Disorders of flushing
Abstract
Disorders of flushing encompass a broad spectrum of diverse acquired and inherited conditions. Chemical mediators involved in the flushing response are incompletely understood. Flushing episodes rarely can be associated with significant morbidity and mortality. The goal of the physician is to separate benign from potentially life-threatening conditions. Accurate diagnosis requires a thorough history and physical examination emphasizing the age of the patient, temporal association of flushing with occupation, environmental, stress, food, or drug exposure, and the duration of the episode. In some cases, despite a thorough evaluation, the etiology for flushing remains unknown. Understanding the distinct mechanisms that lead to flushing helps provide a rational approach to treatment.
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Most symptoms attributable to mast cell activation, such as isolated flushing, pruritus, headache, abdominal pain, or tachycardia, are not specific to mast cells but can be found in other clinical conditions and disorders.
“This is because most symptoms attributable to MCA, such as isolated fl ushing, pruritus, headache, abdominal pain, or tachycardia, are not speci fi c to MCs but can be found in other clinical conditions and disorders as well. 112-118”
From Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review (2021) · cites this paper as [112]
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THE ROLE OF ENDOGENOUS OPIOIDS IN THE CHLORPROPAMIDE ALCOHOL FLUSH
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Pseudocarcinoid Syndrome Associated With Hypogonadism and Response to Testosterone Therapy
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12 APUDomas: acute complications and their medical management
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The effects of naloxone infusion and stellate ganglion blockade on hot flushes in the human male
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Naloxone, Ethanol, and the Chlorpropamide Alcohol Flush
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Chlorpropamide alcohol flushing: A normal response?
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Chlorpropamide-alcohol flush: Significance of body weight, sex and serum chlorpropamide level
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Funny Spells in Neuroendocrine Disorders
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Red Man Syndrome During Administration Of Prophylactic Antibiotic Against Infective Endocarditis
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Flushing and syncopal episode in a 47-year-old female
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Congenital gustatory facial flushing
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Sorted by citations
Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2021.06.011 · Cited by 83 · see citing works
“This is because most symptoms attributable to MCA, such as isolated flushing, pruritus, headache, abdominal pain, or tachycardia, are not specific to MCs but can be found in other clinical conditions and disorders as well.(112-118) Hence, a broad range of differential diagnoses, including cardiovascular, endocrinologi…”
Background
- Authors
- Yale, S. H., Vasudeva, S., Mazza, J. J., Rolak, L., Arrowood, J., Stichert, S., & Stratman, E. S.
- Affiliations
- Marshfield Clinic Research Foundation (US)
- St. Joseph's Hospital (US)
- Corresponding author
- Yale, Steven H.
- Venue
- Comprehensive Therapy
- Published
- 2005
- Volume
- 31
- Issue
- 1
- Pages
- 059-071
- ISSN
- 0098-8243 (ISSN-L)
- OpenAlex
- W2030780654
- Cited by
- 11
- References
- 130
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 1 · 2014: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comprehensive Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Sympathectomy and Hyperhidrosis Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- chemical mediators, differential diagnosis
- MeSH terms
- Alcohol Drinking, Autonomic Nervous System Diseases, Diagnosis, Differential, Flushing, Humans, Marine Toxins, Neoplasms, Rosacea, Syndrome, Occupational Exposure, Postmenopause, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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