Soluble Transition Metals Mediate the Acute Pulmonary Injury and Airway Hyperreactivity Induced by Residual Oil Fly Ash Articles

Dreher, Kevin; Jaskot, Richard; Kodavanti, Urmila; Lehmann, James; Winsett, Darrell; Costa, Daniel

doi:10.1378/chest.109.3_supplement.33s-a

Cited by 48Air Quality and Health ImpactsCoal and Its By-productsImmunotoxicology and immune responses

Soluble Transition Metals Mediate the Acute Pulmonary Injury and Airway Hyperreactivity Induced by Residual Oil Fly Ash Articles

Dreher, Kevin, Jaskot, Richard, Kodavanti, Urmila, Lehmann, James, Winsett, Darrell, Costa, Daniel·1996·Chest

DOI 10.1378/chest.109.3_supplement.33s-a

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1378/chest.109.3_supplement.33s-a

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Compared with PM2.5, PM10-2.5 has lower concentrations of soluble transition metals.
“In addition, compared with PM2.5, PM10-2.5 had lower concentrations of soluble transition metals, which might also contribute to the lower toxicity of PM10-2.5 (Dreher et al. 1996).”
From Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China (2007) · cites this paper as Dreher et al. 1996

Sorted by citations

Airborne Particulate Matter and Human Health: Toxicological Assessment and Importance of Size and Composition of Particles for Oxidative Damage and Carcinogenic Mechanisms
Valavanidis, A., Fiotakis, K., & Vlachogianni, T. (2008) · Journal of Environmental Science and Health Part C · doi:10.1080/10590500802494538 · Cited by 1,491 · see citing works
Oxidative stress: Its role in air pollution and adverse health effects
Kelly, F. J. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.8.612 · Cited by 817 · see citing works
“Langford et al referred to this mechanism as “reactive absorption”.(4) The uptake of ozone is thus related not only to its concentration but also availability of substrates within the lung lining fluid compartment.”
Background
Cytotoxicity and Induction of Proinflammatory Cytokines from Human Monocytes Exposed to Fine (PM2.5) and Coarse Particles (PM10–2.5) in Outdoor and Indoor Air
Monn, C., & Becker, S. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8591 · Cited by 397 · see citing works
Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China
Kan, H., London, S. J., Chen, G., Zhang, Y., Song, G., Zhao, N., Jiang, L., & Chen, B. (2007) · Environment International · doi:10.1016/j.envint.2006.12.001 · Cited by 339 · see citing works
“5 (Dreher et al. 1996).”
Activation of MAPKs in human bronchial epithelial cells exposed to metals
Samet, J. M., Graves, L. M., Quay, J., Dailey, L. A., Devlin, R. B., Ghio, A. J., Wu, W., Bromberg, P. A., & Reed, W. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.3.l551 · Cited by 257 · see citing works
Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter
Valavanidis, A., Fiotakis, K., Bakeas, E. B., & Vlahogianni, T. (2005) · Redox Report · doi:10.1179/135100005x21606 · Cited by 233 · see citing works
Biologic effects of oil fly ash.
Ghio, A. J., Silbajoris, R. A., Carson, J. L., & Samet, J. M. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s1189 · Cited by 198 · see citing works
“Pulmonary inflammatory injury induced by ROFA is reproducible by instillation of a mixture of soluble forms of vanadium, nickel, and iron in the proportions found in a saline leachate of ROFA (31).”
BackgroundMethodInfluential
The association of particulate air metal concentrations with heart rate variability.
Magari, S. R., Schwartz, J. D., Williams, P. L., Hauser, R. B., Smith, T. J., & Christiani, D. C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110875 · Cited by 147 · see citing works
“5, have been shown to induce cytokine proliferation in both in vitro and in animal models (Carter et al. 1997; Dreher et al. 1996).”
Background
ANALYSIS OF AIR POLLUTION PARTICULATE-MEDIATED OXIDANT STRESS IN ALVEOLAR MACROPHAGES
Imrich, C.-A. W. G. A. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158683 · Cited by 141 · see citing works
Particulate Matter Initiates Inflammatory Cytokine Release by Activation of Capsaicin and Acid Receptors in a Human Bronchial Epithelial Cell Line
Veronesi, B., Oortgiesen, M., Carter, J. D., & Devlin, R. B. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8567 · Cited by 140 · see citing works
Lung Macrophage–Epithelial Cell Interactions Amplify Particle-Mediated Cytokine Release
Tao, F., & Kobzik, L. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.4.4749 · Cited by 136 · see citing works
Coarse particles and mortality in three Chinese cities: The China Air Pollution and Health Effects Study (CAPES)
Chen, R., Li, Y., Ma, Y., Pan, G., Zeng, G., Xu, X., Chen, B., & Kan, H. (2011) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2011.08.058 · Cited by 123 · see citing works
“5 (Dreher et al., 1996).”
ENVIRONMENTAL PARTICULATE-MEDIATED CYTOKINE PRODUCTION IN LUNG EPITHELIAL CELLS (A549): ROLE OF PREEXISTING INFLAMMATION AND OXIDANT STRESS
Program, B. S. P. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158601 · Cited by 109 · see citing works
A time-series study of air pollution, socioeconomic status, and mortality in Vancouver, Canada
Villeneuve, P. J., Burnett, R. T., Shi, Y., Krewski, D. R., Goldberg, M. S., Hertzman, C., Chen, Y., & Brook, J. (2003) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/sj.jea.7500292 · Cited by 105 · see citing works
“Moreover, they are more easily deposited in the alveolar region (US Environmental Protection Agency, 1995), and tend to exhibit greater toxicity than coarse particles (Dreher et al., 1996; Costa and Dreher, 1997; Venkataraman and Kao, 1999).”
Background
Epithelial Injury Induced by Exposure to Residual Oil Fly-Ash Particles: Role of Reactive Oxygen Species?
Dye, J. A., Adler, K. B., Richards, J. H., & Dreher, K. L. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.5.2749 · Cited by 96 · see citing works
“Previous studies of the in vivo effects of ROFA in the rat demonstrated that ROFA exposure resulted in acute pulmonary injury and inflammation (including an eosinophilic inflammatory response) (19, 20), increased airway responsiveness (21, 22), and pulmonary fibrosis (23).”
BackgroundSelf-citation
The Surface Charge of Visible Particulate Matter Predicts Biological Activation in Human Bronchial Epithelial Cells
Veronesi, B., de Haar, C. G., Lee, L., & Oortgiesen, M. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9341 · Cited by 92 · see citing works
Particle-induced oxidative damage is ameliorated by pulmonary antioxidants
Greenwell, L. L., Moreno, T., Jones, T. P., & Richards, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00782-7 · Cited by 83 · see citing works
Neurogenic Inflammation and Particulate Matter (PM) Air Pollutants
Veronesi, B., & Oortgiesen, M. (2001) · NeuroToxicology · doi:10.1016/s0161-813x(01)00062-6 · Cited by 77 · see citing works
Alveolar Macrophages Stimulated with Titanium Dioxide, Chrysotile Asbestos, and Residual Oil Fly Ash Upregulate the PDGF Receptor-α on Lung Fibroblasts Through an IL-1β-Dependent Mechanism
Lindroos, P. M., Coin, P. G., Badgett, A., et al. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.16.3.9070613 · Cited by 68 · see citing works
Residual Oil Fly Ash Induces Cytotoxicity and Mucin Secretion by Guinea Pig Tracheal Epithelial Cells via an Oxidant-Mediated Mechanism
Jiang, N.-F., Dreher, K. L., Dye, J. A., Li, Y., Richards, J. H., Martin, L. D., & Adler, K. B. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8886 · Cited by 58 · see citing works
Self-citation
Fine Particulate Air Pollution and All-Cause Mortality within the Harvard Six-Cities Study Variations in Risk by Period of Exposure
Villeneuve, P. J. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00292-7 · Cited by 58 · see citing works
Induction of PDGF receptor-α in rat myofibroblasts during pulmonary fibrogenesis in vivo
Bonner, J. C., Lindroos, P. M., Rice, A. B., et al. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.1.l72 · Cited by 55 · see citing works
“Other investigators have demonstrated with rat models that IL-1b gene expression in vivo occurs within 4 h after the instillation of vanadium sulfate (9) and that increased protein levels of IL-1 in lavage fluid are maximal within 24 h after the inhalation of asbestos fibers (12) or the instillation of bleomycin (15).”
Background
DECREASED CD11B EXPRESSION, PHAGOCYTOSIS, AND OXIDATIVE BURST IN URBAN PARTICULATE POLLUTION-EXPOSED HUMAN MONOCYTES AND ALVEOLAR MACROPHAGES
Becker, S. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158278 · Cited by 54 · see citing works
Heart rate variability, hemostatic and acute inflammatory blood parameters in healthy adults after short-term exposure to welding fume
Scharrer, E. M., Hessel, H., Kronseder, A., Guth, W., Rolinski, B., Jörres, R. A., Radon, K., Schierl, R., Angerer, P., & Nowak, D. (2006) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-006-0127-2 · Cited by 49 · see citing works
Particulate Matter-Induced Inflammation/Oxidative Stress in Macrophages: Fucosterol from Padina boryana as a Potent Protector, Activated via NF-κB/MAPK Pathways and Nrf2/HO-1 Involvement
Jayawardena, T. U., Sanjeewa, K. K. A., Lee, H.-G., Nagahawatta, D. P., Yang, H.-W., Kang, M., & Jeon, Y. (2020) · Marine Drugs · doi:10.3390/md18120628 · Cited by 50 · see citing works
Effects of concentrated ambient particles in rats and hamsters: an exploratory study.
Gordon, T., Nadziejko, C. E., Chen, L., & Schlesinger, R. (2000) · PubMed · Cited by 44 · see citing works
Transcription factor activation following exposure of an intact lung preparation to metallic particulate matter.
Samet, J. M., Silbajoris, R. A., Huang, T., & Jaspers, I. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110985 · Cited by 38 · see citing works
“Levels of IL-6 and other mediators have also been seen to increase in the bronchoalveolar lavage fluid of animals instilled with ROFA (11,42).”
Reactions of macrophages exposed to particles <10μm
Monn, C., Naef, R., & Koller, T. (2003) · Environmental Research · doi:10.1016/s0013-9351(02)00021-x · Cited by 36 · see citing works
Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice
Orona, N. S., Astort, F., Maglione, G. A., et al. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.110120 · Cited by 30 · see citing works
COMBINED AIR POLLUTION PARTICLE AND OZONE EXPOSURE INCREASES AIRWAY RESPONSIVENESS IN MICE
Goldsmith, C. W., Ning, Y., Guozhong, Q., Imrich, A., Lawrence, J. E., Murthy, G. G. K., Catalano, P. J., & Kobzik, L. (2002) · Inhalation Toxicology · doi:10.1080/08958370252870989 · Cited by 30 · see citing works
“…to the adverse effects attributed to particles (Adamson et al., 2000; Bonner et al., 1998; Castranova et al., 1984; Davison et al., 1974; Dreher et al., 1996, 1997; Dye et al., 1999a; Ghio et al., 1999; Goldsmith et al., 1998; Hatch et al., 1985; Imrich et al., 1999; Jimenez et al.,…”
Background
The association of expired nitric oxide with occupational particulate metal exposure
Kim, J. Y., Hauser, R. B., WAND, M. P., Herrick, R. F., Amarasiriwardena, C. J., & Christiani, D. C. (2003) · Environmental Research · doi:10.1016/s0013-9351(03)00017-3 · Cited by 27 · see citing works
“5 (Costa and Dreher, 1997; Dreher et al., 1996).”
The Role of Stable Free Radicals, Metals and PAHs of Airborne Particulate Matter in Mechanisms of Oxidative Stress and Carcinogenicity
Valavanidis, A., Fiotakis, K., & Vlachogianni, T. (2010) · Environmental science and engineering · doi:10.1007/978-3-642-12278-1_21 · Cited by 26 · see citing works
Pulmonary antioxidants exert differential protective effects against urban and industrial particulate matter
Greenwell, L. L., Moreno, T., & Richards, R. J. (2003) · Journal of Biosciences · doi:10.1007/bf02970139 · Cited by 26 · see citing works
“Oxidation; PM10; pulmonary antioxidants ________________ Abbreviations used: ELF, Epithelial lining fluid; PM, particulate matter; PUF, polyurethane foam; sELF, surrogate ELF; ROFA, residual oil fly ash.”
BackgroundResultInfluential
Diesel exhaust particulates affect cell signaling, mucin profiles, and apoptosis in trachea explants of Balb/C mice
Seriani, R., Junqueira, M. D. S., de Toledo, A. C., Martins, M. A., Seckler, M. M., Alencar, A. M., Negri, E. M., da Silva, L. F. F., Mauad, T., Saldiva, P. H. N., et al. (2014) · Environmental Toxicology · doi:10.1002/tox.22000 · Cited by 25 · see citing works
“These compounds trigger a cellular response mediated by the activation of intracellular signaling pathways (Dreher et al., 1996; Ghio et al., 2002), which culminate in proliferation, cell transformation or cell death (Fantl et al., 1993; Hill and Treisman, 1995).”
Background
Pollutant Particles Induce Arginase II in Human Bronchial Epithelial Cells
Hyseni, X., Soukup, J. M., & Huang, Y.-C. T. (2012) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2012.688479 · Cited by 18 · see citing works
“In animal experiments, exposure to pollutant particles induced airway hyperreactivity and inflammation (Chen et al. 1992; Dreher et al. 1996; Gavett et al. 624 1997; Hamada et al. 1999; Lee et al. 2004; Miyabara et al. 1998; Walters et al. 2001).”
Background
Airborne environmental injuries and human health
Borchers, A. T., Chang, C., Keen, C. L., & Gershwin, M. E. (2006) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:31:1:1 · Cited by 17 · see citing works
“All of these constituents have been implicated in the induction of oxidative stress and inflammatory changes in vitro and in experimental animals (485) (486) (487) (488) (489) (490) .”
Background
Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles
Xu, Y., Li, Z., Liu, Y., et al. (2021) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.1c00199 · Cited by 17 · see citing works
Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V 2 O 5 )
Walters, D. M., White, K. M., Patel, U. J., Davis, M. J., Veluci‐Marlow, R. M., Sunkesula, S. R. B., Bonner, J. C., Martin, J. R., Gladwell, W., & Kleeberger, S. R. (2013) · The FASEB Journal · doi:10.1096/fj.13-235044 · Cited by 16 · see citing works
Enriched inorganic compounds in diesel exhaust particles induce mitogen-activated protein kinase activation, cytoskeleton instability, and cytotoxicity in human bronchial epithelial cells
Seriani, R., Junqueira, M. D. S., Carvalho‐Sousa, C. E., et al. (2015) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2015.02.004 · Cited by 14 · see citing works
AMBIENT PM 10 EXTRACTS INHIBIT PHAGOCYTOSIS OF DEFINED INERT MODEL PARTICLES BY ALVEOLAR MACROPHAGES
Monn, C., Fendt, R., & Koller, T. (2002) · Inhalation Toxicology · doi:10.1080/08958370252871005 · Cited by 13 · see citing works
“Experiments with residual oil fly ash (ROFA) underlined the induction of oxidative response against transition metals in vitro and in vivo (Pritchard et al., 1996; Dreher et al., 1996).”
Background
Effects of combined ozone and air pollution particle exposure in mice.
Kobzik, L., Goldsmith, C. A., Ning, Y. Y., Qin, G., Morgan, B., Imrich, A., Lawrence, J. E., Murthy, G. G. K., & Catalano, P. J. (2001) · PubMed · Cited by 9 · see citing works
Investigation of adverse health effects of residual oil fly ash emitted from a heavy-oil-fuelled Hungarian power plant
Tatár, E., Csiky, G. M., Mihucz, V. G., et al. (2004) · Microchemical Journal · doi:10.1016/j.microc.2004.10.021 · Cited by 6 · see citing works
Differential associations of fine and coarse particulate air pollution with cause-specific pneumonia mortality: A nationwide, individual-level, case-crossover study
Zhang, Y., He, Q., Tong, X., Yin, P., Liu, Y., Meng, X., Gao, Y., Shi, S., Li, X., Kan, H., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119054 · Cited by 4 · see citing works
Toxicological effects of Nanoparticles: In vitro studies with Titanium Dioxide
Singh, S. (2005) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver · Cited by 2 · see citing works
Anti-inflammatory effects of the Ecklonia cava and Hizikia fusiformis formula (EH) in Phorbol 12-Myristate 13-acetate (PMA)-induced A549 cells and a particulate matter (PM)-induced pulmonary injury mouse model
Kang, H., & Lee, S.-G. (2026) · Algal Research · doi:10.1016/j.algal.2026.104572 · Cited by 1 · see citing works
Dissolution behavior of metals from particulate matter emissions
Bérubé, D. (2007) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772240701214409 · Cited by 1 · see citing works
Efecto de Contaminantes Ambientales Particulados sobre Individuos de Diferentes Grupos Etarios (Effect of Particulate Air Pollutants on Individuals of Different Age Groups)Preprint
Ostachuk, A. (2017) · SSRN Electronic Journal · doi:10.2139/ssrn.3038035
Toxicity of Airborne Metals
Kodali, V., Erdely, A., & Zeidler-Erdely, P. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00102-9

Authors: Dreher, K., Jaskot, R., Kodavanti, U., Lehmann, J., Winsett, D., & Costa, D.
Affiliations: Environmental Protection Agency (US)
ORCID: Kodavanti, Urmila
Costa, Daniel
Venue: Chest
Publisher: Elsevier BV
Published: 1996-03
Volume: 109
Issue: 3
Pages: 33S-34S
ISSN: 0012-3692 (ISSN-L)
DOI: 10.1378/chest.109.3_supplement.33s-a
OpenAlex: W2092068642
Cited by: 48
References: 0
Citations by year: 2026: 1 · 2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI: 3.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: CHEST Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: residual oil fly ash, acute pulmonary toxicity, airway hyperresponsiveness, vanadium, iron, nickel, metal mixtures, acidic leachate, secondary particles, particulate matter toxicity, intratracheal instillation, bronchoalveolar lavage, acetylcholine challenge, lung inflammation, gene expression, air pollution health effects, power plant emissions
MeSH terms: Acute Disease, Animals, Vehicle Emissions, Fuel Oils, Lung, Male, Respiratory Hypersensitivity, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Soluble Transition Metals Mediate the Acute Pulmonary Injury and Airway Hyperreactivity Induced by Residual Oil Fly Ash Articles

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks