Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults
Open accessAbstract
Objective Choices of pharmacologic therapies for pulmonary arterial hypertension (PAH) are ideally guided by high-level evidence. The objective of this guideline is to provide clinicians advice regarding pharmacologic therapy for adult patients with PAH as informed by available evidence.Methods This guideline was based on systematic reviews of English language evidence published between 1990 and November 2013, identified using the MEDLINE and Cochrane Library databases. The strength of available evidence was graded using the Grades of Recommendations, Assessment, Development, and Evaluation methodology. Guideline recommendations, or consensus statements when available evidence was insufficient to support recommendations, were developed using a modified Delphi technique to achieve consensus.Results Available evidence is limited in its ability to support high-level recommendations. Therefore, we drafted consensus statements to address many clinical questions regarding pharmacotherapy for patients with PAH. A total of 79 recommendations or consensus statements were adopted and graded.Conclusions Clinical decisions regarding pharmacotherapy for PAH should be guided by high-level recommendations when sufficient evidence is available. Absent higher level evidence, consensus statements based upon available information must be used. Further studies are needed to address the gaps in available knowledge regarding optimal pharmacotherapy for PAH.
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Pulmonary vascular health is intimately tied to effective NO bioactivity.
“Given that most efficacious therapies for the treatment of PH involve targeting of NO signaling[48,49], it is clear that pulmonary vascular health is intimately tied to effective NO bioactivity.”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [48]
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The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,577 · see citing works
Grading quality of evidence and strength of recommendations
(2004) · BMJ · doi:10.1136/bmj.328.7454.1490 · Cited by 8,477 · see citing works
Rosa, S. D., Samoni, S., Villa, G., & Ronco, C. (2017) · Blood Purification · doi:10.1159/000452650 · Cited by 5,037 · see citing works
Updated clinical classification of pulmonary hypertension
Simonneau, G., Gatzoulis, M. A., Adatia, I., Celermajer, D., Denton, C., Ghofrani, A., Gomez Sanchez, M. A., Krishna Kumar, R., Landzberg, M., Machado, R. F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.029 · Cited by 4,191 · see citing works
Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Hoeper, M. M., Humbert, M. J. C., Torbicki, A., Vachiéry, J., Barberà, J. A., Beghetti, M., Corris, P. A., Gaine, S., Gibbs, J. S. R., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp297 · Cited by 3,841 · see citing works
Bosentan Therapy for Pulmonary Arterial Hypertension
Rubin, L. J., Badesch, D. B., Barst, R. J., Galiè, N., Black, C. M., KEOGH, A. M., Pulido, T., Frost, A., Roux, S., Leconte, I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012212 · Cited by 2,718 · see citing works
Barst, R. J., Rubin, L. J., Long, W. A., McGoon, M. D., Rich, S., Badesch, D. B., Groves, B. Μ., Tapson, V. F., Bourge, R. C., Brundage, B. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340504 · Cited by 2,688 · see citing works
Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension
Galiè, N., Ghofrani, H. A., Torbicki, A., Barst, R. J., Rubin, L. J., Badesch, D. B., Fleming, T. R., Parpia, T., Burgess, G., Branzi, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050010 · Cited by 2,466 · see citing works
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
McLaughlin, V. V., Archer, S. L., Badesch, D. B., Barst, R. J., Farber, H. W., Lindner, J. R., Mathier, M. A., McGoon, M. D., Park, M., Rosenson, R. S., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.01.004 · Cited by 2,354 · see citing works
Consensus methods: characteristics and guidelines for use
Fink, A., Kosecoff, J., Chassin, M., & Brook, R. H. (1984) · American Journal of Public Health · doi:10.2105/ajph.74.9.979 · Cited by 2,089 · see citing works
Inhaled Iloprost for Severe Pulmonary Hypertension
Olschewski, H., Simonneau, G., Galiè, N., HIGENBOTTAM, T. W., Naeije, R., Rubin, L. J., Nikkho, S. M., Speich, R., Hoeper, M. M., Behr, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020204 · Cited by 1,778 · see citing works
Definitions and Diagnosis of Pulmonary Hypertension
Hoeper, M. M., Bogaard, H. J., Condliffe, R., Frantz, R. P., Khanna, D., Kurzyna, M., Langleben, D., Manes, A., Satoh, T., Torres, F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.032 · Cited by 1,763 · see citing works
The Effect of High Doses of Calcium-Channel Blockers on Survival in Primary Pulmonary Hypertension
Rich, S., Kaufmann, E., & Levy, P. S. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207093270203 · Cited by 1,558 · see citing works
Channick, R. N., Simonneau, G., Sitbon, O., Robbins, I. M., Frost, A., Tapson, V. F., Badesch, D. B., Roux, S., Rainisio, M., Bodin, F., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06250-x · Cited by 1,529 · see citing works
Simonneau, G., Barst, R. J., Galiè, N., Naeije, R., Rich, S., Bourge, R. C., KEOGH, A. M., Oudiz, R. J., Frost, A., Blackburn, S. D., et al. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.6.2106079 · Cited by 1,440 · see citing works
Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension
Pulido, T., Адзерихо, И. Э., Channick, R. N., Delcroix, M., Galiè, N., Ghofrani, H. A., Jansa, P., Jing, Z., Brun, F. L., Mehta, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1213917 · Cited by 1,439 · see citing works
Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension
Ghofrani, H. A., D’Armini, A. M., Grimminger, F., Hoeper, M. M., Jansa, P., Kim, N. H., Mayer, E., Simonneau, G., Wilkins, M. R., Fritsch, A., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209657 · Cited by 1,393 · see citing works
Long-term intravenous epoprostenol infusion in primary pulmonary hypertension
Sitbon, O., Humbert, M. J. C., Nunès, H., Parent, F., Garcia, G., Hervé, P., Rainisio, M., & Simonneau, G. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02012-0 · Cited by 1,374 · see citing works
Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Hoeper, M. M., Humbert, M. J. C., Torbicki, A., Vachiéry, J., Barberà, J. A., Beghetti, M., Corris, P. A., Gaine, S., Gibbs, J. S., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00139009 · Cited by 1,296 · see citing works
Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension
Sitbon, O., Humbert, M. J. C., Jaïs, X., Ioos, V., Hamid, A. M., Provencher, S., Garcia, G., Parent, F., Hervé, P., & Simonneau, G. (2005) · Circulation · doi:10.1161/circulationaha.104.488486 · Cited by 1,244 · see citing works
Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines
Guyatt, G., Gutterman, D., Baumann, M. H., Addrizzo-Harris, D., Hylek, E. M., Phillips, B., Raskob, G., Lewis, S. Z., & Schünemann, H. (2006) · Chest · doi:10.1378/chest.129.1.174 · Cited by 1,220 · see citing works
Survival in Primary Pulmonary Hypertension
McLaughlin, V. V., Shillington, A. C., & Rich, S. (2002) · Circulation · doi:10.1161/01.cir.0000029100.82385.58 · Cited by 1,217 · see citing works
Tadalafil Therapy for Pulmonary Arterial Hypertension
Galiè, N., Brundage, B. H., Ghofrani, H. A., Oudiz, R. J., Simonneau, G., Safdar, Z., Shapiro, S., White, R. J., Chan, M., Beardsworth, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.839274 · Cited by 1,096 · see citing works
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
McLaughlin, V. V., Archer, S. L., Badesch, D. B., Barst, R. J., Farber, H. W., Lindner, J. R., Mathier, M. A., McGoon, M. D., Park, M., Rosenson, R. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192230 · Cited by 1,085 · see citing works
Ambrisentan for the Treatment of Pulmonary Arterial Hypertension
Galiè, N., Olschewski, H., Oudiz, R. J., Torres, F., Frost, A., Ghofrani, H. A., Badesch, D. B., McGoon, M. D., McLaughlin, V. V., Roecker, E. B., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.742510 · Cited by 1,077 · see citing works
Badesch, D. B., Tapson, V. F., McGoon, M. D., Brundage, B. H., Rubin, L. J., Wigley, F. M., Rich, S., Barst, R. J., Barrett, P. S., Kral, K. M., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-6-200003210-00002 · Cited by 1,071 · see citing works
Galiè, N., Rubin, L., Hoeper, M. M., Jansa, P., Al‐Hiti, H., Meyer, G. M. B., Chiossi, E., Kusic‐Pajic, A., & Simonneau, G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60919-8 · Cited by 917 · see citing works
Bosentan Therapy in Patients With Eisenmenger Syndrome
Galiè, N., Beghetti, M., Gatzoulis, M. Α., Granton, J. T., Berger, R. M. F., Lauer, A., Chiossi, E., & Landzberg, M. J. (2006) · Circulation · doi:10.1161/circulationaha.106.630715 · Cited by 844 · see citing works
Medical Therapy For Pulmonary Arterial Hypertension
Badesch, D. B., Abman, S. H., Ahearn, G. S., Barst, R. J., McCrory, D. C., Simonneau, G., & McLaughlin, V. V. (2004) · CHEST Journal · doi:10.1378/chest.126.1_suppl.35s · Cited by 829 · see citing works
Treatment of Primary Pulmonary Hypertension with Continuous Intravenous Prostacyclin (Epoprostenol)
Rubin, L. J., Mendoza, J., Hood, M., McGoon, M., Barst, R., Williams, W. B., Diehl, J. H., Crow, J., & Long, W. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-7-485 · Cited by 701 · see citing works
Outcome of Pulmonary Vascular Disease in Pregnancy: A Systematic Overview From 1978 Through 1996
Weiss, B. M., Zemp, L., Seifert, B., & Hess, O. M. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00162-4 · Cited by 670 · see citing works
McLaughlin, V. V., Genthner, D., Panella, M. M., & Rich, S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380501 · Cited by 660 · see citing works
Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
Humbert, M. J. C., Barst, R. J., Robbins, I. M., Channick, R. N., Galiè, N., Boonstra, A., Rubin, L. J., Horn, E. M., Manes, A., & Simonneau, G. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00028404 · Cited by 638 · see citing works
Randomized Study of Adding Inhaled Iloprost to Existing Bosentan in Pulmonary Arterial Hypertension
McLaughlin, V. V., Oudiz, R. J., Frost, A., Tapson, V. F., Murali, S., Channick, R. N., Badesch, D. B., Barst, R. J., Hsu, H. H., & Rubin, L. J. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200603-358oc · Cited by 624 · see citing works
Simonneau, G., Rubin, L. J., Galiè, N., Barst, R. J., Fleming, T. R., Frost, A. E., Engel, P. J., Kramer, M. R., Burgess, G., Collings, L., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-8-200810210-00004 · Cited by 613 · see citing works
Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive
Jaeschke, R., Guyatt, G. H., Dellinger, P., Schunemann, H., Levy, M. M., Kunz, R., Norris, S., Bion, J., & for the GRADE working group (2008) · BMJ · doi:10.1136/bmj.a744 · Cited by 577 · see citing works
Addition of Inhaled Treprostinil to Oral Therapy for Pulmonary Arterial Hypertension
McLaughlin, V. V., Benza, R. L., Rubin, L. J., Channick, R. N., Voswinckel, R., Tapson, V. F., Robbins, I. M., Olschewski, H., Rubenfire, M., & Seeger, W. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.01.027 · Cited by 564 · see citing works
Survival in Primary Pulmonary Hypertension with Long-Term Continuous Intravenous Prostacyclin
Barst, R. J., Rubin, L. J., McGoon, M. D., Caldwell, E. J., Long, W. A., & Levy, P. S. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-6-199409150-00003 · Cited by 548 · see citing works
Pediatric Pulmonary Hypertension
Ivy, D. D., Abman, S. H., Barst, R. J., Berger, R. M. F., Bonnet, D., Fleming, T. R., Haworth, S. G., Raj, J. U., Rosenzweig, E. B., Schulze‐Neick, I., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.028 · Cited by 543 · see citing works
Long-Term Prostacyclin for Pulmonary Hypertension With Associated Congenital Heart Defects
Rosenzweig, E. B., Kerstein, D., & Barst, R. J. (1999) · Circulation · doi:10.1161/01.cir.99.14.1858 · Cited by 507 · see citing works
Medical Therapy for Pulmonary Arterial Hypertension
Badesch, D. B., Abman, S. H., Simonneau, G., Rubin, L. J., & McLaughlin, V. V. (2007) · CHEST Journal · doi:10.1378/chest.06-2674 · Cited by 438 · see citing works
Jégo, P. (1996) · La Revue de Médecine Interne · doi:10.1016/0248-8663(96)83752-0 · Cited by 409 · see citing works
Primary pulmonary hypertension
Dresdale, D. T., Schultz, M., & Michtom, R. J. (1951) · The American Journal of Medicine · doi:10.1016/0002-9343(51)90020-4 · Cited by 399 · see citing works
Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension
Montani, D., Savale, L., Natali, D., Jaïs, X., Hervé, P., Garcia, G., Humbert, M. J. C., Simonneau, G., & Sitbon, O. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq170 · Cited by 360 · see citing works
Authors/Task Force Members:, Galiè, N., Hoeper, M. M., Humbert, M. J. C., Torbicki, A., Vachiéry, J.-L., Barberà, J. A., Beghetti, M., Corris, P. A., Gaine, S., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr046 · Cited by 314 · see citing works
Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension.
Rubin, L. J., Groves, B. Μ., Reeves, J. Τ., Frosolono, M. F., Handel, F., & Cato, A. E. (1982) · Circulation · doi:10.1161/01.cir.66.2.334 · Cited by 312 · see citing works
Shapiro, S., Oudiz, R. J., Cao, T., Romano, M. A., Beckmann, X. J., Georgiou, D., Mandayam, S., Ginzton, L. E., & Brundage, B. H. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00187-3 · Cited by 302 · see citing works
Safety and Efficacy of IV Treprostinil for Pulmonary Arterial Hypertension
Tapson, V. F., Gomberg‐Maitland, M., McLaughlin, V. V., Benza, R. L., Widlitz, A. C., Krichman, A. D., & Barst, R. J. (2006) · CHEST Journal · doi:10.1378/chest.129.3.683 · Cited by 293 · see citing works
Treatment Goals of Pulmonary Hypertension
McLaughlin, V. V., Gaine, S., Howard, L., Leuchte, H. H., Mathier, M. A., Mehta, S., Palazzini, M., Park, M., Tapson, V. F., & Sitbon, O. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.034 · Cited by 293 · see citing works
Krowka, M. J., Frantz, R. P., McGoon, M. D., Severson, C. J., Plevak, D. J., & Wiesner, R. H. (1999) · Hepatology · doi:10.1002/hep.510300307 · Cited by 291 · see citing works
Pregnancy outcomes in pulmonary arterial hypertension in the modern management era
Jaïs, X., Olsson, K. M., Barberà, J. A., Blanco, I., Torbicki, A., Peacock, A. J., Vizza, C. D., Macdonald, P. S., Humbert, M. J. C., & Hoeper, M. M. (2012) · European Respiratory Journal · doi:10.1183/09031936.00141211 · Cited by 265 · see citing works
Oudiz, R. J., Schilz, R. J., Barst, R. J., Galiè, N., Rich, S., Rubin, L. J., & Simonneau, G. (2004) · CHEST Journal · doi:10.1378/chest.126.2.420 · Cited by 263 · see citing works
Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Hoeper, M. M., Humbert, M. J. C., Torbicki, A., Vachiéry, J., Barberà, J. A., Beghetti, M., Corris, P. A., Gaine, S., Gibbs, J. S. R., et al. (2012) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2011.10.006 · Cited by 257 · see citing works
Transition from Intravenous Epoprostenol to Intravenous Treprostinil in Pulmonary Hypertension
Gomberg‐Maitland, M., Tapson, V. F., Benza, R. L., McLaughlin, V. V., Krichman, A. D., Widlitz, A. C., & Barst, R. J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200505-766oc · Cited by 222 · see citing works
Efficacy of Long-term Subcutaneous Treprostinil Sodium Therapy in Pulmonary Hypertension
Lang, I. M., Gómez‐Sánchez, M. Á., Kneußl, M., Naeije, R., Escribano, P., Skoro‐Sajer, N., & Vachiéry, J. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1636 · Cited by 202 · see citing works
Hiremath, J., Thanikachalam, S., Parikh, K. H., Shanmugasundaram, S., Banġera, S., Shapiro, L., Pott, G. B., Vnencak‐Jones, C. L., Arneson, C. P., Wade, M., et al. (2009) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2009.09.005 · Cited by 197 · see citing works
Epoprostenol (Prostacyclin) Therapy in HIV-associated Pulmonary Hypertension
AGUILAR, R. V., & Farber, H. W. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.5.2004042 · Cited by 172 · see citing works
Treatment of primary pulmonary hypertension intravenous epoprostenol (prostacyclin).
Jones, D. K., Higenbottam, T., & Wallwork, J. L. (1987) · Heart · doi:10.1136/hrt.57.3.270 · Cited by 164 · see citing works
MEYER, S. E., McLaughlin, V. V., Seyfarth, H.-J., Bull, T. M., Vizza, C. D., Gomberg‐Maitland, M., Preston, I. R., Barberà, J. A., Hassoun, P. M., Halank, M., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00089212 · Cited by 160 · see citing works
Evaluation and Management of the Patient with Pulmonary Arterial Hypertension
Rubin, L. J., & Badesch, D. B. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-143-4-200508160-00009 · Cited by 149 · see citing works
Pulmonary hypertension and pregnancy: a series of eight cases
Smedstad, K. G., Cramb, R., & Morison, D. H. (1994) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03011545 · Cited by 149 · see citing works
Simonneau, G., Rubin, L. J., Galiè, N., Barst, R. J., Fleming, T. R., & Frost, A. (2009) · Annals of Internal Medicine · Cited by 129 · see citing works
Combined effects of nitric oxide and oxygen during acute pulmonary vasodilator testing
Atz, A. M., Adatia, I., Lock, J. E., & WESSEL, D. L. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00668-8 · Cited by 127 · see citing works
(2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.12.004 · Cited by 123 · see citing works
Pregnancy and Primary Pulmonary Hypertension
Stewart, R. W., TUAZON, D. M., Duarte, A. G., & Olson, G. (2001) · CHEST Journal · doi:10.1378/chest.119.3.973 · Cited by 120 · see citing works
Oudiz, R. J., Widlitz, A. C., Beckmann, X. J., Camanga, D., Alfie, J., Brundage, B. H., & Barst, R. J. (2004) · CHEST Journal · doi:10.1378/chest.126.1.90 · Cited by 114 · see citing works
PRIMARY PULMONARY HYPERTENSION IN PREGNANCY
McCaffrey, R. M., & Dunn, L. J. (1964) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-196408000-00001 · Cited by 113 · see citing works
Benza, R. L., Seeger, W., McLaughlin, V. V., Channick, R. N., Voswinckel, R., Tapson, V. F., Robbins, I. M., Olschewski, H., & Rubin, L. J. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2011.08.019 · Cited by 108 · see citing works
Kemp, K., Savale, L., O’Callaghan, D. S., Jaïs, X., Montani, D., Humbert, M. J. C., Simonneau, G., & Sitbon, O. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2011.11.002 · Cited by 108 · see citing works
Primary pulmonary hypertension in pregnancy; a role for novel vasodilators
Monnery, L., Nanson, J., & Charlton, G. A. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.2.295 · Cited by 98 · see citing works
Packer, M., Medina, N., & Yushak, M. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80048-0 · Cited by 97 · see citing works
Comparative Acute Effects of Adenosine and Prostacyclin in Primary Pulmonary Hypertension
Nootens, M., Schrader, B. J., Kaufmann, E., Vestal, R. E., Long, W. A., & Rich, S. (1995) · CHEST Journal · doi:10.1378/chest.107.1.54 · Cited by 95 · see citing works
Taichman, D. B., McGoon, M. D., Harhay, M. O., Archer-Chicko, C. L., Sager, J. S., Murugappan, M. N., Chakinali, M. M., Palevsky, H. I., & Gallop, R. (2009) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60747-7 · Cited by 93 · see citing works
Bloodstream Infections in Patients Given Treatment With Intravenous Prostanoids
Kallen, A. J., Lederman, E. R., Balaji, A. B., Trevino-Garrison, I., Petersen, E. E., Shoulson, R. L., Saiman, L. M., Horn, E. M., Gomberg‐Maitland, M., Barst, R. J., et al. (2008) · Infection Control and Hospital Epidemiology · doi:10.1086/529552 · Cited by 92 · see citing works
Rich, S., & Kaufmann, E. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90556-o · Cited by 91 · see citing works
Badesch, D. B., McGoon, M. D., Barst, R. J., Tapson, V. F., Rubin, L. J., Wigley, F. M., Kral, K. M., Raphiou, I., & Crater, G. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081277 · Cited by 85 · see citing works
McLaughlin, V. V., Badesch, D. B., Abman, S. H., Simonneau, G., & Rubin, L. J. (2007) · Cited by 85 · see citing works
Methodologies for the Development of CHEST Guidelines and Expert Panel Reports
Lewis, S. Z., Diekemper, R. L., Ornelas, J., & Casey, K. R. (2014) · CHEST Journal · doi:10.1378/chest.14-0824 · Cited by 80 · see citing works
Anaesthesia for caesarean section in the presence of severe primary pulmonary hypertension
OʼHare, R., McLoughlin, C., Milligan, K. R., McNamee, D., & Sidhu, H. (1998) · British Journal of Anaesthesia · doi:10.1093/bja/81.5.790 · Cited by 78 · see citing works
Colie, C. F. (1991) · Reproductive Toxicology · doi:10.1016/0890-6238(91)90025-b · Cited by 74 · see citing works
Pregnancy outcome in women with pulmonary arterial hypertension: single-center experience from India
Subbaiah, M., Kumar, S., Roy, K. K., Sharma, J. B., & Singh, N. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-013-2761-8 · Cited by 66 · see citing works
Rudolph, A. M., Paul, M. H., Sommer, L. S., & Nadas, A. S. (1958) · American Heart Journal · doi:10.1016/0002-8703(58)90059-0 · Cited by 65 · see citing works
Kitterman, N., Poms, A. D., Miller, D. P., Lombardi, S., Farber, H. W., & Barst, R. J. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.05.014 · Cited by 64 · see citing works
Primary Pulmonary Hypertension and Pregnancy
Dawkins, K. D., Burke, C. M., Billingham, M. E., & Jamieson, S. W. (1986) · CHEST Journal · doi:10.1378/chest.89.3.383 · Cited by 63 · see citing works
Inhaled nitric oxide for primary pulmonary hypertension in pregnancy
Lam, G. K. W. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01549-6 · Cited by 60 · see citing works
Decoene, C., Bourzoufi, K., Moreau, D., Narducci, F., Crepin, F., & Krivosic-Horber, R. (2001) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03016836 · Cited by 58 · see citing works
Rich, J. D., Glassner, C., Wade, M., Coslet, S., Arneson, C. P., Doran, A. K., & Gomberg‐Maitland, M. (2011) · CHEST Journal · doi:10.1378/chest.11-0245 · Cited by 58 · see citing works
Inhaled nitric oxide therapy in pregnancy complicated by pulmonary hypertension
Robinson, J. N., Banerjee, R., Landzberg, M. J., & Thiet, M.-P. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70686-1 · Cited by 50 · see citing works
IOM Sets Out “Gold Standard” Practices for Creating Guidelines, Systematic Reviews
Kuehn, B. M. (2011) · JAMA · doi:10.1001/jama.2011.597 · Cited by 49 · see citing works
Effects of Commercial Air Travel on Patients With Pulmonary Hypertension
Roubinian, N. H., Elliott, C. G., Barnett, C. F., Blanc, P. D., Chen, J. W., Marco, T. D., & Chen, H. (2012) · CHEST Journal · doi:10.1378/chest.11-2016 · Cited by 48 · see citing works
Badalian, S. S., Silverman, R. K., Aubry, R. H., & Longo, J. (2000) · PubMed · Cited by 42 · see citing works
Cesarean section under epidural ropivacaine 0.75% in a parturient with severe pulmonary hypertension
Olofsson, C., Bremme, K. A., Forssell, G., & Öhqvist, G. (2001) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2001.450220.x · Cited by 37 · see citing works
Pulmonary arterial hypertension in pregnant women
Safdar, Z. (2012) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465812461680 · Cited by 30 · see citing works
Hypoxaemia in patients with pulmonary arterial hypertension during simulated air travel
Burns, R. M., Peacock, A., Johnson, M., & Church, C. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.10.007 · Cited by 29 · see citing works
Primary pulmonary hypertenson in pregnancy: A case report
Kiss, H., Egarter, C., Asseryanis, E., Putz, D., & Kneußl, M. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90047-0 · Cited by 29 · see citing works
López‐Medrano, F., Fernández‐Ruiz, M., Caño, M. J., Barrios, E., Vicente-Hernández, M., Aguado, J. M., & Subías, P. E. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2012.06.005 · Cited by 19 · see citing works
López‐Medrano, F., Fernández‐Ruiz, M., Caño, M. J., Barrios, E., Vicente-Hernández, M., Aguado, J. M., & Escribano, P. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2012.09.008 · Cited by 18 · see citing works
Primary pulmonary hypertension and pregnancy.
Carro-Jiménez, E. J., & López, J. E. (2006) · PubMed · Cited by 13 · see citing works
Simonneau, G., D’Armini, A. M., Ghofrani, H. A., Grimminger, F., Hoeper, M. M., Jansa, P., Kim, N. D., Wang, C., Wilkins, M. R., Fritsch, A., et al. (2013) · CHEST Journal · doi:10.1378/chest.1783236 · Cited by 12 · see citing works
Has the 6-Min Walk Distance Run Its Course?
McLaughlin, V. V. (2012) · CHEST Journal · doi:10.1378/chest.12-1110 · Cited by 9 · see citing works
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Antithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830 · see citing works
Pediatric Pulmonary Hypertension
Abman, S. H., Hansmann, G., Archer, S. L., Ivy, D. D., Adatia, I., Chung, W. K., Hanna, B. D., Rosenzweig, E. B., Raj, J. U., Cornfield, D. N., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000329 · Cited by 1,173 · see citing works
Update of EULAR recommendations for the treatment of systemic sclerosis
Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209909 · Cited by 1,104 · see citing works
Pulmonary arterial hypertension: pathogenesis and clinical management
Thenappan, T., Ormiston, M. L., Ryan, J. J., & Archer, S. L. (2018) · BMJ · doi:10.1136/bmj.j5492 · Cited by 1,004 · see citing works
Ezekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676 · see citing works
Pediatric Pulmonary Hypertension
Ivy, D. D., Abman, S. H., Barst, R. J., Berger, R. M. F., Bonnet, D., Fleming, T. R., Haworth, S. G., Raj, J. U., Rosenzweig, E. B., Schulze‐Neick, I., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.028 · Cited by 543 · see citing works
Management of Pulmonary Arterial Hypertension
McLaughlin, V. V., Shah, S. J., Souza, R., & Humbert, M. J. C. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.540 · Cited by 366 · see citing works
Management of interstitial lung disease associated with connective tissue disease
Mathai, S. C., & Danoff, S. K. (2016) · BMJ · doi:10.1136/bmj.h6819 · Cited by 332 · see citing works
Therapy for Pulmonary Arterial Hypertension in Adults
Klinger, J. R., Elliott, C. G., Levine, D. J., Bossone, E., Duvall, L. E., Fagan, K., Frantsve‐Hawley, J., Kawut, S. M., Ryan, J. J., Rosenzweig, E. B., et al. (2019) · CHEST Journal · doi:10.1016/j.chest.2018.11.030 · Cited by 301 · see citing works
Weatherald, J. C., Boucly, A., Chemla, D., Savale, L., Peng, M., Jevnikar, M., Jaïs, X., Taniguchi, Y., O’Connell, C., Parent, F., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.029254 · Cited by 225 · see citing works
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Florentin, J., Coppin, E., Vasamsetti, S. B., Zhao, J., Tai, Y., Tang, Y., Zhang, Y., Watson, A. M. M., Sembrat, J., Rojas, M. M., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701287 · Cited by 162 · see citing works
The molecular targets of approved treatments for pulmonary arterial hypertension
Humbert, M. J. C., & Ghofrani, H. A. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207170 · Cited by 155 · see citing works
Houde, M., Desbiens, L., & D’Orléans-Juste, P. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.05.002 · Cited by 127 · see citing works
The importance of patient perspectives in pulmonary hypertension
McGoon, M. D., Ferrari, P., Armstrong, I. J., Denis, M., Howard, L., Lowe, G., Mehta, S., Murakami, N., & Wong, B. A. (2018) · European Respiratory Journal · doi:10.1183/13993003.01919-2018 · Cited by 123 · see citing works
The Future of Lung Transplantation
Young, K. A., & Dilling, D. F. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.08.1036 · Cited by 121 · see citing works
The Nitric Oxide Pathway in Pulmonary Vascular Disease
Klinger, J. R., & Kadowitz, P. J. (2017) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2017.06.012 · Cited by 117 · see citing works
Price, L., Martinez, G. C., Brame, A., Pickworth, T., Samaranayake, C. B., Alexander, D. J., Garfield, B. E., Aw, T., McCabe, C., Mukherjee, B., et al. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.01.005 · Cited by 113 · see citing works
Anker, S. D., Schroeder, S., Atar, D., Bax, J. J., Ceconi, C., Cowie, M., Crisp, A., Dominjon, F., Ford, I., Ghofrani, H. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.516 · Cited by 99 · see citing works
Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases
Schopfer, F. J., Vitturi, D. A., Jorkasky, D. K., & Freeman, B. Α. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.06.006 · Cited by 91 · see citing works
Lindley, K. J., Merz, C. N. B., Asgar, A., Bello, N. A., Chandra, S., Davis, M. B., Gomberg‐Maitland, M., Gulati, M., Hollier, L. M., Krieger, E. V., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.02.026 · Cited by 94 · see citing works
Medeiros, B. C., Possick, J. D., & Fradley, M. G. (2018) · Blood Reviews · doi:10.1016/j.blre.2018.01.004 · Cited by 89 · see citing works
Group III Pulmonary Hypertension
Klinger, J. R. (2016) · Cardiology Clinics · doi:10.1016/j.ccl.2016.04.003 · Cited by 84 · see citing works
Role of prostacyclin in pulmonary hypertension
Mitchell, J. A., Ahmetaj‐Shala, B., Kirkby, N. S., Wright, W. R., Mackenzie, L. S., Reed, D. M., & Mohamed, N. A. (2014) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2014.53 · Cited by 82 · see citing works
Lau, E., Tamura, Y., McGoon, M. D., & Sitbon, O. (2015) · European Respiratory Journal · doi:10.1183/13993003.01177-2015 · Cited by 82 · see citing works
Hillegass, E. A., Puthoff, M. L., Frese, E., Thigpen, M. T., Sobush, D. C., Auten, B., & for the Guideline Development Group (2015) · Physical Therapy · doi:10.1093/ptj/pzac057 · Cited by 78 · see citing works
Pulmonary arterial hypertension specific therapy: The old and the new
Zolty, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107576 · Cited by 75 · see citing works
The prostacyclin pathway in pulmonary arterial hypertension: a clinical review
del Pozo, R., Hernández‐González, I., & Subías, P. E. (2017) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2017.1317599 · Cited by 76 · see citing works
Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension
Agüero, J., Ishikawa, K., Hadri, L., Santos‐Gallego, C. G., Fish, K. M., Kohlbrenner, E., Hammoudi, N., Kho, C., Lee, A., Ibáñez, B., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.02.049 · Cited by 75 · see citing works
Zelt, J. G. E., Sugarman, J. A., Weatherald, J. C., Partridge, A. C. R., Liang, J., Swiston, J. R., Brunner, N. W., Chandy, G., Stewart, D. J., Contreras-Domínguez, V., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.01552-2021 · Cited by 69 · see citing works
“Treat-to-close”: Non-repairable ASD-PAH in the adult
Bradley, E. A., Ammash, N. M., Martinez, S. C., Chin, K., Hebson, C. L., Singh, H. S., Aboulhosn, J., Grewal, J., Billadello, J. J., Chakinala, M. M., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.03.056 · Cited by 66 · see citing works
McGlothlin, D. P., Granton, J. T., Klepetko, W., Beghetti, M., Rosenzweig, E. B., Corris, P. A., Horn, E. M., Kanwar, M. K., McRae, K. M., Román, A., et al. (2022) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2022.06.013 · Cited by 66 · see citing works
Humanistic and cost burden of systemic sclerosis: A review of the literature
Fischer, A., Zimovetz, E. A., Ling, C. S., Esser, D., & Schoof, N. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.09.010 · Cited by 60 · see citing works
Pulmonary Arterial Hypertension in Pregnancy
Ballard, W., Dixon, B., McEvoy, C. A., & Verma, A. (2020) · Cardiology Clinics · doi:10.1016/j.ccl.2020.09.007 · Cited by 60 · see citing works
Rashid, J., Patel, B., Nozik‐Grayck, E., McMurtry, I. F., Stenmark, K. R., & Ahsan, F. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.003 · Cited by 59 · see citing works
Classification and pathophysiology of pulmonary hypertension
Sysol, J. R., & Machado, R. F. (2018) · Continuing Cardiology Education · doi:10.1002/cce2.71 · Cited by 59 · see citing works
Atrial arrhythmias are associated with increased mortality in pulmonary arterial hypertension
Smith, B., Genuardi, M. V., Koczo, A., Zou, R. H., Thoma, F. W., Handen, A. L., Craig, E., Hogan, C. M., Girard, T. D., Althouse, A. D., et al. (2018) · Pulmonary Circulation · doi:10.1177/2045894018790316 · Cited by 55 · see citing works
Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan
Sidharta, P. N., Treiber, A., & Dingemanse, J. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0255-5 · Cited by 54 · see citing works
Liu, H.-L., Chen, X., Li, J.-R., Su, S., Ding, T., Shi, C., Jiang, Y., & Zhu, Z. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.03.031 · Cited by 54 · see citing works
Liu, C.-M., Shih, E. S. C., Chen, J.-Y., Huang, C.-H., Wu, I.-C., Chen, P.-F., Higa, S., Yagi, N., Hu, Y.-F., Hwang, M.-J., et al. (2022) · JACC: Asia · doi:10.1016/j.jacasi.2022.02.008 · Cited by 46 · see citing works
Trammell, A. W., Pugh, M. E., Newman, J. H., Hemnes, A. R., & Robbins, I. M. (2015) · Pulmonary Circulation · doi:10.1086/681264 · Cited by 46 · see citing works
Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension
Jain, S., Khera, R., Girotra, S. R., Badesch, D. B., Wang, Z., Murad, M. H., Blevins, A., Schmidt, G. A., Singh, S., & Gerke, A. K. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.08.1461 · Cited by 45 · see citing works
Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
Lian, T., Jiang, X., & Jing, Z. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s117277 · Cited by 45 · see citing works
Origin and production of inflammatory perivascular macrophages in pulmonary hypertension
Florentin, J., & Dutta, P. (2017) · Cytokine · doi:10.1016/j.cyto.2017.08.015 · Cited by 44 · see citing works
From comorbidities to heart failure with preserved ejection fraction: a story of oxidative stress
Franssen, C., Chen, H. S., Hamdani, N., & Paulus, W. J. (2015) · Heart · doi:10.1136/heartjnl-2015-307787 · Cited by 45 · see citing works
Shah, N. B., Mitchell, R. E., Proctor, S. T., Choi, L., DeClercq, J., Jolly, J. A., Hemnes, A. R., & Zuckerman, A. D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217798 · Cited by 42 · see citing works
Newer approaches and novel drugs for inhalational therapy for pulmonary arterial hypertension
Keshavarz, A. A., Kadry, H., Alobaida, A., & Ahsan, F. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1729119 · Cited by 42 · see citing works
Endothelin-1 receptor antagonists in fetal development and pulmonary arterial hypertension
de Raaf, M. A., Beekhuijzen, M. E. W., Guignabert, C., Noordegraaf, A. V., & Bogaard, H. J. (2015) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.06.048 · Cited by 42 · see citing works
Pulmonary hypertension: diagnostic and therapeutic challenges
Fares, W. H., & Bazan, I. S. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s74881 · Cited by 40 · see citing works
Riociguat: A Novel New Drug for Treatment of Pulmonary Hypertension
Makowski, C. T., Rissmiller, R. W., & Bullington, W. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1592 · Cited by 40 · see citing works
Healthcare burden of pulmonary hypertension owing to lung disease and/or hypoxia
Heresi, G. A., Platt, D. M., Wang, W., Divers, C., Joish, V. N., Teal, S. A., & Yu, J. S. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0399-1 · Cited by 39 · see citing works
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Mahmud, E., Behnamfar, O., Ang, L., Patel, M. P., Poch, D. S., & Kim, N. H. (2017) · Interventional Cardiology Clinics · doi:10.1016/j.iccl.2017.09.003 · Cited by 39 · see citing works
Chen, M., Shen, H., Zhu, L., Yang, H., Ye, P., Liu, P., Gu, Y., & Chen, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28370 · Cited by 37 · see citing works
Diekemper, R. L., Patel, S., Mette, S. A., Ornelas, J., Ouellette, D. R., & Casey, K. R. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.04.018 · Cited by 36 · see citing works
Corboz, M. R., Li, Z., Malinin, V., Plaunt, A. J., Konicek, D. M., Leifer, F., Chen, K., Laurent, C. E., Yin, H., Biernat, M., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.242099 · Cited by 36 · see citing works
Steppan, J., Diaz-Rodriguez, N., Barodka, V. M., Nyhan, D. P., Pullins, E. H., Housten, T., Damico, R. L., Mathai, S. C., Hassoun, P. M., Berkowitz, D. E., et al. (2018) · Cureus · doi:10.7759/cureus.2072 · Cited by 35 · see citing works
Efficacy of Statin Therapy in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis
Rysz-Górzynska, M., Gluba-Brzózka, A., Sahebkar, A., Serban, M.-C., Mikhailidis, D. P., Ursoniu, S., Toth, P. P., Bittner, V., Watts, G. F., Lip, G. Y. H., et al. (2016) · Scientific Reports · doi:10.1038/srep30060 · Cited by 33 · see citing works
Bazan, I. S., Mensah, K. A., Rudkovskaia, A. A., Adonteng-Boateng, P., Herzog, E. L., Buckley, L. M., & Fares, W. H. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.11.020 · Cited by 33 · see citing works
Frost, A., Janmohamed, M., Fritz, J. S., McConnell, J. W., Poch, D. S., Fortin, T., Miller, C. E., Chin, K., Fisher, M., Eggert, M. S., et al. (2018) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2018.09.003 · Cited by 32 · see citing works
Anderson, J. R., Nawarskas, J. J., & Henrie, A. M. (2015) · Core evidence · doi:10.2147/ce.s58457 · Cited by 31 · see citing works
Mandras, S. A., Kovács, G., Olschewski, H., Broderick, M. J., Nelsen, A. C., Shen, E., & Champion, H. C. (2021) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484211006531 · Cited by 31 · see citing works
Sidharta, P. N., Krähenbühl, S., & Dingemanse, J. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.1000859 · Cited by 30 · see citing works
Emerging therapeutics in pulmonary hypertension
Hensley, M. K., Levine, A. R., Gladwin, M. T., & Lai, Y. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00259.2017 · Cited by 30 · see citing works
Plasma 12‐ and 15‐Hydroxyeicosanoids are Predictors of Survival in Pulmonary Arterial Hypertension
Al‐Naamani, N., Sagliani, K. D., Dolnikowski, G. G., Warburton, R. R., Toksoz, D., Kayyali, U. S., Hill, N. S., Fanburg, B. L., Roberts, K. E., & Preston, I. R. (2016) · Pulmonary Circulation · doi:10.1086/686311 · Cited by 30 · see citing works
Aguirre‐Camacho, A., & Jiménez, B. M. (2018) · Psychosomatics · doi:10.1016/j.psym.2018.04.002 · Cited by 30 · see citing works
Pulmonary hypertension in patients with interstitial lung disease
Karampitsakos, Τ., Tzouvelekis, A., Chrysikos, S., Bouros, D. E., Tsangaris, I., & Fares, W. H. (2018) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2018.03.002 · Cited by 29 · see citing works
Anticoagulation in patients with pulmonary arterial hypertension: An update on current knowledge
Roldan, T., Landzberg, M. J., Deicicchi, D. J., Atay, J. K., & Waxman, A. B. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.10.002 · Cited by 28 · see citing works
What’s new in the treatment of portopulmonary hypertension?
DuBrock, H. M., Channick, R. N., & Krowka, M. J. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1035647 · Cited by 27 · see citing works
How I treat patients with systemic sclerosis in clinical practice
Rossi, D., Zanatta, E., Marson, P., Sciascia, S., Polito, P., Roccatello, D., & Cozzi, F. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.07.018 · Cited by 27 · see citing works
New Therapeutic Paradigms and Guidelines in the Management of Pulmonary Arterial Hypertension
Hill, N. S., Cawley, M. J., & Heggen, C. L. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2016.22.3-a.s3 · Cited by 27 · see citing works
Pulmonary Arterial Hypertension in Women
Memon, H. A., & Park, M. (2017) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-13-4-224 · Cited by 26 · see citing works
Treatment-Related Biomarkers in Pulmonary Hypertension
Swaminathan, A. C., Dusek, A. C., & McMahon, T. J. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0438tr · Cited by 26 · see citing works
Current trends in candidate selection, contraindications, and indications for lung transplantation
Arjuna, A., Olson, M. T., & Walia, R. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-2021-09 · Cited by 26 · see citing works
Evaluation and management approaches for scleroderma lung disease
Schoenfeld, S. R., & Castelino, F. V. (2017) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465817713680 · Cited by 24 · see citing works
Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats
Chang, C., Shih, H., Huang, I., Tsai, P., Chen, K.-Y., & Huang, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184622 · Cited by 26 · see citing works
Selexipag: A Review in Pulmonary Arterial Hypertension
Duggan, S. T., Keam, S. J., & Burness, C. B. (2016) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-016-0209-9 · Cited by 25 · see citing works
Medical treatment update on pulmonary arterial hypertension
Enderby, C. Y., & Burger, C. D. (2015) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622315590757 · Cited by 25 · see citing works
Langendam, M. W., Carrasco‐Labra, A., Santesso, N. A., Mustafa, R. A., Brignardello‐Petersen, R., Ventresca, M., Heus, P., Lasserson, T. J., Moustgaard, R., Brożek, J., et al. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.12.008 · Cited by 25 · see citing works
Qadus, S., Naser, A. Y., Ofori‐Asenso, R., Ademi, Z., Awawdeh, S. A., & Liew, D. (2022) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-022-00553-6 · Cited by 24 · see citing works
Real-World Switching to Riociguat: Management and Practicalities in Patients with PAH and CTEPH
Gall, H. J., Vachiéry, J., Tanabe, N., Halank, M., Orozco‐Levi, M., Mielniczuk, L. M., Chang, M., Vogtländer, K., & Grünig, E. (2018) · Lung · doi:10.1007/s00408-018-0100-3 · Cited by 24 · see citing works
Zhang, Y.-J., Wang, N., Gu, Z., Wei, A., Cheng, A.-N., Fang, S., Du, H., Wang, L., & Zhang, G. (2019) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2019.03.02 · Cited by 23 · see citing works
Singh, V., Singh, S., Sharma, B., Bairwa, M. L., Gothi, D., Desai, U. D., Joshi, J., Talwar, D., Singh, A., Dhar, R., et al. (2020) · Lung India · doi:10.4103/lungindia.lungindia_275_20 · Cited by 21 · see citing works
Milks, M. W., Sahay, S., Benza, R. L., & Farber, H. W. (2020) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2020.12.005 · Cited by 23 · see citing works
Naing, P., Kuppusamy, H., Scalia, G. M., Hillis, G. S., & Playford, D. A. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.10.008 · Cited by 23 · see citing works
Intravenous treprostinil infusion via a fully implantable pump for pulmonary arterial hypertension
Ewert, R., Richter, M. J., Steringer‐Mascherbauer, R., Grünig, E., Lange, T. J., Opitz, C. F., Warnke, C., & Ghofrani, H. A. (2017) · Clinical Research in Cardiology · doi:10.1007/s00392-017-1114-1 · Cited by 23 · see citing works
Fanous, S., & Janmohamed, M. (2018) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp170814 · Cited by 22 · see citing works
Interventional and Surgical Treatments for Pulmonary Arterial Hypertension
Stącel, T., Latos, M., Urlik, M., Nęcki, M., Antończyk, R., Hrapkowicz, T., Kurzyna, M., & Ochman, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153326 · Cited by 24 · see citing works
Burger, C. D., Pruett, J., Lickert, C. A., Berger, A., Murphy, B., & Drake, W. (2017) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2017.17228 · Cited by 22 · see citing works
Connective Tissue Disease–Associated Pulmonary Arterial Hypertension
Sung, Y. K., & Chung, L. S. (2015) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2015.01.003 · Cited by 22 · see citing works
Zhao, Q., Guo, N., Chen, J., Parks, D. C., & Tian, Z. (2021) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13481 · Cited by 21 · see citing works
Aerosolization of COVID-19 and Contamination Risks During Respiratory Treatments.
Benge, C. D., & Barwise, J. (2020) · PubMed Central · Cited by 21 · see citing works
Divers, C., Platt, D. M., Wang, E., Lin, J., Lingohr-Smith, M., & Mathai, S. C. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2017.23.1.92 · Cited by 21 · see citing works
Selexipag for the treatment of pulmonary arterial hypertension
Noel, Z. R., Kido, K., & Macaulay, T. E. (2017) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp160798 · Cited by 21 · see citing works
Liu, P., Hsing, S.-C., Tsai, D., Lin, C. S., Lin, C.-S., Wang, C., & Fang, W. (2024) · Journal of Imaging Informatics in Medicine · doi:10.1007/s10278-024-01225-4 · Cited by 20 · see citing works
Pulmonary Hypertension: Scientometric Analysis and Density-Equalizing Mapping
Götting, M., Schwarzer, M., Gerber, A., Klingelhöfer, D., & Groneberg, D. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169238 · Cited by 20 · see citing works
Managing the Patient with Pulmonary Hypertension
Chakinala, M. M., Duncan, M., & Wirth, J. A. (2016) · Cardiology Clinics · doi:10.1016/j.ccl.2016.04.008 · Cited by 19 · see citing works
Cowie, M., Filippatos, G. S., García, M. D. L. A. A., Anker, S. D., Baczyńska, A., Bloomfield, D. M., Borentain, M., Slot, K. B., Cronin, M., Doevendans, P. A., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.809 · Cited by 19 · see citing works
Agnihotri, V. V., Agrawal, Y. O., Goyal, S. N., Sharma, C., & Ojha, S. K. (2022) · Molecules · doi:10.3390/molecules27113490 · Cited by 22 · see citing works
Protective effect of Alpinetin on rats with chronic obstructive pulmonary disease
Su, Y., Tao, X., & Xu, J. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1952 · Cited by 19 · see citing works
An Update on the Management of Pulmonary Arterial Hypertension and the Pharmacist’s Role
Macaulay, T. E., Covell, M. B., & Pogue, K. T. (2015) · Journal of Pharmacy Practice · doi:10.1177/0897190015615902 · Cited by 19 · see citing works
- Authors
- Taichman, D. B., Ornelas, J., Chung, L., Klinger, J. R., Lewis, S., Mandel, J., Palevsky, H. I., Rich, S., Sood, N., Rosenzweig, E. B., Trow, T. K., Yung, R., Elliott, C. G., & Badesch, D. B.
- Affiliations
- University of Pennsylvania (US)
- American College of Chest Physicians (US)
- VA Palo Alto Health Care System (US)
- Brown University (US)
- University of California San Diego (US)
- University of Chicago (US)
- The Ohio State University (US)
- Columbia University Irving Medical Center (US)
- Yale University (US)
- Johns Hopkins University (US)
- University of Utah (US)
- University of Colorado Denver (US)
- Corresponding author
- Ornelas, Joe
- ORCID
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 146
- Issue
- 2
- Pages
- 449-475
- ISSN
- 0012-3692 (ISSN-L)
- PMC
- PMC4137591
- OpenAlex
- W2157947374
- Cited by
- 256
- References
- 104
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 13 · 2021: 18 · 2020: 14 · 2019: 25 · 2018: 29 · 2017: 43 · 2016: 40 · 2015: 43 · 2014: 5 · 2013: 2
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- CHEST Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Genetics › Vascular Anomalies and Treatments
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- pulmonary arterial hypertension, pharmacotherapy, adult patients, antihypertensive drugs, consensus statement, treatment guidelines, level of evidence
- MeSH terms
- Adult, Antihypertensive Agents, Delphi Technique, Humans, Hypertension, Pulmonary, Practice Guidelines as Topic, Consensus, Familial Primary Pulmonary Hypertension
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