The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Weight Loss and Non-alcoholic Fatty Liver Disease: Falls In Gamma-Glutamyl Transferase Concentrations are Associated with Histologic Improvement
Abstract
Background The ability for aminotransferase levels to track histological features of non-alcoholic fatty liver disease (NAFLD) with weight loss has not been examined. Methods We examined the effect of weight loss following laparoscopic adjustable gastric banding surgery on the histological features of NAFLD and plasma aminotransferase concentrations (AST, ALT and GGT) in 60 (12M, 48F) selected severely obese patients. All 120 paired biopsies were de-identified and scored for lobular steatosis, fibrosis, inflammation, Mallory bodies and NASH. Results 30 patients (50%) had baseline histological features of non-alcoholic steatohepatitis (NASH). Repeat biopsies were taken at 29.5+/-10 months after baseline. Mean weight loss was 31.5+/-18 kg. There were improvements in AST, ALT, GGT, lobular steatosis, inflammation and fibrosis between baseline and follow-up (P<0.001 for all). Only 6 (10%) of repeat biopsies showed NASH. No change in aminotransferase concentrations predicted the change in steatosis, but changes in AST and GGT predicted improved scores for inflammation, fibrosis, Mallory bodies and NASH. The lowering of GGT best predicted the improvements in inflammation, fibrosis and NASH. Conclusion With weight loss, falls in GGT and, to a lesser extent, in AST, are predictive of improved lobular inflammation and fibrosis, key prognostic features of NAFLD.
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“and those with metabolic syndrome experienced the greatest histologic gains [46].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [46]
In the citing paper
“On average, ~30–34 kg of weight loss (~50% excess weight) was achieved in these series”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [46]
In the citing paper
“A subsequent cohort of 60 AGB patients with ~30-month liver biopsies confirmed these findings, with only 10% having persistent NASH postoperatively versus 50% at baseline.”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [46]
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Cites
Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions
Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,166
Dixon, J. B., Bhathal, P. S., & O’Brien, P. E. (2001) · Gastroenterology · doi:10.1053/gast.2001.25540 · Cited by 1,369
Self-citationLiver fibrosis in overweight patients
Ratziu, V., Giral, P., Charlotte, F., Bruckert, É., Thibault, V., Theodorou, I. D., Khalil, L., Turpin, G., Opolon, P., & Poynard, T. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70364-7 · Cited by 969
Nonalcoholic fatty liver disease
Clark, J. M., Brancati, F. L., & Diehl, A. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33573 · Cited by 929
Adams, L. A., Sanderson, S. O., Lindor, K. D., & Angulo, P. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.09.012 · Cited by 912
Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
Dixon, J. B., Bhathal, P. S., Hughes, N. R., & O'Brien, P. E. (2004) · Hepatology · doi:10.1002/hep.20251 · Cited by 727
Self-citationO’Brien, P. E., Dixon, J. B., Brown, W. A., Schachter, L. M., Chapman, L., Burn, A. J., Dixon, M. E., Scheinkestel, C. D., Halket, C., Sutherland, L. J., et al. (2002) · Obesity Surgery · doi:10.1381/096089202321019639 · Cited by 380
Self-citationO’Brien, P. E., Dixon, J. B., Laurie, C., & Anderson, M. (2005) · Obesity Surgery · doi:10.1381/0960892054222858 · Cited by 230
Self-citationDixon, A. F. R., Dixon, J. B., & O’Brien, P. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1546 · Cited by 228
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Fibrosis and adipose tissue dysfunction.
Sun, K., Tordjman, J., Clément, K., & Scherer, P. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.016 · Cited by 960
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674
Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Parker, H. M., Johnson, N. A., Burdon, C. A., Cohn, J. S., O’Connor, H. T., & George, J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.018 · Cited by 569
Chen, C., Yang, H., Yang, W., Liu, C., Chen, P., You, S., Wang, L., Sun, C., Lu, S., Chen, D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.073 · Cited by 548
NAFLD in Asia—as common and important as in the West
Farrell, G. C., Wong, V. W., & Chitturi, S. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.34 · Cited by 437
Metadata
- Authors
- Dixon, J., Bhathal, P., & O'Brien, P.
- Affiliations
- The Alfred Hospital (AU)
- The University of Melbourne (AU)
- ORCID
- Dixon, John
- Venue
- Obesity Surgery
- Published
- 2006-10-01
- Volume
- 16
- Issue
- 10
- Pages
- 1278-1286
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2038159864
- Cited by
- 212
- References
- 17
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 15 · 2021: 10 · 2020: 10 · 2019: 14 · 2018: 8 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 11
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis
- MeSH terms
- Adult, Alanine Transaminase, Transaminases, Aspartate Aminotransferases, Fatty Liver, Female, Fibrosis, gamma-Glutamyltransferase, Humans, Liver, Male, Middle Aged, Obesity, Morbid, Postoperative Period, Gastric Bypass, Weight Loss, Comorbidity
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