Cited by 363Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Synaptic plasticity and mood disorders

Duman, R S·2002·Molecular Psychiatry

Abstract

Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001016

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The relationship of LTP during waking to increased production of slow waves in sleep is likely relevant for depression, in that most effective antidepressants increase expression of plasticity-related genes much like sleep deprivation, although on a longer time course.

    “The relationship of LTP during waking to increased production of slow waves in sleep is likely relevant for depression, in that most effective antidepressants increase expression of plasticity-related genes (reviewed in Duman, 2002; Payne et al., 2002) much like sleep deprivation (Cirelli et al., 2004), although on a longer time course.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Duman, R. S.
Affiliations
Yale University (US)
Corresponding author
Duman, R S
Venue
Molecular Psychiatry
Published
2002-01
Volume
7
Issue
S1
Pages
S29-S34
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W1983914274
Cited by
363
References
46
Citations by year
2026: 2 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 21
FWCI
3.26
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (2P01 MH25642, MH-45481, P01MH025642)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
synaptic plasticity, mood disorders, depression, bipolar disorder, CREB, brain-derived neurotrophic factor, neurotrophic factors, transcription factors, atypical antipsychotics, clozapine, olanzapine, neural circuits, antidepressant mechanism
MeSH terms
Antidepressive Agents, Depressive Disorder, Humans, Synaptic Transmission, Neuronal Plasticity, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Mood Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review