Cited by 83Renin-Angiotensin System StudiesBariatric Surgery and OutcomesAdipokines, Inflammation, and Metabolic Diseases

Morbid Obesity, Hypertensive Disease and the Renin-Angiotensin-Aldosterone Axis

Ruano, M, Silvestre, V, Castro, R, García-Lescún, M C G, Rodríguez, A, Marco, A, García-Blanch, G·2005·Obesity Surgery

Abstract

Background Resistance to insulin and secondary hyperinsulinemia seem to be the putative link between morbid obesity (MO) and hypertensive disease (HD). Adipose tissue can secrete leptin and angiotensinogen, among other substances. Leptin activates the sympathetic nervous system, leading to HD. Angiotensinogen is a substrate for renin, therefore taking part in the renin-angiotensin-aldosterone axis and the regulation of blood pressure. In MO, both hypertrophy and hyperplasia of the adipocytes lead to an increase in the secretion of both substances, leading to loss of the equilibrium between the levels of both hormones. The aim of the present study was to evaluate these abnormalities and their potential reversibility following bariatric surgery.Methods Data from 100 patients with MO was retrospectively evaluated. Anthropometric data, the plasma renin activity (PRA), plasma levels of aldosterone, ACE, potassium and sodium were collected both prior to surgery and 6, 12, 24 and 36 months after surgery.Results The waist-hip ratio (WHR) before surgery allowed classification of our patients in two groups: central obesity (WHR > or =0.90 in men and > or =0.85 in women); peripheral obesity (WHR <0.90 in men and <0.85 in women). In patients with central obesity, high levels of PRA, aldosterone and ACE with sodium retention and potassium loss and high insulin levels, were found. These changes were not found in patients with peripheral obesity. After gastric bypass, these abnormalities tended to disappear, mainly in the first 6 months.Conclusions The reduction of BMI and WHR after gastric bypass confirmed this operation to be effective against MO. The high basal levels of insulin and the high rate of HD and diabetes in patients with central obesity seem to indicate that they suffer a metabolic syndrome with significant hormonal imbalances and sodium retention. Patients with peripheral obesity only showed a peripheral resistance against insulin, probably with a shorter duration of the hormonal action, but they did not show hormonal abnormalities or sodium retention. After gastric bypass these abnormal hormone levels tended to normalize.

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Crossref · 10.1381/0960892053923734

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  • There also appears to be activation of the renin-angiotensin system in obesity.

    “There also appears to be activation of the renin-angiotensin system in obesity (304).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [304]

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Authors
Ruano, M., Silvestre, V, Castro, R., García-Lescún, M. C. G., Rodríguez, A., Marco, A., & García-Blanch, G.
Affiliations
Hospital Universitario de Móstoles (ES)
Venue
Obesity Surgery
Published
2005-05
Volume
15
Issue
5
Pages
670-676
ISSN
  • 0960-8923 (ISSN-L)
  • 1708-0428
OpenAlex
W1974873912
Cited by
83
References
24
Citations by year
2026: 3 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 2 · 2012: 3
FWCI
4.10
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
morbid obesity, hypertension
MeSH terms
Adolescent, Adult, Aldosterone, Analysis of Variance, Anastomosis, Roux-en-Y, Female, Humans, Hypertension, Peptidyl-Dipeptidase A, Male, Middle Aged, Obesity, Morbid, Potassium, Renin, Renin-Angiotensin System, Retrospective Studies, Sodium, Gastric Bypass

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