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Cited by 11Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsStress Responses and Cortisol

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Dexamethasone and Adrenocorticotropin Suppress Prolactin Secretion in Humans

Hubina, Erika, Nagy, György M, Tóth, Béla E, Iván, Gabriella, Görömbey, Zoltán, Szabolcs, István, Kovács, László, Góth, Miklós I·2002·Endocrine
DOI 10.1385/endo:18:3:215
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Abstract

It has been demonstrated that the regulatory pathways mediating basal and/or stimulus-induced prolactin (PRL) release in mammals are highly sensitive to adrenal corticoid inhibitory influence. We have investigated the effect of four different doses of dexamethasone (DEX) and the effect of adrenocorticotropin on PRL secretion in 197 patients (169 female, 28 male; age: 18-66 yr) with suspected hypercortisolemia--but only those with a normal glucocorticoid suppression test were involved in the study--and in 66 female patients (age: 18-39 yr) with suspected adrenocorticotropin-dependent hyperandrogenism. Overnight (1 mg), low-dose (0.5 mg every 6 h for 2 d), high-dose (2 mg every 6 h for 2 d), and long-lasting administration of DEX (0.5 mg every 6 h for 5 d) resulted in a significant decrease in PRL levels compared to the baseline. Similarly, a reduction in PRL levels could be detected following injection of adrenocorticotropin (250 microg). In hyperprolactinemic patients, the DEX-induced increase in PRL (APRL, expressed in percentage of baseline) was significantly larger compared with normoprolactinemic subjects in all groups except those who received high-dose DEX) or adrenocorticotropin. These data clearly indicate that the secretory function of PRL cells in humans is sensitive to changes in the activity of the hypothalamo-pituitary-adrenal axis in a dose-dependent manner.

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Crossref · 10.1385/endo:18:3:215

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Metadata

Authors
Hubina, E., Nagy, G. M., Tóth, B. E., Iván, G., Görömbey, Z., Szabolcs, I., Kovács, L., & Góth, M. I.
Affiliations
Semmelweis University (HU)
Corresponding author
Góth, Miklós I
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2002
Volume
18
Issue
3
Pages
215-220
ISSN
0969-711X (ISSN-L)
DOI
10.1385/endo:18:3:215
OpenAlex
W2090059761
Cited by
11
References
40
Citations by year
2023: 1 · 2021: 1 · 2018: 1
FWCI
0.57
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
dexamethasone, ACTH, prolactin secretion, hypercortisolism, hyperprolactinemia, hypothalamic-pituitary-adrenal axis, dose-dependent effects, glucocorticoid feedback
MeSH terms
Adrenocorticotropic Hormone, Adult, Aged, Dexamethasone, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Glucocorticoids, Humans, Hyperprolactinemia, Male, Middle Aged, Obesity, Prolactin, Reference Values, Hyperandrogenism

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