Morbid Obesity, Hypertensive Disease and the Renin-Angiotensin-Aldosterone Axis
Abstract
Background Resistance to insulin and secondary hyperinsulinemia seem to be the putative link between morbid obesity (MO) and hypertensive disease (HD). Adipose tissue can secrete leptin and angiotensinogen, among other substances. Leptin activates the sympathetic nervous system, leading to HD. Angiotensinogen is a substrate for renin, therefore taking part in the renin-angiotensin-aldosterone axis and the regulation of blood pressure. In MO, both hypertrophy and hyperplasia of the adipocytes lead to an increase in the secretion of both substances, leading to loss of the equilibrium between the levels of both hormones. The aim of the present study was to evaluate these abnormalities and their potential reversibility following bariatric surgery.Methods Data from 100 patients with MO was retrospectively evaluated. Anthropometric data, the plasma renin activity (PRA), plasma levels of aldosterone, ACE, potassium and sodium were collected both prior to surgery and 6, 12, 24 and 36 months after surgery.Results The waist-hip ratio (WHR) before surgery allowed classification of our patients in two groups: central obesity (WHR > or =0.90 in men and > or =0.85 in women); peripheral obesity (WHR <0.90 in men and <0.85 in women). In patients with central obesity, high levels of PRA, aldosterone and ACE with sodium retention and potassium loss and high insulin levels, were found. These changes were not found in patients with peripheral obesity. After gastric bypass, these abnormalities tended to disappear, mainly in the first 6 months.Conclusions The reduction of BMI and WHR after gastric bypass confirmed this operation to be effective against MO. The high basal levels of insulin and the high rate of HD and diabetes in patients with central obesity seem to indicate that they suffer a metabolic syndrome with significant hormonal imbalances and sodium retention. Patients with peripheral obesity only showed a peripheral resistance against insulin, probably with a shorter duration of the hormonal action, but they did not show hormonal abnormalities or sodium retention. After gastric bypass these abnormal hormone levels tended to normalize.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There also appears to be activation of the renin-angiotensin system in obesity.
“There also appears to be activation of the renin-angiotensin system in obesity (304).”
From Cardiac remodeling in obesity (2008) · cites this paper as [304]
Cites
Insulin and insulin resistance:
Sowers, J. R., & Frohlich, E. D. (2004) · Medical Clinics of North America · doi:10.1016/s0025-7125(03)00128-7 · Cited by 1,521 · see citing works
Chan, J. L., Heist, K., DePaoli, A. M., Veldhuis, J. D., & Mantzoros, C. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17490 · Cited by 697 · see citing works
Scherrer, U., & Sartori, C. (1997) · Circulation · doi:10.1161/01.cir.96.11.4104 · Cited by 371 · see citing works
Arterial Stiffness and Kidney Function
Safar, M. E., London, G. M., & Plante, G. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000114571.75762.b0 · Cited by 327 · see citing works
Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
Goodfriend, T. L., & Calhoun, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000116223.97436.e5 · Cited by 279 · see citing works
EFFECTS OF INCREASED INTRA-ABDOMINAL PRESSURE IN SEVERE OBESITY
Sugerman, H. J. (2001) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70184-5 · Cited by 218 · see citing works
Aneja, A. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.169 · Cited by 217 · see citing works
Aldosterone Antagonism Attenuates Obesity-Induced Hypertension and Glomerular Hyperfiltration
de Paula, R. B., da Silva, A. A., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000105624.68174.00 · Cited by 207 · see citing works
Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion
Goodfriend, T. L., Ball, D. L., Egan, B. M., Campbell, W. B., & Nithipatikom, K. (2004) · Hypertension · doi:10.1161/01.hyp.0000113294.06704.64 · Cited by 205 · see citing works
Diabetes Mellitus, the Renin-Angiotensin-Aldosterone System, and the Heart
Lim, H. S., MacFadyen, R. J., & Lip, G. Y. H. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.16.1737 · Cited by 138 · see citing works
Sugimori, H., Yoshida, K., Izuno, T., Miyakawa, M., Suka, M., Sekine, M., Yamagami, T., & Kagamimori, S. (2004) · Pediatrics International · doi:10.1111/j.1442-200x.2004.01895.x · Cited by 129 · see citing works
Sayeed, M., Mahtab, H., Latif, Z., Khanam, P. A., Ahsan, K. A., Banu, A., & Khan, A. K. A. (2003) · PubMed · Cited by 106 · see citing works
Impact of the obesity epidemic on hypertension and renal disease
Hall, J. E., Jones, D. W., Kuo, J. J., da Silva, A. A., Tallam, L. S., & Liu, J. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0084-z · Cited by 106 · see citing works
Obesity hypertension, salt sensitivity and insulin resistance.
Rocchini, A. P. (2000) · PubMed · Cited by 93 · see citing works
El-Atat, F. A., Aneja, A., McFarlane, S. I., & Sowers, J. R. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00070-7 · Cited by 82 · see citing works
Prevention of Hypertension and Its Complications
Flack, J. M., Peters, R. M., Shafi, T., Alrefai, H., Nasser, S. A., & Crook, E. D. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000070142.14843.8e · Cited by 81 · see citing works
The Role of Leptin in Regulating Neuroendocrine Function in Humans
Blüher, S., & Mantzoros, C. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2469s · Cited by 72 · see citing works
Reducing Early Technical Complications in Gastric Bypass Surgery
Capella, R. F., & Capella, J. F. (1997) · Obesity Surgery · doi:10.1381/096089297765556060 · Cited by 69 · see citing works
Türkoğlu, Ç., Duman, B. S., Günay, D., Çağatay, P., Özcan, R., & Buyukdevrim, A. S. (2003) · Obesity Surgery · doi:10.1381/096089203322509255 · Cited by 52 · see citing works
Insulin, Prostaglandins, and the Pathogenesis of Hypertension
Axelrod, L. (1991) · Diabetes · doi:10.2337/diab.40.10.1223 · Cited by 52 · see citing works
Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes
Harte, A. L., McTernan, P. G., McTernan, C. L., Crocker, J., Starcynski, J., Barnett, A. H., Matyka, K. A., & Kumar, S. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00274.x · Cited by 38 · see citing works
Insulin, renin-aldosterone system and blood pressure in obese people
Andronico, G., Cottone, S., Mangano, M. T., Ferraro-Mortellaro, R., Baiardi, G., Grassi, N., Ferrara, L., Mulè, G., & Cerasola, G. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801483 · Cited by 37 · see citing works
Funciones endocrinas de la célula adiposa
González-Hita, M. E., Ramírez, B. E. B., Madrigal, B., Godínez, S., & Panduro, A. (2002) · Revista de Endocrinología y Nutrición · Cited by 8 · see citing works
[Overweight and obesity--risk factors in the development and progression of renal disease].
Šebeková, K., Klassen, A. F., Bahner, U., & Heidland, A. (2004) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Mechanisms of obesity-induced hypertension
Kotsis, V., Stabouli, S., Papakatsika, S., Rizos, Z., & Parati, G. (2010) · Hypertension Research · doi:10.1038/hr.2010.9 · Cited by 632 · see citing works
Bays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 531 · see citing works
The Role of Aldosterone in Obesity-Related Hypertension
Kawarazaki, W., & Fujita, T. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw003 · Cited by 167 · see citing works
Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice
Yiannikouris, F. B., Gupte, M., Putnam, K., Thatcher, S. E., Charnigo, R. J., Rateri, D. L., Daugherty, A., & Cassis, L. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.192690 · Cited by 153 · see citing works
Ramani, G. V., McCloskey, C., Ramanathan, R. C., & Mathier, M. A. (2008) · Clinical Cardiology · doi:10.1002/clc.20315 · Cited by 123 · see citing works
Endothelial Function and Weight Loss in Obese Humans
Williams, I. L., Chowienczyk, P., Wheatcroft, S. B., Patel, A. G., Sherwood, R. A., Momin, A., Shah, A. M., & Kearney, M. T. (2005) · Obesity Surgery · doi:10.1381/0960892054621134 · Cited by 113 · see citing works
Bays, H. E., Blonde, L., & Rosenson, R. S. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.6.871 · Cited by 102 · see citing works
Laparoscopic Roux-en-Y Gastric Bypass and Its Early Effect on Blood Pressure
Ahmed, A. R., Rickards, G., Coniglio, D., Xia, Y., Johnson, J. A., Boss, T. J., & O’Malley, W. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9671-z · Cited by 103 · see citing works
A Nephrologist Perspective on Obesity: From Kidney Injury to Clinical Management
García-Carro, C., Vergara, A., Bermejo, S., Azancot, M. A., Sellarés, J., & Soler, M. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655871 · Cited by 91 · see citing works
Aldosterone and glomerular podocyte injury
Nagase, M., & Fujita, T. (2008) · Clinical and Experimental Nephrology · doi:10.1007/s10157-008-0034-9 · Cited by 78 · see citing works
Resolution of Systemic Hypertension after Laparoscopic Gastric Bypass
Hinojosa, M. W., Varela, J. E., Smith, B. R., Che, F., & Nguyen, N. T. (2008) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-008-0759-5 · Cited by 75 · see citing works
Central angiotensin II has catabolic action at white and brown adipose tissue
de Kloet, A. D., Krause, E. G., Scott, K. A., Foster, M. T., Herman, J. P., Sakai, R. R., Seeley, R. J., & Woods, S. C. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00307.2011 · Cited by 74 · see citing works
Obesity and Renal Hemodynamics
Bosma, R. J., Krikken, J. A., van der Heide, J. J. H., de Jong, P. E., & Navis, G. J. (2006) · KARGER eBooks · doi:10.1159/000095329 · Cited by 72 · see citing works
Schüler, R., Osterhoff, M. A., Frahnow, T., Seltmann, A., Busjahn, A., Kabisch, S., Li, X., Mosig, A. S., Spranger, J., Möhlig, M., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004465 · Cited by 65 · see citing works
Mineralocorticoid receptor activation in obesity hypertension
Nagase, M., & Fujita, T. (2009) · Hypertension Research · doi:10.1038/hr.2009.86 · Cited by 64 · see citing works
Russo, V., Ammendola, E., Crescenzo, I. D., Ricciardi, D., Capuano, P., Topatino, A., Docimo, L., Santangelo, L., & Calabrò, R. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9160-9 · Cited by 57 · see citing works
Metabolic Surgery for Hypertension in Patients With Obesity
Pareek, M., Bhatt, D. L., Schiavon, C. A., & Schauer, P. R. (2019) · Circulation Research · doi:10.1161/circresaha.118.313320 · Cited by 57 · see citing works
Long-term pharmacotherapy considerations in the bariatric surgery patient
Bland, C. M., Miller, A. D., Love, B. L., Yeager, C. A., McMichael, B., & Bookstaver, P. B. (2016) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp151062 · Cited by 53 · see citing works
Adiposopathy and bariatric surgery: is ‘sick fat’ a surgical disease?
Bays, H., Laferrère, B., Dixon, J., Aronne, L., González-Campoy, J., Apovian, C., & Wolfe, B. (2009) · International journal of clinical practice · doi:10.1111/j.1742-1241.2009.02151.x · Cited by 55 · see citing works
Impact of bariatric surgery on comorbidities.
Kaul, A., & Sharma, J. (2011) · Surgical Clinics of North America · doi:10.1016/j.suc.2011.08.003 · Cited by 52 · see citing works
Zhang, L., Miyaki, K., Araki, J., Song, Y., Kimura, T., Omae, K., & Muramatsu, M. (2006) · Hypertension Research · doi:10.1291/hypres.29.751 · Cited by 52 · see citing works
Packer, M., Zile, M. R., Kramer, C. M., Murakami, M., Ou, Y., & Borlaug, B. A. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.03.009 · Cited by 49 · see citing works
Severe Obesity and P-Wave Dispersion: The Effect of Surgically Induced Weight Loss
Russo, V., Ammendola, E., Crescenzo, I. D., Docimo, L., Santangelo, L., & Calabrò, R. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9340-7 · Cited by 48 · see citing works
Sušić, D., & Varagić, J. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.008 · Cited by 43 · see citing works
Growth, Obesity, and Cardiac Structures in Early Childhood
de Jonge, L. L., van Osch-Gevers, L. M., Willemsen, S. P., Steegers, E. A. P., Albert Hofman, D., Helbing, W. A., & Jaddoe, V. W. V. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.163303 · Cited by 36 · see citing works
Appachi, S., Kelly, K. R., Schauer, P. R., Kirwan, J. P., Hazen, S. L., Gupta, M. K., & Kashyap, S. R. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0447-5 · Cited by 36 · see citing works
Bariatric surgery and hypertension
Bueter, M., Ahmed, A. R., Ashrafian, H., & le Roux, C. W. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.03.218 · Cited by 34 · see citing works
Role of mineralocorticoid receptor in insulin resistance
Garg, R., & Adler, G. K. (2012) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283533955 · Cited by 30 · see citing works
Russo, V., Rago, A., Pannone, B., Mayer, M. C., Spasiano, A., Calabrò, R., Russo, M. G., Gerardo, N., & Papa, A. A. (2014) · Indian Pacing and Electrophysiology Journal · doi:10.1016/s0972-6292(16)30753-7 · Cited by 30 · see citing works
Paracrine Regulation of Aldosterone Secretion in Physiological and Pathophysiological Conditions
Lefèbvre, H., Duparc, C., Naccache, A., Lopez, A.-G., Castanet, M., & Louiset, E. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.10.001 · Cited by 29 · see citing works
Metabolic Syndrome and Prediabetes
Babu, A. R., & Fogelfeld, L. A. (2006) · Disease-a-Month · doi:10.1016/j.disamonth.2006.03.001 · Cited by 27 · see citing works
Testosterone deficiency and the metabolic syndrome
Lunenfeld, B. (2007) · The Aging Male · doi:10.1080/13685530701390800 · Cited by 27 · see citing works
Atrial Septal Aneurysms and Supraventricular Arrhythmias: The Role of Atrial Electromechanical Delay
Russo, V., Rago, A., Meo, F. D., Papa, A. A., Ciardiello, C., Cristiano, A., Calabrò, R., Russo, M. G., & Nigro, G. (2015) · Echocardiography · doi:10.1111/echo.12908 · Cited by 27 · see citing works
Ubesie, A., Uwaezuoke, S., Okoli, C., & Ikefuna, A. (2016) · Nigerian Journal of Clinical Practice · doi:10.4103/1119-3077.188706 · Cited by 25 · see citing works
Fain, J. N., Nesbit, A. S., Sudlow, F. F., Cheema, P. S., Peeples, J. M., Madan, A. K., & Tichansky, D. S. (2007) · Metabolism · doi:10.1016/j.metabol.2007.06.028 · Cited by 25 · see citing works
Hypertension Remission after Colorectal Cancer Surgery: A Single-Center Retrospective Study
Cheng, Y.-X., Tao, W. Y., Liu, X., Yuan, C., Zhang, B., Wei, Z., & Peng, D. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2021.2025256 · Cited by 23 · see citing works
Longitudinal changes of blood pressure after weight loss: factors involved
Flores, L., Vidal, J., Núñez, I., Rueda, S., Viaplana, J., & Esmatjes, E. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.04.028 · Cited by 22 · see citing works
Perioperative Optimization of Patients Undergoing Bariatric Surgery
Owers, C. E., Abbas, Y. H., Ackroyd, R., Barron, N., & Khan, M. A. (2012) · Journal of Obesity · doi:10.1155/2012/781546 · Cited by 22 · see citing works
Hansen, E. N., Torquati, A., & Abumrad, N. N. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111242 · Cited by 22 · see citing works
Nudotor, R. D., Canner, J. K., Haut, E. R., Prokopowicz, G. P., & Steele, K. E. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.09.035 · Cited by 20 · see citing works
The current state of knowledge about the dipping and non-dipping hypertension
Dubielski, Z., Zamojski, M., Wiechecki, B., Możeńska, O., Petelczyc, M., & KOSIOR, D. A. (2016) · Arterial Hypertension · doi:10.5603/ah.2016.0007 · Cited by 19 · see citing works
Obesity and Preclinical Changes of Cardiac Geometry and Function
Sung, J. K., & Kim, J. (2010) · Korean Circulation Journal · doi:10.4070/kcj.2010.40.2.55 · Cited by 18 · see citing works
Suwannasrisuk, P., Boonchaya‐anant, P., Houngngam, N., Udomsawaengsup, S., & Sunthornyothin, S. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-0527-4 · Cited by 15 · see citing works
Bariatric surgery: results in obesity and effects on metabolic parameters
Clifton, P. M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328340b8fd · Cited by 15 · see citing works
Primary hypertension and special aspects of hypertension in older children and adolescents
Ellis, D., & Miyashita (2011) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s11715 · Cited by 15 · see citing works
de León‐Ballesteros, G. P., Sánchez-Aguilar, H. A., Aguilar-Salinas, C. A., & Herrera, M. F. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04770-3 · Cited by 11 · see citing works
Berney, M., Vakilzadeh, N., Maillard, M. P., Faouzi, M., Grouzmann, E., Bonny, O., Favre, L., & Wuerzner, G. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745045 · Cited by 11 · see citing works
Laffin, L. J., Majewski, C., Liao, C., & Bakris, G. L. (2016) · Journal of Clinical Hypertension · doi:10.1111/jch.12857 · Cited by 11 · see citing works
Adachi, H., Enomoto, M., Fukami, A., Kumagai, E., Nakamura, S., Yoshimura, A., Obuchi, A., Hori, K., Nohara, Y., Nakao, E., et al. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu235 · Cited by 11 · see citing works
Serum Aldosterone Levels in Patients With Diabetic Nephropathy in Relation to Vascular Calcification
Salih, B. H., H.Ali, S., & Al-Lehibi, K. I. (2019) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol28iss1pp53-63 · Cited by 8 · see citing works
Increased Aldosterone: Mechanism of Hypertension in Obesity
Flynn, C. A. (2014) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2014.04.009 · Cited by 8 · see citing works
Management of the Hypertensive Child
Ellis, D. (2009) · Springer eBooks · doi:10.1007/978-3-540-76341-3_63 · Cited by 7 · see citing works
Clinical Conditions and Predictive Markers of Non-Dipper Profile in Hypertensive Patients
Ţilea, I., Petra, D. N., Ardeleanu, E., Huţanu, A., & Varga, A. (2018) · Acta Marisiensis. Seria Medica · doi:10.2478/amma-2018-0006 · Cited by 7 · see citing works
The “Weight” of Obesity on Arterial Hypertension
Noce, A., & Daniele, N. D. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87774 · Cited by 7 · see citing works
Wójcik, M., Stępień, A., Bociąga, M., Ciuk, K., Januś, D., Drożdż, D., & Starzyk, J. (2021) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2021.1984502 · Cited by 5 · see citing works
Rizvi, S., Raza, S. T., Siddiqi, Z., Abbas, S., & Mahdi, F. (2015) · Sultan Qaboos University medical journal · doi:10.18295/squmj.2015.15.04.006 · Cited by 5 · see citing works
Surgical Treatment of the Cardiometabolic Syndrome and Obesity
Khan, K. A., & Sowers, J. R. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00021.x · Cited by 5 · see citing works
Pathophysiology and Optimal Management of Hypertension in Patients with Cardiometabolic Syndrome
Ihm, S. (2021) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2021.1.e3 · Cited by 3 · see citing works
Song, Y. H. (2014) · Korean Journal of Pediatrics · doi:10.3345/kjp.2014.57.1.35 · Cited by 3 · see citing works
Moraba, M. M., & Mabusela, M. S. (2014) · African Journal for Physical Health Education Recreation and Dance · Cited by 3 · see citing works
A patient with atrial fibrillation and comorbidities in clinical practice
Skotnikov, A. S., Алгиян, Е. А., & Sizova, Z. M. (2020) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2020-4178 · Cited by 3 · see citing works
Genetic predictors of chronic heart failure in obese patients
Bogdanov, A. R., Дербенева, С. А., Черняк, О. О., Bogdanova, A. A., Гаппарова, К. М., & Grigorian, O. N. (2019) · Obesity and metabolism · doi:10.14341/omet9667 · Cited by 2 · see citing works
Population Genetics and Pharmacogenetics
Ong, K. K., & Elks, C. E. (2010) · Yearbook of pediatric endocrinology · doi:10.1159/000320661 · Cited by 2 · see citing works
Effect of Bariatric Surgery on Hypertension
Alhomound, H., & Park, S. S. (2015) · Journal of Metabolic and Bariatric Surgery · doi:10.17476/jmbs.2015.4.2.35 · Cited by 2 · see citing works
Link of Obesity With Primary Aldosteronism: Causal or Not?
Flack, J. M., Buhnerkempe, M., Lopez, A., & Byrd, J. B. (2026) · Hypertension · doi:10.1161/hypertensionaha.126.26227 · Cited by 1 · see citing works
Understanding the Molecular Crosstalk in Biological Processes
El-Esawi, M. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77821 · Cited by 1 · see citing works
Management of the Hypertensive Child
Ellis, D., & Miyashita, Y. (2015) · Springer eBooks · doi:10.1007/978-3-662-43596-0_82 · Cited by 1 · see citing works
Resolución de las patologías comórbidas bariátricas
MacDonald, K. G., & Pender, J. R. (2009) · Elsevier eBooks · doi:10.1016/b978-84-8086-428-2.50043-5
Early Growth and Cardiovascular Development in Childhood
de Jonge, L. L., Haag, C. D., van den Hooven, E. H., & Taal, H. R. (2013)
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
The Renin-Angiotensin System and the Neuroendocrine Regulation of Energy Balance
de Kloet, E. R., & Annette, D. R. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
de Souza, S. I. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Rizvi, S., Raza, S. T., Siddiqi, Z., Abbas, S., & Mahdi, F. (2015)
Resolution of Bariatric Comorbidities: Hypertension
MacDonald, K. G., & Pender, J. R. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-0089-1.50048-0
Antihypertensive Effects of Total Gastrectomy on Spontaneous Hypertensive Rats
Hashimoto, N. (2020) · OALib · doi:10.4236/oalib.1105994
Obesity, Weight Loss and Cardiovascular Risk
Jamaly, S., Ali, M., & Talib, A. (2020) · Gothenburg University Publications Electronic Archive (Gothenburg University) · doi:10.13140/rg.2.2.11917.56808 · Cited by 2 · see citing works
Management of the Hypertensive Child
Ellis, D., & Miyashita, Y. (2014) · Springer eBooks · doi:10.1007/978-3-642-27843-3_82-1
Renin Angiotensin System and Obesity-Related Organ Damage
Galcerán, I., & Oliveras, A. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-14952-8_16
Zahnd, J., Vakilzadeh, N., Schwotzer, N., Hendriks‐Balk, M., Mantziari, S., Sauser, J., Maillard, M. P., Grouzmann, E., Favre, L., & Wuerzner, G. (2025) · Blood Pressure · doi:10.1080/08037051.2025.2555452
Antza, C., Belančić, A., Jordan, J., Esteban, A., Oliveras, A., McNally, R., Anyfanti, P., Versmissen, J., Fernández‐Alfonso, M. S., Kotsis, V., et al. (2026) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70798
Nassiri, S., Handoko, M. L., van de Bovenkamp, A. A., van Empel, V. P. M., van Raalte, D. H., & Eringa, E. C. (2026) · Heart Failure Reviews · doi:10.1007/s10741-026-10671-x
- Authors
- Ruano, M., Silvestre, V, Castro, R., García-Lescún, M. C. G., Rodríguez, A., Marco, A., & García-Blanch, G.
- Affiliations
- Hospital Universitario de Móstoles (ES)
- Venue
- Obesity Surgery
- Published
- 2005-05
- Volume
- 15
- Issue
- 5
- Pages
- 670-676
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W1974873912
- Cited by
- 83
- References
- 24
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 2 · 2012: 3
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- morbid obesity, hypertension
- MeSH terms
- Adolescent, Adult, Aldosterone, Analysis of Variance, Anastomosis, Roux-en-Y, Female, Humans, Hypertension, Peptidyl-Dipeptidase A, Male, Middle Aged, Obesity, Morbid, Potassium, Renin, Renin-Angiotensin System, Retrospective Studies, Sodium, Gastric Bypass
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review