The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
BDNF and COMT Polymorphisms: Relation to Memory Phenotypes in Young Adults With Childhood-Onset Mood Disorder
Abstract
Recent investigations in several species have suggested a role for brain-derived neurotrophic factor (BDNF) in memory, which may be mediated by the influence of BDNF on neuronal plasticity in the hippocampus. BDNF polymorphisms have also been associated with mood disorders. Catechol-O-methyltransferase (COMT) metabolizes dopamine and has been implicated in prefrontal function, another area of the brain relevant for memory. In a sample of 63 young adults with a history of childhood-onset mood disorder, we typed three BDNF polymorphisms, including the BDNF Val66Met single nucleotide polymorphism (SNP), and the COMT Val108/158Met SNP. Multivariate analysis of variance was used to test the association between BDNF and COMT markers and measures of declarative memory. Variants at the three BDNF markers and one COMT marker were not associated with declarative memory function p-values ranged from 0.25 to 0.98. Higher IQ (F = 6.18, df = 4, 58, p = 0.0003) and female gender (F = 4.41, df = 4, 58, p = 0.0035) were associated with more optimal performance on the memory tasks. This study did not provide evidence supporting an association between BDNF and COMT genes and declarative memory phenotypes.
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BDNF polymorphisms have been found in adults with young-onset depression.
“In humans, BDNF polymorphisms were found in adults with young-onset depression78.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [78]
BDNF+/- mice show less dendritic branching and dendritic retraction and simplification in CA3 and dentate gyrus, and dysregulation of BDNF/TrkB pathways has been reported in major depressive disorder and animal models of depression.
“BDNF+/− mice show less dendritic branching as well as dendritic retraction and simplification in CA381 and DG80 and dysregulation of BDNF/TrkB pathways has been reported in MDD and animal models of depression78, 169-171.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [78]
Citations
Cites
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232
Maternal care, hippocampal synaptogenesis and cognitive development in rats
Liu, D., Diorio, J., Day, J. C., Francis, D. D., & Meaney, M. J. (2000) · Nature Neuroscience · doi:10.1038/77702 · Cited by 1,195
Synaptic plasticity and mood disorders
Duman, R. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001016 · Cited by 363
Russo-Neustadt, A., Ha, T., Ramirez, R., & Kesslak, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00364-8 · Cited by 346
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Verhagen, M., van der Meij, A., van Deurzen, P. A. M., Janzing, J. G. E., Arias-Vásquez, A., Buitelaar, J. K., & Franke, B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.109 · Cited by 470
Gratacòs, M., González, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., & Estivill, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.025 · Cited by 428
Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408
Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.005 · Cited by 412
Metadata
- Authors
- Strauss, J., Barr, C. L., George, C. J., Ryan, C. M., King, N., Shaikh, S., Kovacs, M., & Kennedy, J. L.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- University of Pittsburgh Medical Center (US)
- Corresponding author
- Kennedy, J. L.
- Venue
- NeuroMolecular Medicine
- Published
- 2004
- Volume
- 5
- Issue
- 3
- Pages
- 181-192
- ISSN
- 1535-1084 (ISSN-L)
- OpenAlex
- W2047784996
- Cited by
- 42
- References
- 4
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroMolecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute of Mental Health (P01 MH56193-06, P01MH056193)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, catechol-O-methyltransferase, COMT Val158Met polymorphism, bipolar disorder, depression, declarative memory, genetic association, IQ, sex differences, young adults
- MeSH terms
- Adolescent, Adult, Age Factors, Brain, Brain Chemistry, Catechol O-Methyltransferase, Child, Dopamine, Female, Gene Frequency, Humans, Intelligence, Male, Memory, Methionine, Phenotype, Polymorphism, Genetic, Sex Factors, Valine, Age of Onset, Brain-Derived Neurotrophic Factor, Mood Disorders, Genetic Predisposition to Disease
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