Oxidative stress: Its role in air pollution and adverse health effects

Kelly, Frank J

doi:10.1136/oem.60.8.612

Cited by 817Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureAntioxidant Activity and Oxidative Stress

Oxidative stress: Its role in air pollution and adverse health effects

Open access

Kelly, Frank J·2003·Occupational and Environmental Medicine

DOI 10.1136/oem.60.8.612PMC PMC1740593

Open this paper in CoChat — free account Open PDF

Abstract

Increasing concern exists over the adverse effects of air pollution on human health.Epidemiological studies have shown a clear association between cardiovascular morbidity,decreased lung function, increased hospital admissions, mortality, and airborne concentrations of photochemical and particulate pollutants. Human exposure chamber studies of specific pollut-ants have shown that short term exposure leads to an acute inflammatory effect on normal human airways in a small (10–20%) proportion of healthy individuals. The consequences of long term exposure to air pollution are more difficult to access but are generally believed to be much worse. Studies in both children and adults have shown that exposure to particulates, nitrogen dioxide and sulphur dioxide, are associated with symptoms of bronchitis. Moreover, exposure to particulates has been related to reduced lung function growth in children and is reversed if the family relocates to a area with lower particulate concentrations. As with any toxic challenge the obvious solution is to remove, or at least decrease to an accept-able level, the source of trouble. In many countries, air pollution levels have fallen in recent years, while additional measures are in place in several more to decrease concentrations further. It is unlikely however, that these practical measures will completely eliminate the problem, even in the medium term. As a consequence, it has been recognised for some time that there is also a need to improve our understanding of the impact of air pollution on biological systems. For example, a bet-

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/oem.60.8.612

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Exposure to air pollution is mediated by oxidative stress in its damaging effects on many physiological functions.
“Additionally, there is a strong body of evidence that indicates exposure to air pollution is mediated by oxidative stress in its damaging effects on many physiological functions [35,37,38].”
From Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation (2018) · cites this paper as [35]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works
Fine Particulate Air Pollution and Mortality in 20 U.S. Cities, 1987–1994
Samet, J. M., Dominici, F., Curriero, F. C., Coursac, I., & Zeger, S. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012143432401 · Cited by 2,235 · see citing works
Fine Particulate Air Pollution and Mortality in 20 U.S. Cities
Sarnat, J. A., Schwartz, J. D., & Suh, H. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104193441614 · Cited by 1,894 · see citing works
Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation.
Gurgueira, S. A., Lawrence, J. E., Coull, B. A., Murthy, G. G. K., & González‐Flecha, B. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110749 · Cited by 555 · see citing works
Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models.
Costa, D. L., & Dreher, K. L. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51053 · Cited by 533 · see citing works
Association between Air Pollution and Lung Function Growth in Southern California Children
Gauderman, W. J., McConnell, R., Gilliland, F. D., London, S. J., Thomas, D. C., Avol, E. L., VORA, H., Berhane, K. T., Rappaport, E. B., LURMANN, F., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9909096 · Cited by 477 · see citing works
Lung Function and Long-Term Exposure to Air Pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team
Ackermann-Liebrich, U. A., Leuenberger, P., Schwartz, J. D., Schindler, C., Monn, C., BOLOGNINI, G., Bongard, J. P., Brändli, O., Domenighetti, G. M., Elsässer, S., et al. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001300 · Cited by 386 · see citing works
Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro.
Li, X. Y., Gilmour, P. S., Donaldson, K., & MacNee, W. (1996) · Thorax · doi:10.1136/thx.51.12.1216 · Cited by 379 · see citing works
The Role of Free Radicals in the Toxic and Inflammatory Effects of Four Different Ultrafine Particle Types
Dick, C. A. J., Brown, D. M., Donaldson, K., & Stone, V. (2003) · Inhalation Toxicology · doi:10.1080/08958370304454 · Cited by 366 · see citing works
Altered lung antioxidant status in patients with mild asthma
Kelly, F. J., Mudway, I., Blomberg, A., Frew, A. J., & Sandström, T. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01812-7 · Cited by 343 · see citing works
Self-citation
Ozone and the lung: a sensitive issue
Mudway, I. (2000) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(00)00003-0 · Cited by 341 · see citing works
Health Effects of Acid Aerosols on North American Children: Respiratory Symptoms
Dockery, D. W., Cunningham, J., Damokosh, A. I., Neas, L., Spengler, J. D., Koutrakis, P., Ware, J. H., Raizenne, M. E., & Speizer, F. E. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104500 · Cited by 339 · see citing works
Comparison of the Pro-Oxidative and Proinflammatory Effects of Organic Diesel Exhaust Particle Chemicals in Bronchial Epithelial Cells and Macrophages
Li, N., Wang, M., Oberley, T. D., Sempf, J. M., & Nel, A. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4531 · Cited by 332 · see citing works
Respiratory Effects of Relocating to Areas of Differing Air Pollution Levels
Avol, E. L., Gauderman, W. J., Tan, S., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.11.2102005 · Cited by 289 · see citing works
Long-Term Ambient Air Pollution and Respiratory Symptoms in Adults (SAPALDIA Study)
Zemp, E., Elsässer, S., Schindler, C., Künzli, N., Perruchoud, A. P., Domenighetti, G. M., Medici, T., Ackermann-Liebrich, U. A., Leuenberger, P., Monn, C., et al. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9807052 · Cited by 282 · see citing works
Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter
Li, N., Kim, S., Wang, M., Froines, J., Sioutas, C., & Nel, A. (2002) · Inhalation Toxicology · doi:10.1080/089583701753678571 · Cited by 249 · see citing works
Respiratory Health and Long-Term Exposure to Air Pollutants in Swiss Schoolchildren. SCARPOL Team. Swiss Study on Childhood Allergy and Respiratory Symptoms With Respect to Air Pollution, Climate and Pollen
Braun‐Fahrländer, C., Vuille, J. C., Sennhauser, F. H., Neu, U., Künzle, T., Grize, L., Gassner, M., Minder, C., Schindler, C., Varonier, H. S., et al. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.3.9116984 · Cited by 249 · see citing works
Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components
Brown, D. M., Stone, V., Findlay, P., MacNee, W., & Donaldson, K. (2000) · Occupational and Environmental Medicine · doi:10.1136/oem.57.10.685 · Cited by 247 · see citing works
Health Effects of Acid Aerosols on North American Children: Pulmonary Function
Raizenne, M. E., Neas, L., Damokosh, A. I., Dockery, D. W., Spengler, J. D., Koutrakis, P., Ware, J. H., & Speizer, F. E. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104506 · Cited by 243 · see citing works
Ozone Dose and Effect in Humans and Rats. A Comparison Using Oxygen-18 Labeling and Bronchoalveolar Lavage
Hatch, G. E., Slade, R., Harris, L. P., McDonnell, W. F., Devlin, R. B., Koren, H. S., Costa, D. L., & McKee, J. M. T. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.3.8087337 · Cited by 239 · see citing works
Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles
Gilmour, P. S., Rahman, I., Donaldson, K., et al. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00277.2002 · Cited by 206 · see citing works
Immunocytochemical localization of extracellular superoxide dismutase in human lung.
Oury, T. D., Chang, L. Y., Marklund, S. L., Day, B. J., & Crapo, J. D. (1994) · PubMed · Cited by 202 · see citing works
In Vivo Evidence of Free Radical Formation in the Rat Lung after Exposure to an Emission Source Air Pollution Particle
Kadiiska, M. B., Mason, R. P., Dreher, K. L., Costa, D. L., & Ghio, A. J. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970049r · Cited by 174 · see citing works
Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry
Prahalad, A. K., Soukup, J. M., Inmon, J., Willis, R. D., Ghio, A. J., Becker, S., & Gallagher, J. E. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8701 · Cited by 173 · see citing works
Particle characteristics responsible for effects on human lung epithelial cells.
Aust, A. E., Ball, J. C., Hu, A. A., Lighty, J. S., Smith, K. R., Straccia, A. M., Veranth, J. M., & Young, W. C. (2002) · PubMed · Cited by 170 · see citing works
Can vitamin E protect humans against the pathological effects of ozone in smog?
Pryor, W. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.3.702 · Cited by 118 · see citing works
The free radical basis of air pullution: focus on ozone
Kelly, F. J., Mudway, I. S., Krishna, M. T., et al. (1995) · Respiratory Medicine · doi:10.1016/0954-6111(95)90131-0 · Cited by 114 · see citing works
Self-citation
Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: a dose-response study
Sandström, T., Stjernberg, N., Eklúnd, A., et al. (1991) · European Respiratory Journal · doi:10.1183/09031936.93.04030332 · Cited by 114 · see citing works
Role of free radicals in the pathogenesis of cystic fibrosis.
Brown, R., & Kelly, F. J. (1994) · Thorax · doi:10.1136/thx.49.8.738 · Cited by 83 · see citing works
Self-citation
Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects
Mudway, I., Stenfors, N., Blomberg, A., Helleday, R., Dunster, C., Marklund, S. L., Frew, A. J., Sandström, T., & Kelly, F. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00671-2 · Cited by 76 · see citing works
Self-citation
Nitrogen dioxide depletes uric acid and ascorbic acid but not glutathione from lung lining fluid
Kelly, F. J., & Tetley, T. D. (1997) · Biochemical Journal · doi:10.1042/bj3250095 · Cited by 67 · see citing works
Self-citation
Redox signaling.
Forman, H. J., Torrès, M., & Fukuto, J. M. (2002) · PubMed · Cited by 67 · see citing works
Ozone Exposure Increases Aldehydes in Epithelial Lining Fluid in Human Lung
Frampton, M. W., Pryor, W. A., Cueto, R., Cox, C., Morrow, P. E., & Utell, M. J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9807057 · Cited by 62 · see citing works
Airway Epithelial Cell Responses to Ozone Injury
Leikauf, G. D., Simpson, L. G., Santrock, J., Zhao, Q., Abbinante-Nissen, J. M., Zhou, S., & Driscoll, K. E. (1995) · Environmental Health Perspectives · doi:10.2307/3432455 · Cited by 60 · see citing works
Modeling the Interactions of Ozone with Pulmonary Epithelial Lining Fluid Antioxidants
Mudway, I. S., & Kelly, F. J. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8318 · Cited by 60 · see citing works
Self-citation
Ozone-Reactive Absorption by Pulmonary Epithelial Lining Fluid Constituents
Langford, S. D., Bidani, A., & Postlethwait, E. M. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1093 · Cited by 53 · see citing works
EFFECTS OF DIESEL EXHAUST ENRICHED CONCENTRATED PM2.5 IN OZONE PREEXPOSED OR MONOCROTALINE-TREATED RATS
Cassee, F. R., Boere, A. J. F., van den Bos, J. W., Fokkens, P. H. B., Dormans, J. A. M. A., & Loveren, H. V. (2002) · Inhalation Toxicology · doi:10.1080/08958370290084601 · Cited by 51 · see citing works
Soluble Transition Metals Mediate the Acute Pulmonary Injury and Airway Hyperreactivity Induced by Residual Oil Fly Ash Articles
Dreher, K., Jaskot, R., Kodavanti, U., Lehmann, J., Winsett, D., & Costa, D. (1996) · Chest · doi:10.1378/chest.109.3_supplement.33s-a · Cited by 48 · cited 1× · see citing works
“Langford et al referred to this mechanism as “reactive absorption”.(4) The uptake of ozone is thus related not only to its concentration but also availability of substrates within the lung lining fluid compartment.”
Background
Measurement of antioxidants, oxidants and oxidant products in bronchoalveolar lavage fluid.
Kelly, F. J., Sandström, T., & Bühler, R. (1999) · European Respiratory Review · Cited by 11 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Ozone, Particulate Matter, and Newly Diagnosed Alzheimer's Disease: A Population-Based Cohort Study in Taiwan
Jung, C.-R., Lin, Y.-T., & Hwang, B.-F. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-140855 · Cited by 380 · see citing works
SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?
Woodby, B., Arnold, M. M., & Valacchi, G. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14512 · Cited by 160 · see citing works
The effect of ambient air pollution during early pregnancy on fetal ultrasonic measurements during mid-pregnancy
Hansen, C. A., Barnett, A. G., & Pritchard, G. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10720 · Cited by 107 · see citing works
A time-stratified case-crossover study of ambient ozone exposure and emergency department visits for specific respiratory diagnoses in California (2005-2008)
Malig, B. J., Pearson, D. L., Chang, Y. B., Broadwin, R., Basu, R., Green, R. S., & Ostro, B. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1409495 · Cited by 103 · see citing works
Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project
Liu, S., Jørgensen, J. T., Ljungman, P., Pershagen, G., Bellander, T., Leander, K., Magnusson, P. K. E., Rizzuto, D., Hvidtfeldt, U. A., Raaschou-Nielsen, O., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.03099-2020 · Cited by 142 · see citing works
Maternal serum metabolome and traffic-related air pollution exposure in pregnancy
Yan, Q., Liew, Z., Uppal, K., Cui, X., Ling, C., Heck, J. E., von Ehrenstein, O. S., Wu, J., Walker, D. I., Jones, D. P., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.05.066 · Cited by 91 · see citing works
Particulate matter and the airway epithelium: the special case of the underground?
Cooper, D. M., & Loxham, M. (2019) · European Respiratory Review · doi:10.1183/16000617.0066-2019 · Cited by 80 · see citing works
Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation
Lephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42 · see citing works

Authors: Kelly, F. J.
Affiliations: King's College London (GB)
Corresponding author: Kelly, Frank J
ORCID: Kelly, Frank J
Venue: Occupational and Environmental Medicine
Publisher: BMJ
Published: 2003-07-25
Volume: 60
Issue: 8
Pages: 612-616
ISSN: 0007-1072 (ISSN-L)
1351-0711
1470-7926
DOI: 10.1136/oem.60.8.612
PMC: PMC1740593
OpenAlex: W2157427270
Cited by: 817
References: 39
Citations by year: 2026: 30 · 2025: 48 · 2024: 48 · 2023: 68 · 2022: 46 · 2021: 56 · 2020: 71 · 2019: 54 · 2018: 49 · 2017: 32 · 2016: 42 · 2015: 38 · 2014: 30 · 2013: 35 · 2012: 17
FWCI: 9.33
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Occupational and Environmental Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Medical Research Council
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, air pollution, air pollution health effects, particulate matter, nitrogen dioxide, sulfur dioxide, photochemical pollutants, cardiovascular morbidity, lung function, bronchitis, airway inflammation, children's lung function, air pollution control
MeSH terms: Air Pollution, Humans, Public Health, Respiratory Tract Diseases, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative stress: Its role in air pollution and adverse health effects

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks