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A Randomized Trial of a Single Bolus Dosage Regimen of Recombinant Tissue Plasminogen Activator in Patients with Acute Pulmonary Embolism
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Statistical Methods for Rates and Proportions
Fleiss, J. L., Levin, B., & Paik, M. C. (2003) · Wiley Series in Probability and Statistics · doi:10.1002/0471445428 · Cited by 18,646
Research works printed but not linked: 27
- 1970, Phase I results, JAMA, 214, 2163
- 1974, Phase II results, JAMA, 229, 1606
- Fennerty, 1989, Hemorrhagic complications of thrombolytic therapy in the treatment of myocardial infarction and venous thromboembolism, Chest, 95, 88, 10.1378/chest.95.2_Supplement.88S · DOI
- Collen, 1984, Biological properties of human tissue-type plasminogen activator obtained by expression of recombinant DNA in mammalian cells, J Pharm Exp Therapy, 231, 146
- Pennica, 1983, Cloning and expression of human tissue-type plasminogen activator cDNA in E coli, Nature, 301, 214, 10.1038/301214a0 · DOI · Paper page
- Hoylaerts, 1982, Kinetics of the activation of plasminogen by human tissue plasminogen activator, J Biol Chem, 257, 2912, 10.1016/S0021-9258(19)81051-7 · DOI · Paper page
- Collen, 1986, Tissue-type plasminogen activator: therapeutic potential in thrombotic disease states, Drugs, 31, 1, 10.2165/00003495-198631010-00001 · DOI
- Collen, 1984, Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized placebo controlled trial, Circulation, 70, 1012, 10.1161/01.CIR.70.6.1012 · DOI · Paper page
- Verstraete, 1985, Randomized trial of intravenous recombinant human tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction, Lancet, 1, 842, 10.1016/S0140-6736(85)92208-1 · DOI · Paper page
- 1985, The thrombolysis in myocardial infarction trial, N Engl J Med, 312, 932, 10.1056/NEJM198504043121437 · DOI · Paper page
- 1988, Trial of tissue plasminogen activator for mortality reduction in acute myocardial infarction, Lancet, 2, 525
- Goldhaber, 1986, Acute pulmonary embolism treated with tissue plasminogen activator, Lancet, 2, 886, 10.1016/S0140-6736(86)90411-3 · doi:10.1016/s0140-6736(86)90411-3
- Goldhaber, 1988, Randomized controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism, Lancet, 2, 293, 10.1016/S0140-6736(88)92354-9 · DOI · Paper page
- Verstraete, 1988, Intravenous and intrapulmonary recombinant tissue-type plasminogen activator in the treatment of acute massive pulmonary embolism, Circulation, 77, 353, 10.1161/01.CIR.77.2.353 · DOI · Paper page
- Agnelli, 1985, A comparison of the thrombolytic and hemorrhagic effects of tissue-type plasminogen activator and streptokinase in rabbits, Circulation, 72, 178, 10.1161/01.CIR.72.1.178 · DOI
- Agnelli, 1985, The thrombolytic and hemorrhagic effects of tissue-type plasminogen activator: influence of dosage regimens in rabbits, Thromb Res, 40, 769, 10.1016/0049-3848(85)90314-7 · DOI
- Agnelli, 1985, Sustained thrombolysis with DNA-recombinant tissue-type plasminogen activator in rabbits, Blood, 66, 399, 10.1182/blood.V66.2.399.399 · doi:10.1182/blood.v66.2.399.399
- Shiffman, 1988, Treatment of canine embolic pulmonary hypertension with recombinant tissue plasminogen activator. Efficacy of dosing regimens, Circulation, 19, 214, 10.1161/01.CIR.78.1.214 · doi:10.1161/01.cir.78.1.214
- Hull, 1983, Pulmonary angiography, ventilation lung scanning and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan, Ann Intern Med, 98, 891, 10.7326/0003-4819-98-6-891 · DOI · Paper page
- 1973, Perfusion lung scanning, Circulation, 47, 46
- Parker, 1988, Pulmonary perfusion after rt-PA therapy for actue embolism: early improvement assessed with segmental perfusion scanning, Radiology, 166, 441, 10.1148/radiology.166.2.3122266 · doi:10.1148/radiology.166.2.3122266
- van Clauss, 1957, Gerinnungs physiologische Schnellmethode zur Bestimmung des Fibrinogens, Acta Haematol (Basel), 17, 237, 10.1159/000205234 · DOI · Paper page
- Teger-Nilsson, 1977, Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate, Scan J Clin Lab Invest, 37, 403, 10.3109/00365517709091499 · doi:10.3109/00365517709091499
- Verstraete, 1989, Bolus alteplase, Lancet, 2, 989, 10.1016/S0140-6736(89)91004-0 · doi:10.1016/s0140-6736(89)91004-0
- Tebbe, 1989, Single bolus injection of recombinant tissue-type plasminogen activator (rt-PA) in acute myocardial infarction, Am J Cardiol, 64, 448, 10.1016/0002-9149(89)90419-0 · doi:10.1016/0002-9149(89)90419-0
- Smalling, 1990, Improved infarct-related arterial patency after high dose, weight-adjusted, rapid infusion of tissue-type plasminogen activator in myocardial infarction. Results of a multicentre randomized trial of two dosage regimens, J Am Coll Cardiol, 15, 915, 10.1016/0735-1097(90)90216-C · doi:10.1016/0735-1097(90)90216-c
- Neuhas, 1989, Improved thrombolysis with a modified dose regimen of recombinant tissue-type plasminogen activator, J Am Coll Cardiol, 14, 1566, 10.1016/0735-1097(89)90399-9 · DOI · Paper page
Cited by
Kearon (2012) · doi:10.1378/chest.11-2301 · Cited by 6,119
Antithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830
Ortel, T. L., Neumann, I., Ageno, W., Beyth, R., Clark, N. P., Cuker, A., Hutten, B. A., Jaff, M. R., Manja, V., Schulman, S., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001830 · Cited by 1,489
“Summary of the evidence We identified 29 systematic reviews(151-179) and 26 RCTs (n 5 2787).(130,180-204) Trials included individuals with an objectively confirmed symptomatic PE.”
BackgroundAntithrombotic Therapy for Venous Thromboembolic Disease
Büller, H. R., Agnelli, G., Hull, R. D., Hyers, T. M., Prins, M. H., & Raskob, G. E. (2004) · Chest · doi:10.1378/chest.126.3_suppl.401s · Cited by 1,249
Antithrombotic Therapy for VTE Disease
Stevens, S. M., Woller, S. C., Kreuziger, L. B., Bounameaux, H., Doerschug, K., Geersing, G.-J., Huisman, M. V., Kearon, C., King, C. S., Knighton, A. J., et al. (2021) · Chest · doi:10.1016/j.chest.2021.07.055 · Cited by 1,043
Metadata
- Authors
- Levine, M., Hirsh, J., Weitz, J., Cruickshank, M., Neemeh, J., Turpie, A. G., & Gent, M.
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 98
- Issue
- 6
- Pages
- 1473-1479
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2041176958
- Cited by
- 308
- References
- 1
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- CoChat. (2026). Citation check: A Randomized Trial of a Single Bolus Dosage Regimen of Recombinant Tissue Plasminogen Activator in Patients with Acute Pulmonary Embolism. https://app.cochat.ai/papers/10.1378/chest.98.6.1473
- The paper
- Levine, M., Hirsh, J., Weitz, J., Cruickshank, M., Neemeh, J., Turpie, A. G., & Gent, M. (1990). A Randomized Trial of a Single Bolus Dosage Regimen of Recombinant Tissue Plasminogen Activator in Patients with Acute Pulmonary Embolism. Chest. https://doi.org/10.1378/chest.98.6.1473
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
