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Cited by 630Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesCystic Fibrosis Research Advances

Mortality after hospitalization for COPD

Almagro, Pedro, Calbo, Esther, Ochoa de Echaguïen, Anna, Barreiro, Bienvenido, Quintana, Salvador, Heredia, José L., Garau, Javier·2002·Chest
DOI 10.1378/chest.121.5.1441
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Abstract

Objectives To identify variables associated with mortality in patients admitted to the hospital for acute exacerbation of COPD.Design Prospective cohort study.Setting Acute-care hospital in Barcelona (Spain).Patients One hundred thirty-five consecutive patients hospitalized for acute exacerbation of COPD, between October 1996 and May 1997.Measurements and results Clinical, spirometric, and gasometric variables were evaluated at the time of inclusion in the study. Socioeconomic characteristics, comorbidity, dyspnea, functional status, depression, and quality of life were analyzed. Mortality at 180 days, 1 year, and 2 years was 13.4%, 22%, and 35.6%, respectively. Sixty-four patients (47.4%) were dead at the end of the study (median follow-up duration, 838 days). Greater mortality was observed in the bivariate analysis among the oldest patients (p < 0.0001), women (p < 0.01), and unmarried patients (p < 0.002). Hospital admission during the previous year (p < 0.001), functional dependence (Katz index) [p < 0.0004], greater comorbidity (Charlson index) [p < 0.0006], depression (Yesavage Scale) [p < 0.00001]), quality of life (St. George's Respiratory Questionnaire [SGRQ]) [p < 0.01], and PCO(2) at discharge (p < 0.03) were also among the significant predictors of mortality. In the multivariate analysis, the activity SGRQ subscale (p < 0.001; odds ratio [OR], 2.62; confidence interval [CI], 1.43 to 4.78), comorbidity (p < 0.005; OR, 2.2; CI, 1.26 to 3.84), depression (p < 0.004; OR, 3.6; CI, 1.5 to 8.65), hospital readmission (p < 0.03; OR, 1.85; CI, 1.26 to 3.84), and marital status (p < 0.0002; OR, 3.12; CI, 1.73 to 5.63) were independent predictors of mortality.Conclusions Quality of life, marital status, depressive symptoms, comorbidity, and prior hospital admission provide relevant information of prognosis in this group of COPD patients.

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  • Depression may be a significant predictor of mortality following hospitalization for acute exacerbations of COPD.

    “Depression may also be a significant predictor of mortality following hospitalization for acute exacerbations.61”

    From Anxiety and Depression in COPD (2008) · cites this paper as [61]

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Authors
Almagro, P., Calbo, E., Ochoa de Echaguïen, A., Barreiro, B., Quintana, S., Heredia, J. L., & Garau, J.
Affiliations
University Hospital Mútua de Terrassa (ES)
Corresponding author
Almagro, Pedro
ORCID
Venue
Chest
Publisher
Elsevier BV
Published
2002-05
Volume
121
Issue
5
Pages
1441-1448
ISSN
0012-3692 (ISSN-L)
DOI
10.1378/chest.121.5.1441
OpenAlex
W2134232280
Cited by
630
References
35
Citations by year
2026: 5 · 2025: 5 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 22 · 2020: 16 · 2019: 23 · 2018: 22 · 2017: 23 · 2016: 37 · 2015: 32 · 2014: 33 · 2013: 51 · 2012: 37
FWCI
17.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • CHEST Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Keywords
chronic obstructive pulmonary disease, COPD exacerbations, mortality, risk factors, depression, comorbidities, quality of life, St George's Respiratory Questionnaire, hospital readmission, functional dependence, marital status, socioeconomic factors, hypercapnia, Spain, Catalonia
MeSH terms
Acute Disease, Aged, Carbon Dioxide, Depression, Dyspnea, Female, Forced Expiratory Volume, Hospitalization, Humans, Male, Oxygen, Prognosis, Prospective Studies, Quality of Life, Surveys and Questionnaires, Risk Factors, Socioeconomic Factors, Spain, Vital Capacity, Comorbidity, Survival Rate, Multivariate Analysis, Confidence Intervals, Odds Ratio, Pulmonary Disease, Chronic Obstructive

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