The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Epidemiology and Outcomes of Health-care–Associated Pneumonia
Abstract
Context Traditionally, pneumonia developing in patients outside the hospital is categorized as community acquired, even if these patients have been receiving health care in an outpatient facility. Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired.Objective To characterize the microbiology and outcomes among patients with culture-positive community-acquired pneumonia (CAP), health-care-associated pneumonia (HCAP), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP).Design and setting A retrospective cohort study based on a large US inpatient database.Patients A total of 4,543 patients with culture-positive pneumonia admitted into 59 US hospitals between January 1, 2002, and December 31, 2003, and recorded in a large, multi-institutional database of US acute-care hospitals (Cardinal Health-Atlas Research Database; Cardinal Health Clinical Knowledge Services; Marlborough, MA).Main measures Culture data (respiratory and blood), in-hospital mortality, length of hospital stay (LOS), and billed hospital charges.Results Approximately one half of hospitalized patients with pneumonia had CAP, and > 20% had HCAP. Staphylococcus aureus was a major pathogen in all pneumonia types, with its occurrence markedly higher in the non-CAP groups than in the CAP group. Mortality rates associated with HCAP (19.8%) and HAP (18.8%) were comparable (p > 0.05), and both were significantly higher than that for CAP (10%, all p < 0.0001) and lower than that for VAP (29.3%, all p < 0.0001). Mean LOS varied significantly with pneumonia category (in order of ascending values: CAP, HCAP, HAP, and VAP; all p < 0.0001). Similarly, mean hospital charge varied significantly with pneumonia category (in order of ascending value: CAP, HCAP, HAP, and VAP; all p < 0.0001).Conclusions The present analysis justified HCAP as a new category of pneumonia. S aureus was a major pathogen of all pneumonias with higher rates in non-CAP pneumonias. Compared with CAP, non-CAP was associated with more severe disease, higher mortality rate, greater LOS, and increased cost.
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“Staphylococcus aureus is one of the most common causes of bacterial pneumonia and the most common pathogen isolated in skin and soft tissue infections (53,54).”
From The Staphylococcus aureus non-coding RNA IsrR regulates TCA cycle activity and virulence (2025) · cites this paper as [53]
In the citing paper
“It is also a common cause of pneumonia (Kollef et al., 2005);”
From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Kollef et al., 2005
Citations
Cites
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200405-644st · Cited by 5,932
CDC definitions for nosocomial infections, 1988
Garner, J. S., Jarvis, W. R., Emori, T. G., Horan, T. C., & Hughes, J. M. (1988) · American Journal of Infection Control · doi:10.1016/0196-6553(88)90053-3 · Cited by 5,665
A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia
Fine, M. J., Auble, T. E., Yealy, D. M., Hanusa, B. H., Weissfeld, L. A., Singer, D. E., Coley, C. M., Marrie, T. J., & Kapoor, W. N. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701233360402 · Cited by 4,592
CDC definitions for nosocomial infections
Yangco, B. G. (1989) · American Journal of Infection Control · doi:10.1016/s0196-6553(89)80013-6 · Cited by 3,774
Infectious Diseases Society of America
Enders, J. F. (1969) · The Journal of Infectious Diseases · doi:10.1093/infdis/119.3.317 · Cited by 3,296
Ventilator-associated Pneumonia
Chastre, J. E., & Fagon, J.-Y. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2105078 · Cited by 2,884
Practice Guidelines for the Management of Community-Acquired Pneumonia in Adults
Bartlett, J. G., Dowell, S. F., Mandell, L. A., File, T. M., Musher, D. M., & Fine, M. J. (2000) · Clinical Infectious Diseases · doi:10.1086/313954 · Cited by 2,283
Guidelines for the Management of Adults with Community-acquired Pneumonia
Niederman, M. S., Mandell, L. A., Anzueto, A., Bass, J. B., Broughton, W. A., Campbell, G. D., Dean, N. C., File, T. M., Fine, M. J., Gross, P. A., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.at1010 · Cited by 2,144
Naimi, T. S. (2003) · JAMA · doi:10.1001/jama.290.22.2976 · Cited by 1,688
Friedman, N., Kaye, K., Stout, J., McGarry, S. A., Trivette, S. L., Briggs, J. P., Lamm, W., Clark, C., MacFarquhar, J. K., Walton, A., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-10-200211190-00007 · Cited by 1,593
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Sorted by citations
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Kalil, A. C., Metersky, M. L., Klompas, M., Muscedere, J., Sweeney, D. A., Palmer, L. B., Napolitano, L. M., O'Grady, N. P., Bartlett, J. G., Carratalà, J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw353 · Cited by 3,892
Metlay, J. P., Waterer, G. W., Long, A. C., Anzueto, A., Brozek, J., Crothers, K., Cooley, L. A., Dean, N. C., Fine, M. J., Flanders, S. A., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201908-1581st · Cited by 3,657
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Lister, P., Wolter, D. J., & Hanson, N. D. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00040-09 · Cited by 1,901
Metadata
- Authors
- Kollef, M. H., Shorr, A., Tabak, Y. P., Gupta, V., Liu, L. Z., & Johannes, R. S.
- Affiliations
- Washington University in St. Louis (US)
- Walter Reed National Military Medical Center (US)
- Cardinal Health (United States) (US)
- Pfizer (United States) (US)
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 128
- Issue
- 6
- Pages
- 3854-3862
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2135191756
- Cited by
- 948
- References
- 38
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 18 · 2023: 10 · 2022: 21 · 2021: 31 · 2020: 32 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 61 · 2015: 73 · 2014: 64 · 2013: 77 · 2012: 72
- FWCI
- 30.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- healthcare-associated pneumonia, community-acquired pneumonia, nosocomial pneumonia, ventilator-associated pneumonia, Staphylococcus aureus, in-hospital mortality, length of hospital stay, hospital charges, pneumonia classification, hospitalized patients
- MeSH terms
- Aged, Aged, 80 and over, Cross Infection, Female, Follow-Up Studies, Gram-Negative Bacteria, Gram-Positive Bacteria, Humans, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Cohort Studies, Incidence, Survival Rate, Multivariate Analysis, Logistic Models, Age Distribution, Sex Distribution, Community-Acquired Infections, Pneumonia, Bacterial, Statistics, Nonparametric
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