The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss
Abstract
Background Obesity is a worldwide pandemic that causes a multitude of co-morbid conditions.However, there has been slow progress in understanding the basic pathophysiology that underlies co-morbid conditions associated with obesity. Recently, there has been intense interest in the role of inflammation in obesity. Using the inflammatory hypothesis, many of the mechanisms by which co-morbid conditions are associated with obesity are being elucidated.Methods We searched the literature and reviewed all relevant articles. We focused on hormones and cytokines that have been associated with other inflammatory conditions such as sepsis and systemic inflammatory response syndrome.Findings Angiotensinogen (AGT), transforming growth factor beta (TGFbeta), tumor necrosis factor alpha (TNFalpha), and interleukin six (IL-6) are all elevated in obesity and correlate with several markers of adipocyte mass. These mediators have detrimental effects on hypertension, diabetes, dyslipidemia, thromboembolic phenomena, infections, and cancer. Weight loss results in a reduction of inflammatory mediators and a diminution of the associated co-morbid conditions.Conclusions The success of weight loss surgery in treating the complications associated with obesity is most probably related to the reduction of inflammatory mediators. While some aspects of bariatric physiology remain unclear, there appears to be a strong association between obesity and inflammation, thereby rendering obesity a chronic inflammatory state. A clearer understanding of the physiology of obesity will allow physicians who treat the obese to develop better strategies to promote weight loss and improve the well-being of millions of individuals.
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“However, in spite of substantial evidence demonstrating the existence of a low-grade inflammatory component in obesity [5], the molecular mechanisms that link inflammatory changes to the development, aggravation, maintenance, and resistance to treatment that characterize obesity states remain poorly understood.”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [5]
Citations
Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Elevated C-reactive protein levels in overweight and obese adults
Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952
Annual Deaths Attributable to Obesity in the United States
Allison, D. B. (1999) · JAMA · doi:10.1001/jama.282.16.1530 · Cited by 1,863
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775
Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.98.8.731 · Cited by 1,642
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THE ROLE OF DIETARY FAT AND CARBOHYDRATES IN DEVELOPMENT OF ADIPOSE TISSUE INFLAMMATION
Ngo, H. T. (2009) · NORA - Norwegian Open Research Archives
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Králová, A., Lesná, I. K., Froněk, J., Čejková, S., Sekerková, A., Janoušek, L., Thieme, F., Střı́ž, I., Ždychová, J., & Poledne, R. (2015) · Physiological Research · doi:10.33549/physiolres.933150
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Robinson, M. K., González, J. E., & Jacobs, D. O. (2006) · Fundamental and clinical cardiology · doi:10.3109/9781420018905.014
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Brown, B., & Hall, K. (2015) · CRC Press eBooks · doi:10.1201/b18386-45
Skaar, D. A., Jirtle, R. L., & Hoyo, C. (2016) · Energy balance and cancer · doi:10.1007/978-3-319-41610-6_5
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Strilchuk, L. M. (2015) · Bukovinian Medical Herald · doi:10.24061/2413-0737.xix.2.74.2015.110
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Urai, T., Nakajima, Y., Mukai, K., Asano, K., Okuwa, M., Sugama, J., & Nakatani, T. (2017) · Health · doi:10.4236/health.2017.912122
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Iwan-Zietek, I., Szot, K., Michalska, M., Adamczyk, P., Chojnowski, J., Góralczyk, K., Ruszkowska-Ciastek, B., Bednarek, G., Sulikowski, T., Ziętek, Z. M., et al. (2018) · Pomeranian Journal of Life Sciences · doi:10.21164/pomjlifesci.372
Hamm, R. L. (2018) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_105
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Hoekstra, S. P. (2018) · Loughborough University Institutional Repository (Loughborough University)
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Bastos, E. L. D. S., & RAMOS, A. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-28936-2_3
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Pandey, A., Saluja, H. S., & Mittal, A. (2019) · Apollo Medicine · doi:10.4103/am.am_63_19
Obstructive sleep apnea in adults : evolution, and related inflammation in early stages of disease
Sahlman, J. (2011) · UEF eRepo (University of Eastern Finland)
El-Yamany, M., Elewa, S., Khairy, E. Y., Salama, O., Kandil, N. S., & Sherif, M. (2021) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2020.36714.1070
Impact of adipose tissue on endothelial cells: effect of metabolic disorders
Papageorgiou, K. (2013) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
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Schernthaner, G.-H., Kopp, H.-P., Brix, J., & Schernthaner, G.-H. (2010) · Der Diabetologe · doi:10.1007/s11428-010-0623-6
Efficacy of Tight Sleeve Gastrectomy in Superobesity: Single Surgeon Experience
Yıldız, B. D., & Alimoğulları, M. (2022) · Indian Journal of Surgery · doi:10.1007/s12262-021-03227-w
(2007) · Humana Press eBooks · doi:10.1007/978-1-59259-979-0_2
The Impact of Chronic Disease on Response to Infection
Reade, M. C., Milbrandt, E. B., & Angus, D. C. (2007) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-540-49433-1_18
Viguerie, N. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8334-3_5
Kim, O. (2022) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2022.51.8.780
Efeito do exercício físico sobre a resposta inflamatória na endotoxemia em ratos obesos e não obesos
Matias, V. D. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.22.2023.tde-02062023-155321
Single-Dose Enoxaparin for Portomesenteric Venous Thrombosis Prophylaxis after Sleeve Gastrectomy
Nofal, M. N., Wadi, W. I., Yousef, A. J., Rashdan, M., Alkhasawneh, M. H., Dwairi, R., Alhalasa, Y. F., Majali, B. M., & Abushaqra, R. K. (2024) · Annals of African Medicine · doi:10.4103/aam.aam_133_23
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Fayed, A., Hegazy, M. T., Abdulazim, D. O., Ibrahim, M. I., & Din, U. A. S. E. (2023) · Urology & Nephrology Open Access Journal · doi:10.15406/unoaj.2023.11.00340
Wu, Y., Chen, J., Liao, M., Deng, X., & Li, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-5401476/v1
Clinical-laboratory evaluation of overweight and obese cats seen in routine clinical practice
Araújo, S. L., Martins, P. L., Pereira, T. H. D. S., da Silva, I. N. G., de Morais, G. B., & Evangelista, J. S. A. M. (2025) · Pesquisa Veterinária Brasileira · doi:10.1590/1678-5150-pvb-7448 · Cited by 1
Oteri, E., Bar, I., Melvin, S. D., Raffan, E., & Nash, S. B. (2025) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2025.101670
Tang, H., Liu, N., Feng, X., Yang, Y., Fang, Y., Zhuang, S., Dai, Y., Liu, M., & Tang, L. (2021) · Figshare · doi:10.6084/m9.figshare.13719121
Tang, H., Liu, N., Feng, X., Yang, Y., Fang, Y., Zhuang, S., Dai, Y., LIU, M., & Tang, L. (2021) · Figshare · doi:10.6084/m9.figshare.13719124
Youssef, H. A. (2008) · OpenGrey (Institut de l'Information Scientifique et Technique)
Metabolic syndrome and psoriatic arthritis
Fragoulis, G., Vassilakis, K. D., & Dimopoulou, A. E. (2026) · Technical report · doi:10.1016/b978-0-443-23722-5.00005-4
Spindler, B., Hannemann, A., Völzke, H., Groß, S., Bahls, M., Budde, K., Petersmann, A., Henning, A., Winter, T., Könemann, S., et al. (2026) · International Journal of Obesity · doi:10.1038/s41366-026-02138-8
Severe dengue evolution in obesity: Possible role of angiotensin II
Pedreáñez, A. B., Carrero, Y. N., Hernández–Fonseca, H., Vargas, R., Fonseca, J. P. H., & Mosquera-Sulbarán, J. (2026) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/14703203261485159
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de Jonge, C. (2014) · Research Publications (Maastricht University) · doi:10.26481/dis.20140905cj
Sirois‐Gagnon, D. (2011) · Constellation (Université du Québec à Chicoutimi) · doi:10.1522/030175066
Metadata
- Authors
- Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Obesity Surgery
- Published
- 2004-05-01
- Volume
- 14
- Issue
- 5
- Pages
- 589-600
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2166558587
- Cited by
- 461
- References
- 150
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 13 · 2023: 13 · 2022: 17 · 2021: 23 · 2020: 11 · 2019: 27 · 2018: 16 · 2017: 24 · 2016: 22 · 2015: 25 · 2014: 21 · 2013: 22 · 2012: 25
- FWCI
- 19.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, chronic inflammation
- MeSH terms
- Acute-Phase Proteins, Adipose Tissue, Angiotensin II, Angiotensinogen, C-Reactive Protein, Humans, Inflammation, Insulin Resistance, Liver, Lymphotoxin-alpha, Morbidity, Obesity, Tumor Necrosis Factor-alpha, Weight Loss, Interleukin-6
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