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Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro
Open accessAbstract
We have studied the effects of dentin proteins, of Transforming Growth Factor beta 1 (TGF beta 1) and Bone Morphogenetic Protein (BMP2) on the differentiation of odontoblasts in vitro. The total EDTA-soluble fraction of dentin proteins, prepared from rabbit incisors was further separated by chromatography on DEAE-Cellulose and heparin-agarose columns. While the total EDTA-soluble fraction of dentin had no effect on cultured dental papillae, fractions retained on both columns were able to initiate functional differentiation of preodontoblasts of isolated day-17 first lower mouse molar dental papillae cultured in vitro. TGF beta 1 and BMP2, both stimulated the matrix secretion by dental papillae cells. TGF beta 1 and BMP2, combined with the inactive total EDTA-soluble fraction, stimulated odontoblast differentiation. An active fraction retained on DEAE-Cellulose completely lost the inductive activity after incubation with a neutralizing anti-TGF beta antibody. These results demonstrate that a TGF beta-like molecule present in dentin could interact with some component which acts as a modulator of its activity on the initiation of the cytological and functional differentiation of odontoblasts.
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Citations
Cited by
The Application of Tissue Engineering to Regeneration of Pulp and Dentin in Endodontics
Nakashima, M., & Akamine, A. (2005) · Journal of Endodontics · doi:10.1097/01.don.0000164138.49923.e5 · Cited by 435
Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics
Galler, K. M., D’Souza, R. N., Federlin, M., Cavender, A. C., Hartgerink, J. D., Hecker, S., & Schmalz, G. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.08.027 · Cited by 323
Nakashima, M. (1994) · Journal of Dental Research · doi:10.1177/00220345940730090601 · Cited by 275
Palosaari, H., Pennington, C. J., Larmas, M., Edwards, D. R., Tjäderhane, L., & Salo, T. (2003) · European Journal Of Oral Sciences · doi:10.1034/j.1600-0722.2003.00026.x · Cited by 188
Smith, A. J., Tobias, R. S., Cassidy, N., Bégue-Kirn, C., Ruch, J. V., & Lesot, H. (1995) · Connective Tissue Research · doi:10.3109/03008209509013736 · Cited by 43
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Metadata
- Authors
- Begue-Kirn, C., Smith, A. J., Ruch, J. V., Wozney, J. M., Purchio, A., Hartmann, D., & Lesot, H.
- Venue
- The International Journal of Developmental Biology
- Publisher
- EHU Press
- Published
- 1992
- Volume
- 36
- Issue
- 4
- Pages
- 491-503
- ISSN
- 0214-6282 (ISSN-L)
- 1696-3547
- OpenAlex
- W2225905028
- Cited by
- 288
- References
- 0
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro. https://app.cochat.ai/papers/10.1387/ijdb.1295560
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- Begue-Kirn, C., Smith, A. J., Ruch, J. V., Wozney, J. M., Purchio, A., Hartmann, D., & Lesot, H. (1992). Effects of dentin proteins, transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 (BMP2) on the differentiation of odontoblast in vitro. The International Journal of Developmental Biology. https://doi.org/10.1387/ijdb.1295560
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