200210000-00003 · Cited by 111
Tayebjee, M. H., Lip, G. Y. H., Tan, K. T., Patel, J. V., Hughes, E. A., & MacFadyen, R. J. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.072 · Cited by 103
Plasma Adiponectin Levels and Sonographic Phenotypes of Subclinical Carotid Artery Atherosclerosis
Iglseder, B., Mackēvičs, V., Stadlmayer, A., Tasch, G., Ladurner, G., & Paulweber, B. (2005) · Stroke · doi:10.1161/01.str.0000190834.00284.fd · Cited by 97
de Lemos, J. A., Zirlik, A., Schönbeck, U., Varo, N., Murphy, S. A., Khera, A., McGuire, D. K., Stanek, G., Lo, H. S., Nuzzo, R., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000182904.08513.60 · Cited by 94
Self-citationAmorino, G. P., & Hoover, R. L. (1998) · PubMed · Cited by 88
Lim, S. K., Koo, B. K., Cho, S. W., Kihara, S., Funahashi, T., Cho, Y. M., Kim, S. Y., Lee, H. K., Shimomura, I., & Park, K. S. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.017 · Cited by 85
Inflammatory Biomarkers in Stable Atherosclerosis
Kinlay, S., & Egido, J. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.09.014 · Cited by 84
Soluble CD40 Ligand Levels Indicate Lipid Accumulation in Carotid Atheroma
Blake, G. J., Ostfeld, R. J., Yucel, E. K., Varo, N., Schönbeck, U., Blake, M. A., Gerhard, M. D., Ridker, P. M., Libby, P., & Lee, R. T. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000050143.22910.62 · Cited by 84
Self-citationHormone Replacement Therapy and Risk of Cardiovascular Disease
Kuller, L. H. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000046033.32478.6d · Cited by 83
Mora, S., Rifai, N., Buring, J. E., & Ridker, P. M. (2006) · Circulation · doi:10.1161/circulationaha.106.634089 · Cited by 82
Eldrup, N., Grønholdt, M.-L. M., Sillesen, H. H., & Nordestgaard, B. G. (2006) · Circulation · doi:10.1161/circulationaha.105.593483 · Cited by 81
Forst, T. M., Pfützner, A., Lübben, G., Weber, M. M., Marx, N., Karagiannis, E., Koehler, C., Baurecht, W., Hohberg, C., & Hanefeld, M. (2007) · Metabolism · doi:10.1016/j.metabol.2006.11.007 · Cited by 67
Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study
Patel, D. A., Srinivasan, S. R., Xu, J.-H., Chen, W., & Berenson, G. S. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.028 · Cited by 62
Soluble CD40L and Cardiovascular Risk in Asymptomatic Low-Grade Carotid Stenosis
Novo, S., Basili, S., Tantillo, R., Falco, A., Davì, V., Novo, G., Corrado, E., & Davı̀, G. (2005) · Stroke · doi:10.1161/01.str.0000154878.58398.14 · Cited by 62
Influence of pre-analytical and analytical factors on soluble CD40L measurements
Varo, N., Nuzzo, R., Natal, C., Libby, P., & Schönbeck, U. (2006) · Clinical Science · doi:10.1042/cs20060047 · Cited by 59
Self-citationMorishige, K. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00710-1 · Cited by 59
Brown, N. J., Abbas, A., Byrne, D. W., Schoenhard, J. A., & Vaughan, D. E. (2002) · Circulation · doi:10.1161/hc0302.102570 · Cited by 58
Gerszten, R. E., Luscinskas, F. W., Ding, H. T., Dichek, D. A., Stoolman, L. M., Gimbrone, M. A., & Rosenzweig, A. (1996) · Circulation Research · doi:10.1161/01.res.79.6.1205 · Cited by 58
Dullaart, R. P. F., de Vries, R., van Tol, A., & Sluiter, W. J. (2007) · European Journal of Endocrinology · doi:10.1530/eje-06-0681 · Cited by 57
Steinberg, D. H. (2005) · Journal of Lipid Research · doi:10.1194/jlr.r500014-jlr200 · Cited by 56
Influence of Sample Type and Storage Conditions on Soluble CD40 Ligand Assessment
Weber, M. W., Rabenau, B., Stanisch, M., Elsaesser, A., Mitrovic, V., Heeschen, C., & Hamm, C. W. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.062083 · Cited by 49
Blankenberg, S., & Yusuf, S. (2006) · Circulation · doi:10.1161/circulationaha.106.652081 · Cited by 33
Chapman, C., McQuillan, B., Beilby, J. P., Thompson, P. L., & Hung, J. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.026 · Cited by 29
Lu, G., Chiem, A. T., Anuurad, E., Havel, P. J., Pearson, T. A., Ormsby, B., & Berglund, L. (2007) · Translational research · doi:10.1016/j.trsl.2006.12.008 · Cited by 26
Lee, W.-L., Lee, W., Chen, Y., Liu, T.-J., Liang, K., Ting, C.-T., & Sheu, W. H. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.013 · Cited by 23
Hocher, B., Liefeldt, L., Quaschning, T., Kalk, P., Ziebig, R., Godes, M., Relle, K., Asmus, G., & Stasch, J.-P. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070684 · Cited by 19
(2006) · The American Journal of Cardiology · doi:10.1016/s0002-9149(06)01415-9 · Cited by 10
Flagged first, then by citations
Research works printed but not linked: 11
- 2004, Am J Med, 116 Suppl 6A, 9S
- 1996, Atherosclerosis, 124 Suppl, S1
- 1998, Am J Pathol, 152, 199
- 1992, Am J Pathol, 140, 301
- 2006, J Clin Invest, 116, 59
- 1993, Am J Pathol, 143, 1551
- 2007, Arterioscler Thromb Vasc Biol, 27, e302
- 2006, Atherosclerosis
- 2007, Am J Epidemiol, 165, 164
- 2007, Arterioscler Thromb Vasc Biol
- 2001, Clin Chem Lab Med, 39, 380
Cited by
Sorted by citations
Inflammatory responses and inflammation-associated diseases in organs
Chen, L., Deng, H., Cui, H., Fang, J. S., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23208 · Cited by 5,541
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,139
Lippi, G., Targher, G., Montagnana, M., Salvagno, G. L., Zoppini, G., & Guidi, G. C. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.4.628 · Cited by 1,095
Milk-derived bioactive peptides: From science to applications
Korhonen, H. J. T. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.01.007 · Cited by 729
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Metadata
- Authors
- Packard, R. R. S., & Libby, P.
- Affiliations
- Leducq Center for Cardiovascular Research, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
- Brigham and Women's Hospital (US)
- Corresponding author
- Libby, Peter
- ORCID
- Libby, Peter
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-01
- Volume
- 54
- Issue
- 1
- Pages
- 24-38
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2023647145
- Cited by
- 925
- References
- 169
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 10 · 2023: 20 · 2022: 19 · 2021: 39 · 2020: 44 · 2019: 39 · 2018: 37 · 2017: 39 · 2016: 61 · 2015: 69 · 2014: 65 · 2013: 93 · 2012: 81
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- atherosclerosis, vascular inflammation, inflammatory markers, cardiovascular risk prediction, C-reactive protein, interleukin-6, atherothrombosis, platelets, adipose tissue, soluble CD40 ligand, adiponectin, IL-18, MMP-9, endothelial adhesion molecules, acute phase proteins, low LDL cholesterol
- MeSH terms
- Cardiovascular Diseases, Humans, Inflammation, Risk, Biomarkers, Inflammation Mediators, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review