CoChat
Sign Up
Cited by 11Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsStress Responses and Cortisol

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Dexamethasone and Adrenocorticotropin Suppress Prolactin Secretion in Humans

Hubina, Erika, Nagy, György M, Tóth, Béla E, Iván, Gabriella, Görömbey, Zoltán, Szabolcs, István, Kovács, László, Góth, Miklós I·2002·Endocrine
DOI 10.1385/endo:18:3:215
Open this paper in CoChat — free account

Abstract

It has been demonstrated that the regulatory pathways mediating basal and/or stimulus-induced prolactin (PRL) release in mammals are highly sensitive to adrenal corticoid inhibitory influence. We have investigated the effect of four different doses of dexamethasone (DEX) and the effect of adrenocorticotropin on PRL secretion in 197 patients (169 female, 28 male; age: 18-66 yr) with suspected hypercortisolemia--but only those with a normal glucocorticoid suppression test were involved in the study--and in 66 female patients (age: 18-39 yr) with suspected adrenocorticotropin-dependent hyperandrogenism. Overnight (1 mg), low-dose (0.5 mg every 6 h for 2 d), high-dose (2 mg every 6 h for 2 d), and long-lasting administration of DEX (0.5 mg every 6 h for 5 d) resulted in a significant decrease in PRL levels compared to the baseline. Similarly, a reduction in PRL levels could be detected following injection of adrenocorticotropin (250 microg). In hyperprolactinemic patients, the DEX-induced increase in PRL (APRL, expressed in percentage of baseline) was significantly larger compared with normoprolactinemic subjects in all groups except those who received high-dose DEX) or adrenocorticotropin. These data clearly indicate that the secretory function of PRL cells in humans is sensitive to changes in the activity of the hypothalamo-pituitary-adrenal axis in a dose-dependent manner.

Overview

Integrity signals

Registry

Crossref · 10.1385/endo:18:3:215

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Cited by

See all 11

Related

See all

Metadata

Authors
Hubina, E., Nagy, G. M., Tóth, B. E., Iván, G., Görömbey, Z., Szabolcs, I., Kovács, L., & Góth, M. I.
Affiliations
Semmelweis University (HU)
Corresponding author
Góth, Miklós I
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2002
Volume
18
Issue
3
Pages
215-220
ISSN
0969-711X (ISSN-L)
DOI
10.1385/endo:18:3:215
OpenAlex
W2090059761
Cited by
11
References
40
Citations by year
2023: 1 · 2021: 1 · 2018: 1
FWCI
0.57
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
dexamethasone, ACTH, prolactin secretion, hypercortisolism, hyperprolactinemia, hypothalamic-pituitary-adrenal axis, dose-dependent effects, glucocorticoid feedback
MeSH terms
Adrenocorticotropic Hormone, Adult, Aged, Dexamethasone, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Glucocorticoids, Humans, Hyperprolactinemia, Male, Middle Aged, Obesity, Prolactin, Reference Values, Hyperandrogenism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review