Brain-specific small Nucleolar RNAs
Abstract
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that function mainly as guides for modification of ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). A subgroup of snoRNAs was found to be predominantly expressed in the brain; and interestingly, these brain-specific snoRNAs (b-snoRNAs) appear not to be involved in modification of rRNAs and snRNAs, raising the question of what their function and targets might be. Expression studies of b-snoRNAs in mice have shown potential involvement of two b-snoRNAs, MBII-48 and MBII-52, in learning and memory. HBII-52, the human homolog of MBII-52, appears to be involved with regulation of 5-HT(2C) receptor subunit mRNA. Furthermore, several reports link the disruption of expression of a specific b-snoRNA, HBII-85, with a neurobehavioral disorder, Prader-Willi syndrome. This paper reviews the current knowledge of the properties, expression, and functions of b-snoRNAs.
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All genes of the SNORD115 cluster are exclusively expressed in brain.
“All genes of SNORD115 cluster, for example are exclusively expressed in brain (Chamberlain, 2013; Jorjani et al., 2016; Rogelj, 2006).”
From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Rogelj, 2006
Cites
Regulation of serotonin-2C receptor G-protein coupling by RNA editing
Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010 · see citing works
Genome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes
Nicholls, R. D., & Knepper, J. L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.153 · Cited by 625 · see citing works
Biogenesis of small nucleolar ribonucleoproteins
Filipowicz, W., & Pogačić, V. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00334-4 · Cited by 394 · see citing works
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Functional diversity of small nucleolar RNAs
Bratkovič, T., Božič, J., & Rogelj, B. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz1140 · Cited by 272 · see citing works
Self-citationRegulatory role of small nucleolar RNAs in human diseases
Stepanov, G. A., Filippova, J. A., Komissarov, A. B., Kuligina, E. V., Richter, V. A., & Semenov, D. V. (2015) · BioMed Research International · doi:10.1155/2015/206849 · Cited by 154 · see citing works
Fitz, N. F., Wang, J., Kamboh, M. I., Koldamova, R., & Lefterov, I. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105481 · Cited by 49 · see citing works
“All genes of SNORD115 cluster, for example are exclusively expressed in brain (Chamberlain, 2013; Jorjani et al., 2016; Rogelj, 2006).”
- Authors
- Rogelj, B.
- Affiliations
- King's College London (GB)
- Corresponding author
- Rogelj, Boris
- ORCID
- Rogelj, Boris
- Venue
- Journal of Molecular Neuroscience
- Published
- 2006
- Volume
- 28
- Issue
- 2
- Pages
- 103-110
- ISSN
- 0895-8696 (ISSN-L)
- OpenAlex
- W1975190048
- Cited by
- 33
- References
- 3
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- small nucleolar RNA, non-coding RNA, learning and memory, 5-HT2C receptor, Prader-Willi syndrome, neurobehavioral disorders
- MeSH terms
- Animals, Brain, Humans, Learning, Nucleic Acid Conformation, RNA Processing, Post-Transcriptional, RNA, Ribosomal, RNA, Small Nuclear, RNA Editing, RNA, Small Nucleolar, Mice
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