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Associations Among Plasma Selenium, Zinc, Copper, and Iron Concentrations and Immunoregulatory Cytokine Levels in Patients with Cutaneous Leishmaniasis
Abstract
Plasma essential trace elements, selenium, copper, zinc, and iron concentrations and the levels of immunoregulatory cytokines, interleukin-1beta (IL-1beta), interleukin-2 receptor (IL-2r), IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) were evaluated in patients with cutaneous leishmaniasis (CL) to investigate a possible role of these cytokines on selenium, zinc, copper, and iron homeostasis in CL patients. Plasma albumin levels were measured as an index of nutritional status. Plasma selenium, zinc, and iron concentrations, and IL-2r levels were significantly lower, and copper concentrations and IL-1beta, IL-8, IL-6 and TNF-alpha levels were significantly higher in patients with CL than those of healthy controls. There was no significant difference in plasma albumin levels between two groups. There were positive important correlations between plasma selenium and IL-2r, copper and IL-6, and copper and IL-1beta, and negative correlations between selenium and IL-8, iron and TNF-alpha, and zinc and IL-1beta contents in patients with CL. Our results showed that plasma trace element contents change in patients with CL. These changes may not be a result of a specific deficiency from dietary inadequacies or imbalances, but, probably, a result of a part of the defense strategies of an organism that is regulated by immunoregulatory cytokines.
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Higher TNF-α and IL-1β have been linked to cutaneous leishmaniasis, and more lipid peroxidation products have been linked to zinc deficiency in children with chronic giardiasis.
“Increases in inflammatory cytokines TNF-␣ and IL-1 have been associated with cutaneous leishmaniasis (17), and increases in lipid peroxidation products were associated with zinc deficiency in children with chronic giardiasis (18).”
From Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress (2007) · cites this paper as [17]
Citations
Cites
Cousins, R. J. (1985) · Physiological Reviews · doi:10.1152/physrev.1985.65.2.238 · Cited by 1,331
Beisel, W. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.2.417 · Cited by 517
Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS)
Dworkin, B. M. (1994) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)90038-8 · Cited by 148
Iron depletion: A defense against intracellular infection and neoplasia
Weinberg, E. D. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90279-x · Cited by 131
Ockenhouse, C. F., & Shear, H. L. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.1.424 · Cited by 113
Weigle, K. A., & Saravia, N. G. (1996) · Clinics in Dermatology · doi:10.1016/0738-081x(96)00036-3 · Cited by 112
Zoli, A., Altomonte, L., Caricchio, R., Galossi, A., MIRONE, L., Mp, R., & Magar, M. T. (1998) · Clinical Rheumatology · doi:10.1007/bf01450895 · Cited by 96
Selenium and Interleukins in Persons Infected with Human Immunodeficiency Virus Type 1
Baum, M. K., Míguez‐Burbano, M. J., Campa, A. L., & Shor‐Posner, G. (2000) · The Journal of Infectious Diseases · doi:10.1086/315911 · Cited by 95
Herman Award Lecture, 1995: infection-induced malnutrition--from cholera to cytokines
Beisel, W. R. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.4.813 · Cited by 90
Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice
Rofe, A. M., Philcox, J. C., & Coyle, P. V. (1996) · Biochemical Journal · doi:10.1042/bj3140793 · Cited by 85
Interleukin-1-Stimulated Induction of Ceruloplasmin Synthesis in Normal and Copper-Deficient Rats
Barber, E. F., & Cousins, R. J. (1988) · Journal of Nutrition · doi:10.1093/jn/118.3.375 · Cited by 81
Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi
Wilson, M. E., Vorhies, R. W., Andersen, K. A., & Britigan, B. E. (1994) · Infection and Immunity · doi:10.1128/iai.62.8.3262-3269.1994 · Cited by 79
Oxidative killing of intracellular parasites mediated by macrophages
Hughes, H. P. A. (1988) · Parasitology Today · doi:10.1016/0169-4758(88)90003-8 · Cited by 70
Selenium supplementation of symptomatic human immunodeficiency virus infected patients
Olmsted, L., Schrauzer, G. N., Flores-Arce, M. F., & Dowd, J. (1989) · Biological Trace Element Research · doi:10.1007/bf02919098 · Cited by 66
Reduced zinc in peripheral blood cells from patients with inflammatory connective tissue diseases
Svenson, K. L. G., Halloren, R., Johansson, E., & Lindh, U. (1985) · Inflammation · doi:10.1007/bf00917591 · Cited by 61
Koçyiğit, A., Erel, Ö., Gürel, M. S., Avci, S., & Aktepe, N. (1998) · Biological Trace Element Research · doi:10.1007/bf02789102 · Cited by 40
Serum selenium in adult Czechoslovak (central bohemia) population
Korunová, V., Škodová, Z., Dědina, J., Valenta, Z., Parizek, J., Pisa, Z., & Stýblo, M. (1993) · Biological Trace Element Research · doi:10.1007/bf02783784 · Cited by 38
de la Cruz, A. J. M. D. A., Burguera, J. L., Burguera, M., & Áñez, N. (1993) · Biological Trace Element Research · doi:10.1007/bf02789401 · Cited by 36
Immunoregulatory And Proinflammatory Cytokine Production In Visceral And Cutaneous Leishmaniasis
Raziuddin, S., Abdalla, R. E., EI-Awad, E.-H., & AI-Janadi, M. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/170.4.1037 · Cited by 31
Daffada, A. A. I., & Young, S. P. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01036-4 · Cited by 24
Study of oxidative-stress in rotavirus infected infant mice.
Sodhi, C. P., Katyal, R., Rana, S. V., Attri, S., & Singh, V. (1996) · PubMed · Cited by 23
Cytokines and anaemia in human immunodeficiency virus infection.
Means, R. T. (1997) · PubMed · Cited by 20
The effect of interleukin‐1 on iron metabolism in rats
Uchida, T., Yamagiwa, A., & Nakamura, K. (1991) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1991.tb00505.x · Cited by 19
Svenson, K. L. G., Hällgren, R., Johansson, E., & Lindh, U. (1986) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1986.tb02785.x · Cited by 7
Wada, M., Morimoto, A., Watanabe, T., Sakata, Y., & Murakami, N. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018309 · Cited by 6
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Prasad, A. S., Beck, F. W., Bao, B., Fitzgerald, J. T., Snell, D. C., Steinberg, J. D., & Cardozo, L. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.837 · Cited by 516
Antioxidant effect of zinc in humans
Prasad, A. S., Bao, B., Beck, F. W. J., Kucuk, O., & Sarkar, F. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.007 · Cited by 520
Clinical, immunological, anti-inflammatory and antioxidant roles of zinc
Prasad, A. S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.013 · Cited by 454
Catov, J. M., Bodnar, L. M., Ness, R. B., Marković, N., & Roberts, J. M. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm071 · Cited by 83
Systematic Review of Biomarkers To Monitor Therapeutic Response in Leishmaniasis
Kip, A. E., Balasegaram, M., Beijnen, J. H., Schellens, J. H. M., de Vries, P. J., & Dorlo, T. P. C. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04298-14 · Cited by 66
Cauwenbergh, R. V., Robberecht, H. J., Vlaslaer, V. V., & Deelstra, H. A. (2004) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2004.04.004 · Cited by 62
Biomarkers of Cutaneous Leishmaniasis
Bahrami, F., Harandi, A. M., & Rafati, S. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00222 · Cited by 43
Seyrek, A., Koçyiğit, A., & Erel, Ö. (2005) · Biological Trace Element Research · doi:10.1385/bter:106:2:107 · Cited by 34
The Biological Significance of Zinc in Inflammation and Aging
Bao, B., Ahmad, A., Azmi, A. S., Li, Y., Prasad, A. S., & Sarkar, F. H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00002-2 · Cited by 26
Evaluation of serum levels of zinc, copper, iron, and zinc/copper ratio in cutaneous leishmaniasis.
Pourfallah, F., Javadian, S., Zamani, Z., Saghiri, R., Sadeghi, S., Zarea, B., Faiaz, S., Mirkhani, F., & Fatemi, N. A.-S. (2009) · Europe PMC (PubMed Central) · Cited by 24
Leishmaniasis and Trace Element Alterations: a Systematic Review
Taghipour, A., Abdoli, A., Ramezani, A., Abolghazi, A., Jahromi, M. A. M., Maani, S., Heidarnejadi, S. M., Rasti, S., Shams, M., & Ghasemi, E. (2021) · Biological Trace Element Research · doi:10.1007/s12011-020-02505-0 · Cited by 24
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Dabbaghmanesh, M. H., Salehi, N., Siadatan, J., & Omrani, G. R. (2011) · Biological Trace Element Research · doi:10.1007/s12011-011-9074-1 · Cited by 17
Camp, O. G., Bembenek, J. N., Goud, P. T., Awonuga, A. O., & Abu‐Soud, H. M. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01212-0 · Cited by 13
El‐Deeb, W., & El-Bahr, S. M. (2014) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2013.09.012 · Cited by 10
Loglo, A. D., Aniagyei, W., Vivekanandan, M. M., Agbanyo, A., Adu, E. A., Phillips, R. O., Annan, R. A., Engel, B., & Simmonds, R. E. (2024) · Access Microbiology · doi:10.1099/acmi.0.000800.v3 · Cited by 9
Pal, B., Mishra, A. K., Raj, H., Chaudhary, V., Khurana, N., Azharuddin, M., & Kumari, S. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03797-8 · Cited by 9
Palladini, G., Ferrigno, A., Pasqua, L. G. D., Berardo, C., Rizzo, V., Perlini, S., & Vairetti, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243179 · Cited by 9
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Quintavalla, F., Basini, G., Bussolati, S., Carrozzo, G. G., Inglese, A., & Ramoni, R. (2021) · Animals · doi:10.3390/ani11010119 · Cited by 8
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PRANDOTA, J. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318195e34d · Cited by 7
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Hussein, A. M., & Ali, H. Z. (2022) · Iraqi Journal of Science · doi:10.24996/ijs.2022.63.8.6 · Cited by 5
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Barrouin‐Melo, S. M., Morejón-Terán, Y. A., Anturaniemi, J., & Hielm-Björkman, A. K. (2018) · Experientia supplementum · doi:10.1007/978-3-319-74932-7_2 · Cited by 5
The Interaction of Zinc as an Essential Trace Element with Leishmania Parasites: A Systematic Review
Aghaei, M., Aghaei, S., Kouhiyan, M., Shahmoradi, Z., & Hejazi, S. H. (2024) · Advanced Biomedical Research · doi:10.4103/abr.abr_187_23 · Cited by 3
Najafzade, M. R., Mosapour, A., Nahrevanian, H., Zamani, Z., Javadian, S., & Mirkhani, F. (2015) · Europe PMC (PubMed Central) · Cited by 3
Sobotyk, C., Baldissera, F. G., Rodrigues, L. C., Romão, P. R. T., de Oliveira, J. S., Dornelles, G. L., de Andrade, C. M., Maciel, R. M., Danesi, C. C., Ferreira, R. V. D. P., et al. (2023) · Acta Parasitologica · doi:10.1007/s11686-023-00666-1 · Cited by 2
The Protective Role of Zinc in Cancer: A Potential Chemopreventive Agent
Bao, B., Ahmad, A., Azmi, A. S., Wang, Z., Banerjee, S., & Sarkar, F. H. (2012) · Springer eBooks · doi:10.1007/978-94-007-2923-0_12 · Cited by 2
Akiş, M. E., & Dede, S. (2009) · DergiPark (Istanbul University) · Cited by 1
Anthropometry and Infectious and Parasitic Diseases
Romão, P. R. T., Teixeira, F. M., Schalcher, T. R., & Monteiro, M. C. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1788-1_142 · Cited by 1
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Metadata
- Authors
- Kocyigit, A., Gur, S., Erel, O., & Gurel, M. S.
- Venue
- Biological Trace Element Research
- Published
- 2002
- Volume
- 90
- Issue
- 1-3
- Pages
- 47-56
- ISSN
- 0163-4984 (ISSN-L)
- OpenAlex
- W2080914419
- Cited by
- 30
- References
- 25
- Citations by year
- 2024: 4 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- AYBU AVESIS (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- cutaneous leishmaniasis, plasma selenium, zinc, copper, iron, trace element homeostasis, immunoregulatory cytokines, IL-1β, interleukin-2 receptor, interleukin-6, interleukin-8, TNF-α, serum albumin, nutritional status
- MeSH terms
- Adolescent, Adult, Animals, Child, Copper, Female, Humans, Interleukins, Iron, Male, Selenium, Tumor Necrosis Factor-alpha, Turkeys, Zinc, Body Mass Index, Cytokines, Leishmaniasis, Cutaneous
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