Synaptic plasticity and mood disorders
Abstract
Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.
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The relationship of LTP during waking to increased production of slow waves in sleep is likely relevant for depression, in that most effective antidepressants increase expression of plasticity-related genes much like sleep deprivation, although on a longer time course.
“The relationship of LTP during waking to increased production of slow waves in sleep is likely relevant for depression, in that most effective antidepressants increase expression of plasticity-related genes (reviewed in Duman, 2002; Payne et al., 2002) much like sleep deprivation (Cirelli et al., 2004), although on a longer time course.”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Duman, 2002
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- Authors
- Duman, R. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Duman, R S
- ORCID
- Duman, R S
- Venue
- Molecular Psychiatry
- Published
- 2002-01
- Volume
- 7
- Issue
- S1
- Pages
- S29-S34
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W1983914274
- Cited by
- 363
- References
- 46
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 21
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (2P01 MH25642, MH-45481, P01MH025642)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- synaptic plasticity, mood disorders, depression, bipolar disorder, CREB, brain-derived neurotrophic factor, neurotrophic factors, transcription factors, atypical antipsychotics, clozapine, olanzapine, neural circuits, antidepressant mechanism
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Synaptic Transmission, Neuronal Plasticity, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Mood Disorders
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