Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works

Insulin-promoter-factor 1 is required for pancreas development in mice

Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,879 · see citing works

Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

Lumelsky, N. L., Blondel, O., Laeng, P., Velasco, I., Ravin, R., & McKay, R. D. G. (2001) · Science · doi:10.1126/science.1058866 · Cited by 1,453 · see citing works

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells

Lee, S.-H., Lumelsky, N., Studer, L., Auerbach, J., & Mckay, R. (2000) · Nature Biotechnology · doi:10.1038/76536 · Cited by 1,347 · see citing works

Electrophysiology of the pancreatic β-cell

Ashcroft, F. M., & Rorsman, P. (1989) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(89)90013-8 · Cited by 1,127 · see citing works

In vitro cultivation of human islets from expanded ductal tissue

Bonner‐Weir, S., Taneja, M., Weir, G. C., Tatarkiewicz, K., Song, K., Sharma, A., & O’Neil, J. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7999 · Cited by 978 · see citing works

Insulin Staining of ES Cell Progeny from Insulin Uptake

Rajagopal, J., Anderson, W. J., Kume, S., Martinez, O. I., & Melton, D. A. (2003) · Science · doi:10.1126/science.1077838 · Cited by 931 · see citing works

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetesPreprint

Ahlgren, U., Jönsson, J., Jönsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918 · see citing works

Insulin Production by Human Embryonic Stem Cells

Assady, S., Maor, G., Amit, M., Itskovitz‐Eldor, J., Skorecki, K. L., & Tzukerman, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1691 · Cited by 906 · see citing works

Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

Soria, B., Roche, E., Berná, G., León‐Quinto, T., Reig, J. A., & Martı́n, F. (2000) · Diabetes · doi:10.2337/diabetes.49.2.157 · Cited by 862 · see citing works

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

Sosa‐Pineda, B., Chowdhury, K., Torres, M., Oliver, G. C., & Gruß, P. (1997) · Nature · doi:10.1038/386399a0 · Cited by 804 · see citing works

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

Zulewski, H., Abraham, E. J., Gerlach, M. J., Daniel, P. B., Moritz, W., Müller-Stich, B. P., Vallejo, M., Thomas, M. K., & Habener, J. F. (2001) · Diabetes · doi:10.2337/diabetes.50.3.521 · Cited by 785 · see citing works

Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells

Ramiya, V. K., Maraist, M., Arfors, K. E., Schatz, D., Peck, A. B., & Cornelius, J. (2000) · Nature Medicine · doi:10.1038/73128 · Cited by 694 · see citing works

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

Ahlgren, U., Pfaff, S. L., Jessell, T. M., Edlund, H., & Edlund, H. (1997) · Nature · doi:10.1038/385257a0 · Cited by 688 · see citing works

Nestin expression ? a property of multi-lineage progenitor cells?

Wiese, C., Rolletschek, A., Kania, G., Błyszczuk, P., Tarasov, K. V., Tarasova, Y. S., Wersto, R. P., Boheler, K. R., & Wobus, A. M. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4144-6 · Cited by 616 · see citing works

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

Seaberg, R. M., Smukler, S. R., Kieffer, T. J., Enikolopov, G., Shyr, Z. A., Wheeler, M. B., Korbutt, G. S., & van der Kooy, D. (2004) · Nature Biotechnology · doi:10.1038/nbt1004 · Cited by 558 · see citing works

Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics

Herrmann, H. O., & Aebi, U. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00060-5 · Cited by 517 · see citing works

Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells

Błyszczuk, P., Czyż, J., Kania, G., Wagner, M., Roll, U., St‐Onge, L., & Wobus, A. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237371100 · Cited by 439 · see citing works

Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

Hori, Y., Rulifson, I. C., Tsai, B. C., Heit, J. J., Cahoy, J. D., & Kim, S. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252618999 · Cited by 419 · see citing works

Rapid Movements of Vimentin on Microtubule Tracks: Kinesin-dependent Assembly of Intermediate Filament Networks

Prahlad, V., Yoon, M., Moir, R. D., Vale, R. D., & Goldman, R. D. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.1.159 · Cited by 348 · see citing works

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells

Miyazaki, S., Yamato, E., & Miyazaki, J. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1030 · Cited by 245 · see citing works

Single-cell transcript analysis of pancreas development.

Chiang, M.-K., & Melton, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00035-2 · Cited by 240 · see citing works

Voltage‐gated and resting membrane currents recorded from B‐cells in intact mouse pancreatic islets

Göpel, S., Kanno, T., Barg, S., Galvanovskis, J., & Rorsman, P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00717.x · Cited by 226 · see citing works

Artifactual Insulin Release From Differentiated Embryonic Stem Cells

Hansson, M., Tonning, A., Frandsen, U., Petri, A., Rajagopal, J., Englund, M. C. O., Heller, R. S., Håkansson, J., Fleckner, J., Sköld, H. N., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2603 · Cited by 225 · see citing works

Embryonic Stem Cells as a Model to Study Cardiac, Skeletal Muscle, and Vascular Smooth Muscle Cell Differentiation

Wobus, A. M., Guan, K., Yang, H., & Boheler, K. R. (2003) · Humana Press eBooks · doi:10.1385/1-59259-241-4:127 · Cited by 220 · see citing works

Nestin expression in pancreatic stellate cells and angiogenic endothelial cells

Lardon, J., Rooman, I., & Bouwens, L. (2002) · Histochemistry and Cell Biology · doi:10.1007/s00418-002-0412-4 · Cited by 215 · see citing works

Proliferation and differentiation in the human fetal endocrine pancreas

Bouwens, L., Lu, W., & de Krijger, R. R. (1997) · Diabetologia · doi:10.1007/s001250050693 · Cited by 183 · see citing works

In-vitro differentiation of pancreatic β-cells

Soria, B. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.680408.x · Cited by 177 · see citing works

Insulin expressing cells from differentiated embryonic stem cells are not beta cells

Sipione, S., Eshpeter, A., Lyon, J. G., Korbutt, G. S., & Bleackley, R. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1349-z · Cited by 176 · see citing works

In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells

León‐Quinto, T., Jones, J., Skoudy, A., Burcin, M. M., & Soria, B. (2004) · Diabetologia · doi:10.1007/s00125-004-1458-8 · Cited by 173 · see citing works

Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas

Selander, L., & Edlund, H. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00023-0 · Cited by 171 · see citing works

Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: present state and future prospects

Rohwedel, J., Guan, K., Hegert, C., & Wobus, A. M. (2001) · Toxicology in Vitro · doi:10.1016/s0887-2333(01)00074-1 · Cited by 168 · see citing works

Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas

Dohrmann, C. E., Gruß, P., & Lemaire, L. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00324-x · Cited by 168 · see citing works

Nestin-Expressing Cells in the Pancreatic Islets of Langerhans

Hunziker, E., & Stein, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2611 · Cited by 160 · see citing works

Analysis of Insulin-Producing Cells During In Vitro Differentiation From Feeder-Free Embryonic Stem Cells

Moritoh, Y., Yamato, E., Yasui, Y., Miyazaki, S., & Miyazaki, J. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1163 · Cited by 152 · see citing works

Nestin expression in pancreatic exocrine cell lineages

Delacour, A., Népote, V., Trumpp, A., & Herrera, P. L. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.11.004 · Cited by 142 · see citing works

Potential of Embryonic and Adult Stem Cells in vitro

Czyż, J., Wiese, C., Rolletschek, A., Błyszczuk, P., Cross, M. A., & Wobus, A. M. (2003) · Biological Chemistry · doi:10.1515/bc.2003.155 · Cited by 138 · see citing works

Differentiation of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promoting factors

Rolletschek, A., Chang, H., Guan, K., Czyż, J., Meyer, M., & Wobus, A. M. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00385-9 · Cited by 138 · see citing works

Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice

Omer, A., Duvivier-Kali, V. F., Trivedi, N., Wilmot, K., Bonner‐Weir, S., & Weir, G. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.69 · Cited by 136 · see citing works

A novel approach to in situ characterization of pancreatic β-cells

Speier, S., & Rupnik, M. S. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1097-9 · Cited by 126 · see citing works

Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas.

Esni, F., Stoffers, D., Takeuchi, T., & Leach, S. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2003.08.010 · Cited by 119 · see citing works

Nestin Is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas

Klein, T., Ling, Z., Heimberg, H., Madsen, O. D., Heller, R. S., & Serup, P. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305100601 · Cited by 108 · see citing works

Cosecretion of amylin and insulin from isolated rat pancreas

Fehmann, H. C., Weber, V., Göke, R., Göke, B., & Arnold, R. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80210-a · Cited by 90 · see citing works

Expression of Carbonic Anhydrase V in Pancreatic Beta Cells Suggests Role for Mitochondrial Carbonic Anhydrase in Insulin Secretion

Parkkila, A., Scarim, A. L., Parkkila, S., Waheed, A., Corbett, J. A., & Sly, W. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24620 · Cited by 81 · see citing works

SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma, and non-malignant pulmonary diseases

Galateau-Sallé, F., Bidet, P., Iwatsubo, Y., Gennetay, E., Renier, A., Letourneux, M., Pairon, J. ‐., Moritz, S., Brochard, P., Jaurand, M., et al. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199803)184:3 · Cited by 80 · see citing works

Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

Humphrey, R. K., Bucay, N., Beattie, G. M., Lopez, A. D., Messam, C. A., Cirulli, V., & Hayek, A. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2519 · Cited by 71 · see citing works

The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

Brembeck, F. H., Moffett, J., Wang, T. C., & Rustgi, A. K. (2001) · Gastroenterology · doi:10.1053/gast.2001.24846 · Cited by 67 · see citing works

Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19, and 20 in vivo and after isolation and culture.

Bouwens, L., Braet, F., & Heimberg, H. (1995) · Journal of Histochemistry & Cytochemistry · doi:10.1177/43.3.7532655 · Cited by 64 · see citing works

Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes.

Jochheim-Richter, A., Hillemann, T., Kania, G., Scharf, J., Attaran-Bandarabadi, M., Manns, M. P., Wobus, A. M., & Ott, M. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15005571 · Cited by 56 · see citing works

Differentiation of Mouse Embryonic Stem Cells into Pancreatic and Hepatic Cells

Kania, G., Błyszczuk, P., Czyż, J., Santos, A. N., & Wobus, A. M. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)65021-4 · Cited by 45 · see citing works

Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker

Street, C., Lakey, Seeberger, K. L., Helms, L., Rajotte, R. V., Shapiro, A. J., & Korbutt, G. S. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1800213 · Cited by 44 · see citing works

In vivo and in vitro development of mouse pancreatic �-cells in organotypic slices

Meneghel‐Rozzo, T., Rozzo, A., Poppi, L., & Rupnik, M. S. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0886-6 · Cited by 39 · see citing works

Carbonic Anhydrase II Gene Expression in Mouse Pancreatic Duct Cells

Githens, S., Schexnayder, J. A., & Frazier, M. L. (1992) · Pancreas · doi:10.1097/00006676-199209000-00008 · Cited by 10 · see citing works

The keratin 19 promoter is potent for cell-specific targeting of genes in transgenic mice

Brembeck, F. H., Wang, T. C., & Rustgi, A. K. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)83235-7 · Cited by 9 · see citing works

Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy

Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 777 · see citing works

New sources of pancreatic β-cells

Bonner‐Weir, S., & Weir, G. C. (2005) · Nature Biotechnology · doi:10.1038/nbt1115 · Cited by 390 · see citing works

Differentiation of mouse embryonic stem cells to insulin-producing cells

Schroeder, I. S., Rolletschek, A., Błyszczuk, P., Kania, G., & Wobus, A. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.71 · Cited by 114 · see citing works

Activin A-Induced Differentiation of Embryonic Stem Cells into Endoderm and Pancreatic Progenitors—The Influence of Differentiation Factors and Culture Conditions

Sulzbacher, S., Schroeder, I., Truong, T., & Wobus, A. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9061-5 · Cited by 107 · see citing works

Embryonic stem cell transplantation: potential applicability in cell replacement therapy and regenerative medicine

Douglas, C. W. (2007) · Frontiers in bioscience · doi:10.2741/2407 · Cited by 106 · see citing works

Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure

Sun, B., Roh, K.-H., Lee, S., Lee, Y.-S., & Kang, K. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.069 · Cited by 97 · see citing works

Embryonic Stem Cells and Their Differentiated Derivatives Have a Fragile Immune Privilege but Still Represent Novel Targets of Immune Attack

Wu, D. C., Boyd, A. S., & Wood, K. J. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0078 · Cited by 90 · see citing works

Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice

Kajiyama, H., Hamazaki, T. S., Tokuhara, M., Masui, S., Okabayashi, K., Ohnuma, K., Yabe, S. G., Yasuda, K., Ishiura, S., Okochi, H., et al. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.092953hk · Cited by 90 · see citing works

Directed engineering of umbilical cord blood stem cells to produce C‐peptide and insulin

Denner, L. A., Bodenburg, Y. H., Zhao, J. G., Howe, M. C., Cappo, J., Tilton, R. G., Copland, J. A., Forraz, N., McGUCKIN, C. P., & Urban, R. J. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00439.x · Cited by 79 · see citing works

Pluripotency of embryonic stem cells

Yamanaka, S., Li, J., Kania, G., Elliott, S., Wersto, R. P., Eyk, J. E. V., Wobus, A. M., & Boheler, K. R. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0520-5 · Cited by 78 · see citing works

Generation of insulin‐secreting cells from human embryonic stem cells

Baharvand, H., Jafary, H., Massumi, M., & Ashtiani, S. K. (2006) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2006.00867.x · Cited by 76 · see citing works

Are stem cells a cure for diabetes?

McCall, M., Toso, C., Baetge, E., & Shapiro, A. M. J. (2009) · Clinical science · doi:10.1042/cs20090072 · Cited by 72 · see citing works

Characterization of immortalized mesenchymal stem cells derived from foetal porcine pancreas

Cao, H., Chu, Y., Zhu, H., Sun, J., Pu, Y., Gao, Z., Yang, C., Peng, S., Dou, Z., & Hua, J. (2010) · Cell Proliferation · doi:10.1111/j.1365-2184.2010.00714.x · Cited by 65 · see citing works

A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE)

Hou, J., Charters, A. M., Lee, S. C., Zhao, Y., Wu, M. K., Jones, S. J., Marra, M. A., & Hoodless, P. A. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-92 · Cited by 56 · see citing works

Beta-cell replacement and regeneration: Strategies of cell-based therapy for type 1 diabetes mellitus

Limbert, C., Päth, G., Jakob, F. J., & Seufert, J. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.06.016 · Cited by 53 · see citing works

Stem Cells for the Treatment of Diabetes

Noguchi, H. (2007) · Endocrine Journal · doi:10.1507/endocrj.kr-86 · Cited by 52 · see citing works

On the origin of the β cellPreprint

Oliver-Krasinski, J. M., & Stoffers, D. A. (2008) · Genes & Development · doi:10.1101/gad.1670808 · Cited by 350 · see citing works

Human embryonic stem cells: Possibilities for human cell transplantation

Liew, C.-G., Moore, H. D. M., Ruban, L., Shah, N., Cosgrove, K. E., Dunne, M. J., & Andrews, P. W. (2005) · Annals of Medicine · doi:10.1080/07853890500379463 · Cited by 49 · see citing works

Exocytosis of Insulin

Rozzo, A., Meneghel‐Rozzo, T., Delakorda, S. L., Yang, S., & Rupnik, M. S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.04003.x · Cited by 48 · see citing works

Insulin - producing cells derived from stem cells: recent progress and future directions

Santana, A., Enseñat‐Waser, R., Arribas, M. I., Reig, J. A., & Roche, E. (2006) · Journal of Cellular and Molecular Medicine · doi:10.2755/jcmm010.004.06 · Cited by 45 · see citing works

Efficient suspension bioreactor expansion of murine embryonic stem cells on microcarriers in serum‐free medium

Alfred, R., Radford, J., Fan, J. H., Boon, K., Krawetz, R. J., Rancourt, D. E., & Kallos, M. S. (2011) · Biotechnology Progress · doi:10.1002/btpr.591 · Cited by 45 · see citing works

Human adipose tissue stem cells: relevance in the pathophysiology of obesity and metabolic diseases and therapeutic applications

Cignarelli, A., Perrini, S., Ficarella, R., Peschechera, A., Nigro, P., & Giorgino, F. (2012) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2012.13 · Cited by 41 · see citing works

Toward cell-based therapy of type I diabetes.

Kabelitz, D., Geissler, E., Soria, B., Schroeder, I., Fändrich, F., & Chatenoud, L. (2008) · Trends in immunology · doi:10.1016/j.it.2007.11.001 · Cited by 45 · see citing works

A Comparison of Protocols Used to Generate Insulin-Producing Cell Clusters from Mouse Embryonic Stem Cells

Boyd, A. S., Wu, D. C., Higashi, Y., & Wood, K. J. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0762 · Cited by 40 · see citing works

In vivo characterization of transplanted human embryonic stem cell‐derived pancreatic endocrine islet cells

Eshpeter, A., Jiang, J., Au, M., Rajotte, R. V., Lu, K., LEBKOWSKI, J. S., Majumdar, A. S., & Korbutt, G. S. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00564.x · Cited by 39 · see citing works

Efficient and Simple Production of Insulin-Producing Cells from Embryonal Carcinoma Stem Cells Using Mouse Neonate Pancreas Extract, As a Natural Inducer

Ebrahimie, M., Esmaeili, F., Cheraghi, S., Houshmand, F., Shabani, L., & Ebrahimie, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090885 · Cited by 42 · see citing works

Differentiation of Stem Cells into Insulin-Producing Cells: Current Status and Challenges

Pokrywczyńska, M., Krzyzanowska, S., Jundziłł, A., Adamowicz, J., & Drewa, T. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0213-y · Cited by 29 · see citing works

Pancreatic Islet-Like Clusters from Bone Marrow Mesenchymal Stem Cells of Human First-Trimester Abortus Can Cure Streptozocin-Induced Mouse Diabetes

Zhang, Y.-H., Shen, W.-Z., Hua, J., Lei, A.-M., Lv, C., Wang, H.-Y., Yang, C.-R., Gao, Z.-M., & Dou, Z. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.1016 · Cited by 36 · see citing works

The Culture of Mouse Embryonic Stem Cells and Formation of Embryoid Bodies

Jackson, M., Taylor, A. H., Jones, E. A., & Forrester, L. M. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-019-5_1 · Cited by 36 · see citing works

Diabetes treatment: A rapid review of the current and future scope of stem cell research

Abdulazeez, S. S. (2013) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.12.012 · Cited by 28 · see citing works

Identification and expansion of pancreatic stem/progenitor cells

Zhang, Y.-Q., Kritzik, M. R., & Sarvetnick, N. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00359.x · Cited by 34 · see citing works

Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters

Boyd, A. S., & Wood, K. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010965 · Cited by 32 · see citing works

Insulin - producing cells derived from stem cells: recent progress and future directions

Santana, A., Enseñat‐Waser, R., Arribas, M. I., Reig, J. A., & Roche, E. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00531.x · Cited by 33 · see citing works

A two-stage perfusion fibrous bed bioreactor system for mass production of embryonic stem cells

Ouyang, A., & Yang, S. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.7.895 · Cited by 30 · see citing works

Potential Stemness of Frozen-Thawed Testicular Biopsies without Sperm in Infertile Men Included into theIn VitroFertilization Programme

Štimpfel, M., Skutella, T., Kubista, M., Maličev, E., Conrad, S., & Virant‐Klun, I. (2012) · BioMed Research International · doi:10.1155/2012/291038 · Cited by 30 · see citing works

Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method

Lin, H. T. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i11.1672 · Cited by 30 · see citing works

Measurement of T1, T2, and magnetization transfer properties during embryonic development at 7 Tesla using the chicken model

Boss, A., Oppitz, M., Wehrl, H. F., Rossi, C., Feuerstein, M., Claussen, C. D., Drews, U., Pichler, B. J., & Schick, F. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21601 · Cited by 30 · see citing works

Stem cells in the treatment of diabetes

Otonkoski, T., Gao, R., & Lundin, K. (2005) · Annals of Medicine · doi:10.1080/07853890500300279 · Cited by 29 · see citing works

Induction of differentiation of undifferentiated cells into pancreatic beta cells in vertebrates.

Hosoya, M., Kunisada, Y., Kurisaki, A., & Asashima, M. (2012) · International Journal of Developmental Biology · doi:10.1387/ijdb.123522mh · Cited by 30 · see citing works

The physiology of rodent beta‐cells in pancreas slices

Rupnik, M. S. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01927.x · Cited by 25 · see citing works

Expression of Pdx1 mediates differentiation from mesenchymal stem cells into insulin-producing cells

Yuan, H., Li, J., Xin, N., Zhao, Z., & Qin, G. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0061-y · Cited by 27 · see citing works

Role of stem cells during diabetic liver injury

Wan, Y., Garner, J., Wu, N., Levine, P., Han, Y., McDaniel, K. M., Annable, T., Zhou, T., Francis, H., Glaser, S. S., et al. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12723 · Cited by 27 · see citing works

Generation of pancreatic insulin-producing cells from embryonic stem cells — ‘Proof of principle’, but questions still unanswered

Rolletschek, A., Kania, G., & Wobus, A. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0441-y · Cited by 27 · see citing works

Differentiation into Endoderm Lineage: Pancreatic differentiation from Embryonic Stem Cells

Lee, D. H., & Chung, H. (2011) · International Journal of Stem Cells · doi:10.15283/ijsc.2011.4.1.35 · Cited by 26 · see citing works

Current advanced therapy cell-based medicinal products for type-1-diabetes treatment

Cañibano-Hernández, A., del Burgo, L. S., Espona‐Noguera, A., Ciriza, J., & Pedraz, J. L. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.03.041 · Cited by 26 · see citing works

β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells

Corritore, E., Lee, Y.-S., Sokal, E. M., & Lysy, P. A. (2016) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018816652059 · Cited by 25 · see citing works

Treatment options for diabetes: potential role of stem cells.

Stanekzai, J., Isenović, E., & Mousa, S. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.09.010 · Cited by 23 · see citing works

Three-Dimensional Extracellular Matrix Stimulates Gastrulation-like Events in Human Embryoid Bodies

Rust, W. L., Sadasivam, A., & Dunn, N. R. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.889 · Cited by 24 · see citing works

Hedgehog signals in pancreatic differentiation from embryonic stem cells: revisiting the neglected

Mfopou, J. K., & Bouwens, L. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00191.x · Cited by 23 · see citing works

Genetic modification of cells for transplantation.

Lai, Y., Drobinskaya, I., Kolossov, E., Chen, C.-G., & Linn, T. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.039 · Cited by 25 · see citing works

Strategies for Developing Therapeutic Application of Human Embryonic Stem Cells

Raikwar, S. P., Mueller, T. M., & Zavazava, N. (2006) · Physiology · doi:10.1152/physiol.00034.2005 · Cited by 22 · see citing works

Serum‐free scaled up expansion and differentiation of murine embryonic stem cells to osteoblasts in suspension bioreactors

Alfred, R., Gareau, T., Krawetz, R. J., Rancourt, D. E., & Kallos, M. S. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22727 · Cited by 21 · see citing works

Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin‐producing cells in vitro and in vivo

Naujok, O., Francini, F., Picton, S., Bailey, C., Lenzen, S., & Jörns, A. (2009) · Diabetes/Metabolism Research Reviews · doi:10.1002/dmrr.965 · Cited by 22 · see citing works

Stem cell therapy to treat diabetes mellitus.

Liew, C., & Andrews, P. (2008) · The review of diabetic studies : RDS · doi:10.1900/rds.2008.5.203 · Cited by 15 · see citing works

Differentiation of chicken umbilical cord mesenchymal stem cells into beta-like pancreatic islet cells

Bai, C., Gao, Y., Li, Q., Feng, Y., Yu, Y., Meng, G., Zhang, M., & Guan, W. (2013) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2013.864662 · Cited by 18 · see citing works

Regenerative medicine of the pancreatic β cells

Yamada, S., & Kojima, I. (2005) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-005-0983-2 · Cited by 17 · see citing works

Differentiation Analysis of Pluripotent Mouse Embryonic Stem (ES) Cells In Vitro

Schroeder, I. S., Wiese, C., Truong, T. T., Rolletschek, A., & Wobus, A. M. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_12 · Cited by 16 · see citing works

An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin‐19‐positive population of insulin‐producing cells

Naujok, O., Francini, F., Jörns, A., & Lenzen, S. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00541.x · Cited by 17 · see citing works

Induction and Selection of Sox17-Expressing Endoderm Cells Generated from Murine Embryonic Stem Cells

Schroeder, I., Sulzbacher, S., Nolden, T., Fuchs, J., Czarnota, J., Meisterfeld, R., Himmelbauer, H., & Wobus, A. (2011) · Cells Tissues Organs · doi:10.1159/000329864 · Cited by 16 · see citing works

Characterization of mouse embryonic stem cell differentiation into the pancreatic lineage in vitro by transcriptional profiling, quantitative RT-PCR and immunocytochemistry.

Rolletschek, A., Schroeder, I., Schulz, H., Hummel, O., Huebner, N., & Wobus, A. (2010) · International Journal of Developmental Biology · doi:10.1387/ijdb.082694ar · Cited by 18 · see citing works

Therapie des Diabetes mellitus

Dieterle, C. D., Brendel, M. D., Seißler, J., Eckhard, M., Bretzel, R. G., & Landgraf, R. (2006) · Der Internist · doi:10.1007/s00108-006-1607-x · Cited by 16 · see citing works

Generation of Functional Islet-Like Clusters After Monolayer Culture and Intracapsular Aggregation of Adult Human Pancreatic Islet Tissue

Tsang, W.-G., Zheng, T., Wang, Y., Tang, J., Rind, H. B., Francki, A., & Bufius, N. (2007) · Transplantation · doi:10.1097/01.tp.0000256178.57359.4f · Cited by 15 · see citing works

Exendin-4 enhances expression of Neurod1 and Glut2 in insulin-producing cells derived from mouse embryonic stem cells

Zhao, Q., Yang, Y.-Z., Hu, J., Shan, Z.-Y., Wu, Y.-S., & Lei, L. (2016) · Archives of medical science : AMS · doi:10.5114/aoms.2016.57596 · Cited by 17 · see citing works

Stem Cells and Regenerative Medicine - A Review

Ramakrishna, V., Janardhan, P., & Sudarsanareddy, L. (2011) · Annual Research & Review in Biology · Cited by 15 · see citing works

Nuclear Proteomics and Directed Differentiation of Embryonic Stem Cells

Barthéléry, M., Salli, U., & Vrana, K. E. (2007) · Stem Cells and Development · doi:10.1089/scd.2007.0071 · Cited by 15 · see citing works

Redefining the signaling pathways from pluripotency to pancreas development: In vitro β‐cell differentiation

Hashemitabar, M., & Heidari, E. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27736 · Cited by 12 · see citing works

Differential effect of activin on mouse embryonic stem cell differentiation in insulin‐secreting cells under nestin‐positive selection and spontaneous differentiation protocols

Jafary, H., Larijani, B. A., Farrokhi, A., Pirouz, M., Mollamohammadi, S., & Baharvand, H. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.10.001 · Cited by 14 · see citing works

Insulin‐Producing Cells

Schroeder, I. S., Kania, G., Błyszczuk, P., & Wobus, A. M. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)18019-2 · Cited by 15 · see citing works

Mouse ES cells over-expressing the transcription factor NeuroD1 show increased differentiation towards endocrine lineages and insulin-expressing cells.

Marchand, M., Schroeder, I., Markossian, S., Skoudy, A., Nègre, D., Cosset, F., Real, P., Kaiser, C., Wobus, A., & Savatier, P. (2009) · International Journal of Developmental Biology · doi:10.1387/ijdb.092856mm · Cited by 18 · see citing works

Blood into β-Cells: Can Adult Stem Cells be Used as a Therapy for Type 1 Diabetes?

Palma, C. A., Lindeman, R., & Tuch, B. E. (2007) · Regenerative Medicine · doi:10.2217/17460751.3.1.33 · Cited by 13 · see citing works

Therapeutic Potential of Stem Cells in Diabetes

Roche, E., Enseñat‐Waser, R., Reig, J. A., Jones, J., León‐Quinto, T., & Soria, B. (2006) · Handbook of experimental pharmacology · doi:10.1007/3-540-31265-x_7 · Cited by 11 · see citing works

In Vitro Differentiation of Human Umbilical Cord Blood CD133(+)Cells into Insulin Producing Cells in Co-Culture with Rat Pancreatic Mesenchymal Stem Cells.

Samani, F. S., Ebrahimi, M., Zandieh, T., Khoshchehreh, R., Eslaminejad, M. B., Aghdami, N., & Baharvand, H. (2015) · PubMed Central · doi:10.22074/cellj.2016.3717 · Cited by 10 · see citing works

Differentiation of the mesenchymal stem cells to pancreatic β-like cells in alginate/trimethyl chitosan/alginate microcapsules

Hosseini, S. R., Hashemi‐Najafabadi, S., & Bagheri, F. (2022) · Progress in Biomaterials · doi:10.1007/s40204-022-00194-7 · Cited by 9 · see citing works

Therapeutic Potential of Stem Cells in Diabetes

Roche, E., Enseñat‐Waser, R., Reig, J. A., Jones, J., León‐Quinto, T., & Soria, B. (2008) · Springer eBooks · doi:10.1007/978-3-540-77855-4_7 · Cited by 8 · see citing works

Reduced serum concentration is permissive for increased in vitro endocrine differentiation from murine embryonic stem cells.

Vincent, R. K., & Odorico, J. (2009) · Differentiation; research in biological diversity · doi:10.1016/j.diff.2009.03.006 · Cited by 10 · see citing works

What Can We Learn about Breast Cancer from Stem Cells?

Clarke, M. F. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-69080-3_2 · Cited by 8 · see citing works

Beyond Islet Transplantation in Diabetes Cell Therapy: From Embryonic Stem Cells to Transdifferentiation of Adult Cells

Gioviale, M. C., Bellavia, M., Damiano, G., & Monte, A. I. L. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.01.076 · Cited by 7 · see citing works

Cytokeratin 19 (CK19) as a marker for Epithelial Differentiation and Malignant Transformation: Its Clinical relevance in Diagnosis, Prognosis and Treatment response monitoring

Mujyambere, B., Jayaraj, R., & Suja, S. R. (2018) · Iconic Research and Engineering Journals · Cited by 7 · see citing works

Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro

Yu, M. S., & Tanese, N. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00033 · Cited by 6 · see citing works

Rat Pancreatic Stromal Cells (PSC) affect Differentiation of Human Mesenchymal Stem Cells (hMSC) into Insulin-Producing Cells (IPCs) In vitro

Khoshchehreh, R., Ebrahimi, M., Eslaminejad, M. B., Aghdami, N., Samani, F. S., & Baharvand, H. (2012) · Journal of Cell Science & Therapy · doi:10.4172/2157-7013.1000130 · Cited by 5 · see citing works

Milestones of Pancreatic Beta Cell Differentiation from Embryonic Stem Cells

Mfopou, J. K. (2007) · VUBIR (Vrije Universiteit Brussel) · Cited by 5 · see citing works

Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells

Bieberich, E. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.07.042 · Cited by 3 · see citing works

Stem Cell Therapies in Regenerative Medicine and Diabetes Mellitus: Advances, Constraints and Future Prospects

(2016) · Journal of Transplantation & Stem Cell Biology · doi:10.13188/2374-9326.1000009 · Cited by 3 · see citing works

Cell Sources for Treating Diabetes

Sahu, S., Mugdha, V., Yang, S. N. Y., & Anandwardhan, A. (2011) · InTech eBooks · doi:10.5772/24174 · Cited by 2 · see citing works

Cells of mouse submandibular salivary gland in culture in vitro

Gvazava, I. G., Васильев, А. В., Балан, О. В., & Terskikh, V. V. (2011) · Cell and Tissue Biology · doi:10.1134/s1990519x1102009x · Cited by 2 · see citing works

Use of Embryonic Stem Cells for Endocrine Disorders

Trounson, A. O. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097547 · Cited by 2 · see citing works

Pluripotency and differentiation in embryos and stem cells - Pavia, 17-18 January 2008

Adjaye, J., Byskov, A. G., Cibelli, J. B., Maria, R. D., Minger, S. L., Sampaolesi, M., Testa, G., Verfaillie, C. M., Zernicka‐Goetz, M., Boiani, M., et al. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082695ja · Cited by 2 · see citing works

Cell Therapy in Type 1 Diabetes

Gioviale, M. C., Bellavia, M., & Damiano, G. (2011) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.s2-004 · Cited by 2 · see citing works

Pancreatic Cell Differentiation

Fishman, B., Segev, H., & Itskovitz‐Eldor, J. (2007) · Human cell culture · doi:10.1007/978-1-4020-5983-4_11 · Cited by 1 · see citing works

Kinetics of Gene Expression During Exposure of Mouse Stem Cells to Activin A

Hashemi-Ta, M., Orazizadeh, M., Ghanbari, A., & Dehbashi, F. N. (2009) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2009.324.331 · Cited by 1 · see citing works

Murine CD133+CD49flow/+ Cells Derived from ESCs Differentiate into Insulin Producing Cells in vivo

Ciriza, J. (2014) · International Journal of Stem cell Research & Therapy · doi:10.23937/2469-570x/1410004 · Cited by 1 · see citing works

Stem Cell Therapy for Diabetes: Are We Close Enough?

Kadam, S. S. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works

Embryonic stem cell-based therapy for the treatment of diabetes mellitus: a work in progress

Magliocca, J. F., & Odorico, J. S. (2006) · Current Opinion in Organ Transplantation · doi:10.1097/01.mot.0000203883.87439.27 · Cited by 1 · see citing works

Pancreas Biology, Pathology, and Tissue Engineering

Macfarlane, W., Bone, A., & Harrison, M. (2009) · Springer eBooks · doi:10.1007/978-0-387-74660-9_8 · Cited by 3 · see citing works

Die Funktion des Wnt Antagonisten XsFRP5 während der frühembryonalen Musterbildung des Entoderms in Xenopus laevis

Damianitsch, K. (2008) · doi:10.53846/goediss-3453

Stem Cell Therapies for Type I Diabetes

Ciriza, J., & Manilay, J. O. (2012) · InTech eBooks · doi:10.5772/47803

Diferenciação de células-tronco embrionárias murinas (mESCs) em células produtoras de insulina (IPCs) e caracterização funcional do gene Purkinje cell protein 4 (Pcp4) neste processo

Kossugue, P. M. (2013) · doi:10.11606/t.46.2013.tde-09082013-085011

Stem cells: The therapeutic role in the treatment of diabetes mellitus

Adams, G. G., Buttery, L. D. K., Stolnik, S., Morris, G. A., Harding, S. E., & Wang, N. (2010) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2010.10648154

Strategies for Pancreatic Differentiation of Pluripotent Stem Cells

Schroeder, I. S., Daniel-Wójcik, A., & Wobus, A. M. (2011) · Springer eBooks · doi:10.1007/978-94-007-0884-6_28

The generation of insulin-producing cells from embryonic stem cells - a discussion of controversial findings

Kania, G., Błyszczuk, P., & Wobus, A. M. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041925gk · Cited by 41 · see citing works

In Vitro Differentiation of Embryonic Stem Cells Into the Pancreatic Lineage

Błyszczuk, P., & Wobus, A. M. (2006) · Humana Press eBooks · doi:10.1385/1-59745-036-7:373 · Cited by 14 · see citing works

Insulin‐Producing Cells

Schroeder, I. S., Kania, G., Błyszczuk, P., & Wobus, A. M. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)18019-2 · Cited by 15 · see citing works

Pdx-1-independent differentiation of mouse embryonic stem cells into insulin-expressing cells

Takayama, I., Miyazaki, S., Tashiro, F., Fujikura, J., Miyazaki, J., & Yamato, E. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.08.013 · Cited by 5 · see citing works

Experimental study on embryonic stem cell derived nestin positive cells differentiated into insulin-producing cells

Li, Y. (2007) · Shengwu yixue gongcheng yu linchuang