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Cited by 127Adrenal Hormones and DisordersPituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Adrenocortical function in hyperprolactinemic women

CARTER, J. N., TYSON, J. E., WARNE, G. L., McNEILLY, A. S., FAIMAN, C., FRIESEN, H. G.·1977·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-45-5-973
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Abstract

To study the effects of prolactin (PRL) on adrenocortical function in humans, dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (delta) and testosterone (T) were measured in serum obtained from 35 hyperprolactinemic women with galactorrhea and amenorrhea before and after treatment with bromocriptine-induced fall in mean PRL levels from 82 +/- 8 (SE) to 14 +/- 2 ng/ml (n = 39, P less than 0.0005), DHAS fell from 322 +/- 21 to 237 +/- 21 microgram/dl (n = 39); P less than 0.0005), DHA fell from 492 +/- 47 to 378 +/- 30 ng/dl (n = 39; P less than 0.01) while T (n = 16) and delta (n = 13) levels were unchanges (44 +/- 4 vs. 49 +/- 4 ng/dl and 280 +/- 55 vs. 236 +/- 40 ng/dl, respectively). In addition, 4 women were infused iv with 25 microgram synthetic ACTH over 4 h and serial blood samples drawn while hyperprolactinemic, and again 2-4 months later following normalization of PRL levels by bromocriptine. Although pre-infusion levels of DHAS were lower when PRL levels were normalized, no significant differences in responses of circulating DHAS, DHA, T, cortisol and 17-hydroxyprogesterone concentrations were detected between the two infusions. Since DHAS is virtually an exclusive product of the adrenal cortex, and since high PRL levels appear to inhibit ovarian steroid production, the findings suggest that hyperprolactinemia selectively stimulates adrenocortical androgen production.

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Crossref · 10.1210/jcem-45-5-973

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Authors
CARTER, J. N., TYSON, J. E., WARNE, G. L., McNEILLY, A. S., FAIMAN, C., & FRIESEN, H. G.
Affiliations
Johns Hopkins University (US)
ORCID
McNEILLY, A. S.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1977-11
Volume
45
Issue
5
Pages
973-980
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-45-5-973
OpenAlex
W2017313133
Cited by
127
References
26
Citations by year
2023: 1 · 2022: 1 · 2019: 3 · 2013: 2 · 2012: 2
FWCI
14.59
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
hyperprolactinemia, prolactin, adrenocortical function, dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, testosterone, galactorrhea, amenorrhea, bromocriptine, ACTH stimulation test, adrenal androgen production, cortisol, 17-hydroxyprogesterone
MeSH terms
Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Amenorrhea, Androstenedione, Bromocriptine, Dehydroepiandrosterone, Female, Galactorrhea, Humans, Hydrocortisone, Pregnancy, Prolactin, Testosterone

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