The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic and environmental causes of variation in basal levels of blood cells
Open accessAbstract
The genetic and environmental determinants of variation in blood cell size and number were investigated in 392 pairs of 12-year-old twins. The following blood cell indices were measured: haemoglobin, red blood cell count, haematocrit, mean corpuscular volume, platelet number, total white cell count, level of neutrophils, monocytes, eosinophils, total lymphocytes, CD3+ lymphocytes, CD4+ lymphocytes, CD8+ lymphocytes, CD19+ lymphocytes, CD56+ lymphocytes and CD4+/CD8+ ratio. Genetic factors contributed significantly to all blood cell measures accounting for between 61 and 96% of variance. Heritability estimates did not differ significantly between males and females, although the sample size of the present study was not large enough to exclude the possibility of sex-limited gene expression. Common environmental factors were important in determining red blood cell count and haematocrit, but were not important in determining basal levels of any white blood cell type.
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Jinks, J. L., & Fulker, D. W. (1970) · Psychological Bulletin · doi:10.1037/h0029135 · Cited by 808
Cited by
Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.020 · Cited by 1,065
Chen, M.-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., Trivedi, B., Jiang, T., Akbari, P., Vuckovic, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.045 · Cited by 661
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
Ganesh, S. K., Zakai, N. A., van Rooij, F. J. A., Soranzo, N., Smith, A. V., Nalls, M. A., Chen, M.-H., Kottgen, A., Glazer, N. L., Dehghan, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.466 · Cited by 358
Roederer, M., Quaye, L., Mangino, M., Beddall, M. H., Mahnke, Y., Chattopadhyay, P., Tosi, I., Napolitano, L., Terranova Barberio, M., Menni, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.046 · Cited by 296
Metadata
- Authors
- Evans, D. M., Frazer, I. H., & Martin, N. G.
- Venue
- Twin Research (1999)
- Publisher
- Cambridge University Press (CUP)
- Published
- 1999-12-01
- Volume
- 2
- Issue
- 4
- Pages
- 250-257
- ISSN
- 1369-0523 (ISSN-L)
- 0000-0000
- OpenAlex
- W2112526007
- Cited by
- 186
- References
- 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Evans, D. M., Frazer, I. H., & Martin, N. G. (1999). Genetic and environmental causes of variation in basal levels of blood cells. Twin Research (1999). https://doi.org/10.1375/136905299320565735
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